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Graph-based multi-scale analysis of plates and rods in human trabecular bone

Jerome Dias, Sebastien Valette, Julien Dardenne, Remy Prost, Francoise Peyrin
2010 2010 IEEE International Conference on Image Processing  
We propose a novel approach based on 3D multi-scale adjacency graph analysis of high resolution 3D tomographic images of bone structures.  ...  Thus the identification of trabecular plates and rods is important in understanding bone fragility.  ...  This work is in the scope of the scientific topics of the PRC-GDR ISIS and STIC Santé research groups of the French National Center for Scientific Research (CNRS).  ... 
doi:10.1109/icip.2010.5653464 dblp:conf/icip/DiasVDPP10 fatcat:auvkdq35tvea3i2iypzeqvo7ky

Patient-Specific Diagnosis and Visualization of Bone Micro-Structures [chapter]

L. Podshivalov, A. Fischer, P. Z. Bar-Yoseph
2011 Patient-Specific Modeling in Tomorrow's Medicine  
In this chapter we describe state-of-the-art technologies and methods that facilitate the processing of bone structure at the micro-scale.  ...  Because of their complexity and large number of details, these models are considered to be large-scale models.  ...  The inner structure consists of small plates and rods (in Latin trabecula) arranged in complex three-dimensional structures.  ... 
doi:10.1007/8415_2011_88 fatcat:k2abreyzjrdqbakcp4fm2scyxq

Hip osteoarthritis: A novel network analysis of subchondral trabecular bone structures [article]

Mohsen Dorraki, Dzenita Muratovic, Anahita Fouladzadeh, Johan W Verjans, Andrew Allison, David M Findlay, Derek Abbott
2022 bioRxiv   pre-print
We describe a novel network analysis methodology for micro-computed tomography (micro-CT) images of human trabecular bone.  ...  Large-scale automated extraction of the network formed by trabecular bone revealed significant network properties not previously reported for bone.  ...  ACKNOWLEDGEMENTS Funding sources include a project grant funded by the National Health and Medical Research Council of Australia.  ... 
doi:10.1101/2022.03.28.486155 fatcat:yt4rtgatcrgbxf44vzx536nz2q

Development of a multi-scale finite element model of the osteoporotic lumbar vertebral body for the investigation of apparent level vertebra mechanics and micro-level trabecular mechanics

K. McDonald, J. Little, M. Pearcy, C. Adam
2010 Medical Engineering and Physics  
2010) Development of a multi-scale finite element model of the osteoporotic lumbar vertebral body for the investigation of apparent level vertebra mechanics and micro-level trabecular mechanics.  ...  This novel modelling methodology will allow detailed investigation of how trabecular bone loss in osteoporosis affects vertebral stiffness and strength in the lumbar spine.  ...  Healthy trabecular bone is thick and plate-like; however, with the progression of age and osteoporosis, the trabecular microstructure is thinned, plates of bone are perforated, and the bone transforms  ... 
doi:10.1016/j.medengphy.2010.04.006 pmid:20439162 fatcat:37dt4qwsmfb25ankpm7slwjpj4

Micro CT analysis of the subarticular bone structure in the area of the talar trochlea

Andrej Maria Nowakowski, Hans Deyhle, Silvan Zander, André Leumann, Magdalena Müller-Gerbl
2013 Surgical and Radiologic Anatomy  
Results As with mineralization patterns in the subchondral lamella, large variation was observed regarding bone volume, trabecular quantity, thickness, and spacing, as well as for structure model index  ...  Purpose Certain regions of the talar trochlea are recognized as exhibiting varying cartilage thickness and degrees of subchondral bone mineralization.  ...  Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s)  ... 
doi:10.1007/s00276-012-1069-x pmid:23307423 pmcid:PMC3631120 fatcat:za5ehggrtbf5dotr47dffusa7y

