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Design and fabrication of low-noise superconducting quantum interference device magnetometer

Hao-Xuan Han, Guo-Feng Zhang, Xue Zhang, Tian-Tian Liang, Li-Liang Ying, Yong-Liang Wang, Wei Peng, Zhen Wang
2019 Wuli xuebao  
韩昊轩 1)2)3) 张国峰 1)2) † 张雪 1)2)3) 梁恬恬 1)2)3) 应利良 1)2) 王永良 1)2) 彭炜 1)2)3) 王镇 1)2)3) 1) (中国科学院上海微系统与信息技术研究所,信息功能材料国家重点实验室,上海 200050) 2) (中国科学院超导电子学卓越创新中心,上海 200050) 3) (中国科学院大学,北京 100049)
doi:10.7498/aps.68.20190483 fatcat:7elmkf4urnfntojhoptkleor3a

Tensor index for large scale image retrieval

Liang Zheng, Shengjin Wang, Peizhen Guo, Hanyue Liang, Qi Tian
2014 Multimedia Systems  
discriminative power of visual words, thus improving precision; on the other hand, the introduction of multiple codebooks corrects quantization artifacts, thus improving recall. Extensive experiments on two benchmark datasets demonstrate that tensor index significantly improves the baseline approach. Moreover, when incorporating methods such as Hamming embedding, we achieve competitive performances compared to the state-of-the-art ones.
doi:10.1007/s00530-014-0415-8 fatcat:g6vz6okgffgkpfepc4zsd72uaa

HAUS8 regulates RLR‑VISA antiviral signaling positively by targeting VISA

Tian‑Sheng He, Tian Chen, Dan‑Dan Wang, Liang‑Guo Xu
2018 Molecular Medicine Reports  
Mitochondrial anti-viral signaling protein (VISA), additionally termed MAVS, IPS-1 and Cardif, is located at the outer membrane of mitochondria and is an essential adaptor in the Rig-like receptor (RLRs) signaling pathway. Upon viral infection, activated RLRs interact with VISA on mitochondria, forming a RLR-VISA platform, leading to the recruitment of different TRAF family members, including TRAF3, TRAF2 and TRAF6. This results in the phosphorylation and nuclear translocation of interferon
more » ... latory factors 3 and 7 (IRF3/IRF7) by TANK binding kinase 1 (TBK1) and/or IKKε, as well as activation of NF-κB, to induce type I interferons (IFNs) and pro-inflammatory cytokines. It remains to be elucidated how VISA functions as a scaffold for protein complex assembly in mitochondria to regulate RLR-VISA antiviral signaling. In the present study, it was demonstrated that HAUS augmin like complex subunit 8 (HAUS8) augments the RLR-VISA-dependent antiviral signaling pathway by targeting the VISA complex. Co-immunoprecipitation verified that HAUS8 was associated with VISA and the VISA signaling complex components retinoic acid-inducible gene I (RIG-I) and TBK1 when the RLR-VISA signaling pathway was activated. The data demonstrated that overexpression of HAUS8 significantly promoted the activity of the transcription factors NF-κB, IRF3 and the IFN-β promoter induced by Sendai virus-mediated RLR-VISA signaling. HAUS8 increased the polyubiquitination of VISA, RIG-I and TBK1. Knockdown of HAUS8 inhibited the activation of the transcription factors IRF-3, NF-κB and the IFN-β promoter triggered by Sendai virus. Collectively, these results demonstrated that HAUS8 may function as a positive regulator of RLR-VISA dependent antiviral signaling by targeting the VISA complex, providing a novel regulatory mechanism of antiviral responses.
doi:10.3892/mmr.2018.9171 pmid:29916539 fatcat:vcjj2cpgafcrfbif3zqjdh7wqu

