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[Re] Weakly-Supervised Semantic Segmentation via Transformer Explainability

Ioannis Athanasiadis, Georgios Moschovis, Alexander Tuoma, \\ Sharath Chandra Raparthy Koustuv Sinha
2022 Zenodo  
ReScience C 8.2 (#4) -Athanasiadis, Moschovis and Tuoma 2022  ...  CAM [10] AffinityNet [2] Ours Ours AffinityNet [VGG-16] [VGG-16] [ViT-Hybrid] [ViT-Hybrid] mIoU 46.60 54.00 44.60 50.90 ReScience C 8.2 (#4) -Athanasiadis, Moschovis and Tuoma 2022 Rectified  ... 
doi:10.5281/zenodo.6574631 fatcat:fvti4isywzcxvnvsolx3hill2e

Knowledge-Driven Segmentation and Classification [chapter]

Thanos Athanasiadis, Phivos Mylonas, Georgios Th. Papadopoulos, Vasileios Mezaris, Yannis Avrithis, Ioannis Kompatsiaris, Michael G. Strintzis
2011 Multimedia Semantics  
doi:10.1002/9781119970231.ch10 fatcat:mp5le4xp4nacfo6fw5sktndloy

Sympathetic Nerve Injury in Thyroid Cancer

Evangelos Diamantis, Paraskevi Farmaki, Spyridon Savvanis, Georgios Athanasiadis, Theodoros Troupis, Christos Damaskos
2017 Acta Medica  
The double innervation of the thyroid comes from the sympathetic and parasympathetic nervous system. Injury rates during surgery are at 30% but can be minimized by upwardly preparing the thyroid vessels at the level of thyroid capsule. Several factors have been accused of increasing the risk of injury including age and tumor size. Our aim was to investigate of there is indeed any possible correlations between these factors and a possible increase in injury rates following thyroidectomy. Seven
more » ... udies were included in the meta-analysis. Statistical correlation was observed for a positive relationship between injury of the sympathetic nerve and thyroid malignancy surgery (p < 0.001; I2 = 74%) No statistical correlations were observed for a negative or positive relationship between injury of the sympathetic nerve and tumor size. There was also no statistically significant value observed for the correlation of the patients' age with the risk of sympathetic nerve injury (p = 0.388). Lack of significant correlation reported could be due to the small number of studies and great heterogeneity between them.
doi:10.14712/18059694.2018.8 pmid:29716678 fatcat:x5x7kfq5zjc4tmqocichlwytgi

The role of remote ischemic preconditioning in the treatment of atherosclerotic diseases

Spyros N. Vasdekis, Dimitrios Athanasiadis, Andreas Lazaris, Georgios Martikos, Aristeidis H. Katsanos, Georgios Tsivgoulis, Anastasios Machairas, Theodoros Liakakos
2013 Brain and Behavior  
Acknowledgment Georgios Tsivgoulis has been supported by European Regional Development Fund -Project FNUSA-ICRC (No. CZ.1.05/1.1.00/02.0123).  ... 
doi:10.1002/brb3.161 pmid:24363964 pmcid:PMC3868166 fatcat:jalmqe4pnrexrofadox6bezlfa

A survey of genetic simulation software for population and epidemiological studies

Youfang Liu, Georgios Athanasiadis, Michael E Weale
2008 Human Genomics  
A number of programs have been developed for simulating population genetic and genetic epidemiological data conforming to one of three main algorithmic approaches: 'forwards', 'backwards' and 'sideways'. This review aims to make the reader aware of the range of options currently available to them. While no one program emerges as the best choice in all circumstances, we nominate a set of those which currently appear most promising.
doi:10.1186/1479-7364-3-1-79 pmid:19129092 pmcid:PMC3525177 fatcat:3hn322lhajakjmrjwmergnaooq

Real-World Data on Thromboprophylaxis in Active Cancer Patients: Where Are We? Are We Getting There?

