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Galaxy Learning -- A Position Paper [article]

Chao Wu, Jun Xiao, Gang Huang, Fei Wu
2019 arXiv   pre-print
The recent rapid development of artificial intelligence (AI, mainly driven by machine learning research, especially deep learning) has achieved phenomenal success in various applications. However, to further apply AI technologies in real-world context, several significant issues regarding the AI ecosystem should be addressed. We identify the main issues as data privacy, ownership, and exchange, which are difficult to be solved with the current centralized paradigm of machine learning training
more » ... thodology. As a result, we propose a novel model training paradigm based on blockchain, named Galaxy Learning, which aims to train a model with distributed data and to reserve the data ownership for their owners. In this new paradigm, encrypted models are moved around instead, and are federated once trained. Model training, as well as the communication, is achieved with blockchain and its smart contracts. Pricing of training data is determined by its contribution, and therefore it is not about the exchange of data ownership. In this position paper, we describe the motivation, paradigm, design, and challenges as well as opportunities of Galaxy Learning.
arXiv:1905.00753v1 fatcat:q7wb5gcejnbc3ear5r4jmy6equ

SBAS-InSAR-Based Analysis of Surface Deformation in the Eastern Tianshan Mountains, China

Qingsong Du, Qingsong Du, Qingsong Du, Guoyu Li, Guoyu Li, Dun Chen, Dun Chen, Dun Chen, Yu Zhou, Yu Zhou, Yu Zhou, Shunshun Qi (+9 others)
2021 Frontiers in Earth Science  
Copyright © 2021 Du, Li, Chen, Zhou, Qi, Wu, Chai, Tang, Jia and Peng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).  ... 
doi:10.3389/feart.2021.729454 doaj:479c7859f1ce49c3ab5753589c16be88 fatcat:nvl2ggx2orgahdt5qm2je6tmme

SOT for MOT [article]

Qizheng He, Jianan Wu, Gang Yu, Chi Zhang
2017 arXiv   pre-print
In this paper we present a robust tracker to solve the multiple object tracking (MOT) problem, under the framework of tracking-by-detection. As the first contribution, we innovatively combine single object tracking (SOT) algorithms with multiple object tracking algorithms, and our results show that SOT is a general way to strongly reduce the number of false negatives, regardless of the quality of detection. Another contribution is that we show with a deep learning based appearance model, it is
more » ... asy to associate detections of the same object efficiently and also with high accuracy. This appearance model plays an important role in our MOT algorithm to correctly associate detections into long trajectories, and also in our SOT algorithm to discover new detections mistakenly missed by the detector. The deep neural network based model ensures the robustness of our tracking algorithm, which can perform data association in a wide variety of scenes. We ran comprehensive experiments on a large-scale and challenging dataset, the MOT16 benchmark, and results showed that our tracker achieved state-of-the-art performance based on both public and private detections.
arXiv:1712.01059v1 fatcat:hyvshkkogfgkdkj3qmynkxsa3e

Serum parathyroid hormone levels in patients with chronic right heart failure

Gang‑Yong Wu, Qin Shen, Ting Wu, Yi‑Cheng Shi, Tian‑Xiao Wang, Gang‑Jun Zong, Xiang‑Jun Yang
2019 Biomedical Reports  
Parathyroid hormone (PTH) is a novel cardiovascular biomarker which is particularly useful for detection and assessment of heart failure (HF). However, previous studies examining PTH in heart failure have primarily focused on left HF; thus, the relationship between PTH and right HF remains unclear. The aim of the present study was to evaluate the serum PTH levels in patients with chronic right HF. A total of 154 patients with chronic right HF were enrolled in the present study. A binary
more » ... regression analysis model was used to assess the independent predictive value of PTH levels in chronic right HF. Partial correlative analysis was used to demonstrate the relevance of PTH levels on the parameters of assessment of right heart function. A multiple linear regression analysis model was used to evaluate the independent factors of PTH levels in patients with right HF. The results showed that the serum PTH levels in the right HF group were significantly higher compared with the control group. After adjusting for predictors of right HF, serum PTH levels were associated with right HF with an odds ratio of 1.066 (95% confidence interval: 1.030-1.102, P<0.001. Serum PTH levels were independently correlated with plasma N-terminal pro-B-type natriuretic peptide levels, right ventricular end-diastolic diameter and severity of lower extremity edema (all P<0.05). Therefore, based on the results of the present study, PTH may be a useful biomarker for detection and assessment of right HF.
doi:10.3892/br.2019.1262 pmid:31929877 pmcid:PMC6951227 fatcat:ci3puhhjivctfccj3iinfrp5b4

