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Controlled Drug Delivery Using Microdevices
<span title="2016-06-06">2016</span>
<i title="Bentham Science Publishers Ltd.">
<a target="_blank" rel="noopener" href="https://fatcat.wiki/container/jtrgituzsbhlnocyztzahww7kq" style="color: black;">Current Pharmaceutical Biotechnology</a>
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Therapeutic drugs administered systematically are evenly distributed to the whole body through blood circulation and have to cross many biological barriers before reaching the pathological site. Conventional drug delivery may make drugs inactive or reduce their potency as they may be hydrolyzed or degraded enzymatically and are rapidly excreted through the urinary system resulting in suboptimal concentration of drugs at the desired site. Controlled drug delivery aims to localize the
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<a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2174/1389201017666160127110440">doi:10.2174/1389201017666160127110440</a>
<a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/26813304">pmid:26813304</a>
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... cal activity of the drug to the desired site at desired release rates. The advances made by micro/nanofluidic technologies have provided new opportunities for bettercontrolled drug delivery. Various components of a drug delivery system can be integrated within a single tiny micro/nanofluidic chip. This article reviews recent advances of controlled drug delivery made by microfluidic/nanofluidic technologies. We first discuss microreservoir-based drug delivery systems. Then we highlight different kinds of microneedles used for controlled drug delivery, followed with a brief discussion about the current limitations and the future prospects of controlled drug delivery systems.
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Multi-scale image semantic recognition with hierarchical visual vocabulary
<span title="">2011</span>
<i title="National Library of Serbia">
<a target="_blank" rel="noopener" href="https://fatcat.wiki/container/rhtuh2ifczhapmhplqzald63za" style="color: black;">Computer Science and Information Systems</a>
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Local features have been proved to be effective in image/video semantic analysis. The BOVW (bag of visual words) scheme can cluster local features to form the visual vocabulary which includes an amount of words, where each word is the center of one clustering feature. The vocabulary is used to recognize the image semantic. In this paper, a new scheme to construct semantic-binding hierarchical visual vocabulary is proposed. Some attributes and relationship of the semantic nodes in the model are
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... iscussed. The hierarchical semantic model is used to organize the multi-scale semantic into a level-by-level structure. Experiments are performed based on the LabelMe dataset, the performance of our scheme is evaluated and compared with the traditional BOVW scheme, experimental results demonstrate the efficiency and flexibility of our scheme.
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A Low-Frequency MEMS Magnetoelectric Antenna Based on Mechanical Resonance
<span title="2022-05-30">2022</span>
<i title="MDPI AG">
<a target="_blank" rel="noopener" href="https://fatcat.wiki/container/4clw6v34prcbvk2usotmbz6v3q" style="color: black;">Micromachines</a>
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Antenna miniaturization technology has been a challenging problem in the field of antenna design. The demand for antenna miniaturization is even stronger because of the larger size of the antenna in the low-frequency band. In this paper, we consider MEMS magnetoelectric antennas based on mechanical resonance, which sense the magnetic fields of electromagnetic waves through the magnetoelectric (ME) effect at their mechanical resonance frequencies, giving a voltage output. A 70 μm diameter
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<a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/mi13060864">doi:10.3390/mi13060864</a>
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... ver disk with SiO2/Cr/Au/AlN/Cr/Au/FeGaB stacked layers is prepared on a 300 μm silicon wafer using the five-masks micromachining process. The MEMS magnetoelectric antenna showed a giant ME coefficient is 2.928 kV/cm/Oe in mechanical resonance at 224.1 kHz. In addition, we demonstrate the ability of this MEMS magnetoelectric antenna to receive low-frequency signals. This MEMS magnetoelectric antenna can provide new ideas for miniaturization of low-frequency wireless communication systems. Meanwhile, it has the potential to detect weak electromagnetic field signals.
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Biomarker detection for disease diagnosis using cost-effective microfluidic platforms
<span title="">2015</span>
<i title="Royal Society of Chemistry (RSC)">
<a target="_blank" rel="noopener" href="https://fatcat.wiki/container/z67ov6nbqjbm3ed3ajuqegnudi" style="color: black;">The Analyst</a>
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Guanglei Fu
Microfluidic platforms for biomarker detection In the early stage of microfluidics, microfluidic devices were predominantly made with methods borrowed from microelectronics field and involved ...
Fu received his Ph.D. in biomedical engineering in 2013 from Harbin Institute of Technology, China. ...
