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Growth simulation of human embryo brain

S. Czanner, R. Durikovic, H. Inoue
Proceedings Spring Conference on Computer Graphics  
We employed this to create a growth simulation of the human embryo brain. The idea of this technique is the following.  ...  The growth of the brain of human embryo is changing through a long time in the body of mother. So it is very difficult to observe and to understand that process.  ...  Acknowledgements Authors wish to thank Mineo Yasuda from Medical School of Hiroshima University for sharing the knowledge as an embryologist.  ... 
doi:10.1109/sccg.2001.945348 fatcat:ls4w5j3hvvakfkf7ktmaqy4piq

Researches in National Institute of Radiological Sciences (NIRS) for radiation protection of non-human biota and ecosystems in Japanese environment

S. Yoshida, N. Ishii, Y. Ishikawa, I. Kawaguchi, Y. Kubota, K. Tagami, H. Takeda, M. Doi, T. Nakamori, T. Ban-nai, A. Fujimori, S. Fuma (+5 others)
2009 Radioprotection - Revue de la Societé Francaise de Radioprotection  
Dose-effect relationships of acute gamma radiation on the survival, growth, and reproduction of selected organisms have been studied.  ...  The microcosm has been simulated as a computer simulation code. Developments of more complicated and practical model ecosystems have been started.  ...  The grown irradiated embryos, however, had smaller brains and eyes than the non-irradiated control embryos.  ... 
doi:10.1051/radiopro/20095103 fatcat:4x5tp3gycjd4zefq4tohmcp3ta

Mechanisms of Brain Morphogenesis [chapter]

Benjamen A. Filas, Gang Xu, Larry A. Taber
2013 Computer Models in Biomechanics  
Specifically, we focus on two processes: formation of the primary brain vesicles and folding of the cerebral cortex.  ...  In this review we discuss recent advances in our understanding of the physical mechanisms of morphogenesis during brain development.  ...  Acknowledgements We gratefully acknowledge funding support from NIH grants R01 GM075200 and R01 NS070918 (LAT), as well as a fellowship for BAF from NIH T90 DA022871 and the Mallinckrodt Institute of Radiology  ... 
doi:10.1007/978-94-007-5464-5_24 fatcat:5yweefpswrhjlieqltpinofs4q

Page 457 of JAMA Pediatrics Vol. 87, Issue 4 [page]

1954 JAMA Pediatrics  
Rat embryos exposed to radia- tion on the ninth day of gestation developed tumor-like growths in the brain, which microscopically consisted of closely packed masses of cells of the developing neu- ral  ...  Enzyme inhibitors, especially those that simulate radiation reactions by interfering with sulfhydryl enzymes, have been used to produce brain malforma- tions in rat and mice fetuses.® Little attention  ... 

A potential role for differential contractility in early brain development and evolution

Benjamen A. Filas, Alina Oltean, David C. Beebe, Ruth J. Okamoto, Philip V. Bayly, Larry A. Taber
2012 Biomechanics and Modeling in Mechanobiology  
Differences in brain structure between species have long fascinated evolutionary biologists. Understanding how these differences arise requires knowing how they are generated in the embryo.  ...  round cross sections of the tubular brain into shapes resembling triangles, diamonds, and narrow slits.  ...  and Xenopus laevis embryos, respectively.  ... 
doi:10.1007/s10237-012-0389-4 pmid:22466353 pmcid:PMC3475747 fatcat:pdq7vmc3gjfjlfkvimxkkbx7me

Zebrafish as an experimental model for the simulation of neurological and craniofacial disorders

