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Intermediate phenotypes in psychiatric disorders

Roberta Rasetti, Daniel R Weinberger
2011 Current Opinion in Genetics and Development  
Neuroimaging-based intermediate phenotypes have emerged as particularly promising because they map risk associated gene effects onto physiological processes in brain that are altered in patients and in  ...  The small effect size of most individual risk factors for psychiatric disorders likely reflects biological heterogeneity and diagnostic imprecision, which has encouraged genetic studies of intermediate  ...  Acknowledgments This research was supported by the Intramural Research Program of the National Institute of Mental Health, National Institutes of Health. We thank Venkata S.  ... 
doi:10.1016/j.gde.2011.02.003 pmid:21376566 pmcid:PMC3138621 fatcat:b7olk2f6azbspkdsrbcvfmk2om

Executive Function, Neural Circuitry and Genetic Mechanisms in Schizophrenia

Daniel Paul Eisenberg, Karen Faith Berman
2009 Neuropsychopharmacology  
links between schizophrenia risk genetics and characteristic executive circuit aberrancies observed with neuroimaging methods.  ...  With this expansive network of interactions in mind, the present chapter takes a systems-level approach to executive dysfunction in schizophrenia, by identifying key regions both within and outside of  ...  ACKNOWLEDGEMENTS This work was supported by the National Institute of Mental Health Intramural Research Program. DISCLOSURE The authors declared no conflict of interest.  ... 
doi:10.1038/npp.2009.111 pmid:19693005 pmcid:PMC2794926 fatcat:5pz6hmdfofhxpas3tdkq6bk67i

Brain Structure and Function Changes During the Development of Schizophrenia: The Evidence From Studies of Subjects at Increased Genetic Risk

S. M. Lawrie, A. M. McIntosh, J. Hall, D. G.C. Owens, E. C. Johnstone
2007 Schizophrenia Bulletin  
This article reviews the evidence for changes in the structure and function of the brain in subjects at high risk of schizophrenia for genetic reasons during the genesis of the disorder.  ...  We conclude by quoting our own and others' imaging studies of the associations of genetic and other risk factors for schizophrenia, including stressful life events and cannabis use, which provide mechanistic  ...  PFC (DLPFC) on working memory tasks in relatives vs CONs 40-43 -whereas only one small study of unaffected twins has not. 44 In 3 of the studies, there were no significant performance differences observed  ... 
doi:10.1093/schbul/sbm158 pmid:18227083 pmcid:PMC2632417 fatcat:mtgfw5zs25ho7fqafwmo7pzfxq


Paul D. Morrison, Robin M. Murray
2005 Current Biology  
A very interesting recent finding is that variation in the COMT gene, mentioned earlier, modulates the risk conferred by cannabis.  ...  Individually, each gene (and environmental risk factor) has a small effect size; for example, the relative risk for those carrying the respective risk haplotypes of neuregulin1 and dysbindin is less than  ...  The editors of Current Biology welcome correspondence on any article in the journal, but reserve the right to reduce the length of any letter to be published.  ... 
doi:10.1016/j.cub.2005.11.059 pmid:16360673 fatcat:mv2xcqezpnfijhnrcyr3z6vpya

Genes, dopamine and cortical signal-to-noise ratio in schizophrenia

Georg Winterer, Daniel R. Weinberger
2004 Trends in Neurosciences  
Seamans and Patricio O'Donnell, both of whom also critiqued the manuscript and, most especially, we thank the late Patricia Goldman-Rakic, whose unique work and generosity guided our efforts, and to whose  ...  treasured memory we dedicate this paper.  ...  with cognitive deficits in prefrontal-type working memory tasks.  ... 
doi:10.1016/j.tins.2004.08.002 pmid:15474169 fatcat:yem32fkh6bbpvfmvrilqkafbli

The 3rd Schizophrenia International Research Society Conference, 14–18 April 2012, Florence, Italy: Summaries of oral sessions

