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Gait Analysis in Parkinson's Disease: An Overview of the Most Accurate Markers for Diagnosis and Symptoms Monitoring

Lazzaro di Biase, Alessandro Di Santo, Maria Letizia Caminiti, Alfredo De Liso, Syed Ahmar Shah, Lorenzo Ricci, Vincenzo Di Lazzaro
2020 Sensors  
The aim of this review is to summarize that most relevant technologies used to evaluate gait features and the associated algorithms that have shown promise to aid diagnosis and symptom monitoring in Parkinson's  ...  Despite a large number of studies on the topic of objective gait analysis in PD, only a limited number of studies reported algorithms that were accurate enough deemed to be useful for diagnosis and symptoms  ...  diagnosis and symptom monitoring in Parkinson's disease (PD) patients.  ... 
doi:10.3390/s20123529 pmid:32580330 fatcat:c3ajfkdb3nctvdbmyhpiinq66i

Gait analysis for early Parkinson's disease detection based on deep learning

Jyothsna Kondragunta, Christian Wiede, Gangolf Hirtz
2019 Current Directions in Biomedical Engineering  
This paper outlines the advantages and disadvantages of the state-of-the-art methods in application of gait analysis for early PD identification.  ...  Better handling of neurological or neurodegenerative disorders such as Parkinson's Disease (PD) is only possible with an early identification of relevant symptoms.  ...  But there doesn't exist a literature overview, where the combination of human pose estimation for gait analysis is used and a review on most recent methodologies.  ... 
doi:10.1515/cdbme-2019-0003 fatcat:bophatxhnnhgtnnmb4c7pupwti

Detection and assessment of Parkinson's disease based on gait analysis: A survey

Yao Guo, Jianxin Yang, Yuxuan Liu, Xun Chen, Guang-Zhong Yang
2022 Frontiers in Aging Neuroscience  
Parkinson's Disease (PD), for example, affecting millions of people worldwide is often manifested as impaired posture and gait.  ...  These impairments have been used as a clinical sign for the early detection of PD, as well as an objective index for pervasive monitoring of the PD patients in daily life.  ...  Yunbo Li and Miss Mengnan He for the contribution of literature search.  ... 
doi:10.3389/fnagi.2022.916971 pmid:35992585 pmcid:PMC9382193 fatcat:pmugk3unr5g3vktd4e5g73usza

Parkinson's Disease Management via Wearable Sensors: A Systematic Review

Huma Mughal, Abdul Rehman Javed, Muhammad Rizwan, Ahmad S. Almadhor, Natalia Kryvinska
2022 IEEE Access  
This paper presents a Systematic Literature Review (SLR) that provides an in-depth analysis of the PD symptoms, Motor and Non-Motor Symptoms (NMS), the current diagnosis and management techniques used  ...  Wearable technology has played an essential role in the Mobile Health (mHealth) sector for diagnosis, treatment, and rehabilitation of numerous diseases and disorders.  ...  It includes an analysis of different wearable devices used for early detection, monitoring, and managing PD symptoms.  ... 
doi:10.1109/access.2022.3162844 fatcat:56lrxqe5vnfttkrdlskoykfkee

Parkinson's disease biomarkers: perspective from the NINDS Parkinson's Disease Biomarkers Program

Katrina Gwinn, Karen K David, Christine Swanson-Fischer, Roger Albin, Coryse St Hillaire-Clarke, Beth-Anne Sieber, Codrin Lungu, F DuBois Bowman, Roy N Alcalay, Debra Babcock, Ted M Dawson, Richard B Dewey (+14 others)
2017 Biomarkers in Medicine  
Potential role of biomarkers in the diagnosis & management of Parkinson's disease There has been significant progress in our understanding of the biology of Parkinson's disease (PD); however, current therapies  ...  Even with the correct diagnosis, PD has wide variability in disease course, rate of progression and response to treatment, making an objective marker extremely useful [135] .  ... 
doi:10.2217/bmm-2016-0370 pmid:28644039 pmcid:PMC5619098 fatcat:oqsqf3h7zbh37eujrg2mxo63qq

