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Multi-channel registration of fractional anisotropy and T1-weighted images in the presence of atrophy: application to multiple sclerosis

Eloy Roura
2015 Functional Neurology  
Multi-channel registration of fractional anisotropy and T1-weighted images in the presence of atrophy: application to multiple sclerosis Both qualitative and quantitative evaluations are presented, showing  ...  Co-registration of structural T1-weighted (T1w) scans and diffusion tensor imaging (DTI)-derived fractional anisotropy (FA) maps to a common space is of particular interest in neuroimaging, as T1w scans  ...  Roura for a research stay in IoN/UCL. Declan Chard has received research support from the MS Society of Great Britain and Northern Ireland, and the UCLH/UCL NIHR Biomedical Research Centre.  ... 
doi:10.11138/fneur/2015.30.4.245 fatcat:rtsyylwckbhznmn623xmez3tay

A two-sample distribution-free test for functional data with application to a diffusion tensor imaging study of multiple sclerosis

Gina-Maria Pomann, Ana-Maria Staicu, Sujit Ghosh
2016 Journal of the Royal Statistical Society, Series C: Applied Statistics  
Application to the diffusion tensor imaging data reveals that all the tracts studied are associated with multiple sclerosis and the choice of the diffusion tensor image measurement is important when assessing  ...  The objective is to formally compare white matter tract profiles between healthy individuals and multiple sclerosis patients, as assessed by conventional diffusion tensor imaging measures.  ...  Acknowledgments We thank Daniel Reich and Peter Calabresi for the DTI data and Ingrid Van Keilegom for sharing the R code used in Hall and Van Keilegom (2007  ... 
doi:10.1111/rssc.12130 pmid:27041772 pmcid:PMC4812165 fatcat:5n3ljca6jbaingnqwqhgm6qag4

Imaging biomarkers in multiple Sclerosis: From image analysis to population imaging

Christian Barillot, Gilles Edan, Olivier Commowick
2016 Medical Image Analysis  
This paper illustrates this issue in one acute neuro-inflammatory pathology: Multiple Sclerosis (MS).  ...  MRI has often a low specificity for differentiating between possible pathological changes which could help in discriminating between the different pathological stages or grades.  ...  Image processing in Multiple Sclerosis Context Today Image processing in MS Current computer assisted analysis of MR images in MS requires the application of complex image processing workflows.  ... 
doi:10.1016/ pmid:27374128 fatcat:uri6wo5zifbohn2nwquzbkehky

Diagnostic Accuracy of Diffusion Tensor Imaging in Amyotrophic Lateral Sclerosis

Bradley R. Foerster, Ben A. Dwamena, Myria Petrou, Ruth C. Carlos, Brian C. Callaghan, Cristina L. Churchill, Mona A. Mohamed, Claudia Bartels, Michael Benatar, Laura Bonzano, Olga Ciccarelli, Mirco Cosottini (+13 others)
2013 Academic Radiology  
Rationale and Objectives-There have been a large number of case-control studies using diffusion tensor imaging (DTI) in amyotrophic lateral sclerosis (ALS). The objective of this study  ...  A promising biomarker for ALS is diffusion tensor imaging (DTI), an advanced magnetic resonance imaging (MRI) application.  ...  Search keywords included: amyotrophic lateral sclerosis, Lou Gehrig's, magnetic resonance imaging, diagnostic imaging, diagnostic tests, diffusion tensor imaging, or fractional anisotropy.  ... 
doi:10.1016/j.acra.2013.03.017 pmid:23931423 pmcid:PMC4384461 fatcat:42ejetvovrgsdo3s6mevcpg44q

Imaging in multiple sclerosis

S A Trip
2005 Journal of Neurology, Neurosurgery and Psychiatry  
The NMR Research Unit is supported by The Multiple Sclerosis Society of Great Britain and Northern Ireland.  ...  ACKNOWLEDGEMENTS We thank Drs Li, Fernando, Swanton, and Lanyon for their assistance with the reproduction of the MR images.  ...  Changes in normal appearing brain tissue in MS patients have been detected by diffusion measures.  ... 
doi:10.1136/jnnp.2005.073213 pmid:16107385 pmcid:PMC1765701 fatcat:7cd427lc25cdvdp7issktlsxpu

Physiological Basis and Image Processing in Functional Magnetic Resonance Imaging: Neuronal and Motor Activity in Brain [chapter]

