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Polymorphisms in Serotonergic Pathways Influence the Outcome of Antidepressant Therapy in Psychiatric Inpatients

Julia Staeker, Stefan Leucht, Barbara Laika, Werner Steimer
2014 Genetic Testing and Molecular Biomarkers  
during working memory tasks and also predicts personality traits.  ...  indicated that genetic variation within ANK3 may exert gene-specific modulating effects on working memory deficits in schizophrenia." 44 The cognitive impact of the ANK3 risk variant for bipolar disorder  ... 
doi:10.1089/gtmb.2013.0217 pmid:24192302 fatcat:5k7hq3dzvfddln6s7nxsc4x6d4

Exploring Genetic Influences on Cognition: Emerging Strategies for Target Validation and Treatment Optimization

John Fossella, Sonia Bishop, B. Casey
2003 Current Drug Targets - CNS & Neurological Disorders  
A major goal of this initiative is to identify the neural and neurochemical substrates of basic cognitive processes that are disrupted in psychiatric disorders and to examine the influence of genetic factors  ...  Functional neuroimaging, meanwhile, has provided detailed new insights into the neural circuits involved in emotional and cognitive control.  ...  task and associated levels of regional neural activity.  ... 
doi:10.2174/1568007033482689 pmid:14683463 fatcat:vzdtj7advfa3vkgtu627nh6rwe

Longitudinal genetic studies of cognitive characteristics

R. N. Mustafin, A. V. Kazantseva, R. F. Enikeeva, S. B. Malykh, E. K. Khusnutdinova
2020 Vavilovskij Žurnal Genetiki i Selekcii  
, thus indicating the role of the similar mechanisms of genetic and neural networks in both normal cognition and cognitive impairment.  ...  As a result, the role of genes actively expressed in the brain, such as BDNF, COMT, CADM2, CYP2D6, APBA1, CHRNA7, PDE1C, PDE4B, and PDE4D in cognitive abilities was revealed.  ...  Longitudinal studies proved that an increasing phenotypic stability in cognitive abilities in human development was mediated by genetic factors.  ... 
doi:10.18699/vj20.599 pmid:33659785 pmcid:PMC7716536 fatcat:2tnqkg6geveftlpajdhvlasdju

Genomics of schizophrenia and pharmacogenomics of antipsychotic drugs

Ramón Cacabelos, Pablo Cacabelos, Gjumrakch Aliev
2013 Open Journal of Psychiatry  
Genetic studies in SCZ have revealed the presence of chromosome anomalies, copy number variants, multiple single-nucleotide polymorphisms of susceptibility distributed across the human genome, aberrant  ...  Efficacy and safety issues in the pharmacological treatment of SCZ are directly linked to genetic clusters involved in the pharmacogenomics of antipsychotic drugs and also to environmental factors.  ...  Most studies on pharmacogenomics of CNS disorders in our institution are funded by the International Agency for Brain Research and Aging (IABRA).  ... 
doi:10.4236/ojpsych.2013.31008 fatcat:cqyqrictxvcqloaaco3eigy2xi

The Influence of Genetic and Environmental Factors among MDMA Users in Cognitive Performance

Elisabet Cuyàs, Antonio Verdejo-García, Ana Beatriz Fagundo, Olha Khymenets, Joan Rodríguez, Aida Cuenca, Susana de Sola Llopis, Klaus Langohr, Jordi Peña-Casanova, Marta Torrens, Rocío Martín-Santos, Magí Farré (+2 others)
2011 PLoS ONE  
metabolites may contribute to explain variations in the cognitive impact of MDMA across regular users of this drug.  ...  This study is aimed to clarify the association between MDMA cumulative use and cognitive dysfunction, and the potential role of candidate genetic polymorphisms in explaining individual differences in the  ...  reduced DLPFC and parietal activation during planning tasks [50] .  ... 
doi:10.1371/journal.pone.0027206 pmid:22110616 pmcid:PMC3217947 fatcat:5lf5luw74nh4bckwki7omdoz3e

Endophenotypes and biomarkers: an approach to molecular genetic studies of mental disorders - Endofenotipos y biomarcadores: un enfoque hacia el estudio genético molecular de los trastornos mentales

Adriana Díaz-Anzaldúa, Junior Velázquez-Pérez, Andrés Nani Vázquez, Carlos Berlanga
2013 Salud mental (Mexico)  
ACKNOWLEDGEMENTS The authors thank Adriana Estrella González Ramirez for her participation in the initial search of scientific literature.  ...  Moreover, codeine is bioactivated by CYP2D6 into morphine. Due to genetic polymorphisms, there is high individual variability regarding CYP2D6 catalytic activity.  ...  In addition, poor CYP2D6 activity in healthy volunteers is associated with personality traits of social cognitive anxie-ty, which may resemble mild psychotic-like symptoms. 55 Other CYP genes that have  ... 
doi:10.17711/sm.0185-3325.2013.023 fatcat:ufwrzhfwurfzfj3uqs5z7tys4u

Irritable Bowel Syndrome: Methods, Mechanisms, and Pathophysiology. Genetic epidemiology and pharmacogenetics in irritable bowel syndrome

Michael Camilleri, David A. Katzka
2012 American Journal of Physiology - Gastrointestinal and Liver Physiology  
Similarly, the impact of genetic variation on the targets of therapy in IBS may enhance the efficacy of pharmacological therapies.  ...  These targets include receptors and regulators of gut function and variations in drug metabolism. This review addresses the available literature on the role of genetics in IBS.  ...  There is also evidence that the same variation results in altered cold pain perception without affecting cognition (66) .  ... 
doi:10.1152/ajpgi.00537.2011 pmid:22403795 pmcid:PMC3362100 fatcat:kfztaqlmavh5vaqtkf7k5ehi3e

