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GiardiaDB and TrichDB: integrated genomic resources for the eukaryotic protist pathogens Giardia lamblia and Trichomonas vaginalis

C. Aurrecoechea, J. Brestelli, B. P. Brunk, J. M. Carlton, J. Dommer, S. Fischer, B. Gajria, X. Gao, A. Gingle, G. Grant, O. S. Harb, M. Heiges (+16 others)
2009 Nucleic Acids Research  
GiardiaDB (http://GiardiaDB.org) and TrichDB (http://TrichDB.org) house the genome databases for Giardia lamblia and Trichomonas vaginalis, respectively, and represent the latest additions to the EuPathDB  ...  GiardiaDB and TrichDB employ the same framework as other EuPathDB sites (CryptoDB, PlasmoDB and ToxoDB), supporting fully integrated and searchable databases.  ...  ACKNOWLEDGEMENTS The authors wish to thank members of the Giardia and Trichomonas research communities for their willingness to share genomic-scale datasets, often prior to publication, and for numerous  ... 
doi:10.1093/nar/gkn631 pmid:18824479 pmcid:PMC2686445 fatcat:6cdetdt2nvbbdipsjoja6pidkq

The Cytoskeleton of Parabasalian Parasites Comprises Proteins that Share Properties Common to Intermediate Filament Proteins

Harald Preisner, Eli Levy Karin, Gereon Poschmann, Kai Stühler, Tal Pupko, Sven B. Gould
2016 Protist  
cytoskeletal filaments. (2009) GiardiaDB and TrichDB: integrated genomic resources for the eukaryotic protist pathogens Giardia lamblia and Trichomonas vaginalis.  ...  Cell 115:705-713 Baldauf SL (2008) An overview of the phylogeny and diversity of eukaryotes.  ...  HP and SBG wish to thank Ramona Stach and Maria Handrich for their help in the laboratory. We also thank Jan Tachezy and Marlene Benchimol for providing the strains. Appendix A.  ... 
doi:10.1016/j.protis.2016.09.001 pmid:27744090 fatcat:eg3hiuc4cbakbokzsrvqbjegwq

Phosphoglycerate kinase: structural aspects and functions, with special emphasis on the enzyme from Kinetoplastea

Maura Rojas-Pirela, Diego Andrade-Alviárez, Verónica Rojas, Ulrike Kemmerling, Ana J. Cáceres, Paul A. Michels, Juan Luis Concepción, Wilfredo Quiñones
2020 Open Biology  
Our analysis of the genomes of different kinetoplastids revealed the presence of open-reading frames (ORFs) for multiple PGK isoforms in several species.  ...  Some of these ORFs code for unusually large PGKs. The products appear to contain additional structural domains fused to the PGK domain.  ...  ) [87] , Database for Dictyostelium discoideum (DictyBase) [88] , Ensembl Protists, The Amoeba Genomics Resource (AmoebaDB) [89] , The Giardia Genomics Resource (GiardiaDB) [90] , The Trichomonas Genomics  ... 
doi:10.1098/rsob.200302 pmid:33234025 fatcat:4l5tjrqnfzguhfpk2vzskqqmji

Identification and Functional Characterization of Divergent 3'-Phosphate tRNA Ligase From Entamoeba histolytica

Ruofan Peng, Shigeo Yoshinari, Tetsuro Kawano-Sugaya, Ghulam Jeelani, Tomoyoshi Nozaki
2021 Frontiers in Cellular and Infection Microbiology  
EhRtcB1 was demonstrated to be localized to the nucleus, while EhRtcB2 was in the cytosol. EhRtcB1, but not EhRtcB2, was required for optimal growth of E. histolytica trophozoites.  ...  Entamoeba histolytica, a protozoan parasite responsible for human amebiasis, possesses two RtcB proteins (EhRtcB1 and 2), but their biological functions remain unknown.  ...  GiardiaDB and TrichDB: Integrated Genomic Resources for the Eukaryotic Protist Pathogens Giardia Lamblia and Trichomonas Vaginalis.  ... 
doi:10.3389/fcimb.2021.746261 pmid:34976851 pmcid:PMC8718801 fatcat:gkuwnku7xffjhmocbqiyb5mqpi

The compact genome of Giardia muris reveals important steps in the evolution of intestinal protozoan parasites [article]

Feifei Xu, Alejandro Jiménez-González, Elin Einarsson, Ásgeir Ástvaldsson, Dimitra Peirasmaki, Lars Eckmann, Jan O. Andersson, Staffan G. Svärd, Jon Jerlström-Hultqvist
2019 bioRxiv   pre-print
The human-pathogenic Giardia species, Giardia intestinalis, has been extensively studied at the genome and gene expression level, but no such information is available for other Giardia species.  ...  Here we report the draft-genome of G. muris. We discovered a highly streamlined genome, amongst the most densely encoded ever described for a nuclear eukaryotic genome.  ...  GiardiaDB and TrichDB: integrated genomic resources for the eukaryotic protist pathogens Giardia lamblia and Trichomonas vaginalis.  ... 
doi:10.1101/870949 fatcat:zzr5i5wgrvesvd2a5b3xk5hoei

Genome annotation and genotype-phenotype association in two non-model parasites

Daniel D Ence
2018
increased and require rigorous and sophisticated methods for genome annotation.  ...  My PhD research has focused on the application and development of genome annotation methods for non-model organisms.  ...  Acknowledgements We would like to thank John Wang for helpful discussions during the initial phase of the project and Andrés Moya for encouraging comments at an earlier stage of writing.  ... 
doi:10.26053/0h-e49z-9kg0 fatcat:ucvagv3svvfjrbttktaomoxoiq

Molecular epidemiology of Giardia spp. in different hosts and watersheds

Natalie Anne Prystajecky
2010
Giardia lamblia has been problematic in British Columbia (BC) since the 1980s, having been the etiological agent in 13 of the 29 documented waterborne outbreaks in the province.  ...  , for the third stage of the study.  ...  GiardiaDB and TrichDB: integrated genomic resources for the eukaryotic protist pathogens Giardia lamblia and Trichomonas vaginalis. Nucleic Acids Research. 37(database issue): D526-D530.  ... 
doi:10.14288/1.0069441 fatcat:6ijqqkjcp5axppi3nhdv744y5a