Rakesh Sharma, Avdhesh Sharm
2012 Functional Magnetic Resonance Imaging - Advanced Neuroimaging Applications  
Diffusion tensor imaging Diffusion tensor imaging (DTI) is a related use of MR to measure anatomical connectivity between areas.  ...  For detecting changes in local brain functional activity, fMRI signal-to-noise ratio (fSNR) refers to the time-averaged value of signal divided by the temporal standard deviation of the signal: fSNR =  ...  Physiological Basis and Image Processing in Functional Magnetic Resonance Imaging: Neuronal and Motor Activity in Brain, Functional Magnetic Resonance Imaging -Advanced Neuroimaging Applications, Prof.  ... 
doi:10.5772/39036 fatcat:gfm4ab5j6vhc5f22niia3f3nzu

Current Clinical Applications of Diffusion-Tensor Imaging in Neurological Disorders

Woo-Suk Tae, Byung-Joo Ham, Sung-Bom Pyun, Shin-Hyuk Kang, Byung-Jo Kim
2018 Journal of Clinical Neurology  
Diffusion-tensor imaging (DTI) is a noninvasive medical imaging tool used to investigate the structure of white matter.  ...  Postprocessed DTI scalars can be used to evaluate changes in the brain tissue caused by disease, disease progression, and treatment responses, which has led to an enormous amount of interest in DTI in  ...  INTRODUCTION Diffusion-tensor imaging (DTI) is a relatively new magnetic resonance imaging (MRI) technique that has mostly been used to evaluate microstructural changes in the brain by measuring the motility  ... 
doi:10.3988/jcn.2018.14.2.129 pmid:29504292 pmcid:PMC5897194 fatcat:alz5viikuvhwpao5wddk4mre3e

The Role of Advanced Magnetic Resonance Imaging Techniques in Multiple Sclerosis Clinical Trials

Kedar R. Mahajan, Daniel Ontaneda
2017 Neurotherapeutics  
The current landscape of multiple sclerosis clinical trials is currently expanding to include testing not only of anti-inflammatory agents, but also neuroprotective, remyelinating, neuromodulating, and  ...  Imaging techniques of the brain and spinal cord have rapidly evolved in the last decade to permit in vivo characterization of tissue microstructural changes, connectivity, metabolic changes, neuronal loss  ...  Diffusion Tensor Imaging Diffusion tensor imaging (DTI) is an imaging technique that reflects microstructual changes in tissue by investigating the Gaussian diffusivity of water.  ... 
doi:10.1007/s13311-017-0561-8 pmid:28770481 fatcat:nwefozrjtjafngwma3aibamu3a

Diffusion tensor imaging of post mortem multiple sclerosis brain

Klaus Schmierer, Claudia A.M. Wheeler-Kingshott, Phil A. Boulby, Francesco Scaravilli, Daniel R. Altmann, Gareth J. Barker, Paul S. Tofts, David H. Miller
2007 NeuroImage  
Diffusion tensor imaging of post mortem multiple sclerosis brain. NeuroImage, 35 (2).  ...  Diffusion tensor imaging (DTI) has shown promise to be more specific for MS pathology.  ...  Acknowledgments We are grateful to the UK Multiple Sclerosis Tissue Bank (MSTB) for providing the tissue samples for this study, to Ros Gordon, Christopher Benton, and David G.  ... 
doi:10.1016/j.neuroimage.2006.12.010 pmid:17258908 pmcid:PMC1892244 fatcat:o5ef4ocjzfa3xapbrbtupz6s5i

Deep learning with diffusion basis spectrum imaging for classification of multiple sclerosis lesions

Zezhong Ye, Ajit George, Anthony T Wu, Xuan Niu, Joshua Lin, Gautam Adusumilli, Robert T Naismith, Anne H Cross, Peng Sun, Sheng-Kwei Song
2020 Annals of Clinical and Translational Neurology  
DBSI, diffusion tensor imaging (DTI), and magnetization transfer ratio (MTR) were applied to the 43,261 imaging voxels extracted from these ROIs.  ...  The efficacy and efficiency of DBSI-DNN shows great promise for clinical applications in automatic MS lesion detection and classification.  ...  Cross has performed consulting for: Biogen, Celgene, EMD Serono, Genentech/Roche, Novartis and TG Therapeutics. Robert T.  ... 
doi:10.1002/acn3.51037 pmid:32304291 fatcat:vn5bowacrffdrb4jvghf27wy7a

Investigating Cervical Spinal Cord Structure Using Axial Diffusion Tensor Imaging

Claudia A.M. Wheeler-Kingshott, Simon J. Hickman, Geoffrey J.M. Parker, Olga Ciccarelli, Mark R. Symms, David H. Miller, Gareth J. Barker
2002 NeuroImage  
This study describes a new technique for Diffusion Tensor Imaging (DTI) that acquires axial (transverse) images of the cervical spinal cord.  ...  Because of the high sensitivity to motion of diffusion-weighted magnetic resonance imaging and the small size of the spinal cord, a fast imaging method with high in-plane resolution was developed.  ...  The success of DTI in the brain is well established because of its capability for detecting structural pathological changes, which are not evident on the conventional images, even at a very early stage  ... 
doi:10.1006/nimg.2001.1022 pmid:11969321 fatcat:l33v3vaharclrjp4fve3nl26l4