Neurobiology of Attention Deficit/Hyperactivity Disorder

DIANE PURPER-OUAKIL, NICOLAS RAMOZ, AUDE-MARIE LEPAGNOL-BESTEL, PHILIP GORWOOD, MICHEL SIMONNEAU
2011 Pediatric Research  
of brain structure and activation patterns.  ...  Recent findings have drawn attention to the involvement of rare genetic variants in the pathophysiology of ADHD, some being shared with other neurodevelopmental disorders.  ...  Gene-environment interactions (GxE) operate in two ways: 1) a genetic factor may enhance or diminish the impact of a particular environment and 2) an environmental factor may activate a genetic effect.  ... 
doi:10.1203/pdr.0b013e318212b40f pmid:21289544 fatcat:5x4c2cxckbdzjiqku4f7h4twhi

Cytochrome P450–mediated drug metabolism in the brain

Sharon Miksys, Rachel Tyndale
2013 Journal of Psychiatry & Neuroscience  
This review summarizes the characterization of CYPs in the brain, using examples from the CYP2 subfamily, and discusses sources of variation in brain CYP levels and metabolism.  ...  This is important for CNSacting drugs, as variation in brain CYP-mediated metabolism may be a contributing factor when plasma levels do not predict drug response.  ...  Mental Health; the Centre for Addiction and Mental Health Foundation; the National Institute on Drug Abuse (R21DA029160); the Canadian Institutes of Health Research (MOP97751); a Canada Research Chair in  ... 
doi:10.1503/jpn.120133 pmid:23199531 pmcid:PMC3633708 fatcat:y6dof5ohezcbxmtycbftjbe6pq

Donepezil in Alzheimer's disease: From conventional trials to pharmacogenetics

Ramón Cacabelos
2007 Neuropsychiatric Disease and Treatment  
Although donepezil represents a non cost-effective treatment, most studies convey that this drug can provide a modest benefit on cognition, behavior, and activities of the daily living in both moderate  ...  profile in terms of cognitive improvement, responders rate (40%-58%), dropout cases (5%-13%), and side-effects (6%-13%) in AD.  ...  The genetic variation between AD and controls associated with CYP2D6 genotypes is 13.35% in EMs, 15.89% in IMs, 0.38% in PMs, and 2.16% in UMs, with an absolute genetic variation of 31.78% between both  ... 
pmid:19300564 pmcid:PMC2654795 fatcat:rurc64sbffd2dkn4u44ls4lkqe

ACNP 58th Annual Meeting: Panels, Mini-Panels and Study Groups

2019 Neuropsychopharmacology  
Activation of the Autophagy/Lysosomal Degradation Pathway Rescues Cognitive and Sensory Deficits in Fragile X Mice Abstract not included. ACNP 58 th Annual Meeting: Panels, Mini-Panels. . .  ...  In parallel, two analogues were assayed in brain slices using genetically-encoded optical sensors for dynorphin developed by Lin Tian's lab at UC Davis.  ...  in functional activation connectivity across tasks designed to probe systems of emotion valence and cognition.  ... 
doi:10.1038/s41386-019-0544-z pmid:31801977 pmcid:PMC6957922 fatcat:hjyvf7fcpbf2fhxit6rlhsvg2y

Prevention: an achievable goal in personalized medicine

2009 Phlebolymphology  
In the past 15 years a considerable number of studies have found evidence that it may be possible to prevent the onset of some mental disorders.  ...  More than 20 studies have examined prevention of depressive disorders, and they have found an overall reduction in the incidence of about 25% compared with control groups.  ...  Ethical challenges of personalized medicine in psychiatry -Evers  ... 
doi:10.31887/dcns.2009.11.4/pcuijpers fatcat:skxdna6cjrh23osyxznlzng2z4

ACNP 55th Annual Meeting: Poster Session III

2016 Neuropsychopharmacology  
human.  ...  In our presentation last year at the ACNP, we reported a) the pharmacological characterization of the COX-1 and COX-2 radioligands using in vitro enzymatic assays in monkey and human blood, and b) initial  ...  CYP2D6 activity scores have previously been shown to predict neural activation during working memory and emotional face matching tasks.  ... 
doi:10.1038/npp.2016.242 fatcat:4efd43swjbboranfrcs3pp32h4

A Review on Current Strategies and Future Perspective in Respect to Alzheimer's Disease Treatment

Souravh Bais, Renu Kumari, Yash Prashar
2016 Current Research in Neuroscience  
It is probably caused by complex interactions among multiple genetic, epigenetic and environmental factors.  ...  Arise due to tau proteins and further study on amyloids in underway.  ...  The change in connectivity will remain in default mode due to hyperactivation of the hippocampus during execution of memory tasks 5, 6 .  ... 
doi:10.3923/crn.2016.1.15 fatcat:g57xe7efgfchxlhfgogpmzasj4

Poster Session III

2010 Neuropsychopharmacology  
humans that lead to abnormal brain function and psychosis.  ...  It is generally regarded that acute LSD in humans can reproduce many of the positive symptoms of psychosis, including hallucinations and detachment from reality.  ...  Receptor signaling activities were determined as described below.  ... 
doi:10.1038/npp.2010.218 fatcat:i5knteqsgveybffza7g6b4iqei
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