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Hemispheric specialization within the inferior parietal lobe across cognitive domains [article]

Ole Numssen, Danilo Bzdok, Gesa Hartwigsen
2020 bioRxiv   pre-print
The inferior parietal lobe (IPL) is a key neural substrate underlying diverse mental processes, from basic attention to language and social cognition that define human interactions. Its putative domain-global role appears to tie into poorly understood functional differences between both hemispheres. Across attentional, semantic, and social cognitive experiments, our study explored hemispheric specialization within the IPL. The task specificity of IPL subregion activity was substantiated by
more » ... nct predictive signatures identified by multivariate pattern-learning algorithms. Moreover, the left and right IPL exerted domain-specific modulation of effective connectivity among their subregions. Task-evoked functional interactions of the anterior and posterior IPL subregions involved recruitment of distributed cortical partners. While each anterior IPL subregion was engaged in strongly lateralized coupling links, both posterior subregions showed more symmetric coupling patterns across hemispheres. Our collective results shed light on how under-appreciated lateralization effects within the IPL support some of the most distinctive human mental capacities.
doi:10.1101/2020.07.01.181602 fatcat:sptz7j2alrawjd3a6nmyi65tvm

A novel approach to localize cortical TMS effects [article]

Konstantin Weise, Ole Numssen, Axel Thielscher, Gesa Hartwigsen, Thomas R. Knösche
2019 bioRxiv   pre-print
F1000Research 2017, 5:1945 (doi: .12688/f1000research.9277.3) Siebner HR, Hartwigsen G, Kassuba T, Rothwell JC.  ... 
doi:10.1101/595603 fatcat:wewzsgoilbbh7lbzkqgonbzwmi

Age-dependent contribution of domain-general network interactions to semantic cognition [article]

Sandra Martin, Dorothee Saur, Gesa Hartwigsen
2020 bioRxiv   pre-print
Aging is characterized by a decline of cognitive control. In semantic cognition, this leads to the paradox that older adults usually show poorer task performance than young adults despite their greater semantic knowledge. So far, the underlying neural changes of these behavioral differences are poorly understood. In the current neuroimaging study, we investigated the interplay of domain-specific and domain-general networks in young and older adults during a verbal semantic fluency task. In both
more » ... age groups, task processing was characterized by a strong interaction between the domain-general multiple-demand and the default mode system during semantic fluency. However, the behavioral relevance of strengthened connectivity differed between groups: While within- and between-network functional connectivity predicted better performance in young adults, these increases were associated with a performance decline in older adults. Our findings lend novel support to the notion of reduced efficiency in the aging brain, due to neural dedifferentiation in semantic cognition.
doi:10.1101/2020.11.06.371153 fatcat:remyxru5pvfpvdmoyr7qinz6iq

Differential contributions of left-hemispheric language regions to basic semantic composition [article]

Astrid Graessner, Emiliano Zaccarella, Gesa Hartwigsen
2019 bioRxiv   pre-print
At the single-word level, Hartwigsen et al. (2015) have shown that left AG and aIFG were able to compensate for a focal disruption of the respective other region induced by transcranial magnetic stimulation  ...  In a TMS study, Hartwigsen et al. (2015) showed that temporary disruption of either aIFG or AG alone did not lead to a significant impairment of semantic decisions, while combined TMS over both regions  ... 
doi:10.1101/2019.12.11.872457 fatcat:joztlosdfvhyticbjdtfybkete

Failure to Improve Verbal Fluency with Transcranial Direct Current Stimulation

Jana Klaus, Gesa Hartwigsen
2020 Neuroscience  
Hartwigsen / Neuroscience xxx (2020) xxx-xxx Please cite this article in press as: Klaus J, Hartwigsen G. Failure to Improve Verbal Fluency with Transcranial Direct Current Stimulation.  ...  Neuroscience (2020), Please cite this article in press as: Klaus J, Hartwigsen G.  ... 
doi:10.1016/j.neuroscience.2020.09.003 pmid:32946806 fatcat:t752ky555rhfzh2dzorfzr3avy

Task-Specific Network Interactions across Key Cognitive Domains

Kathleen A Williams, Ole Numssen, Gesa Hartwigsen
2022 Cerebral Cortex  
Aside from this neural specialization, recent work also demonstrates some overlap among these processes in higher association areas (Bzdok, Hartwigsen, et al. 2016) .  ...  increased coordination of the task-positive VAN with aDMN and temporal lobe networks, likely ref lecting the support of general semantic processes, which may overlap to some degree for both domains (Bzdok, Hartwigsen  ... 
doi:10.1093/cercor/bhab531 pmid:35158372 fatcat:mvqly6kqqbf25dslhfkmzmf7p4

Novel Methods to Study Aphasia Recovery after Stroke [chapter]

Gesa Hartwigsen, Hartwig R. Siebner
2013 Monographs in neural sciences  
Hartwigsen · Siebner [2] .  ...  different aspects of language processing, including phonological decisions, reading, and the processing of paralinguistic features such as (emotional) prosody or metaphor processing (for a review, see Hartwigsen  ... 
doi:10.1159/000346431 pmid:23859969 fatcat:2pxi72t5xfffhd4vzwlnflgaue

Neural modelling of the semantic predictability gain under challenging listening conditions [article]

