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Cystatin C in Alzheimer's disease

Gurjinder Kaur, Efrat Levy
2012 Frontiers in Molecular Neuroscience  
Changes in expression and secretion levels of cystatin C (CysC) in the brain in various neurological disorders and in animal models of neurodegeneration underscore a role for CysC in these conditions.  ...  In vitro studies have shown that CysC binds Aβ and inhibits Aβ oligomerization and fibril formation.  ...  ACKNOWLEDGMENTS This work was supported by the National Institutes of Health (AG017617 and AG037693) and the Alzheimer's Association (IIRG-11-204579).  ... 
doi:10.3389/fnmol.2012.00079 pmid:22783166 pmcid:PMC3390601 fatcat:u3rjc3txkrcr7mthrzrtglyodm

Poster Sessions

2011 Epilepsia  
Conclusion: This study demonstrates that a clinical and, to a lesser degree, EEG response to an acute trial of IV BDZs are predictive of subsequent outcome in patients with suspected NCSE, and warrant  ...  In a prospective study we investigated hypovitaminosis-D and its risk factors.  ...  We tried to find a relationship between the amount of IEDs and cognitive impairment in children.  ... 
doi:10.1111/j.1528-1167.2011.03207.x fatcat:77ayxa5tcbannis7zksyeo57ju

Thirteenth meeting of the European Neurological Society 14–18June 2003,Istanbul, Turkey

2003 Journal of Neurology  
The common binding partner was first identified as a receptor for the 66 extracellular amino acids of Nogo (Nog066) and was termed NgR.  ...  All 3 inhibitors bind NgR with similar mechanisms involved in the onset of migraine attacks and the interaction with migraine trigger factors.  ...  Alzheimer disease (AD) with 70% is the most common cause of dementia, followed by vascular form (VD), mixed dementia (MD) and mild cognitive impairment (MCl).  ... 
doi:10.1007/bf03160427 fatcat:dra3sin345hullyy7lbyrzyjsa

43rd Annual Congress of the: Canadian Neurological Sciences Federation Victoria, BC June 17-20, 2008

2008 Canadian Journal of Neurological Sciences  
Our objective was to study prefrontal cortex (PFC) neurochemistry and its association with cognitive impairment in ALS.  ...  paper suggested that early bilingualism produced a statistically significant 4.1 year delay in onset of memory loss symptoms in older individuals with Alzheimer Disease, reflecting an increase in the cognitive  ...  Method: We reviewed the retrospective data entered into the Multicenter, Medium and Large Intracranial Aneurysm Study that was started in July 2007.  ... 
doi:10.1017/s0317167100009859 fatcat:7qiof5xv2bekrheg3bfxmvszam

Moxonidine-induced central sympathoinhibition improves prognosis in rats with hypertensive heart failure

Nobuhiro Honda, Yoshitaka Hirooka, Koji Ito, Ryuichi Matsukawa, Keisuke Shinohara, Takuya Kishi, Keiji Yasukawa, Hideo Utsumi, Kenji Sunagawa
2013 Journal of Hypertension  
PHENOTYPIC ALTERATION OF NEUROVASCULAR ENDOTHELIUM IN A MOUSE MODEL OF ALZHEIMER DISEASE Shinichiro Hayashi 1 , Naoyuki Sato 2 , Ryuichi Morishita 2 , Yuhei Kawano 1 1 National Cerebral and Cardiovascular  ...  MCP), Osteoprotogerin (OPG), and Osteopontin(OPN)) ; cardiac and renal dysfunction (Nt-proBNP, cystatin C).  ...  main risk factor for cardiovascular diseases in Mongolia.  ... 
doi:10.1097/hjh.0b013e328364a2a1 pmid:24096260 fatcat:qbfbgdbvuvefjgapqhmuu236le

Oral Abstracts

2013 Fundamental & Clinical Pharmacology  
brain injury or cerebral haemorrhage patients: a multicentre randomized controlled trial for the SPIRIT-ICU study and AtlanR ea groups Objectives: Oral use of povidone-iodine to prevent ventilator-associated  ...  Overall, these works suggest that bitter taste receptors may constitute a new pharmacological target for obstructive lung diseases such as asthma and COPD.  ...  phenotype-genotype correlation.  ... 
doi:10.1111/fcp.12025 pmid:23614855 fatcat:hiajqjvj3na27gs42r4nfrbdl4

Abstract book of the XXI Congresso Nazionale della Società Scientifica FADOI, Roma, 14-17 maggio 2016

