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Low gene expression of bone morphogenetic protein 7 in brainstem astrocytes in major depression

Gregory A. Ordway, Attila Szebeni, Michelle J. Chandley, Craig A. Stockmeier, Lianbin Xiang, Samuel S. Newton, Gustavo Turecki, Michelle M. Duffourc, Meng-Yang Zhu, Hobart Zhu, Katalin Szebeni
2011 International Journal of Neuropsychopharmacology  
Bone morphogenetic protein 7 (BMP7), a member of the transforming growth factor-b superfamily, is a critical mediator of noradrenergic neuron differentiation during development and has neurotrophic and  ...  neurons in MDD.  ...  The authors also thank John Kalbfleisch (East Tennessee State University) for advice on statistical analyses.  ... 
doi:10.1017/s1461145711001350 pmid:21896235 fatcat:j6arsxliczgn3ljp3ghlubsk3y

Progress in Functional Neuroanatomy: Precise Automatic Geometric Reconstruction of Neuronal Morphology From Confocal Image Stacks

J. F. Evers, S. Schmitt, M. Sibila, C. Duch
2005 Journal of Neurophysiology  
Therefore we have developed a tool set for automatic geometric reconstruction of neuronal architecture from stacks of confocal images.  ...  Progress in functional neuroanatomy: precise automatic geometric reconstruction of neuronal morphology from confocal image stacks. .  ...  Münch for the confocal image stacks of a Purkinje cell, cultured astrocytes, and locust sensory neurons, respectively. We thank S.  ... 
doi:10.1152/jn.00761.2004 pmid:15537815 fatcat:pblv4rq7qjgcnkz354iqz5zno4

Long-Distance Signals Are Required for Morphogenesis of the Regenerating Xenopus Tadpole Tail, as Shown by Femtosecond-Laser Ablation

Jessica P. Mondia, Michael Levin, Fiorenzo G. Omenetto, Ryan D. Orendorff, Mary Rose Branch, Dany Spencer Adams, Domingos Henrique
2011 PLoS ONE  
With the goal of learning to induce regeneration in human beings as a treatment for tissue loss, research is being conducted into the molecular and physiological details of the regeneration process.  ...  Quantitative comparison of regenerate shapes provided strong evidence against a gradient and for the existence of position-specific morphogenetic information along the entire AP axis.  ...  Acknowledgments The authors wish to acknowledge the contributions of Punita Koustubhan, Amber Currier, Bryan Pennarola, and Ryan Morrie for Xenopus care; Claire Stevenson for histology; N.  ... 
doi:10.1371/journal.pone.0024953 pmid:21949803 pmcid:PMC3174989 fatcat:ndvpcmnsnzavlivsucb4qs75gq

Cultural Recycling of Cortical Maps

Stanislas Dehaene, Laurent Cohen
2007 Neuron  
Neuron Review Neuron 56, October 25, 2007 ª2007 Elsevier Inc. 385  ...  To explain this paradoxical cerebral invariance of cultural maps, we propose a neuronal recycling hypothesis, according to which cultural inventions invade evolutionarily older brain circuits and inherit  ...  We then consider the possible evolutionary precursors of this organization, that is, the corresponding morphogenetic and epigenetic maps that predate cultural learning.  ... 
doi:10.1016/j.neuron.2007.10.004 pmid:17964253 fatcat:mkfshquxknabvkjcpmr3qi2lby

Mitotic Events in Cerebellar Granule Progenitor Cells That Expand Cerebellar Surface Area Are Critical for Normal Cerebellar Cortical Lamination in Mice

Joshua C. Chang, Mark Leung, Hamza Numan Gokozan, Patrick Edwin Gygli, Fay Patsy Catacutan, Catherine Czeisler, José Javier Otero
2015 Journal of Neuropathology and Experimental Neurology  
(C) Predicted internal granular layer (IGL) volume because of migration from the EGL of cerebellar granule neuron progenitor cells.  ...  Thus, CCNA2-null cerebellar granule progenitor cells are capable of selfrenewal of the EGL stem cell niche; this is concordant with prior findings of extensive apoptosis in CCNA2-null mice.  ...  The content is solely the responsibility of the authors and does not necessarily represent official views of the National Center for Advancing Translational Sciences or the National Institutes of Health  ... 
doi:10.1097/nen.0000000000000171 pmid:25668568 pmcid:PMC4333719 fatcat:wtsgc3fniva37g5g6btd62bxia

Programming the Emergence in Morphogenetically Architected Complex Systems

Franck Varenne, Pierre Chaigneau, Jean Petitot, René Doursat
2015 Acta Biotheoretica  
We propose to call them morphogenetically architected complex systems (MACS).  ...  While taking the emergence of properties seriously, the notion of MACS enables at the same time the design (or "metadesign") of operational means that allow controlling and even, paradoxically, programming  ...  The reason might be that bioinspired disciplines, such as gene-inspired evolutionary computation, ant-inspired swarm intelligence, and neuron-inspired machine learning, needed to establish themselves upon  ... 
doi:10.1007/s10441-015-9262-z pmid:26024971 fatcat:whuib62ntnenflkpj5c657uoo4

From normal to leukemic cells featured by a fractal scaling-free analysis

Gabriele A. Losa
2016 Fractal Geometry and Nonlinear Analysis in Medicine and Biology  
and identical morphogenetic idea".  ...  and spatial learning abilities in the adult brain.  ... 
doi:10.15761/fgnamb.1000144 fatcat:rqyhjspdyrbsdgemjsso6ukfa4

