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Genetic and environmental influences of white and gray matter signal contrast: A new phenotype for imaging genetics?

Matthew S. Panizzon, Christine Fennema-Notestine, Thomas S. Kubarych, Chi-Hua Chen, Lisa T. Eyler, Bruce Fischl, Carol E. Franz, Michael D. Grant, Samar Hamza, Amy Jak, Terry L. Jernigan, Michael J. Lyons (+8 others)
2012 NeuroImage  
The ratio of white matter to gray matter signal (WM/GM contrast) has been found to vary as a function of age and Alzheimer's disease status, suggesting a biological component to what might otherwise be  ...  The estimation of cortical thickness is in part dependent on the degree of contrast in T1 signal intensity between white matter and gray matter along the cortical mantle.  ...  Department of Veterans Affairs has provided support for the development and maintenance of the Vietnam Era Twin Registry.  ... 
doi:10.1016/j.neuroimage.2012.01.122 pmid:22500923 pmcid:PMC3328105 fatcat:4y3orpviujdw3hzjsvc3gtyxlm

A Multimodal Assessment of the Genetic Control over Working Memory

K. H. Karlsgodt, P. Kochunov, A. M. Winkler, A. R. Laird, L. Almasy, R. Duggirala, R. L. Olvera, P. T. Fox, J. Blangero, D. C. Glahn
2010 Journal of Neuroscience  
While all cognitive measures, gray matter regions, and white matter tracts assessed were heritable, only performance on a spatial delayed response task and integrity of the superior longitudinal fasciculus  ...  Imaging measures included diffusion tensor imaging indices in major white matter tracts thought to be associated with working memory and structural magnetic resonance imaging measures of frontal and parietal  ...  In addition to evidence for a genetic influence on the gray matter in schizophrenia (Cannon et al., 2002) , white matter changes seem to have a genetic component as well.  ... 
doi:10.1523/jneurosci.0359-10.2010 pmid:20554870 pmcid:PMC2894480 fatcat:if6j7ey6xraovmpdqoabablih4

The Genetic and Environmental Determinants of the Association Between Brain Abnormalities and Schizophrenia: The Schizophrenia Twins and Relatives Consortium

Neeltje E.M. van Haren, Fruhling Rijsdijk, Hugo G. Schnack, Marco M. Picchioni, Timothea Toulopoulou, Matthias Weisbrod, Heinrich Sauer, Theo G. van Erp, Tyrone D. Cannon, Matti O. Huttunen, Dorret I. Boomsma, Hilleke E. Hulshoff Pol (+2 others)
2012 Biological Psychiatry  
These were predominantly due to overlapping genetic effects (77%, 94%, and 83%, respectively). Some of the genes that transmit the risk for Sz also influence cerebral (white matter) volume.  ...  Significant phenotypic correlations were found between Sz and reduced volumes of the cerebrum (-.22 [-.30/-.14]) and white matter (-.17 [-.25/-.09]) and increased volume of the third ventricle (.18 [.08  ...  ) of the gray and white matter volumes (22) .  ... 
doi:10.1016/j.biopsych.2012.01.010 pmid:22341827 pmcid:PMC3343260 fatcat:76xoyr32ijcp7ot3v3yvwoypni

Genetics of the connectome

Paul M. Thompson, Tian Ge, David C. Glahn, Neda Jahanshad, Thomas E. Nichols
2013 NeuroImage  
Here we review a variety of genetic analysis methods--such as genome-wide association studies (GWAS), linkage and candidate gene studies--that have been fruitfully adapted to imaging data to implicate  ...  It is already discovering new genetic loci and even entire genetic networks that affect brain organization and connectivity.  ...  Acknowledgments P.M.T. is supported, in part, by NIH R01 grants NS080655, MH097268, AG040060, EB008432, MH089722, HD050735 and P41 EB015922.  ... 
doi:10.1016/j.neuroimage.2013.05.013 pmid:23707675 pmcid:PMC3905600 fatcat:dv26qigaovc4vdpm6jkealvoly

Genetic Risk Factors of Imaging Measures Associated with Late-Onset Alzheimer's Disease [chapter]

Christiane Reitz
2012 Neuroimaging - Methods  
separately and preferred over gray matter volumes for imaging genetic studies.  ...  cingulate, gray matter of the parahippocampal gyrus and white matter of the superior occipitofrontal fasciculus.  ... 
doi:10.5772/22794 fatcat:ie2nogdhlnb6hec5vjazcxfm4m

