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Long-lasting airway inflammation associated with equid herpesvirus-2 in experimentally challenged horses

Guillaume Fortier, Eric Richard, Erika Hue, Christine Fortier, Stéphane Pronost, Didier Pottier, Laurent Lemaitre, Pierre Lekeux, Kerstin Borchers, Etienne Thiry
2013 The Veterinary Journal  
Please cite this article in press as: Fortier, G., et al. Long-lasting airway inflammation associated with equid herpesvirus-2 in experimentally challenged horses.  ...  Clinical signs associated with EHV-2 lack specificity, ranging from mild respiratory signs in some animals to severe outbreaks in large groups of young horses (Fortier et al., 2010) .  ... 
doi:10.1016/j.tvjl.2012.12.027 pmid:23433569 fatcat:tvk22jh5qfaxdfq4yqcsjw2hfm

Chronique de jurisprudence

Guillaume Busseuil, Jean-Marie Garinot, Clotilde Jourdain-Fortier, Isabelle Moine-Dupuis
2010 Revue internationale de droit économique  
Jourdain-Fortier ; 2.1.1 et 2.2 rédigés par J.-M. Garinot. 7.  ...  Jourdain-Fortier, I. Moine-Depuis, RIDE, 2009, n° 4, p. 465.  ... 
doi:10.3917/ride.244.0475 fatcat:sgddljhuzvbqvikx3ee7omntmq

Equine PBMC Cytokines Profile after In Vitro α- and γ-EHV Infection: Efficacy of a Parapoxvirus Ovis Based-Immunomodulator Treatment

Erika Hue, Eric Richard, Christine Fortier, Guillaume Fortier, Romain Paillot, Rudiger Raue, Stéphane Pronost
2017 Vaccines  
doi:10.3390/vaccines5030028 pmid:28925977 pmcid:PMC5620559 fatcat:xowdmllv7bgttcwghgs4wvghwi

Herpesviruses in respiratory liquids of horses: Putative implication in airway inflammation and association with cytological features

Guillaume Fortier, Emmanuelle van Erck, Christine Fortier, Eric Richard, Didier Pottier, Stéphane Pronost, Fabien Miszczak, Etienne Thiry, Pierre Lekeux
2009 Veterinary Microbiology  
Aust.Vet.J. 79, 695-702. 358 Fortier, G., Pronost, S., Miszczak, F., Fortier, C., Leon, A., Richard, E., Van Erck, E., Thiry, 359 E., Lekeux, P., 2008.  ...  DNA from American Type Culture Collection 111 reference strains for EHV-1 (Kentucky reference strain, KyA), EHV-2 (LK strain) and EHV-4 112 strain 405/76 and DNA from our laboratory for EHV-5 (Fortier  ... 
doi:10.1016/j.vetmic.2009.04.021 pmid:19427139 fatcat:zh4s5c3mdbah7ajijpwwy2cl4y

Chronique de jurisprudence

Guillaume Busseuil, Jean-Marie Garinot, Clotilde Jourdain-Fortier, Isabelle Moine-Dupuis, Valérie Pironon
2013 Revue internationale de droit économique  
Jourdain-Fortier. 9.  ...  Jourdain-Fortier à propos de l'affaire Brésil -Pneumatiques rechapés 117 , sera regardée plus sévèrement, et les exigences à propos de son effectivité dans la réalisation de l'objectif plus importantes  ... 
doi:10.3917/ride.273.0333 fatcat:5x53dzcuxzd3rjxifjm6jmuboa

Automatic micromanipulation using multiscale visual servoing

Brahim Tamadazte, Sounkalo Dembele, Guillaume Fortier, Nadine Le Fort-Piat
2008 2008 IEEE International Conference on Automation Science and Engineering  
The paper deals with the manipulation of silicon microcomponents in order to assembly automatically. The size of the components vary from 600µm×400µm×100µm to 300µm×300µm×100µm with a notch of 100µm thickness on every side. The microassembly process is split up into elementary tasks (aligning component, positioning component, centering component, opening gripper, ...) where every one is achieved by visual servoing. The control laws are of the type exponential or polynomial decrease of error
more » ... rding to the task. The performing of the latter has required the implementation of an effective tracking algorithm in combination with a depthfrom-focus technique in order to maintain the target in focus and to recover the distance between the gripper and the component. The process includes the adaptation of the video microscope magnification to the required resolution (coarse to fine servoings). A multiple scale modelling and calibration of the photon video microscope is performed. The picking and placing of above components were achieved : the errors of positioning are respectively 1.4 µm in x and y and 0.5 degree in orientation.
doi:10.1109/coase.2008.4626460 dblp:conf/case/TamadazteDFF08 fatcat:6tqpv5tw3rb65f5un3622fsy2m

