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The Executive Checklist (EC-10) – a new rating instrument for clinicians assessing dysexecutive behavior

Henrik Viklund, Birgitta Ausén, Göran Hagman, Lisa B. Thorell
2019 Figshare  
Assessment of executive functions (EF) is often criticized for its lack of ecological validity. As a consequence, several self- and partner rating scales for EF have been developed, while rating scales designed for clinicians are lacking. We therefore developed the Executive Checklist (EC-10), a new rating scale for clinicians assessing dysexecutive behavior during neuropsychological assessment and examined its psychometric properties. Consecutive referrals from a memory clinic with subjective
more » ... ognitive impairment (SCI; n = 27), mild cognitive impairment (MCI; n = 29), dementia (DEM; n = 16), as well as 11 healthy controls were assessed with the EC-10 while performing common neuropsychological tests. Results showed that the EC-10 had excellent inter-rater reliability, good internal consistency and modest relations to cognitive laboratory measures. The EC-10 increased the classification rate above and beyond the influence of neuropsychological tests when comparing patients with SCI and MCI or between cognitively impaired and non-impaired patients. Conclusively, the present study demonstrates that clinical observations can be quantified using the EC-10 and that this rating provides valuable information. As executive deficits are common in many neurological and neuropsychiatric disorders, validating the EC-10 in broader patient groups should be an important avenue for future research.
doi:10.6084/m9.figshare.9860663 fatcat:l4flwg5d6ndsnkfslb3nwxmsqa

Machine Learning and Social Robotics for Detecting Early Signs of Dementia [article]

Patrik Jonell, Joseph Mendelson, Thomas Storskog, Goran Hagman, Per Ostberg, Iolanda Leite, Taras Kucherenko, Olga Mikheeva, Ulrika Akenine, Vesna Jelic, Alina Solomon, Jonas Beskow, Joakim Gustafson (+1 others)
2017 arXiv   pre-print
This paper presents the EACare project, an ambitious multi-disciplinary collaboration with the aim to develop an embodied system, capable of carrying out neuropsychological tests to detect early signs of dementia, e.g., due to Alzheimer's disease. The system will use methods from Machine Learning and Social Robotics, and be trained with examples of recorded clinician-patient interactions. The interaction will be developed using a participatory design approach. We describe the scope and method
more » ... the project, and report on a first Wizard of Oz prototype.
arXiv:1709.01613v1 fatcat:bk3udrvhd5b2zmxbje2xd3gbxq

Progression to dementia in memory clinic patients with mild cognitive impairment and normal β-amyloid

Anna Rosenberg, Alina Solomon, Vesna Jelic, Göran Hagman, Nenad Bogdanovic, Miia Kivipelto
2019 Alzheimer's Research & Therapy  
Determination of β-amyloid (Aβ) positivity and likelihood of underlying Alzheimer's disease (AD) relies on dichotomous biomarker cut-off values. Individuals with mild cognitive impairment (MCI) and Aβ within the normal range may still have a substantial risk of developing dementia, primarily of Alzheimer type. Their prognosis, as well as predictors of clinical progression, are not fully understood. The aim of this study was to explore the associations of cerebrospinal fluid (CSF) biomarkers
more » ... 2, total tau, phosphorylated tau) and other characteristics, including modifiable vascular factors, with the risk of progression to dementia among patients with MCI and normal CSF Aβ42.
doi:10.1186/s13195-019-0557-1 pmid:31805990 pmcid:PMC6896336 fatcat:5amxv4a7mrh3zjinv6qabblrva

MID-LIFE WORK-RELATED STRESS INCREASES DEMENTIA RISK IN LATE-LIFE: THE CAIDE 30-YEAR STUDY

Shireen Sindi, Krister Hakansson, Göran Hagman, Jenni Kulmala, Hilkka Soininen, Ingemar Kareholt, Alina Solomon, Miia Kivipelto
2014 Alzheimer's & Dementia  
doi:10.1016/j.jalz.2014.05.1408 fatcat:vjecvc3pize4pjqjiovbubusqq

