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Genetic and environmental influences on functional connectivity within and between canonical cortical resting-state networks throughout adolescent development in boys and girls

Jalmar Teeuw, Rachel M. Brouwer, João P.O.F.T. Guimarães, Philip Brandner, Marinka M.G. Koenis, Suzanne C. Swagerman, Maxime Verwoert, Dorret I. Boomsma, Hilleke E. Hulshoff Pol
2019 NeuroImage  
It remains unknown to what extent genetic and environmental influences on functional connectivity change throughout adolescent development.  ...  In conclusion, longitudinal age-related changes in functional connectivity within and between cortical resting-state networks are subtle but wide-spread throughout adolescence.  ...  Here we report on genetic and environmental influences on functional connectivity within and between eight canonical cortical restingstate networks in a longitudinal adolescent cohort of twins and their  ... 
doi:10.1016/j.neuroimage.2019.116073 pmid:31386921 fatcat:cyowznzilffjrbhkrhcualotcq

The NIMH Intramural Longitudinal Study of the Endocrine and Neurobiological Events Accompanying Puberty: Protocol and Rationale for Methods and Measures

Katherine M. Cole, Shau-Ming Wei, Pedro E. Martinez, Tuong-Vi Nguyen, Michael D. Gregory, J. Shane Kippenhan, Philip D. Kohn, Steven J. Soldin, Lynnette K. Nieman, Jack A. Yanovski, Peter J. Schmidt, Karen F. Berman
2021 NeuroImage  
how gonadal development and maturation is associated with longitudinal changes in brain structure and function in boys and girls.  ...  , myelination) and function (reward processing, emotional processing, inhibition/impulsivity, working memory, resting-state network connectivity, regional cerebral blood flow).  ...  and neuropsychological testing.  ... 
doi:10.1016/j.neuroimage.2021.117970 pmid:33771694 fatcat:gnf2fa4oh5gflgrcggkp5yn2y4

Cumulative Risk on Oxytocin-Pathway Genes Impairs Default Mode Network Connectivity in Trauma-Exposed Youth

Maor Zeev-Wolf, Jonathan Levy, Richard P. Ebstein, Ruth Feldman
2020 Frontiers in Endocrinology  
Although the default mode network (DMN) is a core network essential for brain functioning, little is known about its developmental trajectory, particularly on factors associated with its coherence into  ...  a functional network.  ...  INTRODUCTION The default mode network (DMN) is a cortical network that becomes more active and synchronized during rest and deactivates when one is engaged in a goal-oriented task (1) .  ... 
doi:10.3389/fendo.2020.00335 pmid:32528417 pmcid:PMC7256187 fatcat:xh5ipuvkw5bexlwauezhsntywy

Sex differences and the neurobiology of affective disorders

David R. Rubinow, Peter J. Schmidt
2018 Neuropsychopharmacology  
We then focus on how sex and reproductive hormones regulate systems implicated in the pathophysiology of depression, including neuroplasticity, genetic and neural networks, the stress axis, and immune  ...  We next review sex differences in the brain at the structural, cellular, and network levels.  ...  The views expressed in this article do not necessarily represent the views of the NIMH, NIH, HHS, or the US Government.  ... 
doi:10.1038/s41386-018-0148-z pmid:30061743 pmcid:PMC6235863 fatcat:m5ega6a3qjeqdegdv7n4pkrqdq

Common variants contribute to intrinsic functional architecture of human brain [article]

Bingxin Zhao, Tengfei Li, Stephen M. Smith, Di Xiong, Xifeng Wang, Yue Yang, Tianyou Luo, Ziliang Zhu, Yue Shan, Mads E. Hauberg, Jaroslav Bendl, John F. Fullard (+5 others)
2020 bioRxiv   pre-print
Genetic correlation analysis suggested the shared genetic influences among intrinsic brain function, brain structure, and brain structural connectivity.  ...  Resting-state functional magnetic resonance imaging (rsfMRI) measures brain activity at rest, which is closely linked with cognition and clinical outcomes.  ...  Genetic and environmental influences on functional connectivity 20 within and between canonical cortical resting-state networks throughout 21 adolescent development in boys and girls.  ... 
doi:10.1101/2020.07.30.229914 fatcat:b2gxihmeinhrfdowsscievvuw4