Brandon Abbs, Rashmin M. Achalia, Adegoke O. Adelufosi, Ahmet Yiğit Aktener, Natalie J. Beveridge, Savita G. Bhakta, Rachael K. Blackman, Emre Bora, M.S. Byun, Maurice Cabanis, Ricardo Carrion, Christina A. Castellani (+25 others)
2012 Schizophrenia Research  
an update on current investigations ongoing in the field of schizophrenia research.  ...  The following report is a composite of these reviews.  ...  The information in these reports and the accuracy of each statement were the sole responsibility of each rapporteur and are based on personal interpretations of what was heard.  ... 
doi:10.1016/j.schres.2012.07.024 pmid:22910407 pmcid:PMC3877922 fatcat:kjoz7q232zejnfnvpuogpobsfa

The 2nd Schizophrenia International Research Society Conference, 10–14 April 2010, Florence, Italy: Summaries of oral sessions

Moogeh Baharnoori, Cali Bartholomeusz, Aurelie A. Boucher, Lisa Buchy, Christopher Chaddock, Bonga Chiliza, Melanie Föcking, Alex Fornito, Juan A. Gallego, Hiroaki Hori, Gisele Huf, Gul A. Jabbar (+20 others)
2010 Schizophrenia Research  
., 2009 ) used mean BOLD activation in the dorsolateral prefrontal cortex during a working memory task.  ...  In particular they examined the relationship between stress, COMT methylation and working memory performance as well as related brain activity in healthy subjects.  ...  Specifically, although the schizophrenia group performed more poorly than controls, age, level of education and height were significantly correlated with UPSA-B scores in healthy individuals but not in  ... 
doi:10.1016/j.schres.2010.09.008 pmid:20934307 pmcid:PMC4182935 fatcat:aca7cqdp35gotmhphwkqimwsre

Neural phenotypes of common and rare genetic variants

Carrie E. Bearden, David C. Glahn, Agatha D. Lee, Ming-Chang Chiang, Theo G.M. van Erp, Tyrone D. Cannon, Allan L. Reiss, Arthur W. Toga, Paul M. Thompson
2008 Biological Psychology  
Acknowledgments This work was supported in part by grants K23 MH074644-01 (C.E.B.), the National Institutes of Health through the NIH Roadmap for Medical Research, and grant U54 RR021813 (Center for Computational  ...  Algorithm development and literature mining tools supported by grants from the National Institute for Biomedical Imaging and Bioengineering, the National Center for Research Resources, the National Institute  ...  These findings have now been extended to show a significant effect of COMT genotype on working memory performance (assayed by the n-back task) for patients with schizophrenia, their healthy siblings, and  ... 
doi:10.1016/j.biopsycho.2008.02.005 pmid:18395317 pmcid:PMC2535822 fatcat:tixqx2hds5cg3lycrxshh6ci7a

Endophenotypes in Psychopathology Research: Where Do We Stand?

Gregory A. Miller, Brigitte Rockstroh
2013 Annual Review of Clinical Psychology  
With more grounding in animal neuroscience and other aspects of basic biological and psychological science, exemplified in the Research Domain Criteria initiative, there is every reason to anticipate that  ...  endophenotypes are driven by genetic and environmental factors and in turn drive psychopathology.  ...  ACKNOWLEDGMENTS The authors thank Howard Berenbaum, Tyrone D. Cannon  ... 
doi:10.1146/annurev-clinpsy-050212-185540 pmid:23297790 fatcat:b3qm3653rndtrda7r5pirbk3l4

Why schizophrenia genetics needs epigenetics: a review

Nadja P Maric, Dragan M Svrakic
2012 Psychiatria Danubina  
Schizophrenia (SZ) is a highly heritable disorder, with about 80% of the variance attributable to genetic factors.  ...  On the other hand, rare and large copy number variants (CNVs) with high but incomplete penetrance, variable in different individual, could explain about additional 30% of SZ cases.  ...  Acknowledgements This work was supported in part by the Serbian Ministry of Science and Technological Development, grant III 41029.  ... 
pmid:22447077 fatcat:wide26wjhndajiybn5hib63heq