Nikolaos Tsoukalas, Pavlos Papakotoulas, Athina Christopoulou, Alexandros Ardavanis, Georgios Koumakis, Christos Papandreou, Georgios Papatsimpas, Pavlos Papakostas, Georgios Samelis, Charalambos Andreadis, Gerasimos Aravantinos, Nikolaos Ziras (+14 others)
2020 Cancers  
Cancer patients are at high risk for cancer-associated thrombosis (CAT). CAT is the second leading cause of death in these patients but it can be preventable with thromboprophylaxis. Patients and Methods: An observational, prospective, multicenter study aiming to record CAT management in clinical practice was conducted by the Hellenic Society of Medical Oncology (HeSMO). Results: A total of 426 active cancer patients (mean age 65.3 years, mean BMI: 26.1 kg/m2) who received thromboprophylaxis,
more » ... re included from 18 oncology units. Tumor types were lung 25.1%, pancreas 13.9%, breast 8.7%, stomach 8.5%, ovarian 7.8%, and others 36%, while 69% had metastases. A total of 71% had a Khorana score ≤2 and 61% received High Thrombotic Risk Chemotherapy Agents (HTRCAs, e.g., platinum). For thromboprophylaxis patients received mainly Low Molecular Weight Heparins (LMWHs), on higher than prophylactic doses in 50% of cases. Overall, 16 (3.8%) thrombotic events and 6 (1.4%) bleeding events were recorded. Notably, patients on higher doses of LMWHs compared to patients who received standard prophylactic doses had 70% lower odds to develop thrombotic events (OR: 0.3, 95% CI: 0.10-1.0, p = 0.04). Conclusion: CAT is an important issue in oncology. Along with the Khorana score, factors as metastasis and use of HTRCAs should also be taken into consideration. Thromboprophylaxis for active cancer patients with LMWHs, even on higher doses is safe and efficient.
doi:10.3390/cancers12071907 pmid:32679747 pmcid:PMC7409213 fatcat:ep4hl4wo4bb7hgi5j6m3lq5ssa

Prophylaxis of cancer‑associated venous thromboembolism with low‑molecular‑weight heparin‑tinzaparin: Real world evidence

Athina Christopoulou, Alexandros Ardavanis, Christos Papandreou, Georgios Koumakis, Georgios Papatsimpas, Pavlos Papakotoulas, Nikolaos Tsoukalas, Charalambos Andreadis, Georgios Samelis, Pavlos Papakostas, Gerasimos Aravantinos, Nikolaos Ziras (+13 others)
2022 Oncology Letters  
Thromboprophylaxis, as a preventive measure for cancer-associated thrombosis (CAT), may be beneficial for patients with active cancer and high-risk for thrombosis. The present post hoc analysis include a total of 407 patients enrolled in the Greek Management of Thrombosis study, who received thromboprophylaxis with tinzaparin. The objectives of the present analysis were: i) To obtain sufficient evidence for the administration of prophylaxis in patients with active cancer, irrespective of
more » ... risk assessment model score; ii) to identify the selection criteria for both dose and duration of tinzaparin; and iii) to evaluate the efficacy and safety of tinzaparin administered for CAT prophylaxis. The main tumor types for the patients included in the present study were as follows: Lung (25.1%), pancreatic (14.3%), breast (9.1%), stomach (8.4%), colorectal (7.9%) and ovarian (7.6%). Furthermore, metastatic disease was observed in 69.5% of the patients. High thrombotic burden agents (HTBAs) were administered to 66.3% of the patients, and 17.4% received erythropoietin. A total of 43.7% of the patients exhibited a Khorana score <2. The results of the present study demonstrated that both the presence of metastatic disease and the use of HTBAs seemed to influence oncologists' decisions for the use of thromboprophylaxis in patients with active cancer, regardless of Khorana score. Tinzaparin, in dose expressed in the standard notation for heparins, i.e., anti-Xa factor international units (Anti-Xa IU), was administered at an intermediate dose (InterD; 8,000-12,000 Anti-Xa IU; once daily) to 52.4% of patients, while the remaining patients received a prophylactic dose (ProD; ≤4,500 Anti-Xa IU; once daily). The average duration of thromoprophylaxis was 5 months. Furthermore, a total of 14 (3.4%) thrombotic events and 6 (1.5%) minor bleeding events were recorded. A total of four thrombotic events were observed following an InterD treatment of tinzaparin, while 10 thrombotic events were observed following ProD treatment. The present study also demonstrated that an InterD of tinzaparin was administered more frequently to patients with a body mass index >30 kg/m2, a history of smoking and a history of metastatic disease, along with administration of erythropoietin. InterD tinzaparin treatment was found to be potentially more efficacious and without safety concerns. The present study is a registered clinical trial (ClinicalTrials.gov code, NCT03292107; registration date, September 25, 2017).
doi:10.3892/ol.2022.13235 pmid:35251346 pmcid:PMC8850961 fatcat:oxxr4l6bwnarlbcikbminqsnku

CIRANO: An Integrated Programming Environment for Multi-tier Cloud Based Applications

