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Measuring gravitational effects on antimatter in space [article]

Giovanni Maria Piacentino, Anthony Palladino, Graziano Venanzoni
2016 arXiv   pre-print
We propose an experimental test of the gravitational interaction with antimatter by measuring the branching fraction of the CP violating decay K_L→π^+π^- in space. We show that at the altitude of the International Space Station, gravitational effects may change the level of CP violation such that a 5σ discrimination may be obtained by collecting the K_L produced by the cosmic proton flux within a few years.
arXiv:1605.01751v1 fatcat:tgaa57hu5jgzrjmdokg53uhcsa

The earth sciences in the scientific letters of Giovanni Capellini

Graziano Ferrari, Massimo Caciagli
2009 Annals of Geophysics  
Giovanni Capellini (1833-1922) was one of the leading representatives of the Italian and international scientific community from the mid-19th century until 1922, the year of his death.  ...  Giovanni Capellini was one of them.  ...  A short biography of Giovanni Capellini (1833-1922) Giovanni Capellini ( fig. 1 ) was born to a humble family in La Spezia (Italy) on 23rd August 1833.  ... 
doi:10.4401/ag-4624 doaj:d9476334cb054566b320d6eec279d575 fatcat:m4kyconrorh47pfdrfygovfzp4

Delayed massive subcutaneous emphysema following Robicsek closure

Natalia Pavone, Federico Cammertoni, Piergiorgio Bruno, Giovanni Alfonso Chiariello, Giovanni Graziano, Massimo Massetti
2019 Clinical Case Reports  
A computed tomography scan revealed pneumomediastinum with air passing through the sternum to the left hemithorax (*)(Giovanni Graziano | Massimo Massetti This is an open access article under the terms  ... 
doi:10.1002/ccr3.2518 pmid:31893109 pmcid:PMC6935661 fatcat:les6tic4mnhqhefm7thrgy6vde

Humanization of Care Ethical and Social in Clinical-Care

Graziano Giorgio Maria Paolo, Antonino Graziano, Giovanni Castelli, Antonio Di cataldo
2016 World Journal of Research and Review  
Giovanni Castelli MD Policlinico University of Catania Italy. Antonino Graziano Aggregate Professor .  ... 
doi:10.31871/wjrr.3.6.3 fatcat:itgg4jdxs5aj5n5gc3s57pj67i

The MYSTERY OF LIFE

GrazianoGiorgioMaria. Paolo., Antonino. Graziano., Giovanni. Castelli., AntonioDi. Cataldo.
2017 International Journal of Advanced Research  
doi:10.21474/ijar01/3055 fatcat:a3boigkle5hfnmwhyha3kzwoke

Dynamic pricing strategies: Evidence from European hotels

Graziano Abrate, Giovanni Fraquelli, Giampaolo Viglia
2012 International Journal of Hospitality Management  
How much do hoteliers actually make use of dynamic pricing strategies? We collected data on the price of a single room booked in advance (from three months to a single day), from almost 1000 hotels in eight European capital cities. Pricing strategies were analyzed by means of descriptive statistics, box plots and econometric panel data techniques. The empirical results show that the inter-temporal pricing structure primarily depends on the type of customer, the star rating and the number of suppliers with available rooms.
doi:10.1016/j.ijhm.2011.06.003 fatcat:vqohrlxljfgzlpsycshis2vvc4

Interleaving in Systolic-Arrays: A Throughput Breakthrough

Giovanni Causapruno, Marco Vacca, Mariagrazia Graziano, Maurizio Zamboni
2015 IEEE transactions on computers  
In past years the most common way to improve computers performance was to increase the clock frequency. In recent years this approach suffered the limits of technology scaling, therefore computers architectures are shifting toward the direction of parallel computing to further improve circuits performance. Not only GPU based architectures are spreading in consideration, but also Systolic Arrays are particularly suited for certain classes of algorithms. An important point in favor of Systolic
more » ... ays is that, due to the regularity of their circuit layout, they are appealing when applied to many emerging and very promising technologies, like Quantum-dot Cellular Automata and nanoarrays based on Silicon NanoWire or on Carbon nanotube Field Effect Transistors. In this work we present a systematic method to improve Systolic Arrays performance exploiting Pipelining and Input Data Interleaving. We tackle the problem from a theoretical point of view first, and then we apply it to both CMOS technology and emerging technologies. On CMOS we demonstrate that it is possible to vastly improve the overall throughput of the circuit. By applying this technique to emerging technologies we show that it is possible to overcome some of their limitations greatly improving the throughput, making a considerable step forward toward the post-CMOS era.
doi:10.1109/tc.2014.2346208 fatcat:woot443hfjdi5mpnttvg4wjouy

