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Fast Spiking of a Mott VO2-Carbon Nanotube Composite Device
[article]
2019
arXiv
pre-print
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Chaotic dynamics in nanoscale NbO2 Mott
memristors for analogue Computing. ...
Bohaichuk 1# , Suhas Kumar 2 * # , Greg Pitner 1 , Connor J. McClellan 1 , Jaewoo Jeong 3 , Mahesh G. Samant 3 , H-.S. Philip Wong 1 , Stuart S. P. Parkin 3 , R. ...
arXiv:1903.06234v1
fatcat:qgq7ham4uben5d6agvkg7pobuu
Implicit Entity Recognition in Clinical Documents
2015
Proceedings of the Fourth Joint Conference on Lexical and Computational Semantics
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With the increasing automation of health care information processing, it has become crucial to extract meaningful information from textual notes in electronic medical records. One of the key challenges is to extract and normalize entity mentions. State-of-the-art approaches have focused on the recognition of entities that are explicitly mentioned in a sentence. However, clinical documents often contain phrases that indicate the entities but do not contain their names. We term those implicit
doi:10.18653/v1/s15-1028
dblp:conf/starsem/PereraMSTAHM15
fatcat:h54xjsnj2bd7he6hlrqov35sda
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... ty mentions and introduce the problem of implicit entity recognition (IER) in clinical documents. We propose a solution to IER that leverages entity definitions from a knowledge base to create entity models, projects sentences to the entity models and identifies implicit entity mentions by evaluating semantic similarity between sentences and entity models. The evaluation with 857 sentences selected for 8 different entities shows that our algorithm outperforms the most closely related unsupervised solution. The similarity value calculated by our algorithm proved to be an effective feature in a supervised learning setting, helping it to improve over the baselines, and achieving F1 scores of .81 and .73 for different classes of implicit mentions. Our gold standard annotations are made available to encourage further research in the area of IER.
Mycobacterium tuberculosis-specific CD4+ and CD8+ T cells differ in their capacity to recognize infected macrophages
[article]
2018
bioRxiv
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Containment of Mycobacterium tuberculosis (Mtb) infection requires T cell recognition of infected macrophages. Mtb evolved to tolerate, evade, and subvert host immunity. Despite a vigorous and sustained CD8+ T cell response during Mtb infection, CD8+ T cells make a limited contribution to protection. Here, we ask whether the ability of Mtb-specific T cells to restrict Mtb growth is related to their capacity to recognize Mtb-infected macrophages. We derived CD8+ T cell lines that recognized the
doi:10.1101/262493
fatcat:nxjlcc6p5nchfovsrvetf33xuu
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... tb immunodominant epitope TB10.44-11 and compared them to CD4+ T cell lines that recognized Ag85b240-254 or ESAT63-17. While the CD4+ T cells recognized Mtb-infected macrophages and inhibited Mtb growth in vitro, the TB10.4-specific CD8+ T cells neither recognized Mtb-infected macrophages nor restricted Mtb growth. TB10.4-specific CD8+ T cells recognized macrophages infected with Listeria monocytogenes expressing TB10.4. However, over-expression of TB10.4 in Mtb did not confer recognition by TB10.4-specific CD8+ T cells. Importantly, CD8+ T cells recognized macrophages pulsed with irradiated Mtb, indicating that macrophages can efficiently cross-present the TB10.4 protein and raising the possibility that viable bacilli might suppress cross-presentation. Importantly, polyclonal CD8+ T cells specific for Mtb antigens other than TB10.4 recognized Mtb-infected macrophages in a MHC-restricted manner. As TB10.4 elicits a dominant CD8+ T cell response that poorly recognizes Mtb-infected macrophages, we propose that TB10.4 acts as a decoy antigen. Moreover, it appears that this response overshadows subdominant CD8+ T cell response that can recognize Mtb-infected macrophages. The ability of Mtb to subvert the CD8+ T cell response may explain why CD8+ T cells make a disproportionately small contribution to host defense compared to CD4+ T cells. The selection of Mtb antigens for vaccines has focused on antigens that generate immunodominant responses. We propose that establishing whether vaccine-elicited Mtb-specific T cells recognize Mtb-infected macrophages could be a useful criterion for preclinical vaccine development.
Mycobacterium tuberculosis-specific CD4+ and CD8+ T cells differ in their capacity to recognize infected macrophages
2018
PLoS Pathogens
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Patterns of failure after treatment of atypical meningioma with gamma knife radiosurgery
2012
Journal of Neuro-Oncology
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Atypical meningiomas have poor local control with emerging literature indicating the use of radiosurgery in treatment. The purpose of this study was to evaluate clinical outcomes including local control and failure pattern after Gamma Knife radiosurgery (GKRS) and factors that may affect these outcomes. Between 1999 and 2008, 24 patients were treated with GKRS as either primary or salvage treatment for pathologically proven atypical meningiomas. Treatment failures were determined by serial
doi:10.1007/s11060-012-0828-1
pmid:22359231
pmcid:PMC3794718
fatcat:pmsmhxnfqfc6dgf62akzfmcqji
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... tic resonance imaging. A median marginal dose of 14 Gy was used (range 10.5-18 Gy). Overall local control rates at 1, 2, and 5 years were 75, 51, and 44%, respectively. With median follow-up time of 42.5 months, 14 of 24 patients experienced a treatment failure at time of last follow-up. Eight recurrences were in-field, four were marginal failures, and two were distant failures. Wilcoxon analysis revealed that the conformality index (CI) was a significant predictor of local recurrence (P = 0.04). CI did not predict for distant recurrences (P = 0.16). On multivariate analysis evaluating factors predicting progression free survival, dose >14 Gy was found to be statistically significant (P = 0.01). There appears to be a dose response using GKRS beyond 14 Gy but given the suboptimal local control rates in this study, higher doses may still be needed to obtain better local control.
