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Cognitive and neural plasticity in aging: General and task-specific limitations

Sari Jones, Lars Nyberg, Johan Sandblom, Anna Stigsdotter Neely, Martin Ingvar, Karl Magnus Petersson, Lars Bäckman
2006 Neuroscience and Biobehavioral Reviews  
In the current paper, we argue that the age-related reduction in cognitive plasticity may be due to (a) deficits in general processing resources, and (b) failure to engage in task-relevant cognitive operations  ...  Future attempts to optimize intervention-related gains in old age should consider targeting both general processing and task-specific origins of age-associated reductions in cognitive plasticity. r  ...  Acknowledgments This research was supported by grants from the Swedish Research Council and the Bank of Sweden Tercentenary Foundation to Lars Ba¨ckman.  ... 
doi:10.1016/j.neubiorev.2006.06.012 pmid:16904746 fatcat:kznctyxlnvblrmaamjyqmabg5a

The association of brain structure with gait velocity in older adults: a quantitative volumetric analysis of brain MRI

Ali Ezzati, Mindy J. Katz, Michael L. Lipton, Richard B. Lipton, Joe Verghese
2015 Neuroradiology  
Methods-Gait and cognitive performance was tested in 112 community-residing adults, age 70 years and over, participating in the Einstein Aging Study.  ...  Volumetric MRI measures were estimated using a FreeSurfer software.  ...  Acknowledgments This research was supported by National Institute on Aging Grants AG03949 and AG026728, The Leonard and Sylva Marx Foundation and the Czap Foundation.  ... 
doi:10.1007/s00234-015-1536-2 pmid:25921321 pmcid:PMC4553137 fatcat:3c366gtdoze2nefr7enlaonbye

Comparative Volumetric Analysis of the Brain and Cerebrospinal Fluid in Chiari Type I Malformation Patients: A Morphological Study

Seckin Aydin, Baris Ozoner
2019 Brain Sciences  
The aim of this study was to investigate the brain volume differences between CM-I patients and normal population using a comparative volumetric analysis.  ...  Methods: 140 patients with CM-I and 140 age- and sex-matched healthy controls were included in this study.  ...  Since Chiari is not a pathology affecting a specific cerebral region, we performed a total volumetric analysis rather than a segmental volumetric analysis.  ... 
doi:10.3390/brainsci9100260 pmid:31569471 pmcid:PMC6826836 fatcat:ccj6ztdn5bhozcepesknergjge

Volumetric analysis of the brain structures of children with down's syndrome: A 3D MRI study

Fatma ÖZ, Niyazi ACER, Yasin CEVİZ, Recep ERÖZ, Halit CANATAN, Bircan YÜCEKAYA
2021 Journal of Experimental and Clinical Medicine  
To analyse the overall and regional brain volumes, high-resolution MRI scans were performed and a morphometric analysis was conducted via MRI Studio software.  ...  of specific regional tissue components among such a population.  ...  Acknowledgements All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964  ... 
doi:10.52142/omujecm.38.2.26 fatcat:wln32sethne7teffzn34tt35qa

Volumetric MRI Analysis of Brain Structures in Patients with History of First and Repeated Suicide Attempts: A Cross Sectional Study

Milda Sarkinaite, Rymante Gleizniene, Virginija Adomaitiene, Kristina Dambrauskiene, Nijole Raskauskiene, Vesta Steibliene
2021 Diagnostics  
It remains unclear whether the suicidal behaviors are related to atrophy of brain regions and how the morphology of specific brain areas is changing with each suicide attempt.  ...  Structural brain changes are found in suicide attempters and in patients with mental disorders.  ...  Acknowledgments: The authors wish to thank all patients and control subjects for participating in the study, as well as, radiology technicians from the radiology department for performing MRI scans.  ... 
doi:10.3390/diagnostics11030488 pmid:33801896 pmcid:PMC8000590 fatcat:gycpascv2na5ho3wzh4n5t5dau

Parallel imaging: is GRAPPA a useful acquisition tool for MR imaging intended for volumetric brain analysis?