Ileal antimicrobial peptide expression is dysregulated in old age

Sarah Tremblay, Nathalie Marie Louise Côté, Guillaume Grenier, Gabriella Duclos-Lasnier, Louis-Charles Fortier, Subburaj Ilangumaran, Alfredo Menendez
2017 Immunity & Ageing  
In an effort to understand the mechanisms underlying the high prevalence of gastrointestinal tract disorders in old age, we investigated the expression of intestinal antimicrobial peptides in the terminal small intestine of aged mice. Our results show that old mice have reduced transcript levels of ileal α-defensins and lysozyme, two important types of intestinal antimicrobial peptides produced by Paneth cells. In contrast, expression of the C-type lectins Reg3b and Reg3g, as well as β-defensin
more » ... 1, angiogenin 4 and Relmb, which are made by several epithelial cell types, was significantly upregulated in aged animals suggesting an ongoing response to epithelial distress. Those changes in antimicrobial peptide gene expression associated with histological damage of the ileal epithelium and subtle modifications in the composition of the commensal microbiota. Our findings suggest that dysregulation of antimicrobial peptides expression is a feature of homeostasis disruption in the aged intestine and may contribute to geriatric gastrointestinal dysfunction.
doi:10.1186/s12979-017-0101-8 pmid:28855949 pmcid:PMC5575895 fatcat:rllnpgt6dfacnk6zatr6vyyxk4

Curvature Sensing Using a Novel Hybrid Polycarbonate-Silica Multicore Fiber

Tommy Boilard, Guillaume Bilodeau, Steeve Morency, Younes Messaddeq, Richard Fortier, Francois Trepanier, Martin Bernier
2020 Optics Express  
We report on the development of a novel hybrid glass-polymer multicore fiber integrating three 80 µm polyimide-coated silica fibers inside a 750 µm polycarbonate cladding. By inscribing an array of distributed FBGs along each segment of silica fiber prior to the hybrid fiber drawing, we demonstrate a curvature sensor with an unprecedented precision of 296 pm/m-1 around 1550 nm, about 7 times more sensitive than sensors based on standard 125 µm multicore fibers. As predicted by theory, we show
more » ... perimentally that the measured curvature is insensitive to temperature and strain. Also, a more precise equation to describe the curvature on a simple bending setup is presented. This new hybrid multicore fiber technology has the potential to be extended over several kilometers and can find high-end applications in 3D shape sensing and structural health monitoring.
doi:10.1364/oe.411363 pmid:33379489 fatcat:ysfukdkkb5dmtlrkbfuabio3rq

Improving rotation behaviour of robotic structures for micro-assembly

David Heriban, Arnaud Thiebault, Michael Gauthier, Guillaume Fortier
2008 2008 IEEE International Conference on Automation Science and Engineering  
Serial micro-assembly requires high precision robots able to produce translations and rotations to position and orient objects during assembly. In micro-scale, the translation ranges required are typically up to the millimeter and can be obtained with smart devices (piezomotor, etc.). In the other hand, the rotation ranges stay identical to the macroscale (eg. 90°) and require standard guidings like ball bearings which induce disturbances on the linear position. Thus the ability to produce high
more » ... precision robots where translations and rotations are decoupled is currently one of the major stake in microassembly. This paper deals with an original modeling of the coupling between rotation and linear position. The geometrical model is presented and two calibration methods are discussed. Our method were tested on a 3 DOF planar robotic systems and the coupling was reduced by 93%.
doi:10.1109/coase.2008.4626490 dblp:conf/case/HeribanTGF08 fatcat:6m6jbsml4vetnh2n74ondwiqbu

Herpès virus en pathologie équine : connaissances actuelles et perspectives

Guillaume FORTIER, Pierre-Hugues PITEL, Karine MAILLARD, Stéphane PRONOST
2003 Bulletin de l Académie vétérinaire de France  
(d'après Fortier et al. dans Proceeding des journées AVEF 2002-Le Touquet).  ...  .• FORTIER G, PRONOST S, PITEL PH, MOUSSU C, ZIENTARA S (2003) Equine Rhinopneumonia and Influenza in France: Diagnosis protocols and situation.  ... 
doi:10.4267/2042/47626 fatcat:my3jj7y7zfdf3mqv6lcva2cozq

Supplementary document for Curvature Sensing Using a Novel Hybrid Polycarbonate-Silica Multicore Fiber - 4966364.pdf

Tommy Boilard, Guillaume Bilodeau, Steeve Morency, Younes Messaddeq, Richard Fortier, Francois Trepanier, Martin Bernier
Supplement 1
doi:10.6084/m9.figshare.13336682.v2 fatcat:orzf7oamuvgntaxdh72fozobju

Supplementary document for Curvature Sensing Using a Novel Hybrid Polycarbonate-Silica Multicore Fiber - 4966364.pdf

Tommy Boilard, Guillaume Bilodeau, Steeve Morency, Younes Messaddeq, Richard Fortier, Francois Trepanier, Martin Bernier
Supplement 1
doi:10.6084/m9.figshare.13336682.v1 fatcat:isvbhdzqdzbthesyn6qdkoa7oy