Animal models of schizophrenia

CA Jones, DJG Watson, KCF Fone
2011 British Journal of Pharmacology  
More recently, work has begun to identify specific rodent behavioural tasks with translational relevance to specific cognitive domains affected in schizophrenia, and where available this review focuses  ...  All available animal models of schizophrenia fit into four different induction categories: developmental, drug-induced, lesion or genetic manipulation, and the best characterized examples of each type  ...  Hoffmann-La Roche, Institut de Recherches Servier and Laboratorios Dr Esteve for current or previous funding of their work on animal models of schizophrenia.  ... 
doi:10.1111/j.1476-5381.2011.01386.x pmid:21449915 pmcid:PMC3229756 fatcat:x6s4vm2qvrbmlibxuvhetxexzy

The XVth World Congress of Psychiatric Genetics, October 7–11, 2007: Rapporteur summaries of oral presentations

Anna Alkelai, Amber Baum, Melanie Carless, James Crowley, Tania DasBanerjee, Emma Dempster, Sophia Docherty, Elizabeth Hare, Michael J Galsworthy, Deepak Grover, Dylan Glubb, Robert Karlsson (+12 others)
2008 American Journal of Medical Genetics Part B: Neuropsychiatric Genetics  
The 2007 congress was held in New York City and attracted over 1000 researchers.  ...  The World Congress of Psychiatric Genetics (WCPG) has become an annual event since the early 1990's sponsored by the International Society of Psychiatric Genetics (ISPG).  ...  The work highlighted the key difference in structural brain MRI imaging of Klinefelter men when compared to healthy age matched controls.  ... 
doi:10.1002/ajmg.b.30711 pmid:18297693 fatcat:rrzqey2oyze7bdb3vxetsfw32i

Neuroplasticity signaling pathways linked to the pathophysiology of schizophrenia

Darrick T. Balu, Joseph T. Coyle
2011 Neuroscience and Biobehavioral Reviews  
Although the etiology of schizophrenia is unknown, it appears to be a developmental disorder involving the interaction of a potentially large number of risk genes, with no one gene producing a strong effect  ...  for restoring proper synaptic connectivity in the brain in schizophrenia and related disorders.  ...  Acknowledgments This work was supported by a postdoctoral National Research Service Award F32 MH090697-01 granted to DTB, as well as grants R01MH05190, P50MH0G0450, and an unrestricted grant from Bristol-Myers  ... 
doi:10.1016/j.neubiorev.2010.10.005 pmid:20951727 pmcid:PMC3005823 fatcat:u4iceyuqxbf45ercnmqay6ynqi

ACNP 58th Annual Meeting: Panels, Mini-Panels and Study Groups

2019 Neuropsychopharmacology  
The kinetics of dynorphin signal activation, duration and spread were characterized in striatum using a combination of photorelease, sensor imaging and electrophysiology.  ...  the brain.  ...  Methods: Acute behavioral effects of TMS were explored using a working memory task.  ... 
doi:10.1038/s41386-019-0544-z pmid:31801977 pmcid:PMC6957922 fatcat:hjyvf7fcpbf2fhxit6rlhsvg2y

A role for white matter abnormalities in the pathophysiology of bipolar disorder

Katie Mahon, Katherine E. Burdick, Philip R. Szeszko
2010 Neuroscience and Biobehavioral Reviews  
in the expression of myelin- and oligodendrocyte-related genes are among the most consistent findings.  ...  Taken together, the evidence supports and clarifies a model of BD that involves disconnectivity in regions implicated in emotion generation and regulation.  ...  Acknowledgments This work was supported in part by grants from the Stanley Foundation and the NSLIJ Research Institute General Clinical Research Center (M01 RR018535).  ... 
doi:10.1016/j.neubiorev.2009.10.012 pmid:19896972 pmcid:PMC2847441 fatcat:mtzxa25jirevjae2tcfediihl4
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