Capacity Building Surveys [chapter]

Riccardo Graziano, Pasqualina Porretta, Giovanni Nicola Pes, Cristiana Turchetti, Matteo Re
2016 Microfinance, EU Structural Funds and Capacity Building for Managing Authorities  
doi:10.1057/9781137536020_5 fatcat:mmympigipbbd3hfsvroueunlei

Robotic versus open oncological gastric surgery in the elderly: a propensity score-matched analysis

Giovanni Maria Garbarino, Gianluca Costa, Barbara Frezza, Alessia Biancafarina, Genoveffa Balducci, Paolo Mercantini, Marco De Prizio, Giovanni Gugliemo Laracca, Graziano Ceccarelli
2020 Journal of Robotic Surgery  
Although there is no agreement on a definition of elderly, commonly an age cutoff of ≥ 65 or 75 years is used. Even if robot-assisted surgery is a validated option for the elderly population, there are no specific indications for its application in the surgical treatment of gastric cancer. The aim of this study is to evaluate the safety and feasibility of robot-assisted gastrectomy and to compare the short and long-term outcomes of robot-assisted (RG) versus open gastrectomy (OG). Patients aged
more » ... ≥ 70 years old undergoing surgery for gastric cancer at the Department of Surgery of San Donato Hospital in Arezzo, between September 2012 and March 2017 were enrolled. A 1:1 propensity score matching was performed according to the following variables: age, Sex, BMI, ASA score, comorbidity, T stage and type of resection performed. 43 OG were matched to 43 RG. The mean operative time was significantly longer in the RG group (273.8 vs. 193.5 min, p < 0.01). No differences were observed in terms of intraoperative blood loss, an average number of lymph nodes removed, mean hospital stay, morbidity and mortality. OG had higher rate of major complications (6.9 vs. 16.3%, OR 2.592, 95% CI 0.623–10.785, p = 0.313) and a significantly higher postoperative pain (0.95 vs. 1.24, p = 0.042). Overall survival (p = 0.263) and disease-free survival (p = 0.474) were comparable between groups. Robotic-assisted surgery for oncological gastrectomy in elderly patients is safe and effective showing non-inferiority comparing to the open technique in terms of perioperative outcomes and overall 5-year survival.
doi:10.1007/s11701-020-01168-2 pmid:33151485 pmcid:PMC8423642 fatcat:ycfielidmbhv5cffpuenz5uuua

Engineered cobalt oxide nanoparticles readily enter cells

Elena Papis, Federica Rossi, Mario Raspanti, Isabella Dalle-Donne, Graziano Colombo, Aldo Milzani, Giovanni Bernardini, Rosalba Gornati
2009 Toxicology Letters  
Magnetic nanoparticles (NPs) have great potential for applications not only as catalysts or energy storage devices, but also in biomedicine, as contrast enhancement agents for magnetic resonance imaging, or for drug delivery. The same characteristics that make cobalt-based NPs so attractive raise serious questions about their safety. In this context, we investigated Co 3 O 4 -NPs. Believing that the characterization of NPs is relevant for understanding their biological activity, we analyzed
more » ... by atomic force and electron microscopy to define size, shape, and aggregation. To clarify whether their biological effects could be due to a potential release of cobalt ions, we evaluated spontaneous dissolution in different media. To determine their potential toxicity to human cells, we measured cell viability and ROS formation in two human cell lines using CoCl 2 for comparison. Co 3 O 4 -NPs induced a concentration-and time-dependent impairment of cellular viability, although cobalt ions were more toxic. We also demonstrated that cobalt causes a rapid induction of ROS if supplied in the form of Co 3 O 4 -NPs rather than as ions. Moreover, we evaluated the cellular uptake of NPs. Interestingly, Co 3 O 4 -NPs are able to enter the cell very rapidly, remaining confined in vesicles inside the cytoplasm. They were found also inside the cell nuclei, though less frequently.
doi:10.1016/j.toxlet.2009.06.851 pmid:19539014 fatcat:nedfxqcr2zb5zd26b6vqp2s4dm

