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Both α-and β-cluster larger deletions are novel (Del I and Del III) and were named --CMB /αα (CMB stands for Coimbra the city of patient's origin) and PORTUGUESE εγδβ 0 -Thal, respectively. • The other two smaller deletions (Del II and Del IV), given the uncertainty regarding their breakpoints, might be similar to others already published. • All deletions were found in heterozygosity in the mentioned patients. Their globinic genotypes were well correlated with the different thalassemicdoi:10.1016/s0140-6736(11)60283-3 pmid:21908035 fatcat:3hm7e5ntwrfape6tyimufjyjci
more »... s presented. Clinician were recommended to study patients' closer relatives. Genetic counselling should be provided to them.
Neuron Glia Biology
We mark the passing of George Palade, who died at his home in San Diego on October 7, 2008. ... George Emil Palade was born November 19, 1912 in Romania. His scholarly interests were nourished by his father, a philosophy professor, and by his mother, a teacher. ...doi:10.1017/s1740925x09000040 fatcat:5racioxw4vgf3nbwswfk43nbxi
Compte rendu de [Investments, par GEORGE-W. DOWRIE, DOUGLAS-R. FULLER et FRANCIS-J. CALKINS. Un vol., 6 po. x 9¼, relié, 561 pages -JOHN WILEY & SONS, INC.Investments, par GEORGE-W. ... Cette organisation politique de l'ensemble, basée sur une formule originale et Investments, par GEORGE-W. DOWRIE, DOUGLAS-R. FULLER et FRANCIS-J. CALKINS. ...doi:10.7202/1001718ar fatcat:pghfq64ilraoleod6esp37336a
GEORGE DOUGLAS HUTTON BELL 18 October 1905 -27 June 1993 Elected FRS 1965 BY SIR RALPH RILEY † FRS AND SIR JOHN ENDERBY 1 FRS 1 HH Wills Physics Laboratory, Tyndall Avenue, Bristol BS8 1TL, UK Douglas ...doi:10.1098/rsbm.2004.0003 fatcat:y6ma6fpqhzb47e463v537abwle
DOUGLAS W. SCHWARTZ and R. W. LANG. Santa Fe, NM: School of American Research, 1973. 47 pp., figures, tables, bibli- ography. n.p. (paper). Reviewed by GEORGE J. ...doi:10.1525/aa.1975.77.1.02a00750 fatcat:rbteuqobhnbb7fnklvw56kr6la
R. D. GEORGE. Upper and Lower Huronian in Ontario. By ARTHUR P. COLEMAN. Bulletin of the Geological Society of America, Vol. XI, pp. 107-114. 1900. ... Croix and Douglas copper ranges of Douglas county, Wisconsin. It contains four geological maps and several illustrative plates. ...doi:10.1086/620818 fatcat:2yrdgxu4jbbnbcquomrmj3wwq4
[John R Theobalds] George May Former general practitioner Bolsover, Derbyshire (b Fraserburgh 1923; q Aberdeen 1947) , died from a myocardial infarction on 26 August 1998. ... Alexander Stuart Douglas Emeritus professor of medicine Aberdeen University (b Aberdeen 1921; q Glasgow 1944 (with commendation) ; MD, FRCP), died suddenly of a pontine haemorrhage on 15 November 1998 ...doi:10.1136/bmj.318.7177.197 pmid:9888937 pmcid:PMC1114683 fatcat:omsexgqsq5er5c2plo274y3dlm
Expansion microscopy (ExM) involves the use of hydration-competent polymers to physically expand biological specimens approximately 4-fold linear increase to achieve 70 nanometer resolution using an ordinary diffraction limited optical microscope. Optimal conditions however for antigen retention during the expansion process and the relative expansion between organelles within cells has remained unclear. It is reported that different tissues expand to different extents, suggesting that althoughdoi:10.1101/699579 fatcat:c6nz65xxyrf6fadntr7z6d5s7u
more »... sotropic expansion is believed to occur, different subcellular compartments with different composition would undergo anisotropic or differential expansion (DiEx). Consequently, there would be distortion of the native shape and size of subcellular compartments upon expansion, parameters which are critical in assessing cellular states in health and disease. Here we report optimal fixation and expansion conditions that retain structural integrity of cells while exhibiting up to 8-fold linear and therefore 512-fold volumetric expansion. Anisotropic expansion is observed not just between tissues, but between different subcellular compartments and even within subcellular compartments themselves. Combining image analysis and machine learning, we provide an approach for the rapid and precise measurement of cellular and subcellular structures in expanded tissue. Using both manual and computation assessment of morphometric parameters, we demonstrate expansion to be anisotropic and therefore refer to this method as differential expansion microscopy (DiExM).