Postural Instability in Parkinson's Disease: A Review

Bhavana Palakurthi, Sindhu Preetham Burugupally
2019 Brain Sciences  
At present, the diagnosis of PD is clinical, subjective, nonspecific, and often inadequate. There is a need to quantify the PD factors for an objective disease assessment.  ...  Specifically, we discuss some of the reported factors for an early PI diagnosis, including age, nervous system lesions, genetic mutations, abnormal proprioception, impaired reflexes, and altered biomechanics  ...  Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/brainsci9090239 pmid:31540441 pmcid:PMC6770017 fatcat:75wsv2ocizfunkppg536e3tehq

Wearable Solutions for Patients with Parkinson's Disease and Neurocognitive Disorder: A Systematic Review

Asma Channa, Nirvana Popescu, Vlad Ciobanu
2020 Sensors  
the various fitness and gait wearable-based exercises and their impact on the regression of disease and on the motor diagnosis tests and finally addressing the available wearable insoles and their role  ...  Recent development in wearable technology proclaimed its use in diagnosis, rehabilitation, assessment, and monitoring.  ...  The examination of Parkinson's disease is a tricky one; research has been done for decades and still there is no robust test that serves as the best since Parkinson's disease signs and symptoms vary from  ... 
doi:10.3390/s20092713 pmid:32397516 pmcid:PMC7249148 fatcat:opue4bbdgzaofne4xihb6jrg6a

Analysis of Parkinson's Disease Data

Ram Deepak Gottapu, Cihan H Dagli
2018 Procedia Computer Science  
To our knowledge, the capabilities of deep learning algorithms have not yet been completely utilized in the field of Parkinson's research and we believe that by having an in-depth understanding of data  ...  In this paper, we investigate the diagnostic data from patients suffering with Parkinson's disease (PD) and design classification/prediction model to simplify the diagnosis.  ...  We present an overview of different types of data used and create a classification/prediction problem to simplify the diagnosis.  ... 
doi:10.1016/j.procs.2018.10.306 fatcat:dhlefhw2uffv3hqji53qncatuu

Step Length Is a Promising Progression Marker in Parkinson's Disease

Julius Welzel, David Wendtland, Elke Warmerdam, Robbin Romijnders, Morad Elshehabi, Johanna Geritz, Daniela Berg, Clint Hansen, Walter Maetzler
2021 Sensors  
Current research on Parkinson's disease (PD) is increasingly concerned with the identification of objective and specific markers to make reliable statements about the effect of therapy and disease progression  ...  These results show the importance of carefully evaluating quantitative gait parameters to make assumptions about disease progression, and the potential of the granular evaluation of symptoms such as gait  ...  Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/s21072292 pmid:33805914 fatcat:bswmvq7mqnekxhce4xzgrtvsym

Computer-Vision Based Diagnosis of Parkinson's Disease via Gait: A Survey

Navleen Kour, Sunanda, Sakshi Arora
2019 IEEE Access  
Parkinson's Disease (PD) being the second most hazardous neurological disorder has developed its roots in damaging people's quality of life (QOL).  ...  The study presents a description of PD related gait features, extraction and selection methods used for PD analysis.  ...  OVERVIEW OF PARKINSON'S DISEASE (PD) The most common degenerative neurological disorder occupying the second place next to Alzheimer's disease i.e.  ... 
doi:10.1109/access.2019.2949744 fatcat:pmn6l4zzffbk3fz34o2mchms3y

Free-living monitoring of Parkinson's disease: Lessons from the field

Silvia Del Din, Alan Godfrey, Claudia Mazzà, Sue Lord, Lynn Rochester
2016 Movement Disorders  
True passive 158 monitoring without patient input is as yet an area to be developed but remains the area of greatest 159 interest as it will give the most ecologically valid picture of motor symptom burden  ...  While 78 technology and design have advanced, algorithm development and data analysis have not kept pace. 79 Validity and reliability are paramount and inform accurate detection and monitoring of disease  ...  Acknowledgments 394 The authors would like to acknowledge Dr. Brook Galna for his support in editing Figure 1 . 395  ... 
doi:10.1002/mds.26718 pmid:27452964 fatcat:ae5gwmdy7nhf3mgana6bpyjsom

