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Genetic influences on hippocampal volume differ as a function of testosterone level in middle-aged men

Matthew S. Panizzon, Richard L. Hauger, Lindon J. Eaves, Chi-Hua Chen, Anders M. Dale, Lisa T. Eyler, Bruce Fischl, Christine Fennema-Notestine, Carol E. Franz, Michael D. Grant, Kristen C. Jacobson, Amy J. Jak (+8 others)
2012 NeuroImage  
Genetic influences on hippocampal volume increased substantially as a function of increasing testosterone level, while environmental influences either decreased or remained stable.  ...  We found no evidence for a correlation between testosterone level and hippocampal volume, as well as no indication of shared genetic influences.  ...  Acknowledgments The VETSA project is supported by National Institutes of Health/ National Institute on Aging (NIH/NIA) Grants R01 AG18386, RO1 AG18384, RO1 AG22381, and RO1 AG22982. The U.S.  ... 
doi:10.1016/j.neuroimage.2011.09.044 pmid:21983185 pmcid:PMC3230702 fatcat:rwjrzsqrlfgvdnbbk6chtiqz5m

Testosterone modifies the effect of APOE genotype on hippocampal volume in middle-aged men

M. S. Panizzon, R. Hauger, A. M. Dale, L. J. Eaves, L. T. Eyler, B. Fischl, C. Fennema-Notestine, C. E. Franz, M. D. Grant, A. J. Jak, K. C. Jacobson, M. J. Lyons (+7 others)
2010 Neurology  
Conclusions: These findings demonstrate an interaction effect between testosterone and the APOE ⑀4 allele on hippocampal volume in middle-aged men, and they may suggest 2 low testosterone subgroups.  ...  The aim of the present study was to examine the potential interaction of testosterone and APOE genotype with respect to hippocampal volume in middle age.  ...  Testosterone modifies the effect of APOE genotype on hippocampal volume in middle-aged men The APOE ⑀4 allele is a major risk factor for late-onset Alzheimer disease (AD), 1 but evidence for its association  ... 
doi:10.1212/wnl.0b013e3181f11deb pmid:20819998 pmcid:PMC2938973 fatcat:xhvsgx6ynngx7jdexkd5btzuba

Genetic and environmental influences of daily and intra-individual variation in testosterone levels in middle-aged men

Matthew S. Panizzon, Richard Hauger, Kristen C. Jacobson, Lindon J. Eaves, Timothy P. York, Elizabeth Prom-Wormley, Michael D. Grant, Michael J. Lyons, Ruth McKenzie, Sally P. Mendoza, Hong Xian, Carol E. Franz (+1 others)
2013 Psychoneuroendocrinology  
Genetic influences on hippocampal volume differ as a function of testosterone level in middle-aged men. Neuroimage. 2012 Jan 16;59(2):1123-31.  ...  Testosterone modifies the effect of APOE genotype on hippocampal volume in middle-aged men.H Neurology. 2010 Sep 7;75(10):874-80.PMID: 20819998 Eyler LT, Prom-Wormley E, Fennema-Notestine C, Panizzon MS  ... 
doi:10.1016/j.psyneuen.2013.04.003 pmid:23639251 pmcid:PMC3775872 fatcat:3qshyku5rjghretkvlikhnsr6i

Androgen treatment effects on hippocampus structure in boys with Klinefelter syndrome

Lara C. Foland-Ross, Judith L. Ross, Allan L. Reiss
2019 Psychoneuroendocrinology  
Group differences in hippocampal volume were examined. A significant main effect of group was observed.  ...  Pairwise comparisons indicated smaller hippocampal volume in the placebo group relative to the oxandrolone group, as well as smaller volume in the placebo group relative to the TD control group.  ...  Acknowledgements: We thank the patients and their families for their participation in this study. Funding. Supported by the National Institute of Neurological Disorders and Stroke (NINDS; NS050597).  ... 
doi:10.1016/j.psyneuen.2018.09.039 pmid:30388596 pmcid:PMC6644684 fatcat:ez4mrqi4lbhevpt72pdiqxeetq