Distinct Genetic Influences on Cortical Surface Area and Cortical Thickness

Matthew S. Panizzon, Christine Fennema-Notestine, Lisa T. Eyler, Terry L. Jernigan, Elizabeth Prom-Wormley, Michael Neale, Kristen Jacobson, Michael J. Lyons, Michael D. Grant, Carol E. Franz, Hong Xian, Ming Tsuang (+4 others)
2009 Cerebral Cortex  
Given that cortical volume is a product of thickness and surface area, it is plausible that measures of volume capture at least 2 distinct sets of genetic influences.  ...  We conclude that using volume in a genetically informative study, or as an endophenotype for a disorder, may confound the underlying genetic architecture of brain structure.  ...  The same is true for measures of gray matter density, defined as the proportion of gray matter per 3 dimensional imaging voxel (Wright et al. 1995; Thompson et al. 2001) .  ... 
doi:10.1093/cercor/bhp026 pmid:19299253 pmcid:PMC2758684 fatcat:34b5qqfi7bclblxyyn444ldbpa

Genetic effects on the cerebellar role in working memory: Same brain, different genes?

Gabriëlla A.M. Blokland, Katie L. McMahon, Paul M. Thompson, Ian B. Hickie, Nicholas G. Martin, Greig I. de Zubicaray, Margaret J. Wright
2014 NeuroImage  
Activation on the voxel-level correlated very weakly with cerebellar gray matter volume, suggesting specific genetic influences on the BOLD signal.  ...  Phenotypic correlations between BOLD percent signal change in cerebrum and cerebellum were low, and bivariate modeling indicated that genetic influences on the cerebellum are at least partly specific to  ...  We are very grateful to the twins for their generosity of time and willingness to participate in our studies.  ... 
doi:10.1016/j.neuroimage.2013.10.006 pmid:24128737 pmcid:PMC3925745 fatcat:d53l2ld7tvetpox4xoobgymu3y

On the genetic architecture of cortical folding and brain volume in primates

Jeffrey Rogers, Peter Kochunov, Karl Zilles, Wendy Shelledy, Jack Lancaster, Paul Thompson, Ravindranath Duggirala, John Blangero, Peter T. Fox, David C. Glahn
2010 NeuroImage  
These results provide initial evidence for the heritability of gyrification, and possibly a new perspective on the evolutionary mechanisms underlying long-term changes in the nonhuman primate and human  ...  of a landmark feature of our species.  ...  Acknowledgments This work was supported in part by grants from the US National Institute of Mental Health (MH078111, MH059490, and MH078143), the National Institute of Biomedical Imaging and Bioengineering  ... 
doi:10.1016/j.neuroimage.2010.02.020 pmid:20176115 pmcid:PMC3137430 fatcat:ijmomwl2qrebvhzgzyjj3w72wm

Genetic Polymorphisms: A Cornerstone of Translational Biobehavioral Research

A. R. Hariri
2010 Science Translational Medicine  
The phenotypic effects of the BDNF Met allele also may be influenced by genetic polymorphisms that affect complementary signaling pathways.  ...  In contrast to the effects on frontotemporal white matter, the BDNF Met allele was not associated with differences in amygdala gray matter volumes as compared to the Val allele, although there was a nonsignificant  ... 
doi:10.1126/scitranslmed.3000811 pmid:20371481 fatcat:5pjzn3tlzfbqbneuonzkbgwb3i

Genetic associations between intelligence and cortical thickness emerge at the start of puberty

Rachel M. Brouwer, Inge L.C. van Soelen, Suzanne C. Swagerman, Hugo G. Schnack, Erik A. Ehli, René S. Kahn, Hilleke E. Hulshoff Pol, Dorret I. Boomsma
2013 Human Brain Mapping  
Three years later at age 12, 177/125 twins returned for a follow-up measurement of intelligence/MRI scanning, respectively.  ...  Hum Brain Mapp 35:3760-3773, ; genetic associations r r r Genetic Associations Between IQ and Cortex r r 3763 r  ...  ACKNOWLEDGMENTS The authors thank the participating twins and their families.  ... 
doi:10.1002/hbm.22435 pmid:24382822 fatcat:fkqtvzlwb5fqfd3i7dxgqra2r4

