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Genome-scale metabolic model of the fission yeast Schizosaccharomyces pombe and the reconciliation of in silico/in vivo mutant growth

Seung Sohn, Tae Kim, Jay H Lee, Sang Lee
2012 BMC Systems Biology  
to a newly reconstructed genome-scale metabolic model of the fission yeast, Schizosaccharomyces pombe, SpoMBEL1693.  ...  The predictive capabilities of the genome-scale metabolic model in predicting single-gene mutant growth phenotypes were measured against the single-gene mutant library of S. pombe.  ...  Here we present a strategy in improving the predictive capabilities of genome-scale metabolic model of singlegene knockout growth phenotypes through Reconciliation of In silico/in vivo mutaNt Growth (RING  ... 
doi:10.1186/1752-0509-6-49 pmid:22631437 pmcid:PMC3390277 fatcat:7sjgx3i6o5cpjkk7bl7rq62hrq

Genome-Scale Identification of Essential Metabolic Processes for Targeting the Plasmodium Liver Stage

Rebecca R. Stanway, Ellen Bushell, Anush Chiappino-Pepe, Magali Roques, Theo Sanderson, Blandine Franke-Fayard, Reto Caldelari, Murielle Golomingi, Mary Nyonda, Vikash Pandey, Frank Schwach, Séverine Chevalley (+10 others)
2019 Cell  
We analyze the screen in the context of genomic, transcriptomic, and metabolomic data by building a thermodynamic model of P. berghei liver-stage metabolism, which shows a major reprogramming of parasite  ...  metabolism to achieve rapid growth in the liver.  ...  Pathway representation The metabolic pathways depicted in this manuscript are based on their description in the genome-scale metabolic model of P. berghei iPbe (Table S4) .  ... 
doi:10.1016/j.cell.2019.10.030 pmid:31730853 pmcid:PMC6904910 fatcat:plzd44yjo5ctjahmwovysad6de