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A Novel Self-adaptation Differential Energy Video Watermarking Scheme in Copyright Protection
<span title="2009-06-01">2009</span>
<i title="Academy Publisher">
<a target="_blank" rel="noopener" href="https://fatcat.wiki/container/p7gn6vnxj5hqpb5gvaqprypf4u" style="color: black;">Journal of Multimedia</a>
</i>
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This paper proposes a novel self-adaptation differential energy watermarking based on the Watson visual model, which inserts robust watermark into video streaming according to the differential energy theory. This algorithm can control the watermark's embedding intensity of sub-low AC coefficients in the video streaming adaptively based on the Watson visual model. And it also can be self-adaptive cheesed that the region should be embed watermarks according to the relationship between the energy
<span class="external-identifiers">
<a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.4304/jmm.4.3.153-160">doi:10.4304/jmm.4.3.153-160</a>
<a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/bnng6psipvbcpgz4h2nfzjpqbu">fatcat:bnng6psipvbcpgz4h2nfzjpqbu</a>
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... djustable threshold and their differential energy. So watermark not only meets the non-visual perception, but also has the better robustness. Experiments show that this algorithm has strong robustness and security against the usual video attacks such as noise, filter and compression attack etc with low complexity of energy computation and high capacity.
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Nanoparticle-mediated photothermal effect enables a new method for quantitative biochemical analysis using a thermometer
<span title="">2016</span>
<i title="Royal Society of Chemistry (RSC)">
<a target="_blank" rel="noopener" href="https://fatcat.wiki/container/ugccpkgktvgjxkzlcyxrfrfqeq" style="color: black;">Nanoscale</a>
</i>
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Based on the nanoparticle-mediated photothermal effect, a new photothermal biomolecular quantitation method using a common thermometer as the signal reader was developed.
<span class="external-identifiers">
<a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1039/c5nr09051b">doi:10.1039/c5nr09051b</a>
<a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/26838516">pmid:26838516</a>
<a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5106188/">pmcid:PMC5106188</a>
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Prussian blue nanoparticles operate as a new generation of photothermal ablation agents for cancer therapy
<span title="">2012</span>
<i title="Royal Society of Chemistry (RSC)">
<a target="_blank" rel="noopener" href="https://fatcat.wiki/container/eb2lcnpf2zeezkmfckcvxw2pgi" style="color: black;">Chemical Communications</a>
</i>
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Cost-effective and sensitive colorimetric immunosensing using an iron oxide-to-Prussian blue nanoparticle conversion strategy
<span title="">2016</span>
<i title="Royal Society of Chemistry (RSC)">
<a target="_blank" rel="noopener" href="https://fatcat.wiki/container/z67ov6nbqjbm3ed3ajuqegnudi" style="color: black;">The Analyst</a>
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A novel iron oxide-to-Prussian blue nanoparticle conversion strategy has been developed and applied to a sensitive, cost-effective and user-friendly colorimetric immunoassay without the aid of any complex signal amplification processes.
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<a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/27140740">pmid:27140740</a>
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Progress in the surgical treatment of the patellar fracture
<span title="2021-08-15">2021</span>
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<a target="_blank" rel="noopener" href="https://fatcat.wiki/container/tkev2pyrhjbzlo4xyin7u4vww4" style="color: black;">Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery</a>
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To review research progress of surgical treatment of patellar fractures. The domestic and foreign literature about patellar fracture treatment in recent years was extensively consulted, and the advantages, disadvantages, and indications of various surgical treatments were summarized. The patella plays an important role in knee flexion and extension activities, and the fracture significantly affects the patient's quality of life. At present, the surgical methods include open reduction and
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<a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.7507/1002-1892.202104068">doi:10.7507/1002-1892.202104068</a>
<a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/34387438">pmid:34387438</a>
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... l fixation and patella resection. The internal fixation methods include ring/binding patella fixation, tension band wiring and improved technology, tension band wiring combined with other methods, screw fixation (including absorbable screws), steel plate fixation, and patella fixator fixation. Each surgical method has different indications, advantages, and disadvantages. Choosing an appropriate treatment plan plays a crucial role in clinical prognosis. There are many surgical treatments for patellar fractures. In order to improve the effectiveness and reduce postoperative complications, it is necessary to choose the most appropriate treatment strategy for the type of fracture.
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Lithium storage in a highly conductive Cu3Ge boosted Ge/graphene aerogel
<span title="">2015</span>
<i title="Royal Society of Chemistry (RSC)">
<a target="_blank" rel="noopener" href="https://fatcat.wiki/container/axzcvrir3bc2lazizd7q2innqi" style="color: black;">Journal of Materials Chemistry A</a>
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A Cu3Ge/Ge@G aerogel was synthesized via a simple pyrolysis route and directly employed as a high performance anode for lithium-ion batteries.
