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GPCRDB information system for G protein-coupled receptors
2003
Nucleic Acids Research
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The GPCRDB is a molecular class-specific information system that collects, combines, validates and disseminates heterogeneous data on G proteincoupled receptors (GPCRs). ...
The GPCRDB is updated automatically once every 4-5 months and is freely accessible at ...
F.H. and F.E.C. acknowledge the NIH for support. ...
doi:10.1093/nar/gkg103
pmid:12520006
pmcid:PMC165550
fatcat:ainl4hz5nrd33awwog32akrrei
GPCRDB: information system for G protein-coupled receptors
2010
Nucleic Acids Research
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Recent developments in G protein-coupled receptor (GPCR) structural biology and pharmacology have greatly enhanced our knowledge of receptor structure-function relations, and have helped improve the scientific ...
foundation for drug design studies. ...
ACKNOWLEDGEMENT The COST Actional CM1207 'GLISTEN' has generously hosted the biannual GPCRdb meetings and supported multiple research visits. ...
doi:10.1093/nar/gkq1009
pmid:21045054
pmcid:PMC3013641
fatcat:osdipws46vbonmp4jphxsfzyxe
GPCRDB: an information system for G protein-coupled receptors
1998
Nucleic Acids Research
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Recent developments in G protein -coupled receptor (GPCR) structural biology and pharmacology have greatly enhanced our knowledge of receptor structure-function relations, and have helped improve the scientific ...
foundation for drug design studies. ...
ACKNOWLEDGEMENT The COST Actional CM1207 'GLISTEN' has generously hosted the biannual GPCRdb meetings and supported multiple research visits. ...
doi:10.1093/nar/26.1.275
pmid:9399852
pmcid:PMC147194
fatcat:yor7cqlgmjdwvjogxsfpwuay4q
GPCRdb: an information system for G protein-coupled receptors
2016
Nucleic Acids Research
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For the past 20 years, the GPCRDB (G proteincoupled receptors database; http://www.gpcr.org/ 7tm/) has been a 'one-stop shop' for G proteincoupled receptor (GPCR)-related data. ...
The GPCRDB also provides visualization and analysis tools, plus a number of query systems. ...
ACKNOWLEDGEMENTS
Andrius Senulis, Frantisek Sudzina and Magnus Vesterager Larsen are acknowledged for programming contributions and Kimberley Fidom for the annotation of GPCR crystal structures. ...
doi:10.1093/nar/gkw1218
pmid:27923934
pmcid:PMC5389621
fatcat:6tfaxevq2fewtfz73765zmpgie
GPCRdb: an information system for G protein-coupled receptors
2015
Nucleic Acids Research
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Recent developments in G protein-coupled receptor (GPCR) structural biology and pharmacology have greatly enhanced our knowledge of receptor structure-function relations, and have helped improve the scientific ...
foundation for drug design studies. ...
ACKNOWLEDGEMENT The COST Actional CM1207 'GLISTEN' has generously hosted the biannual GPCRdb meetings and supported multiple research visits. ...
doi:10.1093/nar/gkv1178
pmid:26582914
pmcid:PMC4702843
fatcat:ljkr6qpbm5fvrnlozadbfwntcm
GPCRDB: an information system for G protein-coupled receptors
2013
Nucleic Acids Research
Preserved Fulltext
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Recent developments in G protein-coupled receptor (GPCR) structural biology and pharmacology have greatly enhanced our knowledge of receptor structure-function relations, and have helped improve the scientific ...
foundation for drug design studies. ...
ACKNOWLEDGEMENT The COST Actional CM1207 'GLISTEN' has generously hosted the biannual GPCRdb meetings and supported multiple research visits. ...
doi:10.1093/nar/gkt1255
pmid:24304901
pmcid:PMC3965068
fatcat:rx7hy6i3rvdzdme3prj73erdk4
GPCRdb: the G protein-coupled receptor database - an introduction
2016
British Journal of Pharmacology
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Molecular
GPCRDB: an information system for G protein-coupled receptors. modelling of G protein-coupled receptors through the web. ...
GPCRdb: an information system for G protein-coupled
The authors declare no conflicts of interest. receptors. ...
doi:10.1111/bph.13509
pmid:27155948
pmcid:PMC4919580
fatcat:6ggwl72qrnam7l75j5gx5bjeim
Collecting and harvesting biological data: the GPCRDB and NucleaRDB information systems
2001
Nucleic Acids Research
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These are the GPCRDB and NucleaRDB information systems, which collect and disseminate data related to G protein-coupled receptors and intranuclear hormone receptors, respectively. ...
The NucleaRDB was started recently as an application of the concept for the generalization of this technology. ...
