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Overlapping and Segregating Structural Brain Abnormalities in Twins With Schizophrenia or Bipolar Disorder

G. Caroline M. van Baal
2012 Archives of General Psychiatry  
Design: Magnetic resonance imaging findings of monozygotic (MZ) and dizygotic (DZ) twin pairs discordant for schizophrenia, twin pairs concordant and discordant for BD, and healthy twin pairs were compared  ...  Results: Higher genetic liabilities for schizophrenia and BD were associated with smaller white matter volume, thinner right (and left) parahippocampus, thinner right orbitofrontal cortex, and thicker  ...  Finally, brain measures included volumes (1 study), gray and white matter density based on voxel-based morphometry (4 studies), hippocampal shape (1 study), and pituitary volume (1 study), but none of  ... 
doi:10.1001/archgenpsychiatry.2011.1615 pmid:22474104 fatcat:ttxairqvgrhrlmn7plutzhvjhe

Influence of Genes and Environment on Brain Volumes in Twin Pairs Concordant and Discordant for Bipolar Disorder

Astrid C. van der Schot, Ronald Vonk, Rachel G. H. Brans, Neeltje E. M. van Haren, P. Cédric M.P. Koolschijn, Valerie Nuboer, Hugo G. Schnack, G. Caroline M. van Baal, Dorret I. Boomsma, Willem A. Nolen, Hilleke E. Hulshoff Pol, René S. Kahn
2009 Archives of General Psychiatry  
Design: Magnetic resonance imaging (1.5 T) brain scans of monozygotic (MZ) or dizygotic (DZ) twins concordant and discordant for bipolar disorder were compared with healthy twin pairs.  ...  Significant environmental correlations were found for cortical gray matter. These relationships all became more pronounced when data were corrected for lithium use.  ...  increased genetic risk of developing schizophrenia. 34 Similarly, a voxel-based morphometry study that included patients with schizophrenia, bipolar patients, and their unaffected relatives found the  ... 
doi:10.1001/archgenpsychiatry.2008.541 pmid:19188536 fatcat:k2abk2afwfhr3oww2ozupc7uxm

Heritability of regional and global brain structure at the onset of puberty: A magnetic resonance imaging study in 9-year-old twin pairs

Jiska S. Peper, Hugo G. Schnack, Rachel M. Brouwer, G. Caroline M. Van Baal, Eneda Pjetri, Eszter Székely, Marieke van Leeuwen, Stéphanie M. van den Berg, D. Louis Collins, Alan C. Evans, Dorret I. Boomsma, René S. Kahn (+1 others)
2009 Human Brain Mapping  
Here, we studied the heritability of brain structures at 9 years of age in 107 monozygotic and dizygotic twin pairs (N 5 210 individuals) using volumetric MRI and voxel-based morphometry.  ...  Thus, in 9-year-old children, global brain volumes, white matter density in fronto-occipital and superior longitudinal fascicles, and gray matter density of (pre-)frontal and temporal areas are highly  ...  ACKNOWLEDGMENTS The authors thank all the families who participated in the study.  ... 
doi:10.1002/hbm.20660 pmid:19294640 fatcat:mgmf4aymsrgxljpznk6ghbx77q

Genetic Contributions to Altered Callosal Morphology in Schizophrenia

Katherine L. Narr, Tyrone D. Cannon, Roger P. Woods, Paul M. Thompson, Sharon Kim, Dina Asunction, Theo G. M. van Erp, Veli-Pekka Poutanen, Matti Huttunen, Jouko Lönnqvist, Carl-Gustav Standerksjöld-Nordenstam, Jaakko Kaprio (+2 others)
2002 Journal of Neuroscience  
Vertical displacements of the callosum, pronounced in male patients, were confirmed in schizophrenia and observed between dizygotic, but not monozygotic co-twins discordant for schizophrenia.  ...  High-resolution magnetic resonance images were obtained from co-twins of monozygotic and dizygotic pairs discordant for schizophrenia and healthy control twins (N ϭ 40 pairs).  ...  Brain and ventricle volumes Schizophrenia effects were absent for total intracranial, gray, and white matter volumes.  ... 
doi:10.1523/jneurosci.22-09-03720.2002 pmid:11978848 fatcat:ae5ejkyj5fhpvbzh3dsifxyggm

Increases in Regional Subarachnoid CSF Without Apparent Cortical Gray Matter Deficits in Schizophrenia: Modulating Effects of Sex and Age

