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Iterative Methods for the Computation of the Perron Vector of Adjacency Matrices

Anna Concas, Lothar Reichel, Giuseppe Rodriguez, Yunzi Zhang
2021 Mathematics  
The power method is commonly applied to compute the Perron vector of large adjacency matrices. Blondel et al.  ...  This would imply that the Perron root of M is the Perron root of T k , and therefore the Lanczos method determines the Perron root and Perron vector.  ...  The Perron root of A is 0, with Perron vector e 1 = [1, 0, . . . , 0] T .  ... 
doi:10.3390/math9131522 fatcat:vny2qqlofbb6flkinlnrovzwwm

Oxidative Stress in Preterm Newborns

Chiara Lembo, Giuseppe Buonocore, Serafina Perrone
2021 Antioxidants  
A recent study by Perrone et al. confirmed a significant increase in AOPP blood concentration in response to painful stressors in the newborn [102] .  ... 
doi:10.3390/antiox10111672 pmid:34829543 pmcid:PMC8614893 fatcat:hbl7wfusmrafdjqxg2mgusamve

Metabolomic Profile of Young Adults Born Preterm

Serafina Perrone, Simona Negro, Elisa Laschi, Marco Calderisi, Maurizio Giordano, Giuseppe De Bernardo, Gianni Parigi, Anna Laura Toni, Susanna Esposito, Giuseppe Buonocore
2021 Metabolites  
Prematurity is a risk factor for the development of chronic adult diseases. Metabolomics can correlate the biochemical changes to a determined phenotype, obtaining real information about the state of health of a subject at that precise moment. Significative differences in the metabolomic profile of preterm newborns compared to those born at term have been already identified at birth. An observational case–control study was performed at the University Hospital of Siena. The aim was to evaluate
more » ... d compare the metabolomic profiles of young adults born preterm to those born at term. Urinary samples were collected from 67 young adults (18–23 years old) born preterm (mean gestational age of 30 weeks, n = 49), and at term of pregnancy (mean gestational age of 38 weeks, n = 18). The urinary spectra of young adults born preterm was different from those born at term and resembled what was previously described at birth. The Random Forest algorithm gave the best classification (accuracy 82%) and indicated the following metabolites as responsible for the classification: citrate, CH2 creatinine, fumarate and hippurate. Urine spectra are promising tools for the early identification of neonates at risk of disease in adulthood and may provide insight into the pathogenesis and effects of fetal programming and infants' outcomes.
doi:10.3390/metabo11100697 pmid:34677412 fatcat:zgpdravwlzg3hinlcutajfl7cm

Rooming-in Reduces Salivary Cortisol Level of Newborn

Giuseppe De Bernardo, Marina Riccitelli, Maurizio Giordano, Fabrizio Proietti, Desiree Sordino, Mariangela Longini, Giuseppe Buonocore, Serafina Perrone
2018 Mediators of Inflammation  
Background. Rooming-in practice improves breastfeeding and reduces newborn stress reactivity. When this modality is not available, partial rooming-in after birth can be considered. Salivary cortisol levels (SCLs) are considered reliable biomarkers to indicate stress. Objective. To test the hypothesis that rooming-in duration impacts neonatal stress response in hospitalized newborns. Design/methods. Forty term newborns, enrolled in the Neonatology and Obstetrics Nursing, C.G. Ruesch, Naples,
more » ... y, were divided, according to the mother's choice, into the study (SG; n=20) and control (CG; n=20) groups if they received full (24 hs) or partial (14 hs) rooming-in care, respectively. Saliva samples were collected from all babies between 7:00 a.m. and 8:00 a.m. of the 3rd day of life by using oral swab. Salivary cortisol levels were measured using an enzyme immunoassay kit (Salimetrics LLC, PA, USA). Results. A statistically significant difference in the SCLs between SG and CG was found (median: 258 ng/dl versus 488.5 ng/dl; p=0.048). Conclusions. Data support the practice of full rooming-in care compared with partial rooming-in. The rooming-in duration clearly reduces SCLs and likely neonatal stress. These lower SCLs may have long-term positive effects reducing the risk of metabolic syndrome, high blood pressure, and cognitive and behavioural changes.
doi:10.1155/2018/2845352 pmid:29706798 pmcid:PMC5863308 fatcat:gmp3jvskgzgs7axkp6dpoxph44

Energy stability of plane Couette and Poiseuille flows and Couette paradox [article]

