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Evaluation and Estimation of Gray Matter Volume Using Voxel-Based Morphometry of the Brain Magnetic Resonance Imaging (MRI) in Normal Elderly People and Those with Mild Cognitive Impairment

Saeed Kermani, Zahra Karimi, Majid Barekatain
2015 مجله دانشکده پزشکی اصفهان  
Conclusion: In this study, we found several regions of local brain atrophy in the patients with mild cognitive impairment that could reduce the gray matter volume.  ...  Patients with mild cognitive impairment had significantly lower brain gray matter volume in frontal (P = 0.013) and medial temporal (P = 0.025) lobes.  ...  ;Z+ F +F # . ) ] <F MCI Mild cognitive impairment ( ^Z ) +F #. & . * _/(! " ` B SU 0 7a" b . & ( . " _ /(! # `. % =! 4 ! ( J * ^Z ) Z+F * * " " S* +F # . c & . " #d $ $ 7 \ D 0 [ 5)! ? , . .  ... 
doaj:66a2537d23f54090ad88ba2875e51d9f fatcat:huqdb7tspbawdlxurcahw6hkiq

Brain Structural Network Compensation Is Associated With Cognitive Impairment and Alzheimer's Disease Pathology

Xiaoning Sheng, Haifeng Chen, Pengfei Shao, Ruomeng Qin, Hui Zhao, Yun Xu, Feng Bai, the Alzheimer's Disease Neuroimaging Initiative
2021 Frontiers in Neuroscience  
BackgroundStructural network alterations in Alzheimer's disease (AD) are related to worse cognitive impairment.  ...  The aim of this study was to quantify the alterations in gray matter associated with impaired cognition and their pathological biomarkers in AD-spectrum patients.MethodsWe extracted gray matter networks  ...  AUTHOR CONTRIBUTIONS FB, HZ, and YX designed the study and edited the manuscript. XS and HC analyzed the data and wrote the manuscript. HC, RQ, and PS validated the statistics.  ... 
doi:10.3389/fnins.2021.630278 pmid:33716654 pmcid:PMC7947929 fatcat:npkfmgufuraelm6y6ij6pjypga

Neural Correlates of Impaired Functional Independence in Early Alzheimer's Disease

Eric D. Vidoni, Robyn A. Honea, Jeffrey M. Burns
2010 Journal of Alzheimer's Disease  
Cognitive and physical decline are important predictors of functional independence in Alzheimer's disease (AD).  ...  Loss of independence in early AD is closely related to impaired cognition associated with performing complex behaviors.  ...  Acknowledgments This study was supported by grants R03 AG026374 and R21 AG029615 from the National Institutes of Aging and K23 NS058252 from the National Institute on Neurological Disorders and Stroke.  ... 
doi:10.3233/jad-2010-1245 pmid:20110598 pmcid:PMC2891926 fatcat:i7zno5t6wzgyzptppfhcqdgkte

Optimized VBM in Patients with Alzheimer's Disease: Gray Matter Loss and Its Correlation with Cognitive Function

Seon Hyeong Choi, Won Jin Moon, Eun Chul Chung, Min Hee Lee, Hong Gee Roh, Kwang Bo Park, Duck Ryul Na
2005 Journal of the Korean Radiological Society  
Global and local gray matter loss in mild cogni- tive impairment and Alzheimer s disease. Neuroimage 2004;23: 708-716 20. Smith AD.  ...  In vivo mapping of gray matter loss with voxelbased morphometry in mild Alzheimer s disease. Neuroimage 2001;14:298-309 9. Ohnish T, Matsuda H, Tabira T, Asada T, Uno M.  ...  Purpose: To investigate the regional changes in gray matter volume by using optimized voxel based morphometry in the whole brain of patients with Alzheimer's disease (AD) and to determine its correlation  ... 
doi:10.3348/jkrs.2005.53.5.323 fatcat:44i7ygrv6ncrpha5nvmkp3oqwi

Gray and White Matter Changes in Subjective Cognitive Impairment, Amnestic Mild Cognitive Impairment and Alzheimer's Disease: A Voxel-Based Analysis Study

Kuniaki Kiuchi, Soichiro Kitamura, Toshiaki Taoka, Fumihiko Yasuno, Masami Tanimura, Kiwamu Matsuoka, Daisuke Ikawa, Michihiro Toritsuka, Kazumichi Hashimoto, Manabu Makinodan, Jun Kosaka, Masayuki Morikawa (+3 others)
2014 PLoS ONE  
The subjects in this study were 39 Alzheimer's disease, 43 mild cognitive impairment, 28 subjective cognitive impairment and 41 normal controls.  ...  Alzheimer's disease and mild cognitive impairment had the same extent of brain atrophy and diffusion changes.  ...  impairment; MCI, mild cognitive impairment; AD, Alzheimer's disease; GDS, Global Deterioration Scale; MMSE, Mini Mental State Examination; ADAS-Cog., Alzheimer's disease assessment scale -cognitive subscale  ... 
doi:10.1371/journal.pone.0104007 pmid:25093415 pmcid:PMC4122459 fatcat:w67b57cnqneozm3jo33enlzdse