Anna Rysop, Lea-Maria Schmitt, Jonas Obleser, Gesa Hartwigsen
2019 bioRxiv   pre-print
. /2019 exhibit functional relevance in mediating the comprehension gain (Hartwigsen et al., 2015) , this region has been proposed to serve top-down activation of semantic concepts that facilitate speech  ...  reported a decrease in the functional connectivity between left IFG and right insula under facilitatory neurostimulation that was associated with improved word learning (Fiori, Kunz, Kuhnke, Marangolo, & Hartwigsen  ... 
doi:10.1101/2019.12.20.872614 fatcat:wy6ejlomyzhxlert6jvcnpkimm

Multivariate single-subject analysis of short-term reorganization in the language network

Gesa Hartwigsen, Danilo Bzdok
2018 Cortex  
To cite this version: Gesa Hartwigsen, Danilo Bzdok. Multivariate single-subject analysis of short-term reorganization in the language network. Cortex, Elsevier, 2018, pp.  ...  Here, we re-analyzed data from our recent study (Hartwigsen et al., 2017 ) that investigated functional reorganization in the language network.  ...  Combining focal perturbations induced by transcranial magnetic stimulation (TMS) and fMRI in the healthy brain, we recently provided insight into the reorganization potential of language networks (Hartwigsen  ... 
doi:10.1016/j.cortex.2018.06.013 pmid:30057248 fatcat:exi7ckffh5gjnakoewmnek2vsu

A novel approach to localize cortical TMS effects

Konstantin Weise, Ole Numssen, Axel Thielscher, Gesa Hartwigsen, Thomas R. Knösche
2019 NeuroImage  
Gesa Hartwigsen: Conceptualization, Resources, Writing -Original Draft, Supervision, Project administration, Funding acquisition.  ...  may assist the neurobiological interpretation of TMS effects and aid the localization of the effectively stimulated cortical area that underlies the observed physiological or behavioral effect (see Hartwigsen  ... 
doi:10.1016/j.neuroimage.2019.116486 pmid:31877374 fatcat:auqp4hppwnee5l6oiqatrw3gra

Task-Dependent Functional and Effective Connectivity during Conceptual Processing

Philipp Kuhnke, Markus Kiefer, Gesa Hartwigsen
2021 Cerebral Cortex  
functional magnetic resonance imaging (fMRI) study revealed that both modality-specific and multimodal regions respond to sound and action features of concepts in a task-dependent fashion (Kuhnke P, Kiefer M, Hartwigsen  ...  Such compensatory mechanisms could be further investigated in future studies employing combined TMS-fMRI (Hartwigsen 2018) .  ... 
doi:10.1093/cercor/bhab026 pmid:33677479 pmcid:PMC8196308 fatcat:me3heakxobaefimirt3jatmseu

Predicting speech from a cortical hierarchy of event-based timescales [article]

Lea-Maria Schmitt, Julia Erb, Sarah Tune, Anna Rysop, Gesa Hartwigsen, Jonas Obleser
2020 bioRxiv   pre-print
How can anticipatory neural processes structure the temporal unfolding of context in our natural environment? We here provide evidence for a neural coding scheme that sparsely updates contextual representations at the boundary of events and gives rise to a hierarchical, multi-layered organization of predictive language comprehension. Training artificial neural networks to predict the next word in a story at five stacked timescales and then using model-based functional MRI, we observe a sparse,
more » ... vent-based 'surprisal hierarchy'. The hierarchy evolved along a temporo-parietal pathway, with model-based surprisal at longest timescales represented in inferior parietal regions. Along this hierarchy, surprisal at any given timescale gated bottom-up and top-down connectivity to neighbouring timescales. In contrast, surprisal derived from a continuously updated context influenced temporo-parietal activity only at short timescales. Representing context in the form of increasingly coarse events constitutes a network architecture for making predictions that is both computationally efficient and semantically rich.
doi:10.1101/2020.12.19.423616 fatcat:r4dwhe23kzb6tnau2n5sjlvere

Adaptive Plasticity in the Healthy Language Network: Implications for Language Recovery after Stroke

Gesa Hartwigsen
2016 Neural Plasticity  
Recently, we combined TMS and fMRI to investigate adaptive plasticity in the semantic network after focal perturbation of a key semantic area prior to task processing (Hartwigsen et al., unpublished data  ... 
doi:10.1155/2016/9674790 pmid:27830094 pmcid:PMC5088318 fatcat:qqmwczphgneztao62jbi2stbkq

Rapid short-term reorganization in the language network

Gesa Hartwigsen, Danilo Bzdok, Maren Klein, Max Wawrzyniak, Anika Stockert, Katrin Wrede, Joseph Classen, Dorothee Saur
2017 eLife  
Author ORCIDs Gesa Hartwigsen, Danilo Bzdok, Ethics Human subjects: Written informed consent was obtained before the experiment.The  ...  The stimuli were taken from a previous study (Hartwigsen et al., 2010) .  ...  Hartwigsen et al. examined how this affected the volunteers' performance on a language task, as well as the activity of other language areas.  ... 
doi:10.7554/elife.25964 pmid:28537558 pmcid:PMC5472437 fatcat:ddvqis763zcqjfxzslgrpw44fy

Editorial: Modulating Cortical Dynamics in Language, Speech and Music

Gesa Hartwigsen, Mathias Scharinger, Daniela Sammler
2018 Frontiers in Integrative Neuroscience  
., 1999; Walsh and Cowey, 2000; Kuo and Nitsche, 2012) and allow for an investigation of adaptive network dynamics on the systems level (Hartwigsen, 2018) .  ... 
doi:10.3389/fnint.2018.00058 pmid:30538623 pmcid:PMC6277569 fatcat:5n7p3oxllbhnjoqfyvqurtokle
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