Microcomputed Tomography Applications in Bone and Mineral Research

Zachary Ryan Bart, Joseph Michael Wallace
2013 Advances in Computed Tomography  
Commercially available systems are capable of creating images at sub-micrometer resolutions to map out the complex web of trabecular bone in small animals, and offer an accurate measurement of bone mineral  ...  Microcomputed tomography (µCT) has evolved as a development of simple X-ray imaging into an indispensable technique used in both laboratory research and clinical diagnostics.  ...  Th Trabecular thickness Average thickness of trabecular rods/cones, calculated by 3D analysis Mm Tb. Sp Trabecular spacing Average space between trabecular rods/cones Mm Tb.  ... 
doi:10.4236/act.2013.23021 fatcat:djp7j5jln5fkletxtooipfcpum

Quantification of Trabecular Bone Structure Using Magnetic Resonance Imaging at 3 Tesla—Calibration Studies Using Microcomputed Tomography as a Standard of Reference

C. A. Sell, J. N. Masi, A. Burghardt, D. Newitt, T. M. Link, S. Majumdar
2005 Calcified Tissue International  
The parameters measured by the 2D plate model-based MIL method and the DT method included apparent (App). BV/TV (bone volume/total volume), App. Tb.Th (trabecular thickness), App.  ...  Osteoporosis is a metabolic bone disorder defined as a disease associated with a reduction in bone mass and a deterioration of bone structure, both resulting in an increased bone fragility and susceptibility  ...  The theoretical SMI value for a perfect cylinder (rod) is 3, while a perfect plate is 0. MIL-based measures on trabecular bone structure were also derived.  ... 
doi:10.1007/s00223-004-0111-3 pmid:15868282 pmcid:PMC2838764 fatcat:7ongxpryqfatrisa4yrm7mlglm

High-Resolution Imaging Techniques for the Assessment of Osteoporosis

Roland Krug, Andrew J. Burghardt, Sharmila Majumdar, Thomas M. Link
2010 The Radiologic clinics of North America  
In addition Multidetector-CT has been used for high-resolution imaging of trabecular bone structure, however, the radiation dose is a limiting factor.  ...  This article provides an overview of the different modalities, technical requirements and recent developments in this emerging field.  ...  Acknowledgments This work was supported by NIH R01 AR057336 (RK), NIH AG017762 (SM), 1RC1AR058405-01 (TML) and UC Discovery Grants (7Tesla) LSIT01-10107 and ITL-BIO04-10148.  ... 
doi:10.1016/j.rcl.2010.02.015 pmid:20609895 pmcid:PMC2901255 fatcat:fz2mbtlssjcq7kvbxyu5pre4yi

Imaging Bone Structure and Osteoporosis Using MRI [chapter]

Sandra J. Shefelbine, Sharmila Majumdar
2006 Osteoporosis and the Osteoporosis of Rheumatic Diseases  
Using such images, multiple different image processing and image analysis algorithms have been developed. The goal of all of these is to quantify the trabecular bone structure in 2 or 3 dimensions.  ...  With recent advances in phased array coils and higher strength magnets, the potential of MR imaging of bone structure is ever increasing.  ...  They found that the ratio of plates to rod (surface voxels to curve voxels in their analysis) and bone volume fraction decreased in hypogonadal men.  ... 
doi:10.1016/b978-0-323-03437-1.50016-6 fatcat:6iikns2tmrb25gdx27mjjc74w4

Change of mechanical vertebrae properties due to progressive osteoporosis: combined biomechanical and finite-element analysis within a rat model

Robert Müller, Marian Kampschulte, Thaqif El Khassawna, Gudrun Schlewitz, Britta Hürter, Wolfgang Böcker, Manfred Bobeth, Alexander C. Langheinrich, Christian Heiss, Andreas Deutsch, Gianaurelio Cuniberti
2014 Medical and Biological Engineering and Computing  
and cortical bone and a change in the bone architecture and microstructure, leading to an enhanced fracture risk.  ...  Osteoporosis-induced changes of the microscopic Young's modulus alter the fracture behavior of bone, may influence bone remodeling, and should be considered in the design of implant materials.  ...  Services and High Performance Computing (ZIH) at the Dresden University of technology for computational resources and the Cluster of excellence "Center for regenerative therapies Dresden" (CrtD) for additional  ... 
doi:10.1007/s11517-014-1140-3 pmid:24518991 fatcat:qemtygn46jdu5ig7j7kqbtla6m