Correction to: Survey research with gang and non-gang members in prison: operational lessons from the LoneStar project

Meghan M. Mitchell, Kallee McCullough, Jun Wu, David C. Pyrooz, Scott H. Decker
2018 Trends in Organized Crime  
Table 2 2 Demographics, socioeconomic status, and criminal history by gang and non-gang members Gang and non-gang refers to official gang classifications. Weighted sample statistics are reported.  ...  Statistical significance was determined using sampling weighted bivariate OLS and binary logistic regression between gang and non-gang members Abbreviations: SD standard deviation, Am.  ... 
doi:10.1007/s12117-018-9347-6 fatcat:bibipejqdvc73jhkm4wirvacne

Inverse role of distinct subsets and distribution of macrophage in lung cancer prognosis: a meta-analysis

Pin Wu, Dang Wu, Lufeng Zhao, Lijian Huang, Gang Chen, Gang Shen, Jian Huang, Ying Chai
2016 OncoTarget  
Data collection process Two authors (Pin Wu and Dang Wu) independently extracted information using predefined data abstraction forms.  ...  The following details were extracted by 2 reviewers (Pin Wu and Dang Wu): number of patients, antibody used for the evaluation, technique used to quantify TAM, and cut-off to determine high density of  ... 
doi:10.18632/oncotarget.9625 pmid:27248173 pmcid:PMC5130019 fatcat:glmor5vktnawbhmjjupczspo6e

Epigenetic silencing of DUSP9 induces the proliferation of human gastric cancer by activating JNK signaling

2015 Oncology Reports  
Dual-specificity phosphatase 9 (DUSP9) is a strong negative regulator of transcription factor activating kinases (ERK, JNK and p38) in the mitogen-activated protein kinase (MAPK) pathways. The aim of this study was to examine the CpG island methylation status of DUSP9 using bisulfite sequencing PCR (BSP) in gastric cancer (GC). The investigation was conducted on 30 clinical GC samples and selected corresponding tumor-free normal gastric mucosa tissues, using BSP for the determination of the
more » ... oter methylation status. The methylation status of the tumor samples was compared to the corresponding tumor-free samples. DUSP9 was silenced by promoter region hypermethylation and G2/M phase arrest was induced by DUSP9 in the MKN-1 GC cell line. MKN-1 proliferation was suppressed by DUSP9 by inhibiting c-Jun, which was induced by JNK signaling. The expression levels of CCND1, c-Jun, CDK4 and CDK6 were upregulated while p21 was downregulated by DUSP9 in MKN-1 cells. However, DUSP9-induced resulted in the regulation of the levels of cycle-related molecules, whivh were inhibited when the JNK inhibitor SP600125 was added. In conclusion, DUSP9 was frequently methylated in human GC and the expression of DUSP9 is silenced by promoter region hypermethylation. The results of this study, combined with previous studies, suggested that therapeutic intervention to increase the expression or activity of DUSP9 may enable the activation of anti-proliferation signals in malignant cells.
doi:10.3892/or.2015.3998 pmid:25998184 fatcat:54kk3wyb25btbc2aaf4sgatnc4