Retinal Blood Flow Autoregulation after Dynamic Exercise in Healthy Young Subjects

Michele Iester, Pier Giacomo Torre, Graziano Bricola, Alessandro Bagnis, Giovanni Calabria
2007 Ophthalmologica  
243.9 8 72.24 AU in the inferonasal area. After dynamic exercise the mean retinal blood flow was 249.8 8 86.78 AU in the superotemporal area, 248.7 8 63.87 AU in the superonasal area, 245.4 8 83.85 AU in the inferotemporal area and 228.8 8 62.53 AU in the inferonasal area. No significant change in retinal blood flow was found. Conclusion: Our data support the hypothesis that in normal subjects autoregulation is sufficient to compensate the increase in blood pressure and maintain a stable
more » ... blood flow after exercise. Introduction Vascular resistance is physiologically regulated by changing the local diameter of the arterioles to keep the local blood flow constant. This physiological process is called autoregulation. Different types of regulatory factors such as metabolic, myogenic and neurogenic factors can act on vascular tone systems. Although many factors such as age, heart, blood pressure, intraocular pressure (IOP) and psychic stress can influence the retinal blood flow, only few studies have examined the effect of physical exercise on orbital blood flow velocities of different ocular tissues [1] [2] [3] [4] [5] [6] . Since the Heidelberg retina flowmeter (HRF; Heidelberg Engineering, Heidelberg, Germany) has been intro- Key Words Retinal blood flow, healthy subjects ؒ Heidelberg retina flowmeter ؒ Autoregulation ؒ Dynamic exercise Abstract Purpose: To evaluate the retinal blood flow before and after the increase in systemic blood pressure to assess the autoregulation in healthy young subjects. Methods: Twenty eyes of 20 healthy volunteers were examined. The retinal blood flow was assessed by a Heidelberg retina flowmeter (HRF), while the systemic pressure was assessed by a portable electronic sphygmomanometer. Furthermore intraocular pressure (IOP) was always measured by a Goldmann tonometer immediately after HRF assessments. All measurements of physiological and flow parameters were performed with the subjects seated at rest and then immediately after stair climbing. Results: The IOP decreased significantly after dynamic exercise, while the heart rate and the systemic artery pressure increased significantly. At the baseline, the mean retinal blood flow was 276.8 8 80.7 arbitrary units (AU) in the superotemporal area, 243.4 8 63.68 AU in the superonasal area, 258.2 8 67.37 AU in the inferotemporal area and
doi:10.1159/000099298 pmid:17440280 fatcat:eu3xfjzzw5ae7eb5kjmczmunea

NanoMagnet Logic: An Architectural Level Overview [chapter]

Marco Vacca, Mariagrazia Graziano, Juanchi Wang, Fabrizio Cairo, Giovanni Causapruno, Gianvito Urgese, Andrea Biroli, Maurizio Zamboni
2014 Lecture Notes in Computer Science  
In recent years Field-Coupled devices, like Quantum dot Cellular Automata, are gaining an ever increasing attention from the scientific community. The computational paradigm beyond this device topology is based on the interaction among neighbor cells to propagate information through circuits. Among the various implementations of this theoretical principle, NanoMagnet Logic (NML) is one the most studied, due to some interesting features, like the possibility to combine memory and logic in the
more » ... e device and the possible low power consumption. Since the working principle of Field-Coupled devices is completely different from CMOS technology, it is important to understand all the implications that this new computational paradigm has on complex circuit architectures. In this chapter we deeply analyze the major issues encountered in the design of complex circuits using Field-Coupled devices. Problems are analyzed and techniques to solve them and to improve performance are presented. Finally, a realistic analysis of the applications best suited for this technology is presented. While the analysis is performed using Nano-Magnet Logic as target, the results can be applied to all Field-Coupled devices. This chapter therefore supplies researchers and designers with the essential guidelines necessary to design complex circuits using Nano-Magnet Logic and, more in general, Field-Coupled devices.
doi:10.1007/978-3-662-43722-3_10 fatcat:26yf6o5cnjhk3ipbu4jjwo7iwy