We chose sites in Douglas-fir (Pseudotsuga menziesii) dominated mixed coniferous forest at -1200 m elevation. ... R. Petersen, personal communication) and released immediately adjacent to the array. Because of extremely low recapture frequency (<2%), marking was abandoned for 1996. ...doi:10.2307/2641231 fatcat:tmcmeq4u3vfxlaytzqa4mlxxxu
., Georce R. Minor, M.D., anp Dovatas W. Eastwoop, M.D., Departments of Anesthesiology and Thoracic Surgery, University of Virginia Hospital, Charlottes- ville, Virginia. ...doi:10.1097/00000542-195801000-00019 fatcat:gmzbfoby2nbrdbwzzykmidyl5q
The Electrocardiographic Effects of Intravenous Veratrum Viride By SrerHen R. Exex, M.D., J. Dougtas McNair, M.D., anp GeorGE C. GrirritH, M.D. ... R. ELEK, J. D. McNAIR AND G. C. GRIFFITH 909 3Freis, E. D., ann Stanton, J. R.: A clinical evaluation of veratrum viride in the treatment of essential hypertension. Am. ...doi:10.1161/01.cir.7.6.903 pmid:13051832 fatcat:iuf6ulj7kzgr3n2vevy7trsqse
TABLE 1 . 1 Site data on sampled trees Branchlets sampled for microepiphytes 22 •PSME, P. menziesii; TSHE, T. heterophylla; TABR, T. brevifolia; CACH, C. chrysophylla; RHMA, R. macrophyllum; ACCI ... Finally, when the estimated total cell volumes per square centimetre for all of the Douglas fir branchlets sampled are averaged, a mean microbial population density for Douglas fir twig surfaces results ...doi:10.1139/b80-078 fatcat:nhh6mluu2vfvhopdvrdjm3irru
Key indicators: single-crystal X-ray study; T = 100 K; mean (C-C) = 0.003 Å; disorder in main residue; R factor = 0.038; wR factor = 0.107; data-to-parameter ratio = 14.9. metal-organic compounds m1366 ... E64, m1366 Refinement Refinement on F 2 Least-squares matrix: full R[F 2 > 2σ(F 2 )] = 0.038 wR(F 2 ) = 0.107 S = 1.04 6731 reflections 452 parameters 26 restraints Primary atom site location ... . (<1) Fe1 0.41603 (3) 0.34987 (2) 0.31778 (2) 0.01775 (2,3,7,8,12,13,17,18-Octaethylporphinato)(trifluoromethanesulfonato)iron(III) Crystal data [Fe(CF 3 O 3 S)(C 36 H 44 N 4 )] M r = 737.67 Triclinic ...doi:10.1107/s1600536808031504 pmid:21580825 pmcid:PMC2959619 fatcat:cq3swtlu7ngu5n4vpne4xmg7ku
Species richness was well predicted by annual rainfall (n = 18 sites, r 2 = 0.40, p = 0.0048) and, separately, by area (ha; n = 18 sites, r 2 = 0.77, p < 0.0001). ... The regression was highly significant (F 2,17 = 37.25, p < 0.0001, r 2 = 0.83). ...doi:10.1111/j.1523-1739.2004.00355.x fatcat:4oy7l3uomnaxjn53ylv42s72ty
Human Immunodeficiency Virus (HIV) is a progressive infection that targets the immune system, affecting more than 37 million people around the world. While combinatorial antiretroviral therapy (cART) has lowered mortality rates and improved quality of life in infected individuals, the prevalence of HIV associated neurocognitive disorders is increasing and HIV associated cognitive decline remains prevalent. Recent research has suggested that HIV accessory proteins may be involved in thisdoi:10.1016/j.nbd.2017.04.015 pmid:28457951 pmcid:PMC5541386 fatcat:v6x7yrz3xzf5dcwce7bznjuyri
more »... and several studies have indicated that the HIV protein transactivator of transcription (Tat) can disrupt normal neuronal and glial function. Specifically, data indicate that Tat may directly impact dopaminergic neurotransmission, by modulating the function of the dopamine transporter and specifically damaging dopamine-rich regions of the CNS. HIV infection of the CNS has long been associated with dopaminergic dysfunction, but the mechanisms remain undefined. The specific effect(s) of Tat on dopaminergic neurotransmission may be, at least partially, a mechanism by which HIV infection directly or indirectly induces dopaminergic dysfunction. Therefore, precisely defining the specific effects of Tat on the dopaminergic system will help to elucidate the mechanisms by which HIV infection of the CNS induces neuropsychiatric, neurocognitive and neurological disorders that involve dopaminergic neurotransmission. Further, this will provide a discussion of the experiments needed to further these investigations, and may help to identify or develop new therapeutic approaches for the prevention or treatment of these disorders in HIV-infected individuals. Purohit et al., 2011). A number of recent studies suggest that these changes to the dopaminergic system specifically involve Tat; therefore, this review will focus specifically on the Tat protein and its effect on dopaminergic neurotransmission. This review will briefly discuss both the pathogenesis of HIV in the CNS and dopamine neurotransmission in the brain, and then review what is known about the Tat protein itself. This will be followed by discussion of the model systems used to explore the effects of Tat on the dopaminergic system, the direct effects of Tat on neuropathogenesis and the brain regions implicated in Tat modulation of cognitive function. The review will then explore the direct impact of Tat on the dopamine transporter and on the dopamine receptors. Finally, the discussion will briefly discuss the specific impact of Tat on the dopaminergic effects of psychostimulants, as well as other drugs of abuse. Although the impact of Tat on neuropathogenesis has been covered at length recently (Dahal et al., 2015; Hauser and Knapp, 2014; Maubert et al., 2015; Mediouni et al., 2015a) , these sections will provide a distinct viewpoint on the subject, focusing specifically on the potential synergistic effects of Tat and drug abuse on dopaminergic neurotransmission. Gaskill et al.
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