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Physiological and metabolic flux screening of Saccharomyces cerevisiae single knockout mutants on different carbon sources
[article]
2009
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He is responsible for involving me in the Yeast project in the first place. ...
P Ph hy ys si io ol lo og gi ic ca al l a an nd d M Me et ta ab bo ol li ic c F Fl lu ux x S Sc cr re ee en ni in ng g o of f S Sa ac cc ch ha ar ro om my yc ce es s c ce er re ev vi is si ia ae e S Si ...
by combining all the above analyses and also by graphical Gaussian model approach. ...
doi:10.22028/d291-22608
fatcat:jid6pakduzhezd5ewblvks3cta
Computational Inference of Genome-Wide Protein-DNA Interactions Using High-Throughput Genomic Data Computational Inference of Genome-Wide Protein-DNA Interactions Using High-Throughput Genomic Data
unpublished
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the most accurate inference comes from modeling all available datasets. ...
Therefore, the overarching goal of this dissertation is to provide computational developments for jointly modeling different experimental datasets to achieve a holistic inference on the protein-DNA interaction ...
Gln3 nitrogen catabolite repression
Hcm1 cell cycle regulation
Rap1 chromatin silencing, etc. ...
fatcat:k2ntcgss4jbmvk7l5iapz2hulu
Development and Application of Fluxomics Tools for Analyzing Metabolisms in Non-Model Microorganisms
2012
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This dissertation develops and applies broad-scope tools in metabolic flux analysis to investigate metabolic insights of non-model environmental microorganisms. 13 C-based pathway analysis has been applied ...
Novel pathways, including Re-type citrate synthase in tricarboxylic acid cycle and I would like to express my sincere gratitude to my advisor and mentor, Dr. ...
We sincerely appreciate James Ballard in the Engineering Communication Center of Washington University for editing the manuscript. ...
doi:10.7936/k7p55kkq
fatcat:6zv2vjylkzfkdk235zeyhvjg7a
Ubiquitin-binding domains in polyubiquitin chain synthesis
2020
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Als einziges unter elf E2-Enzymen in S. cerevisiae enthält Ubc1 eine Ub-bindende UBA Domäne, deren Funktion bisher unklar blieb. ...
Uniquely among the eleven E2 enzymes of S. cerevisiae Ubc1 contains a ubiquitin binding UBA domain. ...
to S. cerevisiae. ...
doi:10.18452/21674
fatcat:owmnqd4dkrforgyz5cqbfihany
Role of histone modifications in the recruitment of remodeling complex RSC and lysine deacetylase Hst2 to chromatin
2021
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For example, using pBPA as a crosslinker in budding yeast, I identified a novel preference of the RSC Chromatin Remodeler to H2B SUMOylated nucleosomes. ...
In another project, I investigated the molecular mechanism behind the histone modification H3 S10 phosphorylation mediated chromosome compaction in mitosis. ...
For example, Bmh2 and not Bmh1 primarily regulates genes involved in ribosome biogenesis and nitrogen catabolite repression 268 . ...
doi:10.17877/de290r-22007
fatcat:32ymcrjmgfayrb2sl7qnd667li
Towards the understanding of transcriptional and translational regulatory complexity
[article]
2018
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We developed reliable prediction models to detect these alternative start sites in a given mRNA sequence. ...
The involvement in distinct research areas and projects greatly helped me to constantly expand my knowledge of current methodologies and approaches. ...
or represses certain genes. ...
doi:10.22028/d291-27160
fatcat:736llixqpbca7ohlcoyh2557bq
93rd Annual Meeting of the Virginia Academy of Science: Proceedings
2015
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qseC strain has a quicker generation time than the wild type on both catabolite-repressing and noncatabolite repressing sugars. ...
LOGIT MODEL W ITH GAUSSIAN COPULA.Arjun Poddar, N. ...
Overall, our findings support a model in which, the rate of nuclear degradation of PER2 leads to slow accumulation of the protein in the nucleus and, later in the day, to a temporal switch in which ? ...
doi:10.25778/qsdg-qh02
fatcat:zxpxqtigyzewjap6veodwhetny
Development of Novel Image Analysis Methods for the Morphological Quantification of Filamentous Fungi
2010
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Increasing inoculum concentration was found to result in a decrease in mean pellet diameter and an increase in α-amylase production. ...
The supplementation of fermentation media with non-ionic detergents caused a significant increase in α-amylase production (up to 149%), but this increase did not seem to be related to observed morphological ...
This is typically achieved by the inhibition (or repression) of the synthesis of enzymes involved in the catabolism of other carbon sources (known as catabolite repression) [29] . 3 If the fermentation ...
doi:10.21427/d7730d
fatcat:lgi5kfbi2vbt7nj7qeb2n656gq