Manganese exposure in steel smelters a health hazard to the nervous system

Arne Wennberg, Anders Iregren, Göran Struwe, G Cizinsky, Maud Hagman, L Johansson
1991 Scandinavian Journal of Work, Environment and Health  
WENNBERG A, lREGREN A, STRUWEG, CIZINSKY G, HAGMAN M, JOHANSSON L. Manganese exposure in steel smelters a health hazard to the nervous system. Scand J Work En viron Health 1991 ; 17:255-62.  ... 
doi:10.5271/sjweh.1705 fatcat:qlqak5s5mvb6fbx2ryt3qf5gvq

Multimodal Capture of Patient Behaviour for Improved Detection of Early Dementia: Clinical Feasibility and Preliminary Results

Patrik Jonell, Birger Moëll, Krister Håkansson, Gustav Eje Henter, Taras Kuchurenko, Olga Mikheeva, Göran Hagman, Jasper Holleman, Miia Kivipelto, Hedvig Kjellström, Joakim Gustafson, Jonas Beskow
2021 Frontiers in Computer Science  
Non-invasive automatic screening for Alzheimer's disease has the potential to improve diagnostic accuracy while lowering healthcare costs. Previous research has shown that patterns in speech, language, gaze, and drawing can help detect early signs of cognitive decline. In this paper, we describe a highly multimodal system for unobtrusively capturing data during real clinical interviews conducted as part of cognitive assessments for Alzheimer's disease. The system uses nine different sensor
more » ... es (smartphones, a tablet, an eye tracker, a microphone array, and a wristband) to record interaction data during a specialist's first clinical interview with a patient, and is currently in use at Karolinska University Hospital in Stockholm, Sweden. Furthermore, complementary information in the form of brain imaging, psychological tests, speech therapist assessment, and clinical meta-data is also available for each patient. We detail our data-collection and analysis procedure and present preliminary findings that relate measures extracted from the multimodal recordings to clinical assessments and established biomarkers, based on data from 25 patients gathered thus far. Our findings demonstrate feasibility for our proposed methodology and indicate that the collected data can be used to improve clinical assessments of early dementia.
doi:10.3389/fcomp.2021.642633 fatcat:ekmptngdszg2vci47ynxcbs7xq

Adenovirus-36 Is Associated with Obesity in Children and Adults in Sweden as Determined by Rapid ELISA

Malin Almgren, Richard Atkinson, Jia He, Agneta Hilding, Emilia Hagman, Alicja Wolk, Anders Thorell, Claude Marcus, Erik Näslund, Claes-Göran Östenson, Martin Schalling, Catharina Lavebratt (+1 others)
2012 PLoS ONE  
Experimental and natural human adenovirus-36 (Adv36) infection of multiple animal species results in obesity through increasing adipogenesis and lipid accumulation in adipocytes. Presence of Adv36 antibodies detected by serum neutralization assay has previously been associated with obesity in children and adults living in the USA, South Korea and Italy, whereas no association with adult obesity was detected in Belgium/the Netherlands nor among USA military personnel. Adv36 infection has also
more » ... n shown to reduce blood lipid levels, increase glucose uptake by adipose tissue and skeletal muscle biopsies, and to associate with improved glycemic control in non-diabetic individuals. Principal Findings: Using a novel ELISA, 1946 clinically well-characterized individuals including 424 children and 1522 nondiabetic adults, and 89 anonymous blood donors, residing in central Sweden representing the population in Stockholm area, were studied for the presence of antibodies against Adv36 in serum. The prevalence of Adv36 positivity in lean individuals increased from ,7% in 1992-1998 to 15-20% in 2002-2009, which paralleled the increase in obesity prevalence. We found that Adv36-positive serology was associated with pediatric obesity and with severe obesity in females compared to lean and overweight/mildly obese individuals, with a 1.5 to 2-fold Adv36 positivity increase in cases. Moreover, Adv36 positivity was less common among females and males on antilipid pharmacological treatment or with high blood triglyceride level. Insulin sensitivity, measured as lower HOMA-IR, showed a higher point estimate in Adv36-positive obese females and males, although it was not statistically significant (p = 0.08). Conclusion: Using a novel ELISA we show that Adv36 infection is associated with pediatric obesity, severe obesity in adult females and lower risk of high blood lipid levels in non-diabetic Swedish individuals.
doi:10.1371/journal.pone.0041652 pmid:22848557 pmcid:PMC3407196 fatcat:xzonmafinzgehkpal2xzn3wnve

