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Giga-voxel computational morphogenesis for structural design

Niels Aage, Erik Andreassen, Boyan S. Lazarov, Ole Sigmund
2017 Nature  
Giga-voxel computational morphogenesis for structural design. Nature, 550(7674), 84-86.  ...  Here we report a computational morphogenesis tool, implemented on a supercomputer, that produces designs with giga-voxel resolution-more than two orders of magnitude higher than previously reported.  ...  Acknowledgements This work was funded by the Villum Foundation through the NextTop project and a PRACE (Partnership for Advanced Computing in Europe) grant TopWING giving access to the Curie supercomputer  ... 
doi:10.1038/nature23911 pmid:28980645 fatcat:nk6yf27dzfan5pnaqobpqwe7s4

Closing the gap towards super-long suspension bridges using computational morphogenesis

Mads Baandrup, Ole Sigmund, Henrik Polk, Niels Aage
2020 Nature Communications  
Here we report on a design concept, inspired by computational morphogenesis procedures, demonstrating possible weight savings in excess of 28 percent while maintaining manufacturability.  ...  Girder design for suspension bridges has remained largely unchanged for the past 60 years.  ...  This work was further funded through a PRACE (Partnership for Advanced Computing in Europe) grant TopBridge giving access to the Joliet-Curie supercomputer.  ... 
doi:10.1038/s41467-020-16599-6 pmid:32483204 fatcat:y7zfxjhcqrfebjkkxj45cnjrmu

Developmental constraint through negative pleiotropy in the zygomatic arch

Christopher J. Percival, Rebecca Green, Charles C. Roseman, Daniel M. Gatti, Judith L. Morgan, Stephen A. Murray, Leah Rae Donahue, Jessica M. Mayeux, K. Michael Pollard, Kunjie Hua, Daniel Pomp, Ralph Marcucio (+1 others)
2018 EvoDevo  
Candidate genes in this region were identified and real-time PCR of the maxillary processes of DO founder strain embryos indicated differences in the RNA expression levels for two of the candidate genes  ...  Conclusions: A genomic region underlying negative pleiotropy of two zygomatic arch bones was identified, which provides a mechanism for antagonism in component bone lengths while constraining overall zygomatic  ...  Acknowledgements We thank Wei Liu for completing some of the computed tomography imaging and all craniofacial landmark collection at the University of Calgary.  ... 
doi:10.1186/s13227-018-0092-3 pmid:29423138 pmcid:PMC5787316 fatcat:kz3x7beh2bd6bgqtb6xmwxx6tq

Function of the exocsyt complex in the calyx of Held presynaptic nerve terminal

Darius Schwenger
Also, I would like to thank my brother for standing by my side and for open ears in any regard. Last but not least, thank you Marie for being in my life and for sweetening every day.  ...  Thanks to all of you for the time we had and for sharing and contributing to an unforgettable period.  ...  The mOrange image stacks were P13 P21 cropped to reduce computation time and subjected to a 3D median filter for noise reduction.  ... 
doi:10.11588/heidok.00009885 fatcat:jgck6aes4bd2tptdh6tjtcezle