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Generating Causal Explanation from a Cardio-Vascular Simulation

Sarah A. Douglas, Zheng-Yang Liu
1989 International Joint Conference on Artificial Intelligence  
QUALEX is embedded in a constructive simulation environment called Heart Works which teaches hydraulics principles about the cardio-vascular system to first year college biology students.  ...  In this paper, we present QUALEX, a system and algorithm for generating first-order qualitative causal graphs for tutorial purposes based on de Kleer and Brown's qualitative modeling theory.  ...  By constructive simulation we mean that students build circulatory models from a set of cardio-vascular components such as valves and vessels.  ... 
dblp:conf/ijcai/DouglasL89 fatcat:wnfdxhlnznbzpm3itir2skjpx4

A virtual patient based on qualitative simulation

Marc Cavazza, Altion Simo
2003 Proceedings of the 8th international conference on Intelligent user interfaces - IUI '03  
of the cardio-vascular system to generate clinical syndromes and simulate the consequences of the trainee's therapeutic interventions.  ...  The system integrates AI techniques for simulating medical conditions (shock states) with a realistic visual simulation of the patient in a 3D environment representing an ER roomIt uses qualitative simulation  ...  QUALITATIVE SIMULATION OF THE CARDIO-VASCULAR SYSTEM Qualitative simulation aims at modelling the behaviour of the cardio-vascular system, both in normal and pathological circumstances.  ... 
doi:10.1145/604045.604053 dblp:conf/iui/CavazzaS03 fatcat:xvptqfspkffr3e7wluey5apa6y

Statistical analyses of clinical trials in haematopoietic cell transplantation or why there is a strong correlation between people drowning after falling out of a fishing boat and marriage rate in Kentucky

Robert Peter Gale, Mei-Jie Zhang
2019 Bone Marrow Transplantation  
Our randomized trials are lucky to have 300 subjects; most trials in cardio-vascular disease, diabetes and breast cancer have 10,000 subjects or more.  ...  Our objective is to raise awareness of on some of the complexities in design and interpretation of data from clinical trials. We hope that these typescripts will generate a lively discussion.  ...  Acknowledgements R.P.G. acknowledges support from the National Institute of Health Research (NIHR) Biomedical Research Centre funding scheme.  ... 
doi:10.1038/s41409-019-0431-6 pmid:30914755 fatcat:isz2yxsdavesvczhuh7j7mmr5a

Association Mapping for Compound Heterozygous Traits Using Phenotypic Distance and Integer Programming [chapter]

Dan Gusfield, Rasmus Nielsen
2015 Lecture Notes in Computer Science  
The most common explanation for this is the presence of multiple rare mutations that cannot be identified in GWAS due to a lack of statistical power.  ...  In this paper, we address the problem of finding genes that are causal for CH-traits, by introducing a discrete optimization problem, called the Phenotypic Distance Problem.  ...  Research partially supported by grants IIS-0803564, CCF-1017580, IIS-1219278 from the National Science Foundation.  ... 
doi:10.1007/978-3-662-48221-6_10 fatcat:uuert4cy65acfl3hu5ig36xurm

Selection bias in rheumatic disease research

Hyon K. Choi, Uyen-Sa Nguyen, Jingbo Niu, Goodarz Danaei, Yuqing Zhang
2014 Nature Reviews Rheumatology  
We present index event bias (a type of selection bias) as one of the potentially unifying reasons behind some unexpected findings, such as the 'risk factor paradox'-a phenomenon exemplified by the discrepant  ...  In this Review, we discuss potentially major issues of selection bias-a type of bias frequently overshadowed by other bias and feasibility issues, despite being equally or more problematic-in key areas  ...  , 19 obese patients with RA had a 70% decreased risk of cardio vascular mortality compared with those in the normal BMI range (the 'obesity paradox'). 20 Similarly, unlike in the general population  ... 
doi:10.1038/nrrheum.2014.36 pmid:24686510 pmcid:PMC4260806 fatcat:2cyyvfibhvdlppu4cvda55y2pi

Cardio-metabolic risk factors and cortical thickness in a neurologically healthy male population: Results from the psychological, social and biological determinants of ill health (pSoBid) study

Rajeev Krishnadas, John McLean, David G. Batty, Harry Burns, Kevin A. Deans, Ian Ford, Alex McConnachie, Agnes McGinty, Jennifer S. McLean, Keith Millar, Naveed Sattar, Paul G. Shiels (+3 others)
2013 NeuroImage: Clinical  
The relationship between cardio-vascular risk markers and cortical thickness across the whole brain, was examined using the general linear model.  ...  2013) Cardio-metabolic risk factors and cortical thickness in a neurologically healthy male population : results from the psychological, social and biological determinants of ill health (pSoBid) study.  ...  The potential aetiological links between cardio-metabolic risk factors and brain structure and function need further exploration as possible explanations for the relationship between the burden of physical  ... 
doi:10.1016/j.nicl.2013.04.012 pmid:24179815 pmcid:PMC3777783 fatcat:vgf2ml6mk5gqxh5lfm4rabqami

Page 1133 of The Lancet Vol. 1, Issue 3999 [page]

1900 The Lancet  
Its action was probably that of a powerful cholagogue and of a cardio-vascular depressant.  ...  —Simulation of Gastric Perforation, —Evhibition of Cases and Specimens. A MEETING of this society was held on April 6th, Professor C. J. WRIGHT, the President, being in the chair. . Mr. A. E.  ... 