Ashwin Rohan Rai, Teresa Joy, K. S. Rashmi, Rajalakshmi Rai, N. A. Vinodini, P. J. Jiji
2022 Veterinary World  
This review aimed to highlight some of the most important similarities between zebrafish and humans by emphasizing the relevance of the first in simulating neurological disorders and craniofacial deformity  ...  At present, the zebrafish vertebrate model is increasingly used due to its multifactorial similarities to humans that include genetic, organ, and cellular factors.  ...  [94] have studied the impact of different metal alloy shells of Procelian fused metal alloy crowns on the growth of ZF embryos and larvae.  ... 
doi:10.14202/vetworld.2022.22-29 pmid:35369579 pmcid:PMC8924399 fatcat:jo6nwfyfwvbohekr4y4byt22ya

Page 624 of JAMA Pediatrics Vol. 89, Issue 5 [page]

1955 JAMA Pediatrics  
On about the ninth day, parts of the embryo develop radiosensitivity, and this change in suscepti- bility coincides with a new pattern of growth, namely, rapid differentiation and the appearance of neuroblasts  ...  The quantitative sensitivity of the human neuroblast is not known. , . Hopason, Rochester, Minn. GRowTH, DIFFERENTIATION, AND DisEASE. Epwarp B. D. NeunAusER, Am. J.  ... 

Growth Pattern of 'Matrix Cells' of the Central Nervous System and Formation of Tubular Structure Simulating Neural Tube in Cultures of Human Fetal Brain

Shizuo MIYAKE, Keiji ARAKI, Motoo SUGAHARA, Setsuya FUJITA
1961 Archivum histologicum japonicum  
In order to examine the mitotic behavior and growth pattern of these matrix cells in vitro, we cultured ventricular wall of diencephalon or mesencephalon of seven to eight week human embryos by usual roller  ...  Fig. 1 . 1 Wall of neural tube of seven week human embryo. m indicates mitotic cell in metaphase (so-called germinal cell of HIS).  ... 
doi:10.1679/aohc1950.22.117 fatcat:kgkg3duxhfezbglzjre6mfl4em

Effects of hypergravity environments on amphibian development, gene expression and apoptosis

Satomi Kawakami, Keiko Kashiwagi, Nobuaki Furuno, Masamichi Yamashita, Akihiko Kashiwagi
2006 Comparative Biochemistry and Physiology A  
Apoptosis in brain and eye inner structures of hatching embryos was scored using the TUNEL staining method, and gene expression in tail-bud embryos was analyzed by whole-mount in situ hybridization.  ...  and eye development) and Xag1 (regulating cement gland formation). (3) Eggs and 2 cell stage embryos raised at 5G showed a greater extent of brain and eye apoptosis compared with controls, while those  ...  and growth, including insulin-like growth factor-II (IGF-II), causing an increase in apoptosis, eventually resulting in loss of skeletal muscle mass and function.  ... 
doi:10.1016/j.cbpa.2006.05.006 pmid:16807024 fatcat:foo22twaindgvhjxjfmpwn5iqu

Morphological Study of The Effects of Caffeine Beverages can Cause Birth Defects on Swiss White Mice Embryos

2021 Scientific Journal for Faculty of Science-Sirte University  
Small embryos folded like a ball and curved in the shape of letter C, and the severity of the deformities increased by the appearance of mutated embryos resembling the body of a fish and deformed embryos  ...  characterized by the appearance of elongated and enlarged embryos.  ...  Acknowledgements This work was supported by the department of biology, college of education for pure sciences, Mosul university.  ... 
doi:10.37375/sjfssu.v1i1.65 fatcat:xtn5r2wuljffdbhoqiw26zystu

My Corporis Fabrica Embryo: An ontology-based 3D spatio-temporal modeling of human embryo development

Pierre-Yves Rabattu, Benoit Massé, Federico Ulliana, Marie-Christine Rousset, Damien Rohmer, Jean-Claude Léon, Olivier Palombi
2015 Journal of Biomedical Semantics  
interactive simulation and visualization of 3D embryos.  ...  My Corporis Fabrica Embryo: An ontology-based 3D spatio-temporal modeling of human embryo development.  ...  Computer modeling and simulation of human body allow to express and to visualize complex physiological processes, to make the steps of human embryology more accessible.  ... 
doi:10.1186/s13326-015-0034-0 pmid:26413258 pmcid:PMC4582726 fatcat:sgv4nxqd2vevncli5hdds6udbm