Midlife Work-Related Stress Increases Dementia Risk in Later Life: The CAIDE 30-Year Study

Shireen Sindi, Göran Hagman, Krister Håkansson, Jenni Kulmala, Charlotta Nilsen, Ingemar Kåreholt, Hilkka Soininen, Alina Solomon, Miia Kivipelto
2016 The journals of gerontology. Series B, Psychological sciences and social sciences  
., Hagman, G., Håkansson, K., Kulmala, J., Nilsen, C. et al. (2017) Midlife work-related stress increases dementia risk in later life: The CAIDE 30-year study. The journals of gerontology.  ... 
doi:10.1093/geronb/gbw043 pmid:27059705 fatcat:zqlh2z7k7nhl3mbuculenlea54

Lifestyle Factors Are Important Contributors to Subjective Memory Complaints among Patients without Objective Memory Impairment or Positive Neurochemical Biomarkers for Alzheimer's Disease

Anna Miley-Akerstedt, Vesna Jelic, Kristina Marklund, Håkan Walles, Torbjörn Åkerstedt, Göran Hagman, Christin Andersson
2018 Dementia and Geriatric Cognitive Disorders Extra  
Many patients presenting to a memory disorders clinic for subjective memory complaints do not show objective evidence of decline on neuropsychological data, have nonpathological biomarkers for Alzheimer's disease, and do not develop a neurodegenerative disorder. Lifestyle variables, including subjective sleep problems and stress, are factors known to affect cognition. Little is known about how these factors contribute to patients' subjective sense of memory decline. Understanding how lifestyle
more » ... actors are associated with the subjective sense of failing memory that causes patients to seek a formal evaluation is important both for diagnostic workup purposes and for finding appropriate interventions and treatment for these persons, who are not likely in the early stages of a neurodegenerative disease. The current study investigated specific lifestyle variables, such as sleep and stress, to characterize those patients that are unlikely to deteriorate cognitively. Two hundred nine patients (mean age 58 years) from a university hospital memory disorders clinic were included. Sleep problems and having much to do distinguished those with subjective, but not objective, memory complaints and non-pathological biomarkers for Alzheimer's disease. Lifestyle factors including sleep and stress are useful in characterizing subjective memory complaints from objective problems. Inclusion of these variables could potentially improve health care utilization efficiency and guide interventions.
doi:10.1159/000493749 pmid:30631336 pmcid:PMC6323368 fatcat:lk6dtziuivesxcwxmjqb37xina

Multiple regulatory variants located in cell type-specific enhancers within the PKP2 locus form major risk and protective haplotypes for canine atopic dermatitis in German shepherd dogs

Katarina Tengvall, Sergey Kozyrev, Marcin Kierczak, Kerstin Bergvall, Fabiana H. G. Farias, Brita Ardesjö-Lundgren, Mia Olsson, Eva Murén, Ragnvi Hagman, Tosso Leeb, Gerli Pielberg, Åke Hedhammar (+2 others)
2016 BMC Genetics  
Canine atopic dermatitis (CAD) is a chronic inflammatory skin disease triggered by allergic reactions involving IgE antibodies directed towards environmental allergens. We previously identified a~1.5 Mb locus on canine chromosome 27 associated with CAD in German shepherd dogs (GSDs). Fine-mapping indicated association closest to the PKP2 gene encoding plakophilin 2. Results: Additional genotyping and association analyses in GSDs combined with control dogs from five breeds with low-risk for CAD
more » ... evealed the top SNP 27:19,086,778 (p = 1.4 × 10 −7 ) and a rare~48 kb risk haplotype overlapping the PKP2 gene and shared only with other high-risk CAD breeds. We selected altogether nine SNPs (four top-associated in GSDs and five within the~48 kb risk haplotype) that spanned~280 kb forming one risk haplotype carried by 35 % of the GSD cases and 10 % of the GSD controls (OR = 5.1, p = 5.9 × 10 −5 ), and another haplotype present in 85 % of the GSD cases and 98 % of the GSD controls and conferring a protective effect against CAD in GSDs (OR = 0.14, p = 0.0032). Eight of these SNPs were analyzed for transcriptional regulation using reporter assays where all tested regions exerted regulatory effects on transcription in epithelial and/or immune cell lines, and seven SNPs showed allelic differences. The DNA fragment with the top-associated SNP 27:19,086,778 displayed the highest activity in keratinocytes with 11-fold induction of transcription by the risk allele versus 8-fold by the control allele (p difference = 0.003), and also mapped close (~3 kb) to an ENCODE skin-specific enhancer region. Conclusions: Our experiments indicate that multiple CAD-associated genetic variants located in cell type-specific enhancers are involved in gene regulation in different cells and tissues. No single causative variant alone, but rather multiple variants combined in a risk haplotype likely contribute to an altered expression of the PKP2 gene, and possibly nearby genes, in immune and epithelial cells, and predispose GSDs to CAD.
doi:10.1186/s12863-016-0404-3 pmid:27357287 pmcid:PMC4928279 fatcat:l5big3wj6vbifkvsqwxvxfc7ue