Anatomical Society Summer Meeting, University of Oxford, Oxford, 2018

2018 Journal of Anatomy  
Our results indicate developmental and morphogenetic roles of subplate ECM, transient GFAP-reactive glia, neurons and synapses in providing spatial accommodation, navigation and establishment of connections  ...  and morphogenetic role of this transient compartment.  ...  Student's two-sample t-test analysis was used to determine significant statistics using MINITAB statistical software.  ... 
doi:10.1111/joa.12923 fatcat:ca3uniijyzbijdjytst3lrwdxm

NeuronMetrics: Software for semi-automated processing of cultured neuron images

Martha L. Narro, Fan Yang, Robert Kraft, Carola Wenk, Alon Efrat, Linda L. Restifo
2007 Brain Research  
We developed NeuronMetrics™ for semi-automated, quantitative analysis of two-dimensional (2D) images of fluorescently labeled cultured neurons.  ...  Depending on the need for manual intervention, processing time for a batch of ∼60 2D images is 1.0-2.5 h, from a folder of images to a table of numeric data.  ...  Merchant for suggesting the use of ImageJ and J. Rodriguez for advising the use of a rolling ball algorithm to delimit the neuronal soma.  ... 
doi:10.1016/j.brainres.2006.10.094 pmid:17270152 pmcid:PMC1945162 fatcat:wuu4wfj7rjhdvoszc35psszxoe

A single-cell Raman-based platform to identify developmental stages of human pluripotent stem cell-derived neurons

Chia-Chen Hsu, Jiabao Xu, Bas Brinkhof, Hui Wang, Zhanfeng Cui, Wei E. Huang, Hua Ye
2020 Proceedings of the National Academy of Sciences of the United States of America  
Further analysis with a machine learning classification model, utilizing t-distributed stochastic neighbor embedding (t-SNE)-enhanced ensemble stacking, clearly categorized hiPSCs in different developmental  ...  Nevertheless, clinical applications of stem cells have been hindered partly owing to a lack of standardized techniques to characterize cell molecular profiles noninvasively and comprehensively.  ...  The samples were imaged under a microscope, and the cytoplasm of positive cells was stained purple-red. Statistical Analysis.  ... 
doi:10.1073/pnas.2001906117 pmid:32694205 fatcat:m2ey3mmd5bhutedgoye5dzwdqm

Kinematic analysis of cell lineage reveals coherent and robust mechanical deformation patterns in zebrafish gastrulation [article]

David Pastor-Escuredo, Benoit Lombardot, Thierry Savy, Adeline Boyreau, Jose M. Goicolea, Andres Santos, Paul Bourgine, Juan C. del Alamo, Nadine Peyrieras, Maria J. Ledesma-Carbayo
2016 bioRxiv   pre-print
Digital cell lineages reconstructed from 3D+time imaging data provide unique information to unveil mechanical cues and their role in morphogenetic processes.  ...  Our methodology based on a kinematic analysis of cell lineage data reveals deformation patterns and quantitative morphogenetic landmarks for a new type of developmental table.  ...  Acknowledgments: We thank René Doursat for critical reading of the manuscript and the BioEmergences laboratory, especially Louise Duloquin and Dimitri Fabrèges for their collaboration and support.  ... 
doi:10.1101/054353 fatcat:zof4vquoxnef5fuo4s5m2pi3fu

Artificial Neurogenesis: An Introduction and Selective Review [chapter]

Taras Kowaliw, Nicolas Bredeche, Sylvain Chevallier, René Doursat
2014 Studies in Computational Intelligence  
In much of statistical learning, there is a drive toward finding the most parsimonious representation possible for a solution.  ...  Assuming that connectivity between neurons depends on their geometric location, a second key question concerns the level of stochasticity in the placement of those elements.  ... 
doi:10.1007/978-3-642-55337-0_1 fatcat:xx6nzfvbmfgzjhse6t5il3lbxe

Characterization of Biological Processes through Automated Image Analysis

Jens Rittscher
2010 Annual Review of Biomedical Engineering  
The text includes a review of image registration and image segmentation methods, as well as algorithms that enable the analysis of cellular architecture, cell morphology, and tissue organization.  ...  The goal of this review is to illustrate that, when combined with modern imaging platforms and labeling techniques, automated image analysis methods can provide such quantitative information.  ...  As opposed to a single reference image, multiple instances are being used to learn a statistical representation of the anatomy.  ... 
doi:10.1146/annurev-bioeng-070909-105235 pmid:20482277 fatcat:izhecr6bdzdapmxnnvzhmbpssa

Mapping calcium dynamics in a developing tubular structure [article]

Jorgen Hoyer, Morsal Saba, Daniel Dondorp, Kushal Kolar, Riccardo Esposito, Marios Chatzigeorgiou
2020 bioRxiv   pre-print
Here we image Ca2+ dynamics in the developing notochord of Ciona intestinalis.  ...  In line with this, we show that Ca2+ signalling modulates reorganization of the cytoskeletal network across the morphogenetic events leading up to and during tubulogenesis of the notochord.  ...  A) Additional peak features of stage specific Ca 2+ imaging B) Statistical significance matrices for peak features shown in Figure 1 and Sup. Figure 1. Detailed p-value tables can be found in Sup.  ... 
doi:10.1101/2020.10.16.342535 fatcat:h5z2fpixdvegvdrlu3rshcf5p4

The Free Energy Principle drives neuromorphic development [article]

Chris Fields, Karl Friston, James F. Glazebrook, Michael Levin, Antonino Marcianò
2022 arXiv   pre-print
hierarchical computations in which each level of the hierarchy enacts a coarse-graining of its inputs, and dually a fine-graining of its outputs.  ...  allow the representation of such computations in the fully-general quantum-computational framework of topological quantum neural networks.  ...  This can be cast as structure learning in radical constructivism [59, 60, 61] or Bayesian model selection in statistics [62] .  ... 
arXiv:2207.09734v1 fatcat:pqdkanmnxjbwtfxwpfw7l2hk5u
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