G protein-coupled receptors G protein-coupled receptors (GPCRs) consist of a single protein chain that crosses the membrane seven times. ...
doi:10.1093/nar/29.1.346
pmid:11125133
pmcid:PMC29816
fatcat:zupticzgifhuljearoncktv6wi
GPCRdb in 2021: integrating GPCR sequence, structure and function
2020
Nucleic Acids Research
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G protein-coupled receptors (GPCRs) form both the largest family of membrane proteins and drug targets, mediating the action of one-third of medicines. ...
GPCRdb contains all human non-olfactory GPCRs (and >27 000 orthologs), G-proteins and arrestins. ...
similarity, structure
superposition and site search
tools
GPCRdb: an information
system for G protein-coupled
receptors
Isberg V et al.
2016
Nucleic Acids Research
(33)
Structure constructs ...
doi:10.1093/nar/gkaa1080
pmid:33270898
fatcat:mh56tghzpjhtna3a4ddwrply4e
The design of query interfaces to the GPCRDB biological database
1999
Proceedings User Interfaces to Data Intensive Systems
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In this paper, we describe the query interfaces of a practical biological database system -GPCRDB. ...
Distinguishing features of the system include: an embedded smart query engine (for query relaxation), smooth integration of navigation with the more conventional SQL-based query mechanisms, and the top-down ...
The authors are very glad to acknowledge that Hannelore Eisner has did a lot of implementation work in the GPCRDB query system. ...
doi:10.1109/uidis.1999.791459
dblp:conf/uidis/CheAC99
fatcat:ceyv5e73sfalzb6u2argnyxeze
Coding GPCR-G protein specificity
2017
Cell Research
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These conformational differences may be important for differential G protein coupling and are likely to alter nucleotide exchange [9, 10] . ...
They use this interaction data to develop a footprint for GPCR residues that they propose to be involved in G protein binding selectivity, and this selectivity is informed by sequence comparison across ...
doi:10.1038/cr.2017.92
pmid:28695889
fatcat:ff65gkckrndzxitqinhhsvgrci
GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base
2010
Computer applications in the biosciences : CABIOS
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Rapid expansion of available data about G Protein Coupled Receptor (GPCR) dimers/oligomers over the past few years requires an effective system to organize this information electronically. ...
GPCR-OKB is a system that supports browsing and searching for GPCR oligomer data. Such data were manually derived from the literature. ...
We also thank Dr Andrea Bortolato for retrieving the first batch of relevant papers for system population. Conflict of Interest: none declared. ...
doi:10.1093/bioinformatics/btq264
pmid:20501551
pmcid:PMC2894509
fatcat:6x44wjbvurcfhlr3xo3k2uwaoy
Integrating GPCR-specific information with full text articles
2011
BMC Bioinformatics
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With the continued growth in the volume both of experimental G protein-coupled receptor (GPCR) data and of the related peer-reviewed literature, the ability of GPCR researchers to keep up-to-date is becoming ...
Results: We present work that integrates the biological data and annotations in the GPCR information system (GPCRDB) with next-generation methods for intelligently exploring, visualising and interacting ...
We thank Rob Leurs for stimulating discussions. ...
doi:10.1186/1471-2105-12-362
pmid:21910883
pmcid:PMC3179973
fatcat:uwv5xwkkcjh7hposn2a2s6qpja
GPCR-PEnDB: a database of protein sequences and derived features to facilitate prediction and classification of G protein-coupled receptors
2020
Database: The Journal of Biological Databases and Curation
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G protein-coupled receptors (GPCRs) constitute the largest group of membrane receptor proteins in eukaryotes. ...
Each protein is linked to information about its source organism, classification, sequence lengths and composition, and other derived sequence features. ...
Acknowledgements The authors thank Anastasia Kellogg and Kyle Long for their contributions to the initial data collection and the preliminary design of the database and Gerardo Cardenas for his help with ...
doi:10.1093/database/baaa087
pmid:33216895
pmcid:PMC7678784
fatcat:tq6n2erlazgkbik76adagqvhb4
Coevolution underlies GPCR-G protein selectivity and functionality
2021
Scientific Reports
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AbstractG protein-coupled receptors (GPCRs) regulate diverse physiological events, which makes them as the major targets for many approved drugs. ...
HTR, DAR) and Gα proteins with a coevolutionary tool, statistical coupling analysis. ...
We used multiple sequence alignments from GPCRdb because they provide well-labeled alignments using the Generic-GPCRdb numbering system by each receptor 16 . ...
doi:10.1038/s41598-021-87251-6
pmid:33846507
fatcat:l6rxanvk5zatvpblw46a3azn3u
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