MicroRNA-210 promotes angiogenesis in acute myocardial infarction

Zhong‑Guo Fan, Xin‑Liang Qu, Peng Chu, Ya‑Li Gao, Xiao‑Fei Gao, Shao‑Liang Chen, Nai‑Liang Tian
2018 Molecular Medicine Reports  
has been reported to be associated with angiogenesis and may serve important roles in acute myocardial infarction (AMI), which remain unclear. The present study sought to evaluate the efficacy of miRNA-210 in AMI and to examine the potential associated mechanisms. AMI models were established in Sprague-Dawley rats. The expression of miRNA-210 was upregulated via transfection with lentivirus-mediated agonists and quantitative analysis was performed using the reverse transcription-quantitative
more » ... ymerase chain reaction (RT-qPCR). Immunoblotting and RT-qPCR were separately used to detect the expression levels of hepatocyte growth factor (HGF) in heart samples, while only the protein expression level of β-myosin heavy chain (β-MHC) was assessed. The expression of HGF in human umbilical vein endothelial cells under hypoxic conditions was silenced by transfecting with small interfering RNA, as demonstrated by the determination of associated protein expression levels. The microvessel density (MVD) of the infarcted myocardium was selected to be the angiogenesis efficacy endpoint, which was evaluated by platelet endothelial cell adhesion molecule immunostaining. Markedly increased expression of HGF was observed among the AMI rats receiving miRNA-210 agonists, demonstrated via quantitative analyses using RT-qPCR or western blotting. Promotion of angiogenesis was observed with the increased MVD. Improved cardiac function in the rats was subsequently noted, as they exhibited improved left ventricular fractional shortening and left ventricular ejection fraction percentages, which may result from improved cardiac contractility indicated by attenuating the increase in β-MHC protein expression. Overexpression of miRNA-210 appeared to be an advantageous therapeutic tool for treating AMI, primarily due to its promoting effects on angiogenesis in the infarcted myocardium by stimulating HGF expression and inducing improved left ventricular remodeling, leading to improved cardiac function.
doi:10.3892/mmr.2018.8620 pmid:29484401 pmcid:PMC5866007 fatcat:6cocskawdzdmpe525xf6qcq5ji

Design, Synthesis and Antifungal Activity of Novel Benzofuran-Triazole Hybrids

Zhen Liang, Hang Xu, Ye Tian, Mengbi Guo, Xin Su, Chun Guo
2016 Molecules  
Author Contributions: Zhen Liang designed and carried out the experiments and wrote the paper; Hang Xu, Ye Tian, Mengbi Guo assisted in experiments; Xin Su supervised and directed the biological assays  ...  ; Chun Guo supervised the whole experiment and provided technical guidance.  ... 
doi:10.3390/molecules21060732 pmid:27338311 fatcat:gtog24i26rgznpkbzai7w2k6oy

AMID is a p53-inducible gene downregulated in tumors

Min Wu, Liang-Guo Xu, Tian Su, Yang Tian, Zhonghe Zhai, Hong-Bing Shu
2004 Oncogene  
doi:10.1038/sj.onc.1207909 pmid:15273740 fatcat:nbxfjp7sajaspo3jlm3rq2j65q

Active and Passive Demethylation of Male and Female Pronuclear DNA in the Mammalian Zygote

Fan Guo, Xianlong Li, Dan Liang, Tong Li, Ping Zhu, Hongshan Guo, Xinglong Wu, Lu Wen, Tian-Peng Gu, Boqiang Hu, Colum P. Walsh, Jinsong Li (+2 others)
2014 Cell Stem Cell  
Reduced Representation Bisulfite Sequencing The RRBS was performed following the protocol we recently developed (Guo et al., 2013) .  ...  individually from one-cell zygotes and determined the methylomes at base resolution on a genome-wide scale using an improved reduced representation bisulfite sequencing (RRBS) approach we recently developed (Guo  ... 
doi:10.1016/j.stem.2014.08.003 pmid:25220291 fatcat:yv3poynt3nap3cd5jqv3zqdx2e

Impulsive fractional functional differential equations

Tian Liang Guo, Wei Jiang
2012 Computers and Mathematics with Applications  
In this paper, a class of impulsive fractional functional differential equations is investigated. The first purpose is introducing a natural formula of solutions for impulsive fractional functional differential equations. The second purpose is establishing related new existence, uniqueness and data dependence results. Examples are given to illustrate the results.
doi:10.1016/j.camwa.2011.12.054 fatcat:7hpd5uj3vngyda4ce5oawfegea

Research Progress on Stem Cell Therapies for Articular Cartilage Regeneration

Shuangpeng Jiang, Guangzhao Tian, Xu Li, Zhen Yang, Fuxin Wang, Zhuang Tian, Bo Huang, Fu Wei, Kangkang Zha, Zhiqiang Sun, Xiang Sui, Shuyun Liu (+3 others)
2021 Stem Cells International  
Authors' Contributions Shuangpeng Jiang and Guangzhao Tian contributed equally to this work. Figure 1 : 1 Two theories of articular cartilage regeneration involving stem cells.  ... 
doi:10.1155/2021/8882505 pmid:33628274 pmcid:PMC7895563 fatcat:lbh7fboqv5bw5arwvl56e2v4o4