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Adaptive and Acquired Resistance to EGFR Inhibitors Converge on the MAPK Pathway
<span title="">2016</span>
<i title="Ivyspring International Publisher">
<a target="_blank" rel="noopener" href="https://fatcat.wiki/container/7doy657d75hpdkozsdchkxsg34" style="color: black;">Theranostics</a>
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Both adaptive and acquired resistance significantly limits the efficacy of the epidermal growth factor receptor (EGFR) kinase inhibitors. However, the distinct or common mechanisms of adaptive and acquired resistance have not been fully characterized. Here, through systematic modeling of erlotinib resistance in lung cancer, we found that feedback reactivation of MAPK signaling following erlotinib treatment, which was dependent on the MET receptor, contributed to the adaptive resistance of EGFR
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... nhibitors. Interestingly, acquired resistance to erlotinib was also associated with the MAPK pathway activation as a result of CRAF or NRAS amplification. Consequently, combined inhibition of EGFR and MAPK impeded the development of both adaptive and acquired resistance. These observations demonstrate that adaptive and acquired resistance to EGFR inhibitors can converge on the same pathway and credential cotargeting EGFR and MAPK as a promising therapeutic approach in EGFR mutant tumors.
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Cu2GeS3 derived ultrafine nanoparticles as high-performance anode for sodium ion battery
<span title="2018-03-16">2018</span>
<i title="Springer Nature America, Inc">
<a target="_blank" rel="noopener" href="https://fatcat.wiki/container/bsp6mcrluvf77gro5i6fxehtxi" style="color: black;">Science China Materials</a>
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Author contributions Fu L, Shang C and Cui G conceived the experiment and carried out data analysis. Ma J, Zhang C, Zang X, Chai J and Li J assisted in experimental work. ...
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Effect of Surface Charge of Immortalized Mouse Cerebral Endothelial Cell Monolayer on Transport of Charged Solutes
<span title="2010-01-20">2010</span>
<i title="Springer Nature">
<a target="_blank" rel="noopener" href="https://fatcat.wiki/container/imwgooosl5b4lgzai3w2my5g5y" style="color: black;">Annals of Biomedical Engineering</a>
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We also used a modified theoretical model from Fu et al. 18 to predict the L f using the anatomical parameters of bEnd3 monolayer, either measured in the current study or from the literature. ...
The influence of the free dye on measured permeability to a labeled protein was discussed by Fu et al. 16 The FITC-labeled a-lactalbumin and ribonuclease were stored frozen and used within 2 week of ...
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Theaflavin alleviates inflammatory response and brain injury induced by cerebral hemorrhage via inhibiting the nuclear transcription factor kappa β-related pathway in rats
<span title="">2018</span>
<i title="Dove Medical Press Ltd.">
<a target="_blank" rel="noopener" href="https://fatcat.wiki/container/fiqgu2g3kfawzan3zs5ni7lrfy" style="color: black;">Drug Design, Development and Therapy</a>
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Drug Design, Development and Therapy 2018:12 submit your manuscript | www.dovepress.com Dovepress
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Drug Design, Development and Therapy 2018:12 submit your manuscript | www.dovepress.com Fu ...
Therapy 2018:12 submit your manuscript | www.dovepress.com Dovepress
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Drug Design, Development and Therapy 2018:12 submit your manuscript | www.dovepress.com Dovepress
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1612
Fu ...
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Transcellular Model for Neutral and Charged Nanoparticles Across an In Vitro Blood–Brain Barrier
<span title="2020-10-28">2020</span>
<i title="Springer Science and Business Media LLC">
<a target="_blank" rel="noopener" href="https://fatcat.wiki/container/i7izflr6qzgcxj6ng5kemf3rhu" style="color: black;">Cardiovascular Engineering and Technology</a>
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The therapeutic drug-loaded nanoparticles (NPs, 20-100 nm) have been widely used to treat brain disorders. To improve systemic brain delivery efficacy of these NPs, it is necessary to quantify their transport parameters across the blood-brain barrier (BBB) and understand the underlying transport mechanism. Permeability of an in vitro BBB, bEnd3 (mouse brain microvascular endothelial cells) monolayer, to three neutral NPs with the representative diameters was measured using an automated
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... er system. To elucidate the transport mechanism of the neutral NPs across the in vitro BBB, and that of positively charged NPs whose BBB permeability was measured in a previous study, we developed a novel transcellular model, which incorporates the charge of the in vitro BBB, the mechanical property of the cell membrane, the ion concentrations of the surrounding salt solution and the size and charge of the NPs. Our model indicates that the negative charge of the surface glycocalyx and basement membrane of the BBB plays a pivotal role in the transcelluar transport of NPs with diameter 20-100 nm across the BBB. The electrostatic force between the negative charge at the in vitro BBB and the positive charge at NPs greatly enhances NP permeability. The predictions from our transcellular model fit very well with the measured BBB permeability for both neutral and charged NPs. Our model can be used to predict the optimal size and charge of the NPs and the optimal charge of the BBB for an optimal systemic drug delivery strategy to the brain.
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