Natural Polymorphisms in Tap2 Influence Negative Selection and CD4∶CD8 Lineage Commitment in the Rat
2014
PLoS Genetics
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Genetic variation in the major histocompatibility complex (MHC) affects CD4:CD8 lineage commitment and MHC expression. However, the contribution of specific genes in this gene-dense region has not yet been resolved. Nor has it been established whether the same genes regulate MHC expression and T cell selection. Here, we assessed the impact of natural genetic variation on MHC expression and CD4:CD8 lineage commitment using two genetic models in the rat. First, we mapped Quantitative Trait Loci
doi:10.1371/journal.pgen.1004151
pmid:24586191
pmcid:PMC3930506
fatcat:bzuo3c7tybg5vpk5f7brek7p5m
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... TLs) associated with variation in MHC class I and II protein expression and the CD4:CD8 T cell ratio in outbred Heterogeneous Stock rats. We identified 10 QTLs across the genome and found that QTLs for the individual traits colocalized within a region spanning the MHC. To identify the genes underlying these overlapping QTLs, we generated a large panel of MHC-recombinant congenic strains, and refined the QTLs to two adjacent intervals of ,0.25 Mb in the MHC-I and II regions, respectively. An interaction between these intervals affected MHC class I expression as well as negative selection and lineage commitment of CD8 single-positive (SP) thymocytes. We mapped this effect to the transporter associated with antigen processing 2 (Tap2) in the MHC-II region and the classical MHC class I gene(s) (RT1-A) in the MHC-I region. This interaction was revealed by a recombination between RT1-A and Tap2, which occurred in 0.2% of the rats. Variants of Tap2 have previously been shown to influence the antigenicity of MHC class I molecules by altering the MHC class I ligandome. Our results show that a restricted peptide repertoire on MHC class I molecules leads to reduced negative selection of CD8SP cells. To our knowledge, this is the first study showing how a recombination between natural alleles of genes in the MHC influences lineage commitment of T cells.
Detector arrays for the James Webb Space Telescope near-infrared spectrograph
2007
Focal Plane Arrays for Space Telescopes III
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A con~panion pa.per by Mott et nl. (2007) describes technical progress in the DCL in more detail.' ...
doi:10.1117/12.731759
fatcat:hvlyrwgtvff6lgmhal3zy4k3ya
Page 8 of Review Vol. 44, Issue 1
[page]
1992
Review
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, Trinidad State JC, CO eu Toby Smith, Connors State College, OK Eddie Jeffcoat, Murray State College, OK Karl Carswell, Butler County CC, KS Phillip Perry, Meridian CC, MS James Motte, Trinidad State ...
A. n College, IL
Ha i Phillip Perry, Meridian CC, MS
Lamont Mason, Odessa College, TX
Santi Brendan Haugh, Brown mackie College, KS Luke Potter, Trinidad State JC, CO George Arias, Pima CC, AZ James Motte ...
Page 503 of The Library Vol. 11, Issue 4
[page]
2010
The Library
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Greg, Walter Wilson
Haebler, Konrad
Harrison, Frank Mott
Haselden, Regineld Berti
Hobson, Geoffrey Dudley
Howe, Ellic
Isaac, Francis Swinton t l t t McKerrow, Ronal
I S
Sutherland
PB2-OP21359 $149.10 ...
Page 385 of The Library Vol. 11, Issue 3
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2010
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Gibson, Strickland
Gray, George John
Greg, Walter Wilson . rt
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Page 132 of The Library Vol. 7, Issue 1
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2006
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Gibson, Strickland Abstracts from ri
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Gray, George John
Greg, Walter Wilson
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Hobson, Geoffrey Dudley
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Page 490 of The Library Vol. 7, Issue 4
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2006
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Johnson, Alfred Forbes
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Hobson, Geoffrey Dudley
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Page 383 of The Library Vol. 13, Issue 3
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2012
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Gibson, Stric
kland James, Montague Rhodes
; fr
Oxf PB2-OP21335 $21.60 Oxford
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Jenkinson, Francis
Johnson, Alfred Forb PB2-OP213
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Haebler, Konrad
London, Station
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PR2-OP21223 ) Mactarlan jaselden, Regineld Berti
PB2-OP37490 $37 Madan, Falconer
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Front Matter
2018
Language Arts Journal of Michigan
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Spring 2019 : 2019 The College, Career, and Community Writing Program of the National Writing Project Deadline: March 15th, 2019
Sierra Holmes, Ludington High School Greg Shafer, Mott Community College ...
Petoskey Schools; Amanda Thorpe (Urban/Diversity Chair), Portage Northern High School; Toby Kahn-Loftus (Met Editor), North Central Michigan College; Sierra Holmes (LAJM Editor), Ludington High School; Greg ...
doi:10.9707/2168-149x.2191
fatcat:tboot3l3sjbudmvjdxsafzq6ce
Page 240 of The Library Vol. 12, Issue 2
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2011
The Library
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