Presidente: M. Campanini
2016 Italian Journal of Medicine  
In particular, a moderate cognitive impairment was found in 40% of males and in 47.8% of females, while a severe deterioration was observed in 12% of males and 26.1% of females.  ...  ✪ Direct acting antivirals for the treatment of hepatitis virus C related cryoglobulinemic vasculitis: a multicentre open label study C. Mazzaro 1 , L. Dal Maso 2 , E. Mauro 3 , M.  ...  Phenotype on peripheral blood and echography of organomegalies could guide to diagnosis.  ... 
doi:10.4081/itjm.2016.s2 fatcat:wesribcjhfgv7c3kiyf27px72m

36th International Symposium on Intensive Care and Emergency Medicine

R. M. Bateman, M. D. Sharpe, J. E. Jagger, C. G. Ellis, J. Solé-Violán, M. López-Rodríguez, E. Herrera-Ramos, J. Ruíz-Hernández, L. Borderías, J. Horcajada, N. González-Quevedo, O. Rajas (+2428 others)
2016 Critical Care  
Methods: Hypotensive sepsis was studied in male Sprague-Dawley rats using cecal ligation and perforation, with a 6-hour end point.  ...  We hypothesized that sepsis impaired microvascular autoregulation over the entire capillary network, within a capillary and within the RBC.  ...  In 2050 the population elderly will be a quarter of the total population. Advanced age is associated with increased severity of acute critical illnesses and admission to ICU.  ... 
doi:10.1186/s13054-016-1208-6 pmid:27885969 pmcid:PMC5493079 fatcat:urwtuajkvzcdppeeemfqliq6cq

38th International Symposium on Intensive Care and Emergency Medicine

2018 Critical Care  
Impaired metabolism has been recently proposed as one possible mechanisms underpinning leukocyte dysfunction in sepsis.  ...  Conclusions: The LPS stimulation model could provide a useful approach to study the effect of sepsis on leukocyte metabolism.  ...  However, there is a clear need for improvement in staff's ability to control and change their working environment.  ... 
doi:10.1186/s13054-018-1973-5 pmid:32831123 fatcat:4iyogy3eazcrrm7zpb4pgauuwm

ESICM LIVES 2016: part one

L. Bos, L. Schouten, L. van Vught, M. Wiewel, D. Ong, O. Cremer, A. Artigas, I. Martin-Loeches, A. Hoogendijk, T. van der Poll, J. Horn, N. Juffermans (+2434 others)
2016 Intensive Care Medicine Experimental  
Methods We conducted a retrospective study of patients admitted from 2011 to 2015.  ...  Objectives We aimed to investigate the relationship between time in ED and ICU mortality in a tertiary university affiliated hospital.  ...  Regarding to renal function, basal and after 72 hours, creatinine and cystatine-C plasma levels were similar in both groups.  ... 
doi:10.1186/s40635-016-0098-x fatcat:5257rny3rfc7hpwmqijwjtsabu

Meeti ng the Challenges of a Changing Global Stage University of Puerto Rico

Abstracts, Prhsj
2013 unpublished
This biphasic disease´s ranges from mild illness to a fulminant disease.  ...  HD symptoms include motor decline and cognitive and emotional impairment; however, weight loss and muscle wasting are also characteristic symptoms in HD, suggesting that skeletal muscle (SKM) is also a  ...  This cross-sectional study explored HPE and its association with diet quality (DQ) and obesity in a sample of 117 children aged 12 years (67 girls, 50 boys) from 4 public schools located in the metropolitan  ... 
fatcat:iwqykzlehbaizmulhrphx3dk3a

Managing Editors Editorial Board Cell Membranes, Ion Channels and Calcium Signaling

Mustafa Nazıroğlu, Associate Cihangir Uğuz, Ömer Çelik, Bilal Çiğ, Yener Yazğan, Alexei Tepikin, Jose Pariente, Martyn Smith, Stephan Huber, Neuroscience, Cell Signaling, Abbas Haghparast (+6 others)
2016 Isparta / TURKEY www.cmos.org.tr   unpublished
, respectively; GSTP1:c.313 A>G genotype: 50.0% and 20.0%, G allele: 35.0% and 25.0%, respectively).  ...  Highest urea, creatinine and cystatine C levels were in ovariectomized rats.  ...  In recent years, this has been shown in several studies that food additives play a role in the development of cancer, liver-kidney failure and other diseases via their mutagenic effects (1) .  ... 
fatcat:qlfl33wvfbh37ii3zlshafvtbm