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To assess the gateway hypothesis, we developed the GatewayNet algorithm, a refinement of sequential rule mining called initiation rule mining. ... After a brief mathematical definition, we describe how to perform initiation rule mining and how to infer causal relationships from its rules ("gateway rules"). ... The funding bodies had no role in the design of the study and collection, the analysis, interpretation of the data and in writing the manuscript. ...doi:10.1186/s12911-019-0810-3 pmid:31014328 pmcid:PMC6480909 fatcat:qu7da4qgu5f77ay3hq4z6zdaoe