George Fylaktopoulos, Georgios Goumas, Michael Skolarikis, Aris Sotiropoulos, Dimitrios Athanasiadis, Ilias Maglogiannis
2015 Procedia Computer Science  
This paper describes the CIRANO platform, a cloud Integrated Development Environments (IDE) that substantially supports Model Driven Development (MDD) and team collaboration, in order to facilitate the development of cloud-based applications. The paper presents the state of the art in the field and discusses the technical details of CIRANO architecture and its modular implementation. The main features of the proposed platform are presented as a case study application concerning the update and
more » ... rting of an existing collaboration system, called Comidor. The paper discusses the findings in comparison with existing tools and proposes extensions of the platform as future work.
doi:10.1016/j.procs.2015.09.222 fatcat:r5bwc6dff5an5jwxvi2wwzbwam

Spatial principal component analysis points at global genetic structure in the Western Mediterranean

Georgios Athanasiadis, Pedro Moral
2013 Journal of Human Genetics  
These results are more compatible with a clinal distribution of allele frequencies rather than Genetic structure in the Western Mediterranean G Athanasiadis and P Moral with abrupt changes, suggesting  ... 
doi:10.1038/jhg.2013.94 pmid:24005895 fatcat:q3y2u6r4p5hkxpvkla4qandbhq

A Smart Integrated Vest for the Canine Companion of the K9 Units

Georgios Vosinakis, Maria Krommyda, Angelos Stamou, Nikos Mitro, Marios Palazis-Aslanidis, Katerina Voulgary, Spyros Athanasiadis, Angelos Amditis
2021 Informatics  
Search and rescue operations can range from small, confined spaces, such as collapsed buildings, to large area searches during missing person operations. K9 units are tasked with intervening in such emergencies and assist in the optimal way to ensure a successful outcome for the mission. They are required to operate in unknown situations were the lives of the K9 handler and the canine companion are threatened as they operate with limited situational awareness. Within the context of the
more » ... project, we developed a K9 vest for the canine companion of the unit, aiming to increase the unit's safety while operating in the field, assist the K9 handler in better monitoring the location and the environment of the K9 and increase the information provided to the Command and Control Center during the operation.
doi:10.3390/informatics9010002 fatcat:asr6t46q6vbczk646n4lhf3ipq

Polymorphism FXII 46C>T and cardiovascular risk: additional data from Spanish and Tunisian patients

Georgios Athanasiadis, Esther Esteban, Magdanela Vidal, Robert Torres, Raoudha Bahri, Pedro Moral
2009 BMC Research Notes  
Previous studies showed an association between Coagulation Factor XII 46C>T polymorphism and variation in FXII plasma levels, as 46C>T seems to affect the translation efficiency. Case-control studies in Spanish samples indicated that genotype T/T is an independent risk factor for venous thrombosis, ischemic stroke and acute coronary artery disease. In this study, we tried to reaffirm the importance of 46C>T in two samples from Spain and Tunisia. Findings: A Transmission Disequilibrium Test
more » ... based on 101 family trios from Barcelona with one offspring affected by ischemic heart disease and a classical case-control study based on 76 patients with IHD and 118 healthy individuals from North and Centre-South Tunisia were conducted. Subjects were genotyped for 46C>T and data were analyzed accordingly, revealing no association in any of the two samples (TDT: P = 0.16, relative risk 1.17; case-control study: P = 0.59, odds ratio 1.36). Conclusion: The results suggest that 46C>T is not a risk factor for ischemic heart disease in any of the two analyzed samples and therefore the polymorphism seems not to be a universal risk factor for cardiovascular diseases.
doi:10.1186/1756-0500-2-154 pmid:19646235 pmcid:PMC2732920 fatcat:l64e6qcqtjce3epnbt33akd5yq

Estimating narrow-sense heritability from genome-wide data in admixed populations [article]

Georgios Athanasiadis, Doug Speed, Mette K. Andersen, Emil V. R. Appel, Niels Grarup, Ivan Brandslund, Marit Eika Jørgensen, Christina Viskum Lytken Larsen, Peter Bjerregaard, Torben Hansen, Anders Albrechtsen
2019 bioRxiv   pre-print
AbstractFinding an efficient framework for estimating total narrow-sense heritability in admixed populations remains an open question. In this work, we used extensive simulations to evaluate existing linear mixed model frameworks in estimating total narrow-sense heritability in two population-based cohorts from Greenland and compared the results to data from unadmixed individuals from Denmark. When our analysis focused on Greenlandic sib pairs, the model with two relationship matrices, one
more » ... ring identity by descent and one capturing identity by state, returned heritability estimates close to the true simulated value, while using each of the two matrices alone led to downward biases. When phenotypes correlated with ancestry, heritability estimates were inflated. Based on these observations, we propose a post-estimation PCA-based adjustment that recovers successfully the true simulated heritability. We use this knowledge to estimate the heritability of ten quantitative traits from the two Greenlandic cohorts and report differences such as lower heritability for height in Greenlanders compared to Europeans. In conclusion, narrow-sense heritability in admixed populations is best estimated using a mixture of genetic relationship matrices on individuals with at least one first-degree relative included in the sample.
doi:10.1101/581389 fatcat:goeaqodygrehxem5eo4n7ufxka