Sunflower response to potassium fertilization and nutrient requirement estimation

Shu-tian LI, Yu DUAN, Tian-wen GUO, Ping-liang ZHANG, Ping HE, Kaushik Majumdar
2018 Journal of Integrative Agriculture  
Field experiments were conducted in oil and edible sunflower to study the effects of potassium (K) fertilization on achene yield and quality, and to estimate the nutrient internal efficiency (IE) and nutrient requirement in sunflower production. All trials in edible sunflower and 75% trials in oil sunflower showed positive yield responses to K fertilization. Compared with control without K fertilization, the application of K increased achene yield by an average of 406 kg ha -1 for oil sunflower
more » ... and 294 kg ha -1 for edible sunflower. K application also increased 1 000-achene weight and kernel rate of both oil and edible sunflower. K fertilization improved the contents of oil, oleic acid, linoleic acid and linolenic acid in achenes of oil sunflower, and increased contents of oil, total unsaturated fatty acid and protein in achenes of edible sunflower. The average agronomic efficiency of K fertilizer was 4.0 for oil sunflower and 3.0 kg achene kg -1 K 2 O for edible sunflower. The average IE of N, P and K under balanced NPK fertilization was 22.9, 82.8, and 9.9 kg kg -1 for oil sunflower, and 27.3, 138.9, and 14.3 kg kg -1 for edible sunflower. These values were equivalent to 45.5, 14.1, and 108.1 kg, and 39.0, 8.0, and 71.7 kg of N, P and K, respectively, in above-ground dry matter required for production per ton of achenes. The average harvest index of N, P and K was 0.47, 0.56 and 0.05 kg kg -1 in oil sunflower, and 0.58, 0.58 and 0.14 kg kg -1 in edible sunflower.
doi:10.1016/s2095-3119(18)62074-x fatcat:qzqvkhctoreq5jd3t3sjms2txu

Three-Dimensional Face Reconstruction Using Multi-View-Based Bilinear Model

Liang Tian, Jing Liu, Wei Guo
2019 Sensors  
Face reconstruction is a popular topic in 3D vision system. However, traditional methods often depend on monocular cues, which contain few feature pixels and only use their location information while ignoring a lot of textural information. Furthermore, they are affected by the accuracy of the feature extraction method and occlusion. Here, we propose a novel facial reconstruction framework that accurately extracts the 3D shapes and poses of faces from images captured at multi-views. It extends
more » ... e traditional method using the monocular bilinear model to the multi-view-based bilinear model by incorporating the feature prior constraint and the texture constraint, which are learned from multi-view images. The feature prior constraint is used as a shape prior to allowing us to estimate accurate 3D facial contours. Furthermore, the texture constraint extracts a high-precision 3D facial shape where traditional methods fail because of their limited number of feature points or the mostly texture-less and texture-repetitive nature of the input images. Meanwhile, it fully explores the implied 3D information of the multi-view images, which also enhances the robustness of the results. Additionally, the proposed method uses only two or more uncalibrated images with an arbitrary baseline, estimating calibration and shape simultaneously. A comparison with the state-of-the-art monocular bilinear model-based method shows that the proposed method has a significantly higher level of accuracy.
doi:10.3390/s19030459 fatcat:vlrhchyjvvd43i4e4i4gprjse4

Homogeneity Test of Ratio of Two Proportions in Stratified Bilateral Data

Tingting Zhuang, Guo-Liang Tian, Chang-Xing Ma
2018 Figshare  
Homogeneity is a nonnegligible condition in the statistical analysis of the stratified bilateral data. The correlation between responses from two paired body parts should be taken into account to avoid biased or misleading results. In this article, we derive four test statistics (i.e., likelihood ratio statistic TL, Wald-type statistic TW, and score statistics TSCa and TSCb) for testing common ratios of two proportions across strata under the assumption of equal correlation coefficient within
more » ... ch stratum. Monte Carlo simulations show that the score test (TSCb) generally produces robust Type I error and satisfactory power. Two real examples are used to demonstrate the performance of the four proposed tests. Supplementary materials for this article are available online.
doi:10.6084/m9.figshare.7334765.v1 fatcat:muteomjetncqpfhga7v3x2tm4e

