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GPCRDB information system for G protein-coupled receptors

F. Horn
2003 Nucleic Acids Research  
The GPCRDB is a molecular class-specific information system that collects, combines, validates and disseminates heterogeneous data on G proteincoupled receptors (GPCRs).  ...  The GPCRDB is updated automatically once every 4-5 months and is freely accessible at  ...  F.H. and F.E.C. acknowledge the NIH for support.  ... 
doi:10.1093/nar/gkg103 pmid:12520006 pmcid:PMC165550 fatcat:ainl4hz5nrd33awwog32akrrei

GPCRDB: information system for G protein-coupled receptors

B. Vroling, M. Sanders, C. Baakman, A. Borrmann, S. Verhoeven, J. Klomp, L. Oliveira, J. de Vlieg, G. Vriend
2010 Nucleic Acids Research  
Recent developments in G protein-coupled receptor (GPCR) structural biology and pharmacology have greatly enhanced our knowledge of receptor structure-function relations, and have helped improve the scientific  ...  foundation for drug design studies.  ...  ACKNOWLEDGEMENT The COST Actional CM1207 'GLISTEN' has generously hosted the biannual GPCRdb meetings and supported multiple research visits.  ... 
doi:10.1093/nar/gkq1009 pmid:21045054 pmcid:PMC3013641 fatcat:osdipws46vbonmp4jphxsfzyxe

GPCRDB: an information system for G protein-coupled receptors

F Horn
1998 Nucleic Acids Research  
Recent developments in G protein -coupled receptor (GPCR) structural biology and pharmacology have greatly enhanced our knowledge of receptor structure-function relations, and have helped improve the scientific  ...  foundation for drug design studies.  ...  ACKNOWLEDGEMENT The COST Actional CM1207 'GLISTEN' has generously hosted the biannual GPCRdb meetings and supported multiple research visits.  ... 
doi:10.1093/nar/26.1.275 pmid:9399852 pmcid:PMC147194 fatcat:yor7cqlgmjdwvjogxsfpwuay4q

GPCRdb: an information system for G protein-coupled receptors

Vignir Isberg, Stefan Mordalski, Christian Munk, Krzysztof Rataj, Kasper Harpsøe, Alexander S. Hauser, Bas Vroling, Andrzej J. Bojarski, Gert Vriend, David E. Gloriam
2016 Nucleic Acids Research  
For the past 20 years, the GPCRDB (G proteincoupled receptors database; http://www.gpcr.org/ 7tm/) has been a 'one-stop shop' for G proteincoupled receptor (GPCR)-related data.  ...  The GPCRDB also provides visualization and analysis tools, plus a number of query systems.  ...  ACKNOWLEDGEMENTS Andrius Senulis, Frantisek Sudzina and Magnus Vesterager Larsen are acknowledged for programming contributions and Kimberley Fidom for the annotation of GPCR crystal structures.  ... 
doi:10.1093/nar/gkw1218 pmid:27923934 pmcid:PMC5389621 fatcat:6tfaxevq2fewtfz73765zmpgie

GPCRdb: an information system for G protein-coupled receptors

Vignir Isberg, Stefan Mordalski, Christian Munk, Krzysztof Rataj, Kasper Harpsøe, Alexander S. Hauser, Bas Vroling, Andrzej J. Bojarski, Gert Vriend, David E. Gloriam
2015 Nucleic Acids Research  
Recent developments in G protein-coupled receptor (GPCR) structural biology and pharmacology have greatly enhanced our knowledge of receptor structure-function relations, and have helped improve the scientific  ...  foundation for drug design studies.  ...  ACKNOWLEDGEMENT The COST Actional CM1207 'GLISTEN' has generously hosted the biannual GPCRdb meetings and supported multiple research visits.  ... 
doi:10.1093/nar/gkv1178 pmid:26582914 pmcid:PMC4702843 fatcat:ljkr6qpbm5fvrnlozadbfwntcm

GPCRDB: an information system for G protein-coupled receptors

Vignir Isberg, Bas Vroling, Rob van der Kant, Kang Li, Gert Vriend, David Gloriam
2013 Nucleic Acids Research  
Recent developments in G protein-coupled receptor (GPCR) structural biology and pharmacology have greatly enhanced our knowledge of receptor structure-function relations, and have helped improve the scientific  ...  foundation for drug design studies.  ...  ACKNOWLEDGEMENT The COST Actional CM1207 'GLISTEN' has generously hosted the biannual GPCRdb meetings and supported multiple research visits.  ... 
doi:10.1093/nar/gkt1255 pmid:24304901 pmcid:PMC3965068 fatcat:rx7hy6i3rvdzdme3prj73erdk4

GPCRdb: the G protein-coupled receptor database - an introduction

C Munk, V Isberg, S Mordalski, K Harpsøe, K Rataj, A S Hauser, P Kolb, A J Bojarski, G Vriend, D E Gloriam
2016 British Journal of Pharmacology  
Molecular GPCRDB: an information system for G protein-coupled receptors. modelling of G protein-coupled receptors through the web.  ...  GPCRdb: an information system for G protein-coupled The authors declare no conflicts of interest. receptors.  ... 
doi:10.1111/bph.13509 pmid:27155948 pmcid:PMC4919580 fatcat:6ggwl72qrnam7l75j5gx5bjeim

Collecting and harvesting biological data: the GPCRDB and NucleaRDB information systems