Impacts of COVID on University's Finances

Pier-André Bouchard St-Amant, Yanick Wilfred Tadjiogue, Lucie Raymond-Brousseau, Camille Fortier-Martineau, Franck-Aurelien Tchokouagueu, Guillaume Dumais, Laurence Vallée
2020 International Research in Higher Education  
Did universities benefit from the pandemic? Some did receive more funding than usual. We use vector autoregressive models to forecast both enrollment and public subsidies in a jurisdiction where public funding depends mostly on enrollment. Using unemployment as an established proxy for the impact of recessions on enrollment, we show that the recent COVID pandemic increases pressure on public subsidies. Further, we use our forecasts to decompose the current subsidies between long-term subsidies,
more » ... recession induced subsidies, and additional funding. We find that the subsidies given during the pandemic were higher than what a typical recession would command for 8 universities out of 18.
doi:10.5430/irhe.v5n3p37 fatcat:won36j6qajfpdlwc4m2drro3ja

Multiple molecular detection of respiratory viruses and associated signs of airway inflammation in racehorses

Nadia Doubli-Bounoua, Eric A. Richard, Albertine Léon, Pierre-Hugues Pitel, Stéphane Pronost, Guillaume Fortier
2016 Virology Journal  
The potential involvement of viruses in inflammatory airway disease (IAD) was previously investigated through either serology or PCR from nasopharyngeal swabs (NS). The aims of this study were to determine the prevalence and incidence of viral genome detection by qPCR in the equine airways, and their association with respiratory clinical signs. Methods: Both NS and tracheal washes (TW) were collected monthly on 52 Standardbred racehorses at training, over 27 consecutive months (581 samples).
more » ... id herpesviruses (EHV)-1, −4, −2 and −5, equine rhinitis virus-A and -B (ERBV), equine adenovirus-1 and −2, equine coronavirus and equine influenza virus were systematically investigated in both NS and TW. Nasal discharge, coughing, tracheal mucus score and TW neutrophil proportions were simultaneously recorded. Results: Genome for 7/10 viruses were detected at least once throughout the study; up to 4 different viruses being also concomitantly detected. Monthly incidence in TW was respectively 27.9% (EHV-5), 24.8% (EHV-2), 7.1% (ERBV), 3.8% (EHV-4), 1.9% (EAdV1) and 0.2% (EHV-1; ERAV). Neither agreement nor correlation between NS and TW was found for respectively genome detection and viral loads. Detection of viral genome in NS was not associated with any clinical sign. Coughing was significantly associated with TW detection of EHV-2 DNA (OR 3.1; P = 0.01) and ERBV RNA (OR 5.3; P < 0.001). Detection of EHV-2 DNA in TW was also significantly associated with excess tracheal mucus (OR 2.1; P = 0.02). Conclusions: Detection and quantification of EHV-2 and ERBV by qPCR in TW, but not in NS, should be considered when investigating horses with IAD.
doi:10.1186/s12985-016-0657-5 pmid:27899161 pmcid:PMC5129218 fatcat:bzacpuxfdbhi3jthpuqyenxtle

FKBP5 Moderates the Association between Antenatal Maternal Depressive Symptoms and Neonatal Brain Morphology

Changqing Wang, Mojun Shen, Bryan Guillaume, Yap-Seng Chong, Helen Chen, Marielle V Fortier, Michael J Meaney, Anqi Qiu
2017 Neuropsychopharmacology  
Antenatal maternal depressive symptoms influence fetal brain development and increase the risk for depression in offspring. Such vulnerability is often moderated by the offspring's genetic variants. This study aimed to examine whether FKBP5, a key regulator of the hypothalamic-pituitary-adrenal (HPA) axis, moderates the association between antenatal maternal depressive symptoms and in utero brain development, using an Asian cohort with 161 mother-offspring dyads. Antenatal maternal depressive
more » ... mptoms were measured using the Edinburgh Postnatal Depression Scale (EPDS) during the second trimester of pregnancy. Neonatal structural brain images were acquired using magnetic resonance imaging (MRI) shortly after birth. Maternal and neonatal FKBP5 gene was genotyped using Illumina OmniExpress arrays. A gene set-based mixed effect model for gene-environment interaction (MixGE) was used to examine interactive effects between neonatal genetic variants of FKBP5 and antenatal maternal depressive symptoms on neonatal amygdala and hippocampal volumes, and cortical thickness. Our study revealed that genetic variants in neonatal FKBP5 moderate the association between antenatal maternal depressive symptoms and right hippocampal volume but only show a trend for such moderation on amygdala volumes and cortical thickness. Our findings are the first to reveal that the association between maternal depressive symptoms and in utero neurodevelopment of specific brain regions is modified through complex genetic variation in neonatal FKBP5. Our results suggest that an increased risk for depression may be transmitted from mother to child during fetal life and that the effect is dependent upon neonatal FKBP5 genotype.
doi:10.1038/npp.2017.232 pmid:28975925 fatcat:nul7gjvydvejlkcveatjufak4m
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