Morphological and Microstructural Changes of the Hippocampus in Early MCI: A Study Utilizing the Alzheimer's Disease Neuroimaging Initiative Database

Peter Lee, Hojin Ryoo, Jinah Park, Yong Jeong
2017 Journal of Clinical Neurology  
impairment (EMCI) and late mild cognitive impairment (LMCI).  ...  and Purpose With the aim of facilitating the early detection of Alzheimer's disease, the Alzheimer's Disease Neuroimaging Initiative proposed two stages based on the memory performance: early mild cognitive  ...  Acknowledgements This research was supported by a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health and  ... 
doi:10.3988/jcn.2017.13.2.144 pmid:28176504 pmcid:PMC5392456 fatcat:rosyqmdjyratfkbfqg7ci4fedi

Apolipoprotein E Polymorphism and Brain Morphology in Mild Cognitive Impairment

Philipp A. Thomann, Ann-Sophie Roth, Vasco Dos Santos, Pablo Toro, Marco Essig, Johannes Schröder
2008 Dementia and Geriatric Cognitive Disorders  
How the ApoE genotype and brain morphology relate to each other is only partly understood, particularly in mild cognitive impairment, the assumed prestage of AD.  ...  Conclusion: Our findings support the hypothesis that the ApoE genotype in mild cognitive impairment might be associated with structural changes typically found in the early stages of AD.  ...  In conclusion, we showed ApoE status to significantly influence gray and white matter volume in subjects with mild cognitive impairment.  ... 
doi:10.1159/000161054 pmid:18843182 fatcat:hsu75wf35ze67paho4m4fskqmu

Amyloid and tau accumulate across distinct spatial networks and are differentially associated with brain connectivity

Joana B Pereira, Rik Ossenkoppele, Sebastian Palmqvist, Tor Olof Strandberg, Ruben Smith, Eric Westman, Oskar Hansson
2019 eLife  
The abnormal accumulation of amyloid-β and tau targets specific spatial networks in Alzheimer's disease.  ...  The amyloid-b and tau patterns showed a fair to moderate overlap with distinct functional networks but only tau was associated with white matter integrity loss and multiple cognitive functions.  ...  Marianne and Marcus Wallenberg foundation (OH), the Strategic Research Area MultiPark (Multidisciplinary Research in Parkinson's disease) at Lund University (OH, SP), the Swedish Alzheimer Foundation  ... 
doi:10.7554/elife.50830 pmid:31815669 pmcid:PMC6938400 fatcat:vlfhvk6rljh4hoqiriookz4mga

Subregional Structural Alterations in Hippocampus and Nucleus Accumbens Correlate with the Clinical Impairment in Patients with Alzheimer's Disease Clinical Spectrum: Parallel Combining Volume and Vertex-Based Approach

Xiuling Nie, Yu Sun, Suiren Wan, Hui Zhao, Renyuan Liu, Xueping Li, Sichu Wu, Zuzana Nedelska, Jakub Hort, Zhao Qing, Yun Xu, Bing Zhang
2017 Frontiers in Neurology  
Deep gray matter structures are associated with memory and other important functions that are impaired in Alzheimer's disease (AD) and mild cognitive impairment (MCI).  ...  In this article, we combined complex volumetry-and vertex-based analysis to investigate the pattern of subregional structural alterations in deep gray matter structures and its association with global  ...  AD, Alzheimer's disease; MCI, mild cognitive impairment; NC, normal controls; NBV, normalized brain volume; MMSE, Mini-Mental State Examination; MOCA, Montreal Cognitive Assessment; M, male; F, female  ... 
doi:10.3389/fneur.2017.00399 pmid:28861033 pmcid:PMC5559429 fatcat:whsylafz2fgslj3m5je2nizpiu

Electroencephalography-driven approach to prodromal Alzheimer's disease diagnosis: from biomarker integration to network-level comprehension

Moretti DV
2016 Clinical Interventions in Aging  
Neuropsychological evaluation, EEG recording, and magnetic resonance imaging were conducted in 74 patients with mild cognitive impairment (MCI).  ...  Alzheimer's disease (AD).  ...  EEG markers are associated to gray matter changes in thalamus and basal ganglia in subjects with mild cognitive impairment. Moretti DV, Prestia A, Fracassi C, Binetti G, Zanetti O, Frisoni GB.  ... 
doaj:fa78da26fabd4897b1c6e9c97773b312 fatcat:nouewespbbazrkbxlanbx4bau4