Terri L Lindholm, Lisa Botes, Eva-Lena Engman, Anders Frank, Tomas Jonsson, Leif Svensson, Per Julin
2009 BMC Medical Imaging  
The work presented here investigates parallel imaging applied to T1-weighted high resolution imaging for use in longitudinal volumetric clinical studies involving Alzheimer's disease (AD) and Mild Cognitive  ...  The principle question is, "Can parallel imaging be used to acquire images at 1.5 T of sufficient quality to allow volumetric analysis of patient brains?"  ...  Yvonne Freund-Levi and Professor Lars-Olof Wahlund, in particular for the recruitment of the elderly patient group.  ... 
doi:10.1186/1471-2342-9-15 pmid:19650898 pmcid:PMC2734748 fatcat:z42ebuxnq5bfralczjwgv45hoa

Volumetric brain differences in clinical depression in association with anxiety: a systematic review with meta-analysis

Daniela A Espinoza Oyarce, Marnie E Shaw, Khawlah Alateeq, Nicolas Cherbuin
2020 Journal of Psychiatry & Neuroscience  
We included 112 studies in the meta-analyses, assessing 4911 healthy participants and 5934 participants with depression (mean age 49.8 yr, 68.2% female).  ...  Depression-related differences in brain structure were modulated by comorbid anxiety, chronicity of symptoms and onset of illness.  ...  Management of duplicate samples was specific to brain region and type of analysis.  ... 
doi:10.1503/jpn.190156 pmid:32726102 pmcid:PMC7595741 fatcat:qcneiuslazarfdi4qooethfj5q

A fully-automatic caudate nucleus segmentation of brain MRI: Application in volumetric analysis of pediatric attention-deficit/hyperactivity disorder

Laura Igual, Joan Soliva, Antonio Hernández-Vela, Sergio Escalera, Xavier Jiménez, Oscar Vilarroya, Petia Radeva
2011 BioMedical Engineering OnLine  
Accurate automatic segmentation of the caudate nucleus in magnetic resonance images (MRI) of the brain is of great interest in the analysis of developmental disorders.  ...  It may therefore be useful to introduce a more flexible technique for accurate segmentations.  ...  Moreover, we provide a quantitative volumetric analysis of pediatric ADHD, and obtain specifications and results that are comparable to manual analysis based on caudate nucleus appearance.  ... 
doi:10.1186/1475-925x-10-105 pmid:22141926 pmcid:PMC3252254 fatcat:7deh53lwrzhczlloazsg6bjbwi

Neuroanatomical aging: Universal but not uniform

Kristine B. Walhovd, Anders M. Fjell, Ivar Reinvang, Arvid Lundervold, Anders M. Dale, Brian T. Quinn, David Salat, Nikos Makris, Bruce Fischl
2005 Neurobiology of Aging  
[1] in that data on volumetric brain aging ultimately should help us understand normal agerelated changes in cognition from a biological perspective.  ...  Regarding the generally larger effect sizes for age in our results, it should be noted that the mode of data presentation and analysis may also have contributed to this.  ... 
doi:10.1016/j.neurobiolaging.2005.05.018 fatcat:o2xu3zstbjcajjpnjaivkvxeym

Association of Gray Matter Atrophy with Age, β-Amyloid, and Cognition in Aging

Hwamee Oh, Cindee Madison, Sylvia Villeneuve, Candace Markley, William J. Jagust
2013 Cerebral Cortex  
Both cognitive aging and b-amyloid (Ab) deposition, a pathological hallmark of Alzheimer's disease, are associated with structural and cognitive changes in cognitively normal older people.  ...  To examine independent effects of age and Ab deposition on cognition and brain structure in aging, 83 cognitively normal older adults underwent structural magnetic resonance imaging scans and neuropsychological  ...  Funding National Institutes of Health (AG034570) and Alzheimer's Association (ZEN-08-87090). Notes Conflict of Interest: None declared.  ... 
doi:10.1093/cercor/bht017 pmid:23389995 pmcid:PMC4014182 fatcat:vm7stvhjnve4tjqpeqdvckppre