An Overview of Smart Shoes in the Internet of Health Things: Gait and Mobility Assessment in Health Promotion and Disease Monitoring

Bjoern Eskofier, Sunghoon Lee, Manuela Baron, André Simon, Christine Martindale, Heiko Gaßner, Jochen Klucken
2017 Applied Sciences  
Mobility monitoring technologies demand research in sensor-based data acquisition and its subsequent analysis to support objective and clinically relevant gait analysis outside of conventional clinical  ...  Thus, this paper aims to provide an overview of the important engineering aspects of smart-shoe applications in the field of IoHT.  ...  In this section, we provide an overview of concrete analysis methods that are relevant for both activity pattern and gait signature computation.  ... 
doi:10.3390/app7100986 fatcat:zw5pmendk5cppgchgzo4bcukxi

Biomarkers in Neurodegenerative Diseases: Proteomics Spotlight on ALS and Parkinson's Disease

Rekha Raghunathan, Kathleen Turajane, Li Chin Wong
2022 International Journal of Molecular Sciences  
Both diseases lack biomarkers for diagnosis and treatment efficacy.  ...  We compare relative and absolute quantitative proteomic approaches in key biomarker studies in ALS and PD and discuss recent technological advancements which may identify suitable biomarkers for the early-diagnosis  ...  Acknowledgments: The authors thank David Litwack and Benjamin Shykind for their valuable feedback on the manuscript.  ... 
doi:10.3390/ijms23169299 pmid:36012563 pmcid:PMC9409485 fatcat:6qexgdt2pvdvvhbj3yj3h3eq34

Viewpoint and practical recommendations from a movement disorder specialist panel on objective measurement in the clinical management of Parkinson's disease

Per Odin, K. Ray Chaudhuri, Jens Volkmann, Angelo Antonini, Alexander Storch, Espen Dietrichs, Zvezdan Pirtošek, Tove Henriksen, Malcolm Horne, David Devos, Filip Bergquist
2018 npj Parkinson's Disease  
ACKNOWLEDGEMENTS We thank Global Kinetic Corporation, Melbourne, Australia (manufacturer of the Parkinson's KinetiGraph TM [PKG TM ]) for providing financial assistance for the SP meetings and ESP Bioscience  ...  We also thank Professor Regina Katzenschlager (Department of Neurology and Karl Landsteiner Institute for Neuroimmunological and Neurodegenerative Disorders, Sozialmedizinisches Zen-  ...  INTRODUCTION Motor and non-motor fluctuations in Parkinson's disease (PD) are difficult to evaluate accurately, 1 and while scales such as the wearing-off scale 2 and Hauser diary provide an estimate  ... 
doi:10.1038/s41531-018-0051-7 pmid:29761156 pmcid:PMC5945844 fatcat:pidnb5s4mfdpbau5d5wvt6fjqy

Parkinson Disease, Movement Disorders and Dementia

2012 Basal Ganglia  
Catania, Catania Introduction: Fatigue is a common non-motor symptom in patients with Parkinson's Disease (PD) and one of the most disabling symptoms of this disease, as reported by patients, with serious  ...  The primary objectives included the evaluation of the incidence and severity of fatigue in PD patients measured by Parkinson Fatigue Scale (PFS-16) and assessment of its predisposing factors (age, gender  ...  SESSION 2 ''Molecular and clinical markers in Parkinson's disease: preclinical diagnosis and disease progression'' L4 Molecular markers in Parkinson's disease Paolo Calabresi Clinica Neurologica, Università  ... 
doi:10.1016/j.baga.2012.10.001 fatcat:tgb5tzfxqbeela4ufactz6hqfu
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