Lacunarity analysis of spatial pattern in CT images of vertebral trabecular bone for assessing osteoporosis

Geoffrey Dougherty, Geoffrey M Henebry
2002 Medical Engineering and Physics  
, which is related to the connectivity of the trabecular bone network and the marrow space sizes.  ...  The structural integrity of vertebral trabecular bone is determined by the continuity of its trabecular network and the size of the holes comprising its marrow space, both of which determine the apparent  ...  Although the parallel plate model accurately describes the trabecular bone in the femoral head, it is not appropriate for the lumbar spine in which the trabecular bone has a significant rod-like component  ... 
doi:10.1016/s1350-4533(01)00106-0 pmid:11886832 fatcat:ianxpyett5ge5oxieh3gb7p5cq

High-throughput phenotyping and genetic linkage of cortical bone microstructure in the mouse

Kevin S Mader, Leah Rae Donahue, Ralph Müller, Marco Stampanoni
2015 BMC Genomics  
Results: We demonstrate the framework on a genetic study on the femur bones of in-bred mice.  ...  This map shows 4 areas of overlap with previous studies looking at bone strength and 3 areas not previously associated with bone.  ...  The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.  ... 
doi:10.1186/s12864-015-1617-y pmid:26138817 pmcid:PMC4490749 fatcat:w2lu2a7o3res3hdvob6sih7qiu

Investigation of mechanical, material and compositional determinants of human trabecular bone quality in type 2 diabetes

Praveer Sihota, Ram Naresh Yadav, Ruban Dhaliwal, Jagadeesh Chandra Bose, Vandana Dhiman, Deepak Neradi, Shailesh Karn, Sidhartha Sharma, Sameer Aggarwal, Vijay G Goni, Vishwajeet Mehandia, Deepak Vashishth (+2 others)
2021 Journal of Clinical Endocrinology and Metabolism  
Our findings provide evidence of hyperglycemia's detrimental effects on trabecular bone quality at multiple scales leading to lower energy absorption and toughness-indicative of increased propensity to  ...  Trabecular bone quality parameters were compared in samples of two groups: non-diabetic (n=40) and diabetic (n=30), with a mean duration of disease 7.5±2.8 years.  ...  In the present ex vivo study, we aimed for multi-scale characterization of bone tissue from individuals with and without diabetes, following hip fracture.  ... 
doi:10.1210/clinem/dgab027 pmid:33475711 fatcat:n5pehp3pyva5jden3o327h2wiu

Experimental Models of Arthritis [chapter]

B. Heymer, R. Spanel, O. Haferkamp
1982 Current topics in pathology. Ergebnisse der Pathologie  
Subchondral bone changes include: calcified cartilage thickening, changes in subchondral bone plate thickness and mineralization, changes in trabecular bone remodeling, architecture, and material properties  ...  , mechanical and material properties of bone, and bone mineralization of both traumatic and accelerated spontaneous OA in a single animal model from time 0 to 10, 20, 30, 90, and 180 days after surgery  ...  Experimental Arthritis: in vitro and in vivo Models Acknowledgements This work was supported by a CIHR Proof of Principle Grant # 20020PPP (to T.  ... 
doi:10.1007/978-3-642-68382-4_5 fatcat:i7fetqrkhvgo7onyfec2afj56q

Additive Manufacturing of Customized Metallic Orthopedic Implants: Materials, Structures, and Surface Modifications

Bai, Gong, Chen, Sun, Zhang, Cai, Zhu, Xie
2019 Metals  
A superior customized implant should have good biocompatibility and mechanical properties matching the defect bone.  ...  design and surface modification of the orthopedic implant.  ...  In the case of using a bone plate fixed by screws [39] , bone atrophy and refracturing due to uneven stress transmission between the bone plate and the bone cause the bone screw to loosen, which seriously  ... 
doi:10.3390/met9091004 fatcat:kem5w5h2g5g7pkkw3kuyp33dea
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