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Generalised boundary shift integral for longitudinal assessment of spinal cord atrophy

Ferran Prados, Marcello Moccia, Aubrey Johnson, Marios Yiannakas, Francesco Grussu, Manuel Jorge Cardoso, Olga Ciccarelli, Sebastien Ourselin, Frederik Barkhof, Claudia Wheeler-Kingshott
2019 NeuroImage  
We based our approach on the generalised boundary shift integral (GBSI) method, which registers 2 scans and uses a probabilistic XOR mask over the edge of the spinal cord, thereby measuring atrophy more  ...  The GBSI pipeline is repeatable, reproducible, and provides more precise measurements of longitudinal spinal cord atrophy than segmentation-based methods in longitudinal spinal cord atrophy studies.  ...  Area) and GBSI (Generalised Boundary Shift Integral).  ... 
doi:10.1016/j.neuroimage.2019.116489 pmid:31877375 fatcat:ws7uebsdzvd5tjjxr7zlqt6ofu

Spinal cord atrophy in a primary progressive multiple sclerosis trial: improved sample size using GBSI

Marcello Moccia, Nicola Valsecchi, Olga Ciccarelli, Ronald Van Schijndel, Frederik Barkhof, Ferran Prados
2020 NeuroImage: Clinical  
We aimed to evaluate the implications for clinical trial design of the generalised boundary-shift integral (GBSI) for spinal cord atrophy measurement.  ...  Spinal cord atrophy derived from brain MRI was related to the corresponding measures from dedicated spinal cord MRI, more strongly for GBSI than CSA.  ...  Acknowledgements We thank Teva for providing data access for this study. We thank the UK MS Society for providing support for this study within the MS Outcomes Working Group. Appendix A.  ... 
doi:10.1016/j.nicl.2020.102418 pmid:32961403 pmcid:PMC7509079 fatcat:hfp4rcun2vfzhkvdwcfw4beqyq

MRI Prognostic Factors in Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorder, and Myelin Oligodendrocyte Antibody Disease

Rosa Cortese, Antonio Giorgio, Gianmarco Severa, Nicola De Stefano
2021 Frontiers in Neurology  
as the lack of sensitive outcome measures for the progressive phases of the disease and repair therapies makes the development of effective treatments a big challenge.  ...  Finally, the role of MRI biomarkers in the monitoring of disease activity and the assessment of treatment response in other inflammatory demyelinating diseases of the central nervous system, such as neuromyelitis  ...  Generalised boundary shift integral for longitudinal assessment of spinal cord atrophy. Neuroimage.  ... 
doi:10.3389/fneur.2021.679881 pmid:34867701 pmcid:PMC8636325 fatcat:hktdfscaevfz3pppabwiba7nla

Automatic segmentation of the spinal cord and intramedullary multiple sclerosis lesions with convolutional neural networks [article]

Charley Gros, Benjamin De Leener, Atef Badji, Josefina Maranzano, Dominique Eden, Sara M. Dupont, Jason Talbott, Ren Zhuoquiong, Yaou Liu, Tobias Granberg, Russell Ouellette, Yasuhiko Tachibana, Masaaki Hori, Kouhei Kamiya (+34 others)
2018 arXiv   pre-print
Segmentation of the spinal cord and lesions from MRI data provides measures of damage, which are key criteria for the diagnosis, prognosis, and longitudinal monitoring in MS.  ...  The spinal cord is frequently affected by atrophy and/or lesions in multiple sclerosis (MS) patients.  ...  Acknowledgements: The following people are acknowledged for MRI acquisition: Manuel Taso, Jamie Near, Ives Levesque, Guillaume Gilbert, Robert Barry, Johanna Vannesjo  ... 
arXiv:1805.06349v2 fatcat:n7hwfgvpynbtfg7ryffnq6id4u

Automatic segmentation of the spinal cord and intramedullary multiple sclerosis lesions with convolutional neural networks

Charley Gros, Benjamin De Leener, Atef Badji, Josefina Maranzano, Dominique Eden, Sara M. Dupont, Jason Talbott, Ren Zhuoquiong, Yaou Liu, Tobias Granberg, Russell Ouellette, Yasuhiko Tachibana (+40 others)
2019 NeuroImage  
Segmentation of the spinal cord and lesions from MRI data provides measures of damage, which are key criteria for the diagnosis, prognosis, and longitudinal monitoring in MS.  ...  The spinal cord is frequently affected by atrophy and/or lesions in multiple sclerosis (MS) patients.  ...  We acknowledge the NVIDIA Corporation for the donation of a GPU.  ... 
doi:10.1016/j.neuroimage.2018.09.081 pmid:30300751 pmcid:PMC6759925 fatcat:i5a2d6o5nngophzbnv3mb2bps4

ABN Abstracts: Proceedings of the Association of British Neurologists, Cardiff City Hall, Cathays Park, 2 April-4 April 2003

2003 Journal of Neurology, Neurosurgery and Psychiatry  
Data on the risk of early recurrence by subtype are important for the organisation of stroke prevention services and triage.  ...  Conclusions: The highest risk of early recurrent stroke is in patients with LAD, emphasising the need for carotid endarterectomy and other preventive treatments to be instigated urgently.  ...  Method: Consecutively acquired cerebral volumetric magnetic resonance images (MRIs) were registered and atrophy quantified using a validated technique (boundary shift integral).  ... 
doi:10.1136/jnnp.74.10.1448 fatcat:4bvmay73bbew7psa3pt35peove