Effect of parathyroid hormone on cardiac function in rats with cardiomyopathy

Gang‑Yong Wu, Ting Wu, Bai‑Da Xu, Yi‑Cheng Shi, Zhi‑Yuan Cheng, Xiao Zhang, Xiao Wang, Gang‑Jun Zong
2018 Experimental and Therapeutic Medicine  
The present study investigated the role of parathyroid hormone (PTH) in non-ischemic cardiomyopathy (CM) and its underlying mechanism. A total of 30 Sprague-Dawley male rats were randomly divided into a control group (n=6) and an experimental group (n=24). To induce CM in the rats of the experimental group, 2 mg/kg Adriamycin (ADR) was administered intraperitoneally with 5 equal injections every third day followed by 5 weekly injections resulting in a cumulative dose of 20 mg/kg. Following
more » ... lishment of the model, rats in the experimental group were subdivided into a PTH-untreated CM group that received daily normal saline subcutaneous injections for 7 days and three treated CM groups that received daily subcutaneous injections of 5, 10, or 20 µg/kg of recombinant PTH for 7 days. Rats in the control group accordingly received intraperitoneal and subcutaneous injections of normal saline. Blood sample analysis revealed that B-type natriuretic peptide (BNP), troponin T, C-reactive protein (CRP), creatinine and phosphorus concentrations were increased in the PTH-untreated CM group compared with that in the control group, whereas PTH and calcium concentrations were decreased. Administration of PTH dose-dependently decreased BNP, CRP, creatinine and phosphorus levels, and increased PTH and calcium levels. Notably, there were significant differences in PTH, BNP, troponin T, CRP, creatinine, calcium, and phosphorus levels among the rats in the five groups (P<0.01). Cardiac ultrasonography results indicated that the left ventricular ejection fraction (LVEF) was significantly decreased in rats treated with ADR compared with the rats from the control group (P<0.01). However, the LVEF gradually recovered with elevated PTH treatment doses. The overall differences of LVEF and left ventricular end-systolic volume in the five experimental groups were statistically significant (P<0.01). Furthermore, there were dose-dependent increases in LV mass and left ventricular end-diastolic volume in PTH-treated rats; however, the differences between any two groups did not reach statistical significance (P>0.05). Immunohistochemical staining and western blot analysis using an anti-PTH polyclonal antibody was performed to evaluate the protein expression levels of PTH in myocardial tissues. The mRNA expression levels of PTH and BNP were measured using reverse transcription-quantitative polymerase chain reaction. The results demonstrated that the mRNA and protein expression levels of PTH in myocardial tissues were significantly decreased in ADR-treated rats compared with the levels in the control group rats. Injection of recombinant PTH significantly increased PTH expression and reduced BNP expression in dose-dependent manners (P<0.05). These findings demonstrated that PTH can improve cardiac function in rats with ADR-induced CM, suggesting a potential therapeutic application for PTH in non-ischemic CM.
doi:10.3892/etm.2018.6528 pmid:30214507 pmcid:PMC6125823 fatcat:5hav234f6vfujlfs5o3unrwhku


Gang Wu, Mengdong Yang, Ke Wu, Guilin Qi, Yuzhong Qu
2010 Proceedings of the 19th international conference on World wide web - WWW '10  
Falconer 1 is a semantic Web search engine enhanced SIOC (Semantically-Interlinked Online Communities) application, which is designed to demonstrate the ability of accelerating the creation and reuse process of semantic Web data with easy-to-use user interfaces. In this process, semantic Web search engines feed existing semantic data into the SIOC framework, where new semantic data are composed by the community and indexed again by those search engines. Compared to existing social (semantic)
more » ... applications, Falconer inherently conforms to SIOC specification. It provides semantic search engine based user registration suggestion, friends auto-discovery, and semantic annotation for forum post content. Another distinctive feature is that it enables users to subscribe any resource having a URI as the topic they are interested in. The relationships among users, topics, and posts are further visualized for analyzing the topic trends in the community. As all semantic data are formatted in RDF and RDFa, they can be queried with SPARQL query language.
doi:10.1145/1772690.1772911 dblp:conf/www/WuYWQQ10 fatcat:7zlpkvtwoba7hoqrskk5zj5i2a

Prognostic alternative splicing signatures and underlying regulatory network in esophageal carcinoma