Microstructural brain changes track cognitive decline in mild cognitive impairment

Emilie T. Reas, Donald J. Hagler, Nathan S. White, Joshua M. Kuperman, Hauke Bartsch, Christina E. Wierenga, Douglas Galasko, James B. Brewer, Anders M. Dale, Linda K. McEvoy
2018 NeuroImage: Clinical  
At baseline and two-year follow-up, 29 healthy controls and 21 individuals with mild cognitive impairment or mild Alzheimer's disease underwent neuropsychological evaluation and restriction spectrum imaging  ...  In medial temporal gray and white matter, restricted isotropic diffusion and crossing fibers were lower, and free water diffusion was higher, in impaired participants.  ...  This work was supported by donors of Alzheimer's Disease Research, a program of Bright Focus Foundation; NIA grant 5P50AG005131; and U.S.  ... 
doi:10.1016/j.nicl.2018.09.027 pmid:30290303 pmcid:PMC6171091 fatcat:bkxra2qrbvbfteze2hsb547ije

Callosal thickness profiles for prognosticating conversion from mild cognitive impairment to Alzheimer's disease: A classification approach

Chris Adamson, Richard Beare, Gareth Ball, Mark Walterfang, Marc Seal, the Alzheimer's Disease Neuroimaging Initiative
2018 Brain and Behavior  
Alzheimer's disease (AD) is the most common form of dementia. Finding biomarkers to prognosticate transition from mild cognitive impairment (MCI) to AD is important to clinical medicine.  ...  Promising imaging biomarkers of AD conversion identified so far include atrophy of the cerebral cortex and subcortical gray matter nuclei.  ...  be combined to measure the progression of mild cognitive impairment (MCI) and early Alzheimer's disease (AD).  ... 
doi:10.1002/brb3.1142 pmid:30565884 pmcid:PMC6305917 fatcat:55ucrqi2rbdprm7rtyo4mhlh4u

Structural imaging in early pre-states of dementia

Charles D. Smith
2012 Biochimica et Biophysica Acta - Molecular Basis of Disease  
Findings in mild cognitive impairment (MCI) are described here only for comparison with CN.  ...  In this review focus is on structural imaging in the Alzheimer's disease (AD) pre-states, particularly cognitively normal (CN) persons at future dementia risk.  ...  Acknowledgements I am grateful to my many valued and insightful teachers and colleagues at the Alzheimer's Disease Center, Magnetic Resonance Imaging and Spectroscopy Center, and the College of Medicine  ... 
doi:10.1016/j.bbadis.2011.07.002 pmid:21777674 pmcid:PMC3223541 fatcat:hken5jygojdvfpeeexiqxqf7ge

Cross-sectional and longitudinal atrophy is preferentially associated with tau rather than amyloid β positron emission tomography pathology

Brian A. Gordon, Austin McCullough, Shruti Mishra, Tyler M. Blazey, Yi Su, John Christensen, Aylin Dincer, Kelley Jackson, Russ C. Hornbeck, John C. Morris, Beau M. Ances, Tammie L.S. Benzinger
2018 Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring  
Abstract Introduction: Structural magnetic resonance imaging is a marker of gray matter health and decline that is sensitive to impaired cognition and Alzheimer's disease pathology.  ...  When examined independently in longitudinal models, both Ab and tau were associated with greater antecedent loss of gray matter.  ...  Similarly, lower baseline levels and greater gray matter atrophy have been found in participants with mild cognitive impairment [6] , subjective memory complaints [7] , and cognitively normal individuals  ... 
doi:10.1016/j.dadm.2018.02.003 pmid:29780869 pmcid:PMC5956934 fatcat:qd2dvseb3vgyph4s5253j2n3mm

Multimodal MRI Neuroimaging Biomarkers for Cognitive Normal Adults, Amnestic Mild Cognitive Impairment, and Alzheimer's Disease

Ai-Ling Lin, Angela R. Laird, Peter T. Fox, Jia-Hong Gao
2012 Neurology Research International  
in amnestic mild cognitive impairment (aMCI), and Alzheimer's disease (AD) patients.  ...  therapeutic efficacy in these diseases in future clinical trials.  ...  The maps show the average local rates of loss for gray matter, in groups of controls (top, (a)-(d)) and patients with AD (bottom, (e)-(h)). Loss rates are <1% per year in controls.  ... 
doi:10.1155/2012/907409 pmid:21949904 pmcid:PMC3178148 fatcat:77vt5lka5vd2hmw5bxghubyrn4
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