Katherine L. Narr, Tonmoy Sharma, Roger P. Woods, Paul M. Thompson, Elizabeth R. Sowell, David Rex, Sharon Kim, Dina Asuncion, Seonah Jang, John Mazziotta, Arthur W. Toga
2003 American Journal of Psychiatry  
Objective: The authors investigated the modulating effects of biological sex and age on regional decreases in cortical gray matter and increases in subarachnoid CSF in 25 patients with chronic schizophrenia  ...  To reveal more regional changes in tissue proportions, statistical differences in gray matter and CSF were compared at each cortical surface location and mapped in three dimensions.  ...  The second investigation compared monozygotic and dizygotic twins discordant for chronic schizophrenia along with demographically matched control twins and showed highly significant differences surrounding  ... 
doi:10.1176/appi.ajp.160.12.2169 pmid:14638587 fatcat:abq6vajqtbbrvas7i6vmosio4e

Structural Cerebral Variations as Useful Endophenotypes in Schizophrenia: Do They Help Construct "Extended Endophenotypes"?

K. M. Prasad, M. S. Keshavan
2007 Schizophrenia Bulletin  
However, few studies have examined the structural variations in the brain that might underlie the functional impairments as useful endophenotypes for schizophrenia.  ...  We critically reviewed the extant literature on the neuroanatomical variations in schizophrenia in this paper to evaluate their candidacy as endophenotypes and how useful they are in furthering the understanding  ...  between relatives and patients. 121 Voxel-based morphometry studies have found reduced gray matter in the prefrontal cortex in relatives at high risk for schizophrenia. 127, 128 Reductions in gray  ... 
doi:10.1093/schbul/sbn017 pmid:18408230 pmcid:PMC2632444 fatcat:x3wbupivtreghhzg55ahmxytti

Focal And Global Brain Measurements in Siblings of Patients With Schizophrenia

H. B. M. Boos, W. Cahn, N. E. M. van Haren, E. M. Derks, R. M. Brouwer, H. G. Schnack, H. E. Hulshoff Pol, R. S. Kahn
2011 Schizophrenia Bulletin  
Segmentations of total brain, gray matter (GM), and white matter of the cerebrum, lateral and third ventricle, and cerebellum volumes were obtained.  ...  Group differences in volumes, cortical thickness, and GM density were analyzed using Structural Equation Modeling, hence controlling for familial dependency of the data.  ...  Interestingly, brain volume differences in twins discordant for schizophrenia were more pronounced in the monozygotic than in the dizygotic twins, compared with healthy control twins.  ... 
doi:10.1093/schbul/sbq147 pmid:21242319 pmcid:PMC3406520 fatcat:vuqb4h7oezh4rfjoubl6e6y4bq

Cortical Brain Development in Nonpsychotic Siblings of Patients With Childhood-Onset Schizophrenia

Nitin Gogtay, Deanna Greenstein, Marge Lenane, Liv Clasen, Wendy Sharp, Pete Gochman, Philip Butler, Alan Evans, Judith Rapoport
2007 Archives of General Psychiatry  
Context: Cortical gray matter (GM) loss is marked and progressive in childhood-onset schizophrenia (COS) during adolescence but becomes more circumscribed by early adulthood.  ...  The false-discovery rate procedure was used to control for type I errors due to multiple comparisons.  ...  of cortical GM, using either voxel-based morphometry or cortical thickness measures, show that most cortical GM deficits in schizophrenia are localized to the prefrontal and superior temporal cortices  ... 
doi:10.1001/archpsyc.64.7.772 pmid:17606811 fatcat:fnkezfjm3vd5flewq6c5h4taby

Mapping vulnerability to bipolar disorder: a systematic review and meta-analysis of neuroimaging studies

Paolo Fusar-Poli, Oliver Howes, Andreas Bechdolf, Stefan Borgwardt
2012 Journal of Psychiatry & Neuroscience  
task used.  ...  in preventive interventions for prodromal bipolar disorder.  ...  Fusar-Poli designed the study, acquired the data and wrote the article. All authors analyzed the data, reviewed the article and approved its publication.  ... 
doi:10.1503/jpn.110061 pmid:22297067 pmcid:PMC3341409 fatcat:6mmy2ixbu5hphhzxfndj6l4q3y

Regionally Specific Cortical Thinning and Gray Matter Abnormalities in the Healthy Relatives of Schizophrenia Patients

