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Log-gamma linear-mixed effects models for multiple outcomes with application to a longitudinal glaucoma study

Peng Zhang, Dandan Luo, Pengfei Li, Lucie Sharpsten, Felipe A. Medeiros
2015 Biometrical Journal  
of random effects, to be used in a study of glaucoma.  ...  rates that leads to a better understanding of the progression of glaucoma over time.  ...  Two responses, the visual field index (VFI) and the global average thickness of the retinal nerve fiber layer (RNFL), were collected for 203 patients at 6-month intervals.  ... 
doi:10.1002/bimj.201300001 pmid:26075565 pmcid:PMC4558301 fatcat:lvcqxajuwbfspp6bysywjjfrli

Efficient Learning and Decoding of the Continuous-Time Hidden Markov Model for Disease Progression Modeling [article]

Yu-Ying Liu, Alexander Moreno, Maxwell A. Xu, Shuang Li, Jena C. McDaniel, Nancy C. Brady, Agata Rozga, Fuxin Li, Le Song, James M. Rehg
2021 arXiv   pre-print
We demonstrate the use of CT-HMMs with more than 100 states to visualize and predict disease progression using a glaucoma dataset and an Alzheimer's disease dataset, and to decode and visualize the most  ...  probable state transition trajectory for individuals on the glaucoma dataset, which helps to identify progressing phenotypes in a comprehensive way.  ...  We use a 2D-grid state space model defined by successive value bands of the two main glaucoma markers, Visual Field Index (VFI) (functional marker) and average RNFL (Retinal Nerve Fiber Layer) thickness  ... 
arXiv:2110.13998v1 fatcat:niix36tronccjm3waes4y23rw4

The Eye1 [chapter]

Philippe Labelle
2017 Pathologic Basis of Veterinary Disease  
The lesion progresses to a uniform diffuse loss of photoreceptors and eventually to diffuse full-thickness retinal atrophy.  ...  There is variable progression to full-thickness retinal atrophy over 2 to 4 years. Rods are more severely affected than cones.  ... 
doi:10.1016/b978-0-323-35775-3.00021-7 fatcat:rh2qcg7i6jhsnhehgsyhb32k34

Special Senses [chapter]

Brian P. Wilcock, Bradley L. Njaa
2016 Jubb, Kennedy & Palmer's Pathology of Domestic Animals: Volume 1  
In dogs with high-pressure glaucoma, there is sometimes full-thickness retinal atrophy that even includes damage to the retinal pigment epithelium (Fig. 5-55C ).  ...  Finally, the basal cells maintain a barrier via tight junctions between the intrastrial space and the perilymph.  ...  Unlike most other papillomavirus infections, aural plaques are never observed in horses <1 year of age, and they do not spontaneously resolve or regress.  ... 
doi:10.1016/b978-0-7020-5317-7.00005-9 fatcat:tuvfinzfjje5fjrauagodymxaq

The Eye and Ear [chapter]

1993 Pathology of Domestic Animals  
At this stage, the old name of progressive retinal atrophy continues to be used as a catch-all.  ...  It probably reflects recrudescence of latent infection.  ...  In swine and lambs, the infection usually ascends from the pharynx via the Eustachian tube.  ... 
doi:10.1016/b978-0-08-057133-1.50012-6 fatcat:fl4b6fxuovccznm2n3zkgehndy

Poor glycemic control is associated with neuroretinal dysfunction in short-wavelength colour pathways in adolescents with type 1 diabetes

M. McFarlane, T. Wright, C. Westall
2010 Journal of Vision  
Between-Group Comparisons Before regression modeling, between-group comparisons were conducted using the linear mixed model approach.  ...  The linear mixed model is an extension of the classical linear regression model (Cnaan, et al., 1997) .  ...  Purpose of the Research: The purpose of this study is to help us understand more clearly if early eye and brain changes occur in children and young persons with type I diabetes.  ... 
doi:10.1167/10.15.70 fatcat:wdkzacackfezrbjk4tusfuz44i

Corticosteroids and Anti-Complement Therapy in Retinal Diseases [chapter]

Raja Narayanan, Baruch D. Kuppermann
2016 Handbook of Experimental Pharmacology  
Conflict of Interest Johns Hopkins has filed a patent application on the use of technology to modulate the levels of ANGPTL4 for the treatment of ocular neovascular disease (US patent 14/394, 152).  ...  Acknowledgments This was supported in part by the NIH grants EY022097, EY024072, and EY018940 and the US FDA grants FD004929 and FD004719. The authors are thankful to Dr. Ryan A.  ...  A multiple linear regression analysis was conducted to identify the physicochemical properties that are predictors of half-life of a drug in the vitreous.  ... 
doi:10.1007/164_2016_22 pmid:27815789 fatcat:i5n3rqpvk5dwpp2xmlzh6aq4ei

Abstracts: 46th Annual Meeting of the American College of Veterinary Ophthalmologists, Coeur d'Alene, ID October 7-10, 2015