Antidepressants on Multiple Sclerosis: A Review of In Vitro and In Vivo Models

Eleni Stamoula, Spyridon Siafis, Ioannis Dardalas, Alexandra Ainatzoglou, Alkis Matsas, Theodoros Athanasiadis, Chrysanthi Sardeli, Konstantinos Stamoulas, Georgios Papazisis
2021 Frontiers in Immunology  
Copyright © 2021 Stamoula, Siafis, Dardalas, Ainatzoglou, Matsas, Athanasiadis, Sardeli, Stamoulas and Papazisis.  ... 
doi:10.3389/fimmu.2021.677879 pmid:34093579 pmcid:PMC8173210 fatcat:rt5iqoyrxzefdkmr66zuvqznxe

A Large Lumbar Adnexal Neoplasm Presenting Characteristics of Eccrine Poroma and Poroid Hidradenoma

Adamantios Michalinos, Dimitrios Schizas, Antonios Sarakinos, Georgios Athanasiadis, Eleftherios Spartalis, Dimitrios Vlachodimitropoulos, Theodore Troupis
2017 Case Reports in Surgery  
Poroma is a rare benign neoplasm that derives from eccrine sweat glands epithelium. Its histological subtypes, with respect to its position within skin layers, are eccrine poroma, hidroacanthoma simplex, poroid hidradenoma, and dermal duct tumor. Poromas commonly exhibit benign clinical behavior as they are usually small and asymptomatic and do not exhibit malignant behavior. Although their histological subtypes share similar histological characteristics, they rarely coexist in the same tumor.
more » ... n this report we present the case of an unusual poroma in terms of histological and clinical behavior as it was large and presented histological characteristic of both eccrine poroma and poroid hidradenoma. Coexistence of different histologic subtypes in the same tumor indicates simultaneous tumorigenesis, differentiation from one cell type to another, or parallel differentiation from a common progenitor cell. Implications in treatment remain unknown partly due to the rarity of such cases.
doi:10.1155/2017/9865672 pmid:29057137 pmcid:PMC5625745 fatcat:w7adpwdg7ncqnlpc7exljtvnc4

Cervical Pathology Following HPV Vaccination in Greece: A 10-year HeCPA Observational Cohort Study

EVANGELOS PARASKEVAIDIS, ANTONIOS ATHANASIOU, MARIA PARASKEVAIDI, EVRIPIDIS BILIRAKIS, GEORGIOS GALAZIOS, EMMANUEL KONTOMANOLIS, KONSTANTINOS DINAS, ARISTOTELIS LOUFOPOULOS, MARIA NASIOUTZIKI, IOANNIS KALOGIANNIDIS, APOSTOLOS ATHANASIADIS, ALEXIOS PAPANIKOLAOU (+14 others)
2020 In Vivo  
In Greece the population-level impact of HPV vaccination is unknown due to lack of official registries. This study presents in a pragmatic frame the comparison of cervical pathology data between HPV-vaccinated and unvaccinated women referred for colposcopy. This is an observational prospective cohort study performed in 7 academic Obstetrics and Gynaecology Departments across Greece between 2009-2019. Cases were women that had completed HPV vaccination before coitarche and were referred for
more » ... scopy due to abnormal cytology. For each vaccinated woman an unvaccinated matched control was selected. A total of 849 women who had been vaccinated before coitarche and 849 unvaccinated controls were recruited. The combination of cytological, colposcopic and molecular findings necessitated treatment in only a single case among vaccinated (0.1%) and in 8.4% among unvaccinated. HPV vaccination at a proper age can markedly reduce development of severe cervical precancers and consequently the need for treatment, as well as their long-term related obstetrical morbidity.
doi:10.21873/invivo.11927 pmid:32354944 pmcid:PMC7279786 fatcat:jmowavpzlbazno5u4n2hvcbnki
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