V. M. Goghari, K. Rehm, C. S. Carter, A. W. MacDonald
2006 Cerebral Cortex  
Accumulated evidence suggests that schizophrenia is associated with subtle gray matter deficits throughout the cerebral cortex and regional cortical thinning.  ...  In addition, relatives had a subtle increase in gray matter volume and surface area in the left hemisphere, bilaterally in the parahippocampal gyri, and in the left middle temporal lobe.  ...  McIntosh and others (2004) using whole-brain voxel-based morphometry found no differences in gray matter between healthy relatives and controls.  ... 
doi:10.1093/cercor/bhj158 pmid:16547347 fatcat:t24lwc34ujfopfsbm6ykno377e

Sex differences in brain structure: An autism twin study on restricted and repetitive behaviors [article]

Annelies van't Westeinde, Elodie Cauvet, Roberto Toro, Ralf Kuja-Halkola, Janina Neufeld, Katell Mevel, Sven Bölte
2018 bioRxiv   pre-print
This study used a well-controlled twin design to examine sex differences in brain anatomy in relation to repetitive behaviors.  ...  In 75 twin pairs (n=150, 62 females, 88 males) enriched for autism spectrum disorder (n=32), and other neurodevelopmental disorders (n =32), we explored the association of restricted and repetitive behaviors  ...  (FSL) Volumes of cerebellar white and gray matter were retrieved using volume-based morphometry.  ... 
doi:10.1101/334367 fatcat:4ev6owvvjnh6vebl7f5eg2e2v4

Sex differences in brain structure: a twin study on restricted and repetitive behaviors in twin pairs with and without autism

Annelies van't Westeinde, Élodie Cauvet, Roberto Toro, Ralf Kuja-Halkola, Janina Neufeld, Katell Mevel, Sven Bölte
2019 Molecular Autism  
This study used a well-controlled twin design to examine sex differences in brain anatomy in relation to repetitive behaviors.  ...  In 75 twin pairs (n = 150, 62 females, 88 males) enriched for autism spectrum disorder (n = 32), and other neurodevelopmental disorders (n = 32), we explored the association of restricted and repetitive  ...  Volume-based cerebellar analysis: gray and white matter regional volume (FSL) Volumes of cerebellar white and gray matter were retrieved using volume-based morphometry.  ... 
doi:10.1186/s13229-019-0309-x pmid:31893022 pmcid:PMC6937723 fatcat:upbmpagdmze47h5yphdqor2r7a


Arthur W. Toga, Paul M. Thompson
2005 Annual Review of Neuroscience  
A variety of sophisticated brain-mapping approaches relating genetic influences on brain structure and intelligence establishes a regional distribution for this relationship that is consistent with behavioral  ...  Genetic influences on brain morphology and IQ are well studied.  ...  Additional support was provided by grants from the National Institute for Biomedical Imaging and Bioengineering and the National Center for Research Resources  ... 
doi:10.1146/annurev.neuro.28.061604.135655 pmid:15651931 fatcat:6dct5ykmijb57jso5zq2xop774

The Social Brain in Female Autism: A Structural Imaging Study of Twins

Élodie Cauvet, Annelies van't Westeinde, Roberto Toro, Ralf Kuja-Halkola, Janina Neufeld, Katell Mevel, Sven Bölte
2020 Social Cognitive and Affective Neuroscience  
Twin pairs were discordant or concordant for ASD or autistic traits, discordant or concordant for other neurodevelopmental disorders, or concordant for neurotypical development.  ...  We used a co-twin design, in 77 twin pairs (39 female) aged 12.5 to 31.0 years.  ...  same-sex twin pairs.  ... 
doi:10.1093/scan/nsaa064 pmid:32363404 pmcid:PMC7308659 fatcat:d5mqfcbmd5fzrdvirpheir6lry

Genetic and Environmental Influences on Neuroimaging Phenotypes: A Meta-Analytical Perspective on Twin Imaging Studies

Gabriëlla A. M. Blokland, Greig I. de Zubicaray, Katie L. McMahon, Margaret J. Wright
2012 Twin Research and Human Genetics  
For many phenotypes there was also a significant influence of C. We now have good estimates of heritability for many regional and lobar CT measures, in addition to the global volumes.  ...  Because brain structure and function are affected in neurological and psychiatric disorders, it is important to disentangle the sources of variation in these phenotypes.  ...  cortex; v-b, volume-based; VLPFC, ventrolateral prefrontal cortex; V-W, voxel-wise; WM, white matter; WMd, white matter density; , change.  ... 
doi:10.1017/thg.2012.11 pmid:22856370 pmcid:PMC4291185 fatcat:lbwr2mfmxngdzbk5tnhlqq6ojy
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