CoVaCS: a consensus variant calling system

Matteo Chiara, Silvia Gioiosa, Giovanni Chillemi, Mattia D'Antonio, Tiziano Flati, Ernesto Picardi, Federico Zambelli, David Stephen Horner, Graziano Pesole, Tiziana Castrignanò
2018 BMC Genomics  
The advent and ongoing development of next generation sequencing technologies (NGS) has led to a rapid increase in the rate of human genome re-sequencing data, paving the way for personalized genomics and precision medicine. The body of genome resequencing data is progressively increasing underlining the need for accurate and time-effective bioinformatics systems for genotyping -a crucial prerequisite for identification of candidate causal mutations in diagnostic screens. Results: Here we
more » ... t CoVaCS, a fully automated, highly accurate system with a web based graphical interface for genotyping and variant annotation. Extensive tests on a gold standard benchmark data-set -the NA12878 Illumina platinum genome-confirm that call-sets based on our consensus strategy are completely in line with those attained by similar command line based approaches, and far more accurate than call-sets from any individual tool. Importantly our system exhibits better sensitivity and higher specificity than equivalent commercial software. Conclusions: CoVaCS offers optimized pipelines integrating state of the art tools for variant calling and annotation for whole genome sequencing (WGS), whole-exome sequencing (WES) and target-gene sequencing (TGS) data. The system is currently hosted at Cineca, and offers the speed of a HPC computing facility, a crucial consideration when large numbers of samples must be analysed. Importantly, all the analyses are performed automatically allowing high reproducibility of the results. As such, we believe that CoVaCS can be a valuable tool for the analysis of human genome resequencing studies. CoVaCS is available at: https://bioinformatics.cineca.it/covacs.
doi:10.1186/s12864-018-4508-1 pmid:29402227 pmcid:PMC5800023 fatcat:x3mxp47b4vfo3klkp3ebr7nhay

Modeling, Design, and Analysis of MagnetoElastic NML Circuits

Davide Giri, Marco Vacca, Giovanni Causapruno, Maurizio Zamboni, Mariagrazia Graziano
2016 IEEE transactions on nanotechnology  
The results are computed for circuit Modeling, Design and Analysis of MagnetoElastic NML Circuits Davide Giri, Marco Vacca, Giovanni Causapruno, Maurizio Zamboni, and Mariagrazia Graziano, Member IEEE  ...  Mariagrazia Graziano is also with the London Centre for Nanotechnology (UCL). (B) Magnetic field clock.  ... 
doi:10.1109/tnano.2016.2619377 fatcat:cas4dk7ohvaexcw2jjjagqjn7e

Granulomatose com poliangeíte: evolução atípica com acometimento peritoneal

Giovanni Graziano de Sousa Xavier, Ricardo Coelho Reis
2020 Revista de Medicina da UFC  
A Granulomatose com poliangeíte (GPA) trata-se de uma vasculite de pequenos vasos, que cursa com acometimento inflamatório vascular imunologicamente mediado, determinando dano estrutural e funcional à parede dos vasos. A doença atinge predominantemente as vias aéreas superiores, inferiores e os rins, podendo levar a formações granulomatosas, vasculite e necrose desses órgãos. Apresentações clínicas com acometimento dermatológico, neurológico, genitourinário, e gastrointestinal são atípicas e
more » ... em representar um desafio diagnóstico para o clínico. Relatamos um caso de um paciente de 26 anos, que teve diagnóstico de Granulomatose com poliangeíte, apresentando no início do seu curso clínico um acometimento do trato gastrointestinal de forma isolada, com comprometimento de outros órgãos, posteriormente, na sua evolução clínica. O acometimento gastrointestinal rotineiramente ocorre nos primeiros dois anos de evolução da doença e pode ser o primeiro achado da GPA, precedendo manifestações clínicas mais frequentes da doença, o que pode dificultar o diagnóstico precoce.
doi:10.20513/2447-6595.2020v60n1p47-50 fatcat:yhdgnufhn5fn7a23z6ucvrj7iy
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