F. Horn
2001 Nucleic Acids Research  
These are the GPCRDB and NucleaRDB information systems, which collect and disseminate data related to G protein-coupled receptors and intranuclear hormone receptors, respectively.  ...  The NucleaRDB was started recently as an application of the concept for the generalization of this technology.  ...  G protein-coupled receptors G protein-coupled receptors (GPCRs) consist of a single protein chain that crosses the membrane seven times.  ... 
doi:10.1093/nar/29.1.346 pmid:11125133 pmcid:PMC29816 fatcat:zupticzgifhuljearoncktv6wi

GPCRdb in 2021: integrating GPCR sequence, structure and function

Albert J Kooistra, Stefan Mordalski, Gáspár Pándy-Szekeres, Mauricio Esguerra, Alibek Mamyrbekov, Christian Munk, György M Keserű, David E Gloriam
2020 Nucleic Acids Research  
G protein-coupled receptors (GPCRs) form both the largest family of membrane proteins and drug targets, mediating the action of one-third of medicines.  ...  GPCRdb contains all human non-olfactory GPCRs (and >27 000 orthologs), G-proteins and arrestins.  ...  similarity, structure superposition and site search tools GPCRdb: an information system for G protein-coupled receptors Isberg V et al. 2016 Nucleic Acids Research (33) Structure constructs  ... 
doi:10.1093/nar/gkaa1080 pmid:33270898 fatcat:mh56tghzpjhtna3a4ddwrply4e

The design of query interfaces to the GPCRDB biological database

D. Che, K. Aberer, Y. Chen
1999 Proceedings User Interfaces to Data Intensive Systems  
In this paper, we describe the query interfaces of a practical biological database system -GPCRDB.  ...  Distinguishing features of the system include: an embedded smart query engine (for query relaxation), smooth integration of navigation with the more conventional SQL-based query mechanisms, and the top-down  ...  The authors are very glad to acknowledge that Hannelore Eisner has did a lot of implementation work in the GPCRDB query system.  ... 
doi:10.1109/uidis.1999.791459 dblp:conf/uidis/CheAC99 fatcat:ceyv5e73sfalzb6u2argnyxeze

Coding GPCR-G protein specificity

Sebastian GB Furness, Patrick M Sexton
2017 Cell Research  
These conformational differences may be important for differential G protein coupling and are likely to alter nucleotide exchange [9, 10] .  ...  They use this interaction data to develop a footprint for GPCR residues that they propose to be involved in G protein binding selectivity, and this selectivity is informed by sequence comparison across  ... 
doi:10.1038/cr.2017.92 pmid:28695889 fatcat:ff65gkckrndzxitqinhhsvgrci

GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base

George Khelashvili, Kevin Dorff, Jufang Shan, Marta Camacho-Artacho, Lucy Skrabanek, Bas Vroling, Michel Bouvier, Lakshmi A. Devi, Susan R. George, Jonathan A. Javitch, Martin J. Lohse, Graeme Milligan (+7 others)
2010 Computer applications in the biosciences : CABIOS  
Rapid expansion of available data about G Protein Coupled Receptor (GPCR) dimers/oligomers over the past few years requires an effective system to organize this information electronically.  ...  GPCR-OKB is a system that supports browsing and searching for GPCR oligomer data. Such data were manually derived from the literature.  ...  We also thank Dr Andrea Bortolato for retrieving the first batch of relevant papers for system population. Conflict of Interest: none declared.  ... 
doi:10.1093/bioinformatics/btq264 pmid:20501551 pmcid:PMC2894509 fatcat:6x44wjbvurcfhlr3xo3k2uwaoy

Integrating GPCR-specific information with full text articles

Bas Vroling, David Thorne, Philip McDermott, Teresa K Attwood, Gert Vriend, Steve Pettifer
2011 BMC Bioinformatics  
With the continued growth in the volume both of experimental G protein-coupled receptor (GPCR) data and of the related peer-reviewed literature, the ability of GPCR researchers to keep up-to-date is becoming  ...  Results: We present work that integrates the biological data and annotations in the GPCR information system (GPCRDB) with next-generation methods for intelligently exploring, visualising and interacting  ...  We thank Rob Leurs for stimulating discussions.  ... 
doi:10.1186/1471-2105-12-362 pmid:21910883 pmcid:PMC3179973 fatcat:uwv5xwkkcjh7hposn2a2s6qpja

GPCR-PEnDB: a database of protein sequences and derived features to facilitate prediction and classification of G protein-coupled receptors

Khodeza Begum, Jonathon E Mohl, Fredrick Ayivor, Eder E Perez, Ming-Ying Leung
2020 Database: The Journal of Biological Databases and Curation  
G protein-coupled receptors (GPCRs) constitute the largest group of membrane receptor proteins in eukaryotes.  ...  Each protein is linked to information about its source organism, classification, sequence lengths and composition, and other derived sequence features.  ...  Acknowledgements The authors thank Anastasia Kellogg and Kyle Long for their contributions to the initial data collection and the preliminary design of the database and Gerardo Cardenas for his help with  ... 
doi:10.1093/database/baaa087 pmid:33216895 pmcid:PMC7678784 fatcat:tq6n2erlazgkbik76adagqvhb4

Coevolution underlies GPCR-G protein selectivity and functionality

Min Jae Seo, Joongyu Heo, Kyunghui Kim, Ka Young Chung, Wookyung Yu
2021 Scientific Reports  
AbstractG protein-coupled receptors (GPCRs) regulate diverse physiological events, which makes them as the major targets for many approved drugs.  ...  HTR, DAR) and Gα proteins with a coevolutionary tool, statistical coupling analysis.  ...  We used multiple sequence alignments from GPCRdb because they provide well-labeled alignments using the Generic-GPCRdb numbering system by each receptor 16 .  ... 
doi:10.1038/s41598-021-87251-6 pmid:33846507 fatcat:l6rxanvk5zatvpblw46a3azn3u
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