Age, Alzheimer disease, and brain structure

C. A. Raji, O. L. Lopez, L. H. Kuller, O. T. Carmichael, J. T. Becker
2009 Neurology  
Methods: A total of 169 cognitively normal subjects and 33 persons with probable AD enrolled in the longitudinal Cardiovascular Health Study-Cognition Study underwent 3-dimensional volumetric MRI scans  ...  Lack of clear understanding remains on the overlapping atrophy patterns of aging and early Alzheimer disease (AD) pathology in gray matter (GM) of the brain in vivo.  ...  Geoffrey Murdoch for useful comments and feedback and Victoria Maruca for technical assistance. C.A.R. thanks Dr. William E. Klunk for overall mentorship and guidance.  ... 
doi:10.1212/wnl.0b013e3181c3f293 pmid:19846828 pmcid:PMC2788799 fatcat:wyneuovyczhhxkbvwcy75w3me4

Obesity and Aging

Gérard N. Bischof, Denise C. Park
2015 Psychosomatic Medicine  
The topics covered are guided by the Scaffolding Theory of Aging and Cognition (STAC; Park & Reuter-Lorenz, 2009-a conceptual model designed to relate brain structure and function to one's level of cognitive  ...  Conclusion-While it is clear that obesity negatively affects cognition, more work is needed to better understand how aging plays a role and how brain structure and brain function might mediate the relationship  ...  The authors are grateful to Patrick Evans, Jenny Rieck, and Ian McDonough for helpful comments on a previous version of this manuscript.  ... 
doi:10.1097/psy.0000000000000212 pmid:26107577 pmcid:PMC5648343 fatcat:i6y3g74epnfzpmaesrygslkm7m

Brain age predicts mortality

J H Cole, S J Ritchie, M E Bastin, M C Valdés Hernández, S Muñoz Maniega, N Royle, J Corley, A Pattie, S E Harris, Q Zhang, N R Wray, P Redmond (+6 others)
2017 Molecular Psychiatry  
Brain-predicted age was calculated using machine-learning analysis, trained on neuroimaging data from a large healthy reference sample (N = 2001), then tested in the Lothian Birth Cohort 1936 (N = 669)  ...  Hence, markers of the underlying biological ageing process are needed to help identify people at increased risk of age-associated physical and cognitive impairments and ultimately, death.  ...  Compared to the full population who sat the cognitive test at age 11, LBC1936 participants had higher cognitive ability, 27 and in later life were likely to be healthier than their peers in the general  ... 
doi:10.1038/mp.2017.62 pmid:28439103 pmcid:PMC5984097 fatcat:dfrtajqvnzfydnam3aw64vn6xm

Brain age and other bodily 'ages': implications for neuropsychiatry

James H. Cole, Riccardo E. Marioni, Sarah E. Harris, Ian J. Deary
2018 Molecular Psychiatry  
As our brains age, we tend to experience cognitive decline and are at greater risk of neurodegenerative disease and dementia.  ...  This will help us reach the long-term goal of developing clinically applicable statistical models of biological processes to measure, track and predict brain and body health in ageing and disease.  ...  in brain diseases and more generally.  ... 
doi:10.1038/s41380-018-0098-1 pmid:29892055 pmcid:PMC6344374 fatcat:hqfchcgrlbfydora6taluldrve

Righteousness (and lefteousness) of the old brain

Madalena Esteves, Nuno Sousa, Hugo Leite-Almeida
2019 Aging  
As a general rule we found that asymmetry is associated with better cognitive performance and mood scores and in specific cases, the directionality of the asymmetry was even irrelevant -e.g. working memory  ...  From the above-mentioned volumetric studies one can infer that, in general, both structural and functional laterality may increase with age, and that exceptions (symmetry) are associated with contralateral  ...  As a general rule we found that asymmetry is associated with better cognitive performance and mood scores and in specific cases, the directionality of the asymmetry was even irrelevant -e.g. working memory  ... 
doi:10.18632/aging.102127 pmid:31339862 pmcid:PMC6682508 fatcat:j45ejux5enbvxhwv2dcg7ea5j4
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