Modelling the Neuroanatomical Progression of Alzheimer's Disease and Posterior Cortical Atrophy [article]

Razvan V. Marinescu
2020 arXiv   pre-print
My fourth contribution is the development of novel extensions for the EBM and the DEM, and the development of novel measures for performance evaluation of such models.  ...  In order to find effective treatments for Alzheimer's disease (AD), we need to identify subjects at risk of AD as early as possible.  ...  First of all, I'd like to thank my supervisor Daniel Alexander, for his great advice, ideas and research directions.  ... 
arXiv:2003.04805v1 fatcat:a5gmy75lvnfnhbtvztqoxikukm

ACTRIMS-ECTRIMS MSBoston 2014: Poster Sessions 2

2014 Multiple Sclerosis  
Such data potentially provide readily accessible UCCA estimates for integration in large multi-site trials and can provide an estimate of spinal cord atrophy without direct cord images.  ...  P502 A longitudinal study of spinal cord atrophy in progressive multiple sclerosis Background: Spinal cord atrophy is strongly associated with physical disability in multiple sclerosis (MS) and has previously  ...  Objectives: To identify different spinal cord and brain atrophy patterns in NMO and MS patients and assess their impact on clinical disability.  ... 
doi:10.1177/1352458514547846 pmid:25205049 pmcid:PMC4244175 fatcat:gj757y4jlvejpnrfw22guoit7m

Program and Abstracts of the XV Canadian Congress of Neurological Sciences

1980 Canadian Journal of Neurological Sciences  
central canal of the spinal cord.  ...  spinal cord injury.  ...  In the second group of children with immediate onset of unconsciousness, 60% developed evidence of extracerebral collections, progressive ventricular dilatation, and a pattern which looked like atrophy  ... 
doi:10.1017/s0317167100022836 fatcat:q6qvww2p7rgmpb7vc3uc5gmkfe

XXVth CANADIAN CONGRESS OF NEUROLOGICAL SCIENCES - Program and Abstracts

1990 Canadian Journal of Neurological Sciences  
The uses and limitations of "first aid" acupuncture treatment were assessed after spinal cord injury in rats.  ...  Surgical strategics for the treatment of symptomatic spinal metastases (SSM) must allow for both decompression of the spinal cord and nerve roots, and stabilization of the spinal column.  ...  This figure should be much higher for the female population. The rate of recurrence is also unusual and will be compared to the other series.  ... 
doi:10.1017/s0317167100030468 fatcat:ytncpxstyzcrtbwfojwawiwyoa

Abstracts

2010 Dementia and Geriatric Cognitive Disorders  
We also analyzed TDP-43 and its C-terminal fragments in various brain regions and spinal cords of ALS patients.  ...  Immunoblot analyses of TDP-43 deposited in brains of patients showed that the 18~26 kDa C-terminal fragments differed between ALS and FTLD, but are indistinguishable between brain regions and spinal cord  ...  spinal cord.  ... 
doi:10.1159/000320292 fatcat:3toxl2yk3ffc7kaw4gnbb362wy

Proceedings of the Association of British Neurologists and the British Neuropsychiatry Association, Royal College of Physicians, 2-4 October 2002

2003 Journal of Neurology, Neurosurgery and Psychiatry  
Colleagues around the world will applaud this Association for its recognition of his work and this award of the ABN Medal for 2002.  ...  The disproportionate severity of right amygdala atrophy may underpin some of the behavioural features associated with RTLA atrophy.  ...  Two independent techniques were used to determine rates of brain atrophy: (1) The brain boundary shift integral (BBSI); and (2) sequential measurements of total brain volume (TBV).  ... 
doi:10.1136/jnnp.74.3.397 fatcat:fx5k362d6jatpodtafkws2ko2u

SCIENTIFIC POSTERS

2006 Neuroradiology  
All imaging studies were retrospectively evaluated for exact delineation of tumor boundaries and assessment of structures infiltrated by the tumor.  ...  We should be aware of the fact that venous congestion of the spinal cord also reveals spinal cord swelling and enhancement.  ...  MATERIAL AND METHODS Twenty patients were referred for the onset of acute neurological symptoms after having been neurologically examined.  ... 
doi:10.1007/s00234-006-0139-3 fatcat:hv57hmgk6jchtk65tdirm35j4y

Guideline for the diagnosis and management of multiple sclerosis: A Southern African perspective

D Giampaolo, A Bhigjee, C Retief, M Isaacs, M Britz, D Opperman, R Govender, M Van Rensburg
2013 South African Medical Journal  
for ~12 h/day 7.5 Unable to take more than a few steps; restricted to wheelchair; may need aid in transfer; wheels him-/herself, but cannot carry on in standard wheelchair for a full day; may require motorised  ...  Before applying diagnostic criteria, there should be no better explanation for the patient's presentation.  ...  Evidence of DIS in the spinal cord based on ≥2 T2 lesions in the cord.  ... 
doi:10.7196/samj.7124 pmid:24300689 fatcat:sajb64oz5zh2pbd6cx2nd6x54i

29th Meeting of the Canadian Congress of Neurological Sciences

1994 Canadian Journal of Neurological Sciences  
Cervical MRI revealed atrophy of the spinal cord from C-5 to upper thoracic segments.  ...  Complex spinal surgery has in recent years become an integral part of neurosurgery.  ...  Biceps muscle biopsy was done in five patients and showed neurogenic atrophy in all.  ... 
doi:10.1017/s0317167100040804 fatcat:ikytez2fg5ft5cpvwxgwtsi5de
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