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Cystatin C in Alzheimer's disease
2012
Frontiers in Molecular Neuroscience
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Changes in expression and secretion levels of cystatin C (CysC) in the brain in various neurological disorders and in animal models of neurodegeneration underscore a role for CysC in these conditions. ...
In vitro studies have shown that CysC binds Aβ and inhibits Aβ oligomerization and fibril formation. ...
ACKNOWLEDGMENTS This work was supported by the National Institutes of Health (AG017617 and AG037693) and the Alzheimer's Association (IIRG-11-204579). ...
doi:10.3389/fnmol.2012.00079
pmid:22783166
pmcid:PMC3390601
fatcat:u3rjc3txkrcr7mthrzrtglyodm
Poster Sessions
2011
Epilepsia
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Conclusion: This study demonstrates that a clinical and, to a lesser degree, EEG response to an acute trial of IV BDZs are predictive of subsequent outcome in patients with suspected NCSE, and warrant ...
In a prospective study we investigated hypovitaminosis-D and its risk factors. ...
We tried to find a relationship between the amount of IEDs and cognitive impairment in children. ...
doi:10.1111/j.1528-1167.2011.03207.x
fatcat:77ayxa5tcbannis7zksyeo57ju
Thirteenth meeting of the European Neurological Society 14–18June 2003,Istanbul, Turkey
2003
Journal of Neurology
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The common binding partner was first identified as a receptor for the 66 extracellular amino acids of Nogo (Nog066) and was termed NgR. ...
All 3 inhibitors bind NgR with similar mechanisms involved in the onset of migraine attacks and the interaction with migraine trigger factors. ...
Alzheimer disease (AD) with 70% is the most common cause of dementia, followed by vascular form (VD), mixed dementia (MD) and mild cognitive impairment (MCl). ...
doi:10.1007/bf03160427
fatcat:dra3sin345hullyy7lbyrzyjsa
43rd Annual Congress of the: Canadian Neurological Sciences Federation Victoria, BC June 17-20, 2008
2008
Canadian Journal of Neurological Sciences
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Our objective was to study prefrontal cortex (PFC) neurochemistry and its association with cognitive impairment in ALS. ...
paper suggested that early bilingualism produced a statistically significant 4.1 year delay in onset of memory loss symptoms in older individuals with Alzheimer Disease, reflecting an increase in the cognitive ...
Method: We reviewed the retrospective data entered into the Multicenter, Medium and Large Intracranial Aneurysm Study that was started in July 2007. ...
doi:10.1017/s0317167100009859
fatcat:7qiof5xv2bekrheg3bfxmvszam
Moxonidine-induced central sympathoinhibition improves prognosis in rats with hypertensive heart failure
2013
Journal of Hypertension
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PHENOTYPIC ALTERATION OF NEUROVASCULAR ENDOTHELIUM IN A MOUSE MODEL OF ALZHEIMER DISEASE Shinichiro Hayashi 1 , Naoyuki Sato 2 , Ryuichi Morishita 2 , Yuhei Kawano 1 1 National Cerebral and Cardiovascular ...
MCP), Osteoprotogerin (OPG), and Osteopontin(OPN)) ; cardiac and renal dysfunction (Nt-proBNP, cystatin C). ...
main risk factor for cardiovascular diseases in Mongolia. ...
doi:10.1097/hjh.0b013e328364a2a1
pmid:24096260
fatcat:qbfbgdbvuvefjgapqhmuu236le
Oral Abstracts
2013
Fundamental & Clinical Pharmacology
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brain injury or cerebral haemorrhage patients: a multicentre randomized controlled trial for the SPIRIT-ICU study and AtlanR ea groups Objectives: Oral use of povidone-iodine to prevent ventilator-associated ...
Overall, these works suggest that bitter taste receptors may constitute a new pharmacological target for obstructive lung diseases such as asthma and COPD. ...
phenotype-genotype correlation. ...
doi:10.1111/fcp.12025
pmid:23614855
fatcat:hiajqjvj3na27gs42r4nfrbdl4
Abstract book of the XXI Congresso Nazionale della Società Scientifica FADOI, Roma, 14-17 maggio 2016
2016
Italian Journal of Medicine
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In particular, a moderate cognitive impairment was found in 40% of males and in 47.8% of females, while a severe deterioration was observed in 12% of males and 26.1% of females. ...
✪ Direct acting antivirals for the treatment of hepatitis virus C related cryoglobulinemic vasculitis: a multicentre open label study C. Mazzaro 1 , L. Dal Maso 2 , E. Mauro 3 , M. ...
Phenotype on peripheral blood and echography of organomegalies could guide to diagnosis. ...
doi:10.4081/itjm.2016.s2
fatcat:wesribcjhfgv7c3kiyf27px72m
36th International Symposium on Intensive Care and Emergency Medicine
2016
Critical Care
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Methods: Hypotensive sepsis was studied in male Sprague-Dawley rats using cecal ligation and perforation, with a 6-hour end point. ...
We hypothesized that sepsis impaired microvascular autoregulation over the entire capillary network, within a capillary and within the RBC. ...
In 2050 the population elderly will be a quarter of the total population. Advanced age is associated with increased severity of acute critical illnesses and admission to ICU. ...
doi:10.1186/s13054-016-1208-6
pmid:27885969
pmcid:PMC5493079
fatcat:urwtuajkvzcdppeeemfqliq6cq
38th International Symposium on Intensive Care and Emergency Medicine
2018
Critical Care
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Impaired metabolism has been recently proposed as one possible mechanisms underpinning leukocyte dysfunction in sepsis. ...
Conclusions: The LPS stimulation model could provide a useful approach to study the effect of sepsis on leukocyte metabolism. ...
However, there is a clear need for improvement in staff's ability to control and change their working environment. ...
doi:10.1186/s13054-018-1973-5
pmid:32831123
fatcat:4iyogy3eazcrrm7zpb4pgauuwm
ESICM LIVES 2016: part one
2016
Intensive Care Medicine Experimental
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Methods We conducted a retrospective study of patients admitted from 2011 to 2015. ...
Objectives We aimed to investigate the relationship between time in ED and ICU mortality in a tertiary university affiliated hospital. ...
Regarding to renal function, basal and after 72 hours, creatinine and cystatine-C plasma levels were similar in both groups. ...
doi:10.1186/s40635-016-0098-x
fatcat:5257rny3rfc7hpwmqijwjtsabu
Meeti ng the Challenges of a Changing Global Stage University of Puerto Rico
2013
unpublished
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This biphasic disease´s ranges from mild illness to a fulminant disease. ...
HD symptoms include motor decline and cognitive and emotional impairment; however, weight loss and muscle wasting are also characteristic symptoms in HD, suggesting that skeletal muscle (SKM) is also a ...
This cross-sectional study explored HPE and its association with diet quality (DQ) and obesity in a sample of 117 children aged 12 years (67 girls, 50 boys) from 4 public schools located in the metropolitan ...
fatcat:iwqykzlehbaizmulhrphx3dk3a
Managing Editors Editorial Board Cell Membranes, Ion Channels and Calcium Signaling
2016
Isparta / TURKEY www.cmos.org.tr
unpublished
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, respectively; GSTP1:c.313 A>G genotype: 50.0% and 20.0%, G allele: 35.0% and 25.0%, respectively). ...
Highest urea, creatinine and cystatine C levels were in
ovariectomized rats. ...
In recent years, this has been shown in several studies that food additives play a role in the development of cancer, liver-kidney failure and other diseases via their mutagenic effects (1) . ...
fatcat:qlfl33wvfbh37ii3zlshafvtbm