A Comparative, Developmental, and Clinical Perspective of Neurobehavioral Sexual Dimorphisms

Maria-Paz Viveros, Adriana Mendrek, Tomáš Paus, Ana Belén López-Rodríguez, Eva Maria Marco, Rachel Yehuda, Hagit Cohen, Amy Lehrner, Edward J. Wagner
2012 Frontiers in Neuroscience  
Women and men differ in a wide variety of behavioral traits and in their vulnerability to developing certain mental disorders.  ...  We discuss the challenges in interpreting these phenotypes vis-à-vis the underlying neurobiology and revisit the known sex differences in brain structure from birth, through adolescence, and into adulthood  ...  8 Spontaneous cerebral networks; functional connectivity Paradigm-based functional 6-10 Brain response associated with specific stimuli/tasks; functional connectivity June 2012 |  ... 
doi:10.3389/fnins.2012.00084 pmid:22701400 pmcid:PMC3372960 fatcat:z3eee2xqybabxdj2r3g6p2sebq

The "Primitive Brain Dysfunction" Theory of Autism: The Superior Colliculus Role

Rubin Jure
2022 Frontiers in Integrative Neuroscience  
in order to bridge the gap between basic brain science and clinical studies and to promote future research in this unexplored area.  ...  The results of two separate lines of investigation: 1. the cognitive, etiologic, and pathogenic aspects of autism on one hand, and two. the functional anatomy of the colliculus on the other, are considered  ...  Bjorn Merker who guided me on earlier versions of the manuscript. I dedicate this work to my sons Pablo, Victoria, Leónidas, and to my wife Mary.  ... 
doi:10.3389/fnint.2022.797391 pmid:35712344 pmcid:PMC9194533 fatcat:fkqipeun6rar5l6neohfwb3p5q

ACNP 56th Annual Meeting: Poster Session I, December 4, 2017

2017 Neuropsychopharmacology  
To evaluate the association between PTSD, glycemic regulation, neuroendocrine function and immune activity, we examined associations between PTSD diagnosis and PTSD symptom severity and metabolic, glucocorticoid  ...  These data suggest mechanisms of shared pathophysiology and risk connecting PTSD and T2DM which are both significant public health problems.  ...  on resting-state functional connectivity in youth with ASD.  ... 
doi:10.1038/npp.2017.264 pmid:29192265 fatcat:psc2w4azgrbfhjtxe6oxrnsdaq

Interactions between Growth of Muscle and Stature: Mechanisms Involved and Their Nutritional Sensitivity to Dietary Protein: The Protein-Stat Revisited

D Joe Millward
2021 Nutrients  
Experimental data from rodent and avian animal models illustrate likely changes in DNA domain size and protein turnover during developmental and stretch-induced muscle growth and between different muscle  ...  Information on the influence of dietary protein on muscle mass per se as opposed to lean body mass is limited but suggests that increased protein intake in children is unable to promote muscle growth in  ...  Height is also influenced by foetal programming as indicated by its relationship with birthweight, shown for example in early adolescent boys and girls [15] .  ... 
doi:10.3390/nu13030729 pmid:33668846 pmcid:PMC7996181 fatcat:63qfiafnkrfu7gwcvtikybypce

Panel and Study Groups

2013 Neuropsychopharmacology  
We have had the opportunity to study both genetic variation and expression in genes in this pathway (GAD1, GAD2, SLC12A2 (NKCC1) and SLC12A5 (KCC2) across human brain development in hippocampus and dorsolateral  ...  Although the expression in GAD67 expression is probably one of the most replicated findings to date, there have been relatively few studies of this finding with respect to genetic variation or brain development  ...  resting state connections. 2.  ... 
doi:10.1038/npp.2013.278 fatcat:expu2u3f3reypazj7tt7jhybfa