Paolo Falsaperla, Giuseppe Mulone, Carla Perrone
2021 arXiv   pre-print
We study the nonlinear stability of plane Couette and Poiseuille flows with the Lyapunov second method by using the classical L2-energy. We prove that the streamwise perturbations are L2-energy stable for any Reynolds number. This contradicts the results of Joseph [10], Joseph and Carmi [12] and Busse [4], and allows us to prove that the critical nonlinear Reynolds numbers are obtained along two-dimensional perturbations, the spanwise perturbations, as Orr [16] had supposed. This conclusion
more » ... ined with recent results by Falsaperla et al. [8] on the stability with respect to tilted rolls, provides a possible solution to the Couette-Sommerfeld paradox.
arXiv:2105.06443v1 fatcat:jwdljmq3bzchrfp4fl75tbpbvu

Pomological, Sensorial, Nutritional and Nutraceutical Profile of Seven Cultivars of Cherimoya (Annona cherimola Mill)

Carla Gentile, Giuseppe Mannino, Eristanna Palazzolo, Giuseppe Gianguzzi, Anna Perrone, Graziella Serio, Vittorio Farina
2020 Foods  
In this work, the food quality of four international (Campas, Chaffey, Fino de Jete and White) and three local (Daniela, Torre1 and Torre2) cultivars of Cherimoya (Annona cherimola Mill) was investigated. With this aim, pomological traits, sensorial attributes, physiochemical parameters (pH, total soluble content and total acidity), nutritional composition (macro- and micro-nutrients) and nutraceutical values (bioactive compounds, radical scavenging and antioxidant properties) were evaluated.
more » ... ong the seven observed cultivars, Fino de Jete was identified as the best, not only for its commercial attributes such as pomological traits and physiochemical values, but also for its nutritional composition. On the other hand, Chaffey and Daniela were the cultivars with the highest content of polyphenols, proanthocyanidins, and with the strongest antioxidant capacity. Concerning the two local ecotypes, Torre1 and Torre2, they displayed a balanced nutritional profile that, if combined with their discrete nutraceutical, physicochemical and pomological values, may result in a reassessment of their commercial impact. In conclusion, our data provide interesting information about the pomological, nutritional, and nutraceutical properties of cherimoya fruits. Our results, in addition to promoting the commercial impact of local cultivars, may increase the use of individual cultivars in breeding programs.
doi:10.3390/foods10010035 pmid:33374394 fatcat:u4q32xfcezbifoaka7jkfjcksa

Oxidative Stress in the Newborn

Giuseppe Buonocore, Serafina Perrone, Maria Luisa Tataranno
2017 Oxidative Medicine and Cellular Longevity  
Perrone et al., a relationship between pain degree and OS in healthy full-term newborns. They found that the amount of OS is gender related, being higher in males.  ...  Giuseppe Buonocore Serafina Perrone Maria Luisa Tataranno Hindawi Publishing Corporation Oxidative Medicine and Cellular Longevity Volume 2017, Article ID 1094247, 2 pages http://dx.doi.org/10.1155/2017  ...  Perrone et al., a relationship between pain degree and OS in healthy full-term newborns. They found that the amount of OS is gender related, being higher in males.  ... 
doi:10.1155/2017/1094247 pmid:28250890 pmcid:PMC5307135 fatcat:voobrmxk55binblyzjyafqjxe4

Chemical–physical characteristics, polyphenolic content and total antioxidant activity of three Italian-grown pomegranate cultivars

Roberta Passafiume, Anna Perrone, Giuseppe Sortino, Giuseppe Gianguzzi, Filippo Saletta, Carla Gentile, Vittorio Farina
2019 NFS Journal  
A B S T R A C T Background: In Mediterranean countries, there is an increasing demand for pomegranate fruits due to their antioxidant properties and nutritional values. The large diffusion of new genotypes and cultivars requires the knowledge of all fruit characteristics in connection with the cultivation area, to satisfy the market demand. This study seeks to determine the fruit quality attributes and nutraceutical values of three pomegranate cultivars (Wonderful, Acco and Kamel) grown in the
more » ... editerranean climate. Methods: The fruits were evaluated for their main physico-chemical traits (weight, volume, height, width, thickness, total arils number, total arils weight, juiciness, fruit index, peel index and total soluble solids content/ titratable acidity ratio), bioactive compounds (total phenolic content and total anthocyanin content) and antioxidant activities (radical scavenging activity and ferric reducing power). Results: The data showed that Acco fruit is bigger, juicier and sweeter when compared with the cultivars Wonderful and Kamel. Wonderful is the smallest, least juicy and least sweet but the reddest among all the studied cultivars. Regarding the phenolic compounds and antioxidant activity (radical scavenging activity and ferric reducing power), cultivar Wonderful has the highest values and cultivar Acco contains the most anthocyanin content. Conclusions: This study showed that pomegranate cultivars grown in the Mediterranean area exhibit an appreciable quality, but there are significant differences in quality properties of the arils and juice.
doi:10.1016/j.nfs.2019.06.001 fatcat:hg2giyjcbvhz3etkanpjpoffzm