Interaction of APOE genotype and testosterone on episodic memory in middle-aged men

Matthew S. Panizzon, Richard Hauger, Hong Xian, Eero Vuoksimaa, Kelly M. Spoon, Sally P. Mendoza, Kristen C. Jacobson, Terrie Vasilopoulos, Brinda K. Rana, Ruth McKenzie, Jeanne M. McCaffery, Michael J. Lyons (+2 others)
2014 Neurobiology of Aging  
Age-related changes in testosterone are believed to be a key component of the processes that contribute to cognitive aging in men.  ...  The goals of the present study were to examine the degree to which free testosterone is associated with episodic memory in a community-based sample of middle-aged men, and examine the potential interaction  ...  We also appreciate the time and energy of many staff and students on the VETSA projects.  ... 
doi:10.1016/j.neurobiolaging.2013.12.025 pmid:24444806 pmcid:PMC3980008 fatcat:mliditcvovevlmvce6kjnx7chy

Sex hormones and adult hippocampal neurogenesis: Regulation, implications, and potential mechanisms

Rand Mahmoud, Steven R. Wainwright, Liisa A.M. Galea
2016 Frontiers in neuroendocrinology (Print)  
The review is framed around the potential functional implications of sex hormone regulation of adult hippocampal neurogenesis, with a focus on cognitive function and mood regulation, which may be related  ...  Lastly, we advocate for a more systematic consideration of sex and sex hormones in studying the functional implications of adult hippocampal neurogenesis. 3  ...  Further, the interaction of testosterone with known genetic predispositions, such as APOE, should be considered in research on cognitive ageing in men.  ... 
doi:10.1016/j.yfrne.2016.03.002 pmid:26988999 fatcat:nfzgydclenedfhgfpjaezyp3wq

Sex differences in cognitive impairment and Alzheimer's disease

Rena Li, Meharvan Singh
2014 Frontiers in neuroendocrinology (Print)  
period, as well as in activational effects, where the influence of the sex steroids influence brain function in adulthood.  ...  Studies have shown differences in specific cognitive ability domains and risk of Alzheimer's disease between the men and women at later age.  ...  authors Year Case number Age (years) advantage  ... 
doi:10.1016/j.yfrne.2014.01.002 pmid:24434111 pmcid:PMC4087048 fatcat:sbavjcfp7bbb5lxnargu4pylqe

A quantitative and qualitative review of the effects of testosterone on the function and structure of the human social-emotional brain

Sarah J. Heany, Jack van Honk, Dan J. Stein, Samantha J. Brooks
2015 Metabolic brain disease  
Social and affective research in humans is increasingly using functional and structural neuroimaging techniques to aid the understanding of how hormones, such as testosterone, modulate a wide range of  ...  In children, boys showed a positive correlation between testosterone and brain volume in many regions, including the amygdala, as well as global grey matter volume, while girls showed a neutral or negative  ...  and parietal volumes in the men in old age.  ... 
doi:10.1007/s11011-015-9692-y pmid:26073231 pmcid:PMC4718938 fatcat:o2q6zlt7a5aenh5nt3qv6lv3wq

Sex shapes experimental ischemic brain injury

Jian Cheng, Patricia D. Hurn
2010 Steroids  
The role of androgens in male stroke is understudied and important to pursue given that male sex is a well known risk factor for human stroke.  ...  We review recent advances in our understanding of androgens in the context of ischemic cell death and neuroprotection.  ...  For example, stroke rates in women do not equalize to those of men until beyond 75 years of age [4] .  ... 
doi:10.1016/j.steroids.2009.10.014 pmid:19903490 pmcid:PMC2902572 fatcat:vc5vtakhenckleosd464i7647y

Genetics of brain structure: Contributions from the vietnam era twin study of aging