2015 Veterinary Ophthalmology  
The continuous data on CCT and age were compared between the modalities and between eyes using linear regression analysis for association.  ...  respectively, using progressively longer needles.  ...  We anticipated that the SNP genotyping data from this study can be used as a genetic testing to determine for the first time with precision whether a dog has glaucoma and to predict whether a dog will  ... 
doi:10.1111/vop.12319 fatcat:757r2fbsgbesxivk2qpiha4tem

Abstracts: 43rd Annual Meeting of the American College of Veterinary Ophthalmologists, Portland, Oregon, USA, October 17-20, 2012

2012 Veterinary Ophthalmology  
Methods: Six 2 month-old mini pigs (p23h) were used. Human retinal progenitor cells were injected into the subretinal space of six eyes.  ...  Measurements included epithelial thickness (ET), non-epithelial thickness (NET), and central corneal thickness (CCT).  ...  IOL strength was predicted using three theoretical formulas.  ... 
doi:10.1111/j.1463-5224.2012.01072.x fatcat:fzk26xbuinchzksu6rj4dc7h2i

Solid-State Lasers [chapter]

Rahul Yadav
2018 Encyclopedia of Ophthalmology  
Targeted retinal photocoagulation can be used to treat retinal ischemia anterior to the seafans and has been shown to induce regression of PSR.  ...  This has made the surgery more predictable and precise. • Retinal laser photocoagulation procedure is used in diabetic retinopathy patients.  ...  retinal necrosis syndrome (Gupta et al. 2009 ).  ... 
doi:10.1007/978-3-540-69000-9_669 fatcat:hzsgogaq4zfm3h3455bvg2assm

Abstracts 14th ESASO Retina Academy. November 13-15, 2014, Istanbul, Turkey: Abstracts

2014 Ophthalmologica  
Mean central retinal thickness (CRT) decreased, from 355.13 ± 119.93 μm at baseline to 250.85 ± 45.48 μm at 12 months in group 1, and from 371.88 ± 91.047 μm at baseline to 268.61 ± 53.51 μm at 12 months  ...  VEGF levels were measured using multiplex bead immunoassay. Results: At baseline, VEGF levels were significantly increased in PCV eyes compared with control eyes.  ...  Congenital Glaucoma Keywords : Keywords Primary Congenital Glaucoma, Choroidal Thickness, Retinal Thickness, Retinal Nerve Fiber Layer, Visual Acuities.  ... 
doi:10.1159/000368726 pmid:25402660 fatcat:amyorasbrvgsnk7st37eosomvy

58th Annual Symposium of the International Society for Clinical Electrophysiology of Vision (ISCEV 2020)

2020 Documenta Ophthalmologica  
Data were analysed as a function of amplitude and latency according to age through logarithmic modelling, limits of agreement, regression analysis and descriptive statistics to ascertain the age-dependence  ...  Of note, 63 patients (0.04%) would have been considered to have abnormally low amplitude prVEPs using Oz alone, whereas responses were normal using the Iz amplitude, suggesting that this extra electrode  ...  This implies two separate issues: (1) the spacing of the check sizes (logarithmic or linear), and (2) the scale on which the linear regression is calculated (logarithmic or linear).  ... 
doi:10.1007/s10633-020-09789-6 pmid:32915376 fatcat:uwr4pr2ri5ftvmclukvubbkoca

Birdshot chorioretinopathy: current knowledge and new concepts in pathophysiology, diagnosis, monitoring and treatment

Evangelos Minos, Robert J. Barry, Sue Southworth, Annie Folkard, Philip I. Murray, Jay S. Duker, Pearse A. Keane, Alastair K. Denniston
2016 Orphanet Journal of Rare Diseases  
[54] As BCR progresses these lesions become more confluent, coalescent and form linear patterns around retinal veins.  ...  Recently, Arya and collegues applied pointwise linear regression (PLR) analysis to results of automated HVF in patients with BCR, and were able to identify field loss in patients despite a stable MD, and  ... 
doi:10.1186/s13023-016-0429-8 pmid:27175923 pmcid:PMC4866419 fatcat:zoonemxnenep3g7ode4khwh5cu


2012 Ophthalmologica  
However, we remarked that we should use this therapy with caution until experience is gained.  ...  Currently, CRD is used commonly worldwide, particularly for bilateral retinoblastoma. Long-term toxicities related to intravenous CRD have been few.  ...  Acknowledgments Research support: NIH grants EY06109, International Retinal Research Foundation, Research to Prevent Blindness, Inc., Eye-Sight Foundation of Alabama, Macula Vision Research Foundation.  ... 
doi:10.1159/000339909 pmid:22986708 fatcat:uaupigzbl5ba5fzd6ow5h6h5ty

European Vitreoretinal Update 2013. Abstracts of the Main Sessions,13th Euretina Congress, Hamburg, 2013

2013 Ophthalmologica  
The majority of uveal melanomas is treated by irradiation using various modalities such as brachytherapy or teletherapy.  ...  Surgical resection techniques such as transscleral resection in arterial hypotension in anteriorly located tumors and endoresection via pars plana vitrectomy in posteriorly located tumors can reduce these  ...  That software was used to analyze retinal cell layer thickness in patients with foveal hypoplasia.  ... 
doi:10.1159/000354999 pmid:24081148 fatcat:6wilju3355glze56zsihefzbri
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