Genetic topography of brain morphology

C.-H. Chen, M. Fiecas, E. D. Gutierrez, M. S. Panizzon, L. T. Eyler, E. Vuoksimaa, W. K. Thompson, C. Fennema-Notestine, D. J. Hagler, T. L. Jernigan, M. C. Neale, C. E. Franz (+5 others)
2013 Proceedings of the National Academy of Sciences of the United States of America  
2 A.M.D. and W.S.K. contributed equally to this work. This article contains supporting information online at  ...  The thickness of the gray matter can be computed at any point in the cortex as the shortest distance between the gray/white and pial surfaces.  ...  The resulting surface was covered with a polygonal tessellation. The boundary of the gray and white matter was identified and then deformed outwards to obtain a representation of the pial surface.  ... 
doi:10.1073/pnas.1308091110 pmid:24082094 pmcid:PMC3801007 fatcat:7jzex7p5ljah3eiijqtxqmgxx4

A Genetic Perspective on the Developing Brain

G.C.M. van Baal, C.E.M. van Beijsterveldt, P.C.M. Molenaar, D.I. Boomsma, E.J.C. de Geus
2001 European Psychologist  
Therefore, within these age ranges a more detailed analysis of age-related changes in heritabilities and in the emergence of new genetic influences could be studied.  ...  Changes in genetic and environmental influences on electroencephalographic (EEC) and event-related potential (ERF) indices of neural development were studied in two large cohorts of young (N = 418) and  ...  Acknowledgments This research was supported by two grants of the Netherlands Organization for Scientific Research (NWO), no. 575-65-052 and no.  ... 
doi:10.1027//1016-9040.6.4.254 fatcat:rj3dqo6ddzdnzjaxpks4qbnube

Anatomic Magnetic Resonance Imaging of the Developing Child and Adolescent Brain and Effects of Genetic Variation

Jay N. Giedd, Michael Stockman, Catherine Weddle, Maria Liverpool, Aaron Alexander-Bloch, Gregory L. Wallace, Nancy R. Lee, Francois Lalonde, Rhoshel K. Lenroot
2010 Neuropsychology Review  
Longitudinal studies of children and adolescents demonstrate a general pattern of childhood peaks of gray matter followed by adolescent declines, functional and structural increases in connectivity and  ...  Although over-interpretation and premature application of neuroimaging findings for diagnostic purposes remains a risk, converging data from multiple imaging modalities is beginning to elucidate the influences  ...  Acknowledgments This research was supported by the Intramural Program of the National Institute of Mental Health, National Institutes of Health.  ... 
doi:10.1007/s11065-010-9151-9 pmid:21069466 pmcid:PMC3268519 fatcat:w3noqwsarranthqrw6iyalj7nm

Genetic variation and individual differences in language [chapter]

Jennifer B. Misyak, Morten H. Christiansen
2011 Trends in Language Acquisition Research  
This framework aims to uncover the biological part of an emergentist account to language, and provides a complement to investigations into more experientially based factors.  ...  Drawing upon recent conceptual and analytical trends in molecular genetics, this chapter explores how molecular genetics might be used to elucidate language differences in normally developing individuals  ...  Acknowledgments We would like to thank Stewart McCauley, the editors, and two anonymous reviewers for their comments on a previous version of this chapter.  ... 
doi:10.1075/tilar.7.13mis fatcat:el5tc6p7mndjxleccewmnus3fy

Genetic control of functional brain network efficiency in children

Martijn P. van den Heuvel, Inge L.C. van Soelen, Cornelis J. Stam, René S. Kahn, Dorret I. Boomsma, Hilleke E. Hulshoff Pol
2013 European Neuropsychopharmacology  
The human brain is a complex network of interconnected brain regions. In adulthood, the brain's network was recently found to be under genetic influence.  ...  Using a twin design, young children underwent resting-state functional magnetic resonance imaging brain scans (N = 86 from 21 MZ and 22 DZ twin-pairs, age =12 years).  ...  MvdH was supported by a Fellowship of the Rudolf Magnus Institute of Neuroscience and by a grant of the Dutch Brain Foundation.  ... 
doi:10.1016/j.euroneuro.2012.06.007 pmid:22819192 fatcat:qadbihedvbgdtbvpylexzfjjvm
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