24-month intervention with a specific multinutrient in people with prodromal Alzheimer's disease (LipiDiDiet): a randomised, double-blind, controlled trial

Hilkka Soininen, Alina Solomon, Pieter Jelle Visser, Suzanne B Hendrix, Kaj Blennow, Miia Kivipelto, Tobias Hartmann, Ilona Hallikainen, Merja Hallikainen, Seppo Helisalmi, Tarja Lappalainen, Yawu Liu (+35 others)
2017 Lancet Neurology  
Nutrition is an important modifiable risk factor in Alzheimer's disease. Previous trials of the multinutrient Fortasyn Connect showed benefits in mild Alzheimer's disease dementia. LipiDiDiet investigated the effects of Fortasyn Connect on cognition and related measures in prodromal Alzheimer's disease. Here, we report the 24-month results of the trial.
doi:10.1016/s1474-4422(17)30332-0 pmid:29097166 pmcid:PMC5697936 fatcat:7hbj2ztrzbfsphxokw4xklqxgm

Page 95 of National Union Catalog Vol. 22, Issue [page]

1963 National Union Catalog  
Title, CLU NUC66-43096 Hagman, Dorothy Elizabeth see Parker, Dorothy Elizabeth (Hagman) 1928- Hagman, Lucile Gertrude, The preparation of core teachers in the ie high schools of Dlinois.  ...  InLP NUC63-17861 Haglund, Goran, ed. see Nordisk anaestesiologisk forening. The child and anaesthesia. Aarhus, Uni- versitetsforlaget, 1961.  ... 

Page 594 of National Union Catalog Vol. 18, Issue [page]

1958 National Union Catalog  
Lindblas Foerlag [1957] Haglund, Goran. Hur man skall handla vid livshotande olycksfall. (Stockholm; Forum ;1959; 100 p. illus. (Forums medicinska serie) 1. First aid.  ...  Robert Hagman, Bertil, ed. Jussi Bjirling, en minnesbok. 11960. 212'p. ports. 23 cm. Diseoxraphy : p. 208; 1.  ... 

Page 1879 of Psychological Abstracts Vol. 77, Issue 7 [page]

1990 Psychological Abstracts  
Gregory, 17831 Hamlett, Carol L 428 Hammad, Ibtisam M.., Hampf, Goran, 16203 Hampson, Steven E., 16174 Hancock, P.  ...  ., 17253 Hagiwara, Hiroko, 17584 Hagman, Jennifer, 17738 H ohammed O., 16987 H ue, Sally A., 18379 Hahm, Wendell, 16916 Haines, Bridget, 16306 XXXV Haines, Julia H., 17764 Haith, Marshall M., 16785 Hajnicz  ... 

Page 3259 of Psychological Abstracts Vol. 87, Issue 8 [page]

2000 Psychological Abstracts  
, George, 24253 Hagstrom, Anne, 23717 Hahlweg, Kurt, 23294 Hahn, Steven R., 22051, 22167 Hahn, Wendy Besel, 25047 Hahne, Karen, 25048 Haight, Thaddeus J., 23048 Hails, Kevin C., 24459 Hajak, Goran, 24315  ...  24080 Haddjeri, Nasser, 22743 Hadjimarcou, John, 25158 Hadjistavropoulos, Thomas, 24840 Hafer, Teresa, 22411 Hagedoorn, Mariét, 23953 Hagekull, Berit, 23015 Haggarty, Jack, 23478 Hagthara, Akihito, 25119 Hagman  ... 
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