Poster Session I

2013 Neuropsychopharmacology  
Considering evidence for impairments in both nicotinic and glutamatergic transmission in SZ, these data in animals provide support for the continued focus on the a7nAChR and NMDA receptor as targets for  ...  Cognitive deficits (attention, working memory, and cognitive flexibility) are considered a core symptom cluster in schizophrenia (SZ); predictive of functional outcome yet not alleviated by current drug  ...  Abi-Dargham, and S. Kapur, Arch Gen Psychiatry 69, 776 (2012). 2  ... 
doi:10.1038/npp.2013.279 fatcat:54ipecxjarcvljrvn5fgtgif5u

ACNP 59th Annual Meeting: Poster Session II

2020 Neuropsychopharmacology  
In the current analysis, an initial dataset of 363 participants completed MRI scans within a)~2-weeks, b)~6-months, or c) both~2-weeks and~6-months post-trauma.  ...  Therefore, the present study utilized longitudinal multimodal magnetic resonance imaging (MRI) to investigate potential changes in structural covariance networks.  ...  We analyzed resting-state functional connectivity by parcellating the whole brain data into 718 parcels (Cole-Antecevic parcellation) and then computing within-network connectivity within 12 resting-state  ... 
doi:10.1038/s41386-020-00891-6 pmid:33279935 pmcid:PMC7735200 fatcat:5nfeakhcfnhpnjyuvli34vyxxq

Disrupted development and imbalanced function in the global neuronal workspace: a positive-feedback mechanism for the emergence of ASD in early infancy

Chris Fields, James F. Glazebrook
2016 Cognitive Neurodynamics  
We review evidence suggesting that ASD is characterized by a positive feedback loop that amplifies small functional variations in early-developing sensoryprocessing pathways into structural and functional  ...  Viewing ASD in terms of feedback amplification of small functional variants allows a number of recent models of ASD to be integrated with neuroanatomical, neurofunctional and genetic data.  ...  Sander van de Cruys and from two anonymous referees.  ... 
doi:10.1007/s11571-016-9419-8 pmid:28174609 pmcid:PMC5264757 fatcat:6emdbdl7urh3tig4k6wjirlzqa

Attention-Deficit/Hyperactivity Disorder Predominantly Inattentive Subtype/Presentation: Research Progress and Translational Studies

Ike C. de la Peña, Michael C. Pan, Chau Giang Thai, Tamara Alisso
2020 Brain Sciences  
Impairments in neuropsychological, neurocognitive, and social functioning are also evident in ADHD-PI, which could be specific to the subtype (e.g., processing speed, social perception, and skills), or  ...  There is no solid evidence for ADHD-PI-specific genetic etiologies and differential responses of subtypes to ADHD medications.  ...  Resting-state functional connectivity MRI (rs-fcMRI) studies that incorporated graph theoretical analysis also reported differential neural activation in the sensorimotor and DMN in ADHD-PI vs.  ... 
doi:10.3390/brainsci10050292 pmid:32422912 fatcat:d32nsgxguffzblgei3zz22fso4

ACNP 58th Annual Meeting: Panels, Mini-Panels and Study Groups

2019 Neuropsychopharmacology  
Recent progress has been made on probes to study interactions between the opioid neuropeptide dynorphin and the kappa opioid receptor, which are implicated in the negative aversive states associated with  ...  In parallel, two analogues were assayed in brain slices using genetically-encoded optical sensors for dynorphin developed by Lin Tian's lab at UC Davis.  ...  Relationship Between Resting State Functional Connectivity and Inflammatory Signaling in Mental and Physical Health Abstract not included.  ... 
doi:10.1038/s41386-019-0544-z pmid:31801977 pmcid:PMC6957922 fatcat:hjyvf7fcpbf2fhxit6rlhsvg2y
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