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Physiological and metabolic flux screening of Saccharomyces cerevisiae single knockout mutants on different carbon sources [article]

Vidya R. Velagapudi, Universität Des Saarlandes, Universität Des Saarlandes
He is responsible for involving me in the Yeast project in the first place.  ...  P Ph hy ys si io ol lo og gi ic ca al l a an nd d M Me et ta ab bo ol li ic c F Fl lu ux x S Sc cr re ee en ni in ng g o of f S Sa ac cc ch ha ar ro om my yc ce es s c ce er re ev vi is si ia ae e S Si  ...  by combining all the above analyses and also by graphical Gaussian model approach.  ... 
doi:10.22028/d291-22608 fatcat:jid6pakduzhezd5ewblvks3cta

Computational Inference of Genome-Wide Protein-DNA Interactions Using High-Throughput Genomic Data Computational Inference of Genome-Wide Protein-DNA Interactions Using High-Throughput Genomic Data

Jianling Zhong, Alexander Hartemink, Gregory Crawford, Sayan Mukherjee, Raluca Gordân, Jianling Zhong, Alexander Hartemink, Gregory Crawford, Sayan Mukherjee, Raluca Gordân
the most accurate inference comes from modeling all available datasets.  ...  Therefore, the overarching goal of this dissertation is to provide computational developments for jointly modeling different experimental datasets to achieve a holistic inference on the protein-DNA interaction  ...  Gln3 nitrogen catabolite repression Hcm1 cell cycle regulation Rap1 chromatin silencing, etc.  ... 

Development and Application of Fluxomics Tools for Analyzing Metabolisms in Non-Model Microorganisms

Xueyang Feng
This dissertation develops and applies broad-scope tools in metabolic flux analysis to investigate metabolic insights of non-model environmental microorganisms. 13 C-based pathway analysis has been applied  ...  Novel pathways, including Re-type citrate synthase in tricarboxylic acid cycle and I would like to express my sincere gratitude to my advisor and mentor, Dr.  ...  We sincerely appreciate James Ballard in the Engineering Communication Center of Washington University for editing the manuscript.  ... 
doi:10.7936/k7p55kkq fatcat:6zv2vjylkzfkdk235zeyhvjg7a

Ubiquitin-binding domains in polyubiquitin chain synthesis

Lukas Pluska, Humboldt-Universität Zu Berlin
Als einziges unter elf E2-Enzymen in S. cerevisiae enthält Ubc1 eine Ub-bindende UBA Domäne, deren Funktion bisher unklar blieb.  ...  Uniquely among the eleven E2 enzymes of S. cerevisiae Ubc1 contains a ubiquitin binding UBA domain.  ...  to S. cerevisiae.  ... 
doi:10.18452/21674 fatcat:owmnqd4dkrforgyz5cqbfihany

Role of histone modifications in the recruitment of remodeling complex RSC and lysine deacetylase Hst2 to chromatin

Neha Jain, Technische Universität Dortmund
For example, using pBPA as a crosslinker in budding yeast, I identified a novel preference of the RSC Chromatin Remodeler to H2B SUMOylated nucleosomes.  ...  In another project, I investigated the molecular mechanism behind the histone modification H3 S10 phosphorylation mediated chromosome compaction in mitosis.  ...  For example, Bmh2 and not Bmh1 primarily regulates genes involved in ribosome biogenesis and nitrogen catabolite repression 268 .  ... 
doi:10.17877/de290r-22007 fatcat:32ymcrjmgfayrb2sl7qnd667li

Towards the understanding of transcriptional and translational regulatory complexity [article]

Kerstin Neininger, Universität Des Saarlandes, Universität Des Saarlandes
We developed reliable prediction models to detect these alternative start sites in a given mRNA sequence.  ...  The involvement in distinct research areas and projects greatly helped me to constantly expand my knowledge of current methodologies and approaches.  ...  or represses certain genes.  ... 
doi:10.22028/d291-27160 fatcat:736llixqpbca7ohlcoyh2557bq

93rd Annual Meeting of the Virginia Academy of Science: Proceedings

Virginia Academy Of Science
qseC strain has a quicker generation time than the wild type on both catabolite-repressing and noncatabolite repressing sugars.  ...  LOGIT MODEL W ITH GAUSSIAN COPULA.Arjun Poddar, N.  ...  Overall, our findings support a model in which, the rate of nuclear degradation of PER2 leads to slow accumulation of the protein in the nucleus and, later in the day, to a temporal switch in which ?  ... 
doi:10.25778/qsdg-qh02 fatcat:zxpxqtigyzewjap6veodwhetny

Development of Novel Image Analysis Methods for the Morphological Quantification of Filamentous Fungi

David Barry
Increasing inoculum concentration was found to result in a decrease in mean pellet diameter and an increase in α-amylase production.  ...  The supplementation of fermentation media with non-ionic detergents caused a significant increase in α-amylase production (up to 149%), but this increase did not seem to be related to observed morphological  ...  This is typically achieved by the inhibition (or repression) of the synthesis of enzymes involved in the catabolism of other carbon sources (known as catabolite repression) [29] . 3 If the fermentation  ... 
doi:10.21427/d7730d fatcat:lgi5kfbi2vbt7nj7qeb2n656gq