Spinal cord tract diffusion tensor imaging reveals disability substrate in demyelinating disease

R. T. Naismith, J. Xu, E. C. Klawiter, S. Lancia, N. T. Tutlam, J. M. Wagner, P. Qian, K. Trinkaus, S.-K. Song, A. H. Cross
2013 Neurology  
anisotropy; MD 5 mean diffusivity; MS 5 multiple sclerosis; MTR 5 magnetization transfer ratio; NMO 5 neuromyelitis optica; PC 5 posterior column; RD 5 radial diffusivity; ROI 5 region of interest.  ...  Neurology â 2013;80:2201-2209 GLOSSARY 9HPT 5 9-hole peg test; 25FTW 5 25-foot timed walk; CST 5 corticospinal tract; DTI 5 diffusion tensor imaging; EDSS 5 Expanded Disability Status Scale; FA 5 fractional  ...  ; DTI 5 diffusion tensor imaging; EDSS 5 Expanded Disability Status Scale; FA 5 fractional anisotropy; MD 5 mean diffusivity; MS 5 multiple sclerosis; NMO 5 neuromyelitis optica; RD 5 radial diffusivity  ... 
doi:10.1212/wnl.0b013e318296e8f1 pmid:23667060 pmcid:PMC3721096 fatcat:qttmadh4m5fqfpamaimctmcitm

Relevance of time-dependence for clinically viable diffusion imaging of the spinal cord

Francesco Grussu, Andrada Ianuş, Carmen Tur, Ferran Prados, Torben Schneider, Enrico Kaden, Sébastien Ourselin, Ivana Drobnjak, Hui Zhang, Daniel C. Alexander, Claudia A. M. Gandini Wheeler-Kingshott
2018 Magnetic Resonance in Medicine  
GRUSSU et al. | METHODS | In silico study We ran MC simulations in Camino 43 to characterise patterns of diffusion time-dependence for diffusion sensitisation perpendicular to the axon longitudinal axis  ...  Synthetic data Conclusions: Time-dependence of clinically viable DW MRI metrics can be detected in vivo in spinal cord WM, thus providing new opportunities for the non-invasive estimation of microstructural  ...  Matt Hall for useful discussion.  ... 
doi:10.1002/mrm.27463 pmid:30229564 fatcat:kkh4ysao75hz3ed5g3qbkfla5u

Signal-to-noise ratio-enhancing joint reconstruction for improved diffusion imaging of mouse spinal cord white matter injury

Joong Hee Kim, Sheng-Kwei Song, Justin P. Haldar
2015 Magnetic Resonance in Medicine  
Methods-Four single-average diffusion tensor imaging (DTI) datasets were acquired for each animal from 4 mouse cohorts: two models of spinal cord injury and two control groups.  ...  Conclusion-A 4-fold reduction in the number of averages for quantitative diffusion imaging of small animal white matter injury is feasible using SER.  ...  Acknowledgments This work was supported in part by NSF CAREER award CCF-1350563; NIH grants R01-NS074980, R01-NS047592, and P01-NS059560; National Multiple Sclerosis Society (NMSS) RG 4549A4/1; and Department  ... 
doi:10.1002/mrm.25691 pmid:25824472 pmcid:PMC4589425 fatcat:v3lzgjbejnemnhj7cuebgstpg4

Global diffusion tensor imaging derived metrics differentiate glioblastoma multiforme vs. normal brains by using discriminant analysis: introduction of a novel whole-brain approach

Ernesto Roldan-Valadez, Camilo Rios, David Cortez-Conradis, Rafael Favila, Sergio Moreno-Jimenez
2014 Radiology and Oncology  
A global (whole-brain) calculation of diffusion tensor imaging (DTI) derived tensor metrics offers a valid method to detect the integrity of white matter structures without missing infiltrated brain areas  ...  diffusion, pure anisotropic diffusion, the total magnitude of the diffusion tensor, linear tensor, planar tensor, spherical tensor, relative anisotropy, axial diffusivity and radial diffusivity.  ...  multiple sclerosis 34 , in a model of axonal injury caused by stroke 35 , and in optic neuritis.  ... 
doi:10.2478/raon-2014-0004 pmid:24991202 pmcid:PMC4078031 fatcat:arvgf5j2rvb3dablueq77skk3i
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