Magnetic Resonance Imaging in Pregnancy with Intrauterine Growth Restriction: A Pilot Study

Serafina Perrone, Antonino Santacroce, Giuseppe de Bernardo, Maria Gabriella Alagna, Salvatore Francesco Carbone, Irene Paternò, Giuseppe Buonocore
2019 Disease Markers  
Objective. Intrauterine growth restriction (IUGR) is a major cause of late stillbirth, though not all compromised babies remain small or are considered growth restricted as pregnancy progresses. Fetal Magnetic Resonance Imaging (f-MRI) represents a second-line tool to study pregnancies with IUGR fetuses. The aim of our study was to evaluate the usefulness of f-MRI on predicting fetal growth and the offspring's perinatal respiratory outcome. Design. All f-MRI performed between 2014 and 2016 in
more » ... ena were analysed. Pregnancies with IUGR (Study group (SG)) were recruited together with a control population (Control group (CG)), coupled for gestational age (GA) at the time of f-MRI (mean GA 31 wks). Neonatal information was collected. The f-MRI protocol consisted of T2w images. Six regions of interest (ROI) were placed as follows: 2 on the lung, 2 on the liver, and 2 on the amniotic fluid. The signal intensities (SI) of each ROI were measured. The SI lung to liver ratio (SI lung/liver) and SI lung to amniotic fluid ratio (SI lung/amniotic fluid) were obtained for each fetus. Each ratio was compared between SG and CG. Therefore, SG was divided into two subgroups: adequate and small for gestational age (AGA and SGA) newborns. All measurements were related to offspring's perinatal respiratory outcome. Results. SI lung/liver was linearly related with GA at the time of f-MRI and with EFW. SI lung/amniotic fluid was significantly higher in SG than in CG (p=0,014). In contrast, among SG, lower values of SI lung/amniotic fluid were found in the SGA compared to AGA (p=0,036). The days of oxygen supply were higher in the SGA subgroup than in the AGA subgroup (p=0,028). Conclusions. SI lung/liver increases with fetal lung maturation and appears to be useful to estimate intrauterine fetal growth. SI lung/amniotic fluid seems to be a reliable predictive index to distinguish the IUGR fetuses that can recover their growth from those that were born SGA. f-MRI represents a promising frontier to predict IUGR fetus outcome, thus contributing to ameliorate the perinatal management.
doi:10.1155/2019/4373490 pmid:31827633 pmcid:PMC6881754 fatcat:kvw6s5xxpnd7tczgjzzsjeahca

Immigration and Adverse Pregnancy Outcomes in an Italian Free Care Hospital

Giuseppe Caruso, Eleonora Marcoccia, Roberto Brunelli, Miriam Candelieri, Michele Carlo Schiavi, Ilaria Zannini, Seila Perrone, Oriana Capri, Ludovico Muzii, Giuseppina Perrone, Paola Galoppi
2021 International Journal of Women's Health  
The ever-increasing wave of immigration in Italy has posed demanding challenges in the management of the new multiethnic obstetric population. The aim of this study was to compare pregnancy and perinatal outcomes between immigrants and the native population in an Italian public hospital. Singleton pregnant women (≥ 24 weeks of gestation) who delivered during a 3-year period in an Italian free care hospital were included. Long-term (≥ 2 years of residence) immigrant patients were divided into 4
more » ... roups according to their ethnic origin: Europeans, Asians, Latin Americans, and Africans. Perinatal indicators of obstetric outcomes were collected and compared between immigrants and Italians. Of the 3556 patients included, 1092 were immigrants and 2464 Italians. The immigrant cohort experienced a higher rate of macrosomia (1.8% vs 0.6%; p = 0.001), very low birth weight (1.3% vs 0.6%; p = 0.048), very early preterm delivery (1.4% vs 0.4%; p = 0.048), and gestational diabetes mellitus (1.8% vs 0.5%; p = 003) compared with the native population. The overall rate of cesarean sections was greater among Italians (56% vs 45.8%; p < 0.001). Among ethnic groups, Europeans and Latin Americans reported a higher rate of preterm delivery (20.2% and 19%, respectively; p < 0.001). Latin Americans carried also a greater risk of fetal macrosomia (3.6%; p < 0.008), while the rate of very low birth weight was higher among Europeans and Africans (2% and 1.8%, respectively; p < 0.04). Obstetricians should pay special attention to the potential disparities in pregnancy outcomes between immigrants and the native population. Future efforts should focus on reducing preterm delivery and glucose dysmetabolism among pregnant immigrants.
doi:10.2147/ijwh.s322828 pmid:34675689 pmcid:PMC8504550 fatcat:pthb3bpf2babhn4fnwdaolpxcy