Characterization of Interdependency Between Intracranial Pressure and Heart Variability Signals: A Causal Spectral Measure and a Generalized Synchronization Measure

Xiao Hu, V. Nenov, P. Vespa, M. Bergsneider
2007 IEEE Transactions on Biomedical Engineering  
Causal coherence and generalized synchronization (GS) index were extracted from beat-to-beat mean intracranial pressure (ICP) and intervals between consecutive normal sinus heart beats (RR interval) that  ...  This finding regarding the enhanced directional, from ICP to RR interval, coupling between ICP and RR interval was also confirmed by a modified GS measure.  ...  Then multiple surrogate pairs were generated by simulating the resultant univariate AR models with different realizations of Gaussian white noise series whose variances were determined from the model fitting  ... 
doi:10.1109/tbme.2007.900802 pmid:17694861 pmcid:PMC2140277 fatcat:xzlf4hwifzbgdoeynciz2ur2pa

Experimental Nephritis

E C Dickson
1910 California state journal of medicine  
The relation of chronic kidney lesions to the cardio-vascular system. 4. The relation of kidney lesions and function to the causation of uremia.  ...  little in regard to such great problems of nephritis, as, the causation of edema, the relation of the chronic forms of nephritis to the acute, the relation of chronic kidney lesions to disturbances of the cardio-vascular  ...  The relation of chronic kidney lesions to the cardio-vascular system. 4. The relation of kidney lesions and function to the causation of uremia.  ... 
pmid:18735084 pmcid:PMC1893438 fatcat:qrdvdvigifgcrnnsugyxeqexje

What links ventilator driving pressure with survival in the acute respiratory distress syndrome? A computational study

Anup Das, Luigi Camporota, Jonathan G. Hardman, Declan G. Bates
2019 Respiratory Research  
Our results suggest a credible mechanistic explanation for the proposed association between driving pressure and relative risk of death.  ...  To investigate the association between driving pressures and ventilator induced lung injury (VILI), we calibrated a high fidelity computational simulator of cardiopulmonary pathophysiology against a clinical  ...  The two main models of the simulator, the pulmonary model and the cardio-vascular model, were calibrated against the dataset from Borges et al.  ... 
doi:10.1186/s12931-019-0990-5 pmid:30744629 pmcid:PMC6371576 fatcat:ebiqyvfbdzcc7az7irw7txlbqu


1898 The Lancet  
the pneumogastric system-that is, of motor fibres probably derived from the spinal accessory nerve and coursing in the pneumogastric-to restrain the cardio-vascular organs in excessive visceral motion,  ...  If we regard Begbie's disease as in the first instance a cardio-vascular neurosis, to employ a term expressive ef our ignorance, we can conceive an increased though ineffectual effort upon the part of  ...  the pneumogastric system-that is, of motor fibres probably derived from the spinal accessory nerve and coursing in the pneumogastric-to restrain the cardio-vascular organs in excessive visceral motion,  ... 
doi:10.1016/s0140-6736(01)82967-6 fatcat:7rcohc5rufa2xh7utglvwbfvgy

Risk of Heat‐Related Mortality, Disease, Accident, and Injury among Korean Workers: A National Representative Study from 2002 to 2015

Jin‐Ha Yoon, Won‐Tae Lee, Min Joo Yoon, Wanhyung Lee
2021 GeoHealth  
The relationship between hospitalization attributable to disease and weather variables was analyzed by applying a generalized additional model.  ...  The study demonstrated that heat exposure is a risk factor for death and infectious, cardio-cerebrovascular, and genitourinary diseases, as well as injuries or accidents among workers.  ...  Months and weeks are time series confounding factors, so every step of model building was simulated by the degree of freedom (df) from 2 to 100 in the generalized linear mode.  ... 
doi:10.1029/2021gh000516 pmid:34938932 pmcid:PMC8672090 fatcat:2775b73bsfegnnivivpvm4bhuu


1929 Endocrinology  
Cardio-Respiratory System. Dyspnoea . Palpitation . Pain. Cough . Cardio-Vascular System... Gastro-Intestinal System... Nausea. Vomiting . Pain . Jaundice. Constipation . Diarrhoea . Poor Appetite.  ...  Nervous System 8 18 26 12 11 4 3 29 Metabolism .... . 1 6 9 8 5 1 5 35 Cardio-Vascular.. , 1 6 9 11 11 8 15 44 Blood . . 0 2 2 2 2 6 3 46 Tumors. . 1 0 8 2 5 1 3 37 Syphilis . 2 9 6 11 7 4 4 35 Eye. .  ... 
doi:10.1210/endo-13-2-109 fatcat:tecoi3mhljbtlofowrtx5ja4au

The Case of Sleep Apnoea and Cardiovascular Events

R. Doug McEvoy
2020 Barcelona Respiratory Network  
For 30 years evidence has pointed to sleep apnoea being a cause of cardiovascular (CV) disease and major CV events.  ...  sleep apnoea by focussing on the effects of extremely severe intermittent hypoxia; and 3) Significant heterogeneity in susceptibility to vascular injury may exist between patients.  ...  McEvoy reports grants from National Health and Medical Research Council, Australia, during the conduct of the study; and grants from Philips Respironics outside the submitted work.  ... 
doi:10.23866/brnrev:2020-0001 fatcat:o4nqqh7d65hajkqrttd3s6ebmi

Causal relationships between cardiorespiratory hemodynamics signals: Test analysis using panel Co-integration

Samir Ghouali, Mohammed Feham, Yassine Zakarya Ghouali
2014 2014 World Congress on Computer Applications and Information Systems (WCCAIS)  
The benefit of early diagnosis is that we can detect and make decisions to mitigate the risks of cardio-vascular problems.  ...  The table shows that there is a cause and effect way, except in the case ECG1 with CO2, or where there's no causality, summary Granger causality runs from three ECG leads to hemodynamic respiratory signals  ... 
doi:10.1109/wccais.2014.6916591 fatcat:cmdgpw7opzdntbhqjwdh6ylnwq
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