Establishment and application of a multiplex genetic mutation-detection method of lung cancer based on MassARRAY platform

Hong-Xia Tian, Hong-Xia Tian, Xu-Chao Zhang, Zhen Wang, Jian-Guang Chen, Shi-Liang Chen, Wei-Bang Guo, Yi-Long Wu, Xu-Chao Zhang, Zhen Wang, Jian-Guang Chen, Shi-Liang Chen (+2 others)
2016 Cancer Biology and Medicine  
Objective: This study aims to establish a method for highly parallel multiplexed detection of genetic mutations in Chinese lung cancer samples through Agena iPLEX chemistry and matrix-assisted laser desorption ionization time-of-flight analysis on MassARRAY mass spectrometry platform. Methods: We reviewed the related literature and data on lung cancer treatments. We also identified 99 mutation hot spots in 13 target genes closely related to the pathogenesis, drug resistance, and metastasis of
more » ... ng cancer. A total of 297 primers, composed of 99 paired forward and reverse amplification primers and 99 matched extension primers, were designed using Assay Design software. The detection method was established by analyzing eight cell lines and six lung cancer specimens. The proposed method was then validated through comparisons by using a LungCarta TM kit. The sensitivity and specificity of the proposed method were evaluated by directly sequencing EGFR and KRAS genes in 100 lung cancer cases. Results: The proposed method was able to detect multiplex genetic mutations in lung cancer cell lines. This finding was consistent with the observations on previously reported mutations. The proposed method can also detect such mutations in clinical lung cancer specimens. This result was consistent with the observations with LungCarta TM kit. However, an FGFR2 mutation was detected only through the proposed method. The measured sensitivity and specificity were 100% and 96.3%, respectively. Conclusions: The proposed MassARRAY technology-based multiplex method can detect genetic mutations in Chinese lung cancer patients. Therefore, the proposed method can be applied to detect mutations in other cancer tissues.
doi:10.20892/j.issn.2095-3941.2015.0094 fatcat:7imlmbjxzvcrhnshmaljugnglu

SRSF3 functions as an oncogene in colorectal cancer by regulating the expression of ArhGAP30

Ji-Lin Wang, Chun-Rong Guo, Tian-Tian Sun, Wen-Yu Su, Qiang Hu, Fang-Fang Guo, Lun-Xi Liang, Jie Xu, Hua Xiong, Jing-Yuan Fang
2020 Cancer Cell International  
Splicing factor SRSF3 is an oncogene and overexpressed in various kinds of cancers, however, the function and mechanism involved in colorectal cancer (CRC) remained unclear. The aim of this study was to explore the relationship between SRSF3 and carcinogenesis and progression of CRC. The expression of SRSF3 in CRC tissues was detected by immunohistochemistry. The proliferation and invasion rate was analyzed by CCK-8 assay, colony formation assay, transwell invasion assay and xenograft
more » ... . The expression of selected genes was detected by western blot or real time PCR. SRSF3 is overexpressed in CRC tissues and its high expression was associated with CRC differentiation, lymph node invasion and AJCC stage. Upregulation of SRSF3 was also associated with shorter overall survival. Knockdown of SRSF3 in CRC cells activated ArhGAP30/Ace-p53 and decreased cell proliferation, migration and survival; while ectopic expression of SRSF3 attenuated ArhGAP30/Ace-p53 and increases cell proliferation, migration and survival. Targeting SRSF3 in xenograft tumors suppressed tumor progression in vivo. Taken together, our data identify SRSF3 as a regulator for ArhGAP30/Ace-p53 in CRC, and highlight potential prognostic and therapeutic significance of SRSF3 in CRC.
doi:10.1186/s12935-020-01201-2 pmid:32308565 pmcid:PMC7149931 fatcat:3wk6y2ia4na4vk4anufrl3vcxu

Clinical characteristics of COVID-19 complicated with pleural effusion

Na Zhan, Yingyun Guo, Shan Tian, Binglu Huang, Xiaoli Tian, Jinjing Zou, Qiutang Xiong, Dongling Tang, Liang Zhang, Weiguo Dong
2021 BMC Infectious Diseases  
Wei-guo Dong. Consent for publication Not applicable. Competing interests All authors declared no conflict of interest.  ... 
doi:10.1186/s12879-021-05856-8 pmid:33588779 fatcat:dp44p4qyfvhvnekcemqixn6gaa
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