Zu-Cheng Xie, Hua-Yu Wu, Fu-Chao Ma, Yi-Wu Dang, Zhi-Gang Peng, Hua-Fu Zhou, Gang Chen
2019 American journal of translational research  
Alternative splicing (AS) has been widely reported to play an important role in cancers, including esophageal carcinoma (ESCA). However, no study has comprehensively investigated the clinical use of combination of prognostic AS events and clinicopathological parameters. Therefore, we collected 165 ESCA patients including 83 esophageal adenocarcinoma (EAC) and 82 esophageal squamous cell carcinoma (ESCC) patients from The Cancer Genome Atlas to explore the survival rate associated with seven
more » ... s of AS events. Prognostic predictors for the clinical outcomes of ESCA patients were built. Predictive prognosis models of the alternative acceptor site in ESCA (area under the curve [AUC] = 0.83), alternative donor site in EAC (AUC = 0.99), and alternative terminator site in ESCC (AUC = 0.974) showed the best predictive efficacy. A novel combined prognostic model of AS events and clinicopathological parameters in ESCA was also constructed. Combined prognostic models of ESCA all showed better predictive efficacy than independent AS models or clinicopathological parameters model. Through constructing splicing regulatory network, the expression of AS factor was found to be negatively correlated with the most favorable AS events. Moreover, gene amplification, mutation, and copy number variation of AS genes were commonly observed, which may indicate the molecular mechanism of how the AS events influence survival. Conclusively, the constructed prognostic models based on AS events, especially the combined prognostic models of AS signatures and clinicopathological parameters could be used to predict the outcome of ESCA patients. Moreover, the splicing regulatory network and genomic alteration in ESCA could be used for illuminating the potential molecular mechanism.
pmid:31396315 pmcid:PMC6684923 fatcat:ntikkb6tyrcu7hi7dptrpws5ca

High-Throughput Functional MicroRNAs Profiling by Recombinant AAV-Based MicroRNA Sensor Arrays

Wenhong Tian, Xiaoyan Dong, Xuerong Liu, Gang Wang, Zheyue Dong, Wei Shen, Gang Zheng, Jianxin Lu, Jinzhong Chen, Yue Wang, Zhijian Wu, Xiaobing Wu (+1 others)
2012 PLoS ONE  
microRNAs (miRNAs) are small and non-coding RNAs which play critical roles in physiological and pathological processes. A number of methods have been established to detect and quantify miRNA expression. However, method for high-throughput miRNA function detection is still lacking. Principal Findings: We describe an adeno-associated virus (AAV) vector-based microRNA (miRNA) sensor (Asensor) array for high-throughput functional miRNA profiling. Each Asensor contains a Gaussia luciferase (Gluc)
more » ... a firefly luciferase (Fluc) expression cassette to sense functional miRNA and to serve as an internal control respectively. Using this array, we acquired functional profiles of 115 miRNAs for 12 cell lines and found "functional miRNA signatures" for several specific cell lines. The activities of specific miRNAs including the let-7 family, miR-17-92 cluster, miR-221, and miR-222 in HEK 293 cells were compared with their expression levels determined by quantitative reverse transcriptase polymerase chain reaction (QRT-PCR). We also demonstrate two other practical applications of the array, including a comparison of the miRNA activity between HEK293 and HEK293T cells and the ability to monitor miRNA activity changes in K562 cells treated with 12-Otetradecanoylphorbol-13-acetate (TPA). Conclusions/Significance: Our approach has potential applications in the identification of cell types, the characterization of biological and pathological processes, and the evaluation of responses to interventions.
doi:10.1371/journal.pone.0029551 pmid:22242174 pmcid:PMC3252342 fatcat:bmouinjr3ngslcyjmek2edqlei


Jiahui Wu, Gang Pan, Daqing Zhang, Shijian Li, Zhaohui Wu
2010 Proceedings of the 12th ACM international conference adjunct papers on Ubiquitous computing - Ubicomp '10  
Mobile phones are becoming a kind of must-have portable devices for people. This video demonstrates a mobile phone that can sense what you are pointing to and can act as a physical ubiquitous interaction device in real world, called MagicPhone. If you want to interact with an appliance around you, you just simply point the MagicPhone to it and then operate. The MagicPhone uses both the built-in accelerometer and magnetometer to sense the pointing orientation. Using MagicPhone, you only need to
more » ... oint to a device and sliding your finger, to show a picture on a display, to send a document to a laptop, to share slides on a projector, and to print a photo. In addition, MagicPhone can control a selected device with accelerometer-based gestures, e.g. changing TV channels. It also can serve as a mouse to draw a picture or play clicking games.
doi:10.1145/1864431.1864483 dblp:conf/huc/WuPZLW10 fatcat:vahgzy4w6rb4hhcmllvlv7ziqm