Food quality and nutraceutical value of nine cultivars of mango (Mangifera indica L.) fruits grown in Mediterranean subtropical environment

Carla Gentile, Emanuela Di Gregorio, Vita Di Stefano, Giuseppe Mannino, Anna Perrone, Giuseppe Avellone, Giuseppe Sortino, Paolo Inglese, Vittorio Farina
2019 Food Chemistry  
Bioactive compounds The potential beneficial effects of plant food consumption can be ascribed to a number of peculiar bioactive compounds (Gentile, Perrone, Attanzio, Tesoriere, & Livrea, 2015; Naselli  ... 
doi:10.1016/j.foodchem.2018.10.109 fatcat:kx5o75wpq5gshgoef6bs2loaii

Current prognostic and predictive biomarkers for gastrointestinal tumors in clinical practice

Matteo Fassan, Aldo Scarpa, Andrea Remo, Giovanna De Maglio, Giancarlo Troncone, Antonio Marchetti, Claudio Doglioni, Giuseppe Ingravallo, Giuseppe Perrone, Paola Parente, Claudio Luchini, Luca Mastracci
2020 Pathologica  
The pathologist emerged in the personalized medicine era as a central actor in the definition of the most adequate diagnostic and therapeutic algorithms. In the last decade, gastrointestinal oncology has seen a significantly increased clinical request for the integration of novel prognostic and predictive biomarkers in histopathological reports. This request couples with the significant contraction of invasive sampling of the disease, thus conferring to the pathologist the role of governor for
more » ... oth proper pathologic characterization and customized processing of the biospecimens. This overview will focus on the most commonly adopted immunohistochemical and molecular biomarkers in the routine clinical characterization of gastrointestinal neoplasms referring to the most recent published recommendations, guidelines and expert opinions.
doi:10.32074/1591-951x-158 pmid:33179625 fatcat:pkrtwypsjrgxvfy3vln4kbb664

Bone Involvement in Hodgkin's Lymphoma: Clinical Features and Outcome

Francesco Gaudio, Pasquale Pedote, Artor Niccoli Asabella, Giuseppe Ingravallo, Paola Sindaco, Vito Alberotanza, Tommasina Perrone, Fiomena Emanuela Laddaga, Giuseppe Rubini, Amato Antonio Stabile Ianora, Giorgina Specchia
2018 Acta Haematologica  
Hodgkin's lymphoma (HL) is now a highly curable disease, with an improving 5-year survival rate that has now reached 86%. At the time of presentation, HL is usually almost entirely confined to the lymph nodes. We performed a retrospective single-institution study of 384 cases with a median follow-up of 44 months, with the aim of identifying clinical and radiological characteristics and outcomes of patients with bone HL; 32 patients (8%) had primary bone involvement, always with concurrent nodal
more » ... disease. These included 22 men (69%) and 10 women (31%) with the median age as 41 years. Advanced stages and nodular sclerosis histology prevailed among the subgroup. Radiographic features of bone HL are not specific but indicate a destructive malignant process with osteosclerosis and/or osteolysis. With current chemotherapeutic regimens, the long-term prognosis of patients with osseous HL appears good. The presence of bone lesions in HL should not be interpreted as implying a worse prognosis than without bone involvement.
doi:10.1159/000490489 fatcat:iderozmlhbfa5owqexmn2unzly

Uncommon EGFR mutations in non-small-cell lung cancer

Marco Russano, Giuseppe Perrone, Giuseppina Rita Di Fazio, Alessandro Galletti, Fabrizio Citarella, Valentina Santo, Leonardo Brunetti, Alessia Vendittelli, Bruno Vincenzi, Giuseppe Tonini, Daniele Santini
2021 Precision Cancer Medicine  
doi:10.21037/pcm-22-14 fatcat:vvtpcqogubg7baytlfcz3ywrym

Scan role in diagnosing acute appendicitis

Massimo Summa, Fabrizio Perrone, Fabio Priora, Eliana Giaminardi, Roberta Longhin, Giuseppe Spinoglio
2006 Emergency Care Journal  
, Roberta Longhin, Giuseppe Spinoglio SOC di Chirurgia Generale a Indirizzo Oncologico, Dipartimento Chirurgico Azienda Ospedaliera "Santi Antonio e Biagio e C.  ...  Fig. 3 - 3 Ascesso appendicolare. emergency care journal -organizzazione, clinica, ricerca • Anno II numero VI • Dicembre 2006 • www.ecj.it Massimo Summa, Fabrizio Perrone, Fabio Priora, Eliana Giaminardi  ... 
doi:10.4081/ecj.2006.6.37 fatcat:csfuz54235dtjep2qilhf7pavq
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