William S. Kremen, Christine Fennema-Notestine, Lisa T. Eyler, Matthew S. Panizzon, Chi-Hua Chen, Carol E. Franz, Michael J. Lyons, Wesley K. Thompson, Anders M. Dale
2013 American Journal of Medical Genetics Part B: Neuropsychiatric Genetics  
We also found that testosterone moderates the heritability of hippocampal volume ; genetic influences played a greater role in determining hippocampal volume for men with higher levels of testosterone.  ...  As such, volume conflates two different sets of genetic influences.  ... 
doi:10.1002/ajmg.b.32162 pmid:24132907 pmcid:PMC4754776 fatcat:c7hadr2m6vf3xewdur2bdqar6e

Structural and functional neuroimaging in Klinefelter (47,XXY) syndrome: A review of the literature and preliminary results from a functional magnetic resonance imaging study of language

Kyle Steinman, Judith Ross, Song Lai, Allan Reiss, Fumiko Hoeft
2009 Developmental Disabilities Research Reviews  
Here, we review the literature of structural and functional neural findings in KS identified by neuroimaging and present preliminary results from a functional magnetic resonance imaging study examining  ...  brain activity during a verb generation task in KS.  ...  Warwick et al. [1999] first published a study on TBV differences in KS comparing structural MRI of the brain in 10 men with KS to 26 control men.  ... 
doi:10.1002/ddrr.84 pmid:20014370 pmcid:PMC2876340 fatcat:q4eevket7za23m6nwzupt3ocqa

Testosterone and Adult Neurogenesis

Spritzer, Roy
2020 Biomolecules  
A better understanding of the effects of testosterone upon adult neurogenesis could shed light on neurological diseases that show sex differences.  ...  Subsequent experiments with laboratory rodents have tested the effects of testosterone and its steroid metabolites upon adult neurogenesis, as well as the functional consequences of induced changes in  ...  All authors have read and agreed to the published version of the manuscript. Funding: This research received no external funding. Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/biom10020225 pmid:32028656 pmcid:PMC7072323 fatcat:5lyvzvkdrzfmhdxfhftg6xok3q

Sex differences in hippocampal function

Wendy A. Koss, Karyn M. Frick
2016 Journal of Neuroscience Research  
We conclude by discussing the implications of sex differences in hippocampal function for mental health. V C 2016 Wiley Periodicals, Inc.  ...  Sex differences in the function of the hippocampus have been observed in numerous mammalian species.  ...  on the manuscript.  ... 
doi:10.1002/jnr.23864 pmid:27870401 fatcat:k553uuxkqvgllbcdy4v5juueiy

Pharmacogenomics of mental illnesses: do sex-specific differences matter?

Alena Buretić-Tomljanović
2007 Psychiatria Danubina  
It is believed they result from different brain morphology and function between sexes, factors being highly influenced by sex hormones.  ...  Genetic factors are extensively studied in respect to drug response in psychiatric disorders. Recent evidence suggests that action of reproductive steroid hormones in brain may also have a role.  ...  This work will focus on sex-specific differences in clinical presentation and treatment outcome of mental diseases, as well as differences in brain development, structure and function originating from  ... 
pmid:17914324 fatcat:y5h5qsx4cvcqvklykwaarkugqq

Neuropsychiatric and Behavioral Involvement in AAS Abusers. A Literature Review

Giuseppe Bertozzi, Monica Salerno, Cristoforo Pomara, Francesco Sessa
2019 Medicina  
and behavioral functions, as well as on lifestyle.  ...  Results: The use of AASs through self-administration yields circulating androgens levels, inducing neuron apoptosis, which is linked to thinner cortex and, in general, less cortical volume.  ...  Acknowledgments: We wish to thank the Scientific Bureau of the University of Catania for language support. Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/medicina55070396 pmid:31336641 pmcid:PMC6681542 fatcat:6cu3ej32cfex3gznhbkrtbx7li
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