Forecasting Renminbi Exchange Rate Volatility Using CARR-MIDAS Model

Xinyu Wu, Mengqi Wu, Gang Jin Wang
2022 Complexity  
While Wu et al.  ...  To address this issue, an extension of the CARR model, namely, the CARR-mixeddata sampling (CARR-MIDAS) model has been proposed by Wu et al.  ... 
doi:10.1155/2022/3127761 fatcat:kkgwlkfcazhddg4s625kticxby

Melanotic Xp11-associated tumor of the sigmoid colon: A case report

Gang Wang, Gang-Gang Li, Sheng-Mao Zhu, Bao-Jia Cai, Peng-Jie Yu, Cheng-Wu Zhang
2019 World Journal of Clinical Cases  
Melanotic Xp11-associated tumors are rare mesenchymal-derived tumors. So far, most primary melanotic Xp11-associated tumors have been reported in the kidney, and reports of this tumor in the gastrointestinal tract are rare. Here we describe the case of a 25-year-old woman who presented with a melanotic Xp11-associated tumor in the sigmoid colon. Colonoscopy revealed a large mucosal bulge in the sigmoid colon, approximately 32 cm inside the anus. The surface was rough with local erosion. The
more » ... r was brittle on biopsy and bled easily. Computed tomography revealed thickening of the rectal wall with edema. Postoperative pathology indicated the likelihood of a perivascular epithelioid cell tumor. Histologically, the tumor comprised plump epithelioid cells with abundant clear to lightly eosinophilic cytoplasm and round nuclei arranged in an alveolar or trabecular pattern. The tumor cells were strongly positive for HMB-45, Melan-A, Cathepsin K, and TFE3 but negative for vimentin, smooth muscle actin, S100 protein, CD10, CK20, and desmin. The tumor cells had a low Ki-67 labeling index (approximately 2%). Fluorescence in situ hybridization revealed TFE3 fracture. Based on these histologic and immunohistochemical features, a diagnosis of melanotic Xp11-associated tumor of the sigmoid colon was made. In summary, we report the clinicopathological features of a primary tumor that is extremely rare in the sigmoid colon and review the clinicopathological characteristics of melanotic Xp11-associated tumors, compatible with the very rare tumor termed "melanotic Xp11 translocation renal cancer" in all aspects.
doi:10.12998/wjcc.v7.i5.684 pmid:30863770 pmcid:PMC6406196 fatcat:wotu75eur5hw7ox6tqkvwsdsoq

Determination of the pion distribution amplitude [article]

Tao Huang, Tao Zhong, Xing-Gang Wu
2013 arXiv   pre-print
Right now, we have not enough knowledge to determine the hadron distribution amplitudes (DAs) which are universal physical quantities in the high energy processes involving hadron for applying pQCD to exclusive processes. Even for the simplest pion, one can't discriminate from different DA models. Inversely, one expects that processes involving pion can in principle provide strong constraints on the pion DA. For example, the pion-photon transition form factor (TFF) can get accurate information
more » ... f the pion wave function or DA, due to the single pion in this process. However, the data from Belle and BABAR have a big difference on TFF in high Q^2 regions, at present, they are helpless for determining the pion DA. At the present paper, we think it is still possible to determine the pion DA as long as we perform a combined analysis of the most existing data of the processes involving pion such as π→μν̅, π^0 →γγ, B→π l ν, D →π l ν, and etc. Based on the revised light-cone harmonic oscillator model, a convenient DA model has been suggested, whose parameter B which dominates its longitudinal behavior for ϕ_π(x,μ^2) can be determined in a definite range by those processes. A light-cone sum rule analysis of the semi-leptonic processes B →π l ν and D →π l ν leads to a narrow region B = [0.01,0.14], which indicate a slight deviation from the asymptotic DA. Then, one can predict the behavior of the pion-photon TFF in high Q^2 regions which can be tested in the future experiments. Following this way it provides the possibility that the pion DA will be determined by the global fit finally.
arXiv:1305.7391v1 fatcat:csn5uqzq2vb33abjpxh6hhftku
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