Identify a Blood-Brain Barrier Penetrating Drug-TNB using Zebrafish Orthotopic Glioblastoma Xenograft Model

Anqi Zeng, Tinghong Ye, Dan Cao, Xi Huang, Yu Yang, Xiuli Chen, Yongmei Xie, Shaohua Yao, Chengjian Zhao
2017 Scientific Reports  
However, GBM is characteristic of extremely aggressive growth and surgery is difficult to achieve complete resection of tumor tissue 2 .  ...  We then transplanted human GBM tumor cells into the zebrafish brain, in which implanted GBM cells (U87 and U251) were highly mitotic and invasive, mimicking their malignancy features in rodents' brain.  ...  This work was supported by grants from the National Science Funding of China (81500153; 81502522; 81402275), Postdoctoral Fellowship of China (58-2549) and CSCO-MERCK SERONO ONCLOGY RESEARCH FUND (Y-MX2015  ... 
doi:10.1038/s41598-017-14766-2 pmid:29085081 pmcid:PMC5662771 fatcat:ah7douev7vdtfdnyxkc5iykqce

Formation of the circle of Willis during human embryonic development

Tetsuya Takakuwa, Teppei Koike, Taiga Muranaka, Chigako Uwabe, Shigehito Yamada
2016 Congenital Anomalies  
We examined the timing of formation of CW in 20 Japanese human embryo samples by using 3-dimensional reconstruction of serial histological sections.  ...  The circle of Willis (CW) is a circulatory anastomosis that supplies blood to the brain and adjacent structures.  ...  Acknowledgements 10 This study was supported by Grant Nos. 25461642, 24119002, 26220004, 15H01119, 15K08134, 15H05270, 15H01121, and 15K15014 from the Japan Society for the Promotion of Science.  ... 
doi:10.1111/cga.12165 pmid:27037515 fatcat:ueshciw3yrhtzjxvz3bh5n5cxi

Computational models for mechanics of morphogenesis

Matthew A. Wyczalkowski, Zi Chen, Benjamen A. Filas, Victor D. Varner, Larry A. Taber
2012 Birth Defects Research Part C Embryo Today Reviews  
Mechanics plays a key role in regulating and controlling morphogenesis, and quantitative models help us understand how various mechanical forces combine to shape the embryo.  ...  In the developing embryo, tissues differentiate, deform, and move in an orchestrated manner to generate various biological shapes driven by the complex interplay between genetic, epigenetic, and environmental  ...  Acknowledgments This work was supported by grants R01 GM075200 and R01 NS070918 (LAT), F32 GM093396 (MAW), and T90 DA022871 (BAF) from the National Institutes of Health, the American Academy of Mechanics  ... 
doi:10.1002/bdrc.21013 pmid:22692887 pmcid:PMC3374861 fatcat:5ki7bda4dfgeloyvgsvd3i3uxy

Zebrafish embryo as a tool to study tumor/endothelial cell cross-talk

Chiara Tobia, Giuseppina Gariano, Giulia De Sena, Marco Presta
2013 Biochimica et Biophysica Acta - Molecular Basis of Disease  
Tumor/endothelial cell cross-talk plays a pivotal role in the growth, neovascularization and metastatic dissemination of human cancer.  ...  In particular, grafting of mammalian tumor cells in zebrafish embryo body may simulate early stages of tumor development, neovascularization, and local invasion whereas the injection of cancer cells in  ...  The mechanism of local invasion of tumor cells was investigated further by Lal et al. [34] following the orthotopic injection of human glioblastoma cells into the brain of zebrafish embryos.  ... 
doi:10.1016/j.bbadis.2013.01.016 pmid:23357577 fatcat:id3qq3vbkva75faepnhdhbqyuy
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