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GABA levels are differentially associated with bimanual motor performance in older as compared to young adults
2021
NeuroImage
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Moreover, GABA levels across the motor network and DLPFC were differentially associated with performance in young as opposed to older adults on a manual dexterity and bimanual coordination task but not ...
Results indicated that older adults, as compared to their younger counterparts, performed worse on all bimanual tasks and exhibited lower GABA levels in bilateral SM1 only. ...
differentially predicted performance in young as compared to older adults. ...
doi:10.1016/j.neuroimage.2021.117871
pmid:33607278
pmcid:PMC8275071
fatcat:xvxtngkdobdn7pvgki2sj7d7oq
Age Differences in Interhemispheric Interactions: Callosal Structure, Physiological Function, and Behavior
2011
Frontiers in Neuroscience
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There is a fundamental gap in understanding how brain structural and functional network connectivity are interrelated, how they change with age, and how such changes contribute to older adults' sensorimotor ...
Declines in corpus callosum size and microstructure with advancing age have been well documented, but their contributions to age deficits in unimanual and bimanual function are not well defined. ...
As proposed in the HAROLD model, older adults exhibit cortical over-activation relative to young adults when performing motor tasks. ...
doi:10.3389/fnins.2011.00038
pmid:21519384
pmcid:PMC3077973
fatcat:uvler7omingxxphqvqzwwgv224
The role of MRS-assessed GABA in human behavioral performance
2022
Progress in Neurobiology
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Converging evidence from both animal and human studies indicates that individual variations in GABAergic function are associated with behavioral performance. ...
Nonetheless, additional studies using emerging advanced methods are required to further clarify the role of MRS-assessed GABA in behavioral performance. ...
Thus, the GABA-behavior association may differ between young and older adults as higher overall GABA levels seem to show positive associations with performance in older adults while positive as well as ...
doi:10.1016/j.pneurobio.2022.102247
pmid:35149113
fatcat:3lcoaxvwkbe5lgw44dxf2s3qpq
Sensorimotor network segregation declines with age and is linked to GABA and to sensorimotor performance
2019
NeuroImage
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Second, less segregated networks are associated with lower GABA levels. Third, less segregated networks and lower GABA levels are associated with worse sensorimotor performance. ...
For example, compared to young adults, older adults typically exhibit weaker functional connectivity within the same functional network but stronger functional connectivity between different networks. ...
with poorer bimanual motor performance (King et al., 2018) . ...
doi:10.1016/j.neuroimage.2018.11.008
pmid:30414983
pmcid:PMC6338503
fatcat:zvi5fz2qqvfhhpd5dwutomjucm
Age-Related Reductions in Tactile and Motor Inhibitory Function Start Early but Are Independent
2019
Frontiers in Aging Neuroscience
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Here we examined whether tactile surround inhibition also changes with age and whether these changes are associated with those in the motor domain. ...
Aging is associated with declines in motor and somatosensory function. Some of these motor declines have been linked to age-related reductions in inhibitory function. ...
ACKNOWLEDGMENTS We would like to thank Jameson Holden for providing technical assistance with the vibrotactile stimulation device, Kyle Latack for assistance with data collection, and Thad Polk for helpful ...
doi:10.3389/fnagi.2019.00193
pmid:31417396
pmcid:PMC6682653
fatcat:neypqak2vbglzgtlxx437tqdhm
Age-Related Changes in Frontal Network Structural and Functional Connectivity in Relation to Bimanual Movement Control
2016
Journal of Neuroscience
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Compared with young adults, older adults showed performance declines in the more difficult bimanual conditions, less optimal brain white matter (WM) microstructure, and a decreased ability to regulate ...
Changes in both brain structure and neurophysiological function regulating homotopic as well as heterotopic interhemispheric interactions (IHIs) are assumed to be responsible for the bimanual performance ...
Changes in DLPFC-M1 interaction are associated with declined bimanual movement in older adults In contrast to PMd-M1 IHI, older adults failed to show any taskrelated modulations in the DLPFC-M1 IHI, whereas ...
doi:10.1523/jneurosci.3355-15.2016
pmid:26865607
pmcid:PMC6602021
fatcat:i5zw76ldpbe2vc5shmijsrehwm
Aging alters the mediating effect of endogenous GABA on the interaction between functional connectivity and motor-state transitions
[article]
2020
bioRxiv
pre-print
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Specifically, relatively lower GABA was more beneficial for the connectivity-behavior association in the young, whereas the older showed a beneficial behavioral effect in the presence of higher GABA given ...
the specificity of the indirect effect of GABA concentration as measured with magnetic resonance spectroscopy. ...
Acknowledgments We thank René Clerckx for software and technical support and Paul Meugens for technical support and skillful building the technical equipment, and all volunteers for their motivation to ...
doi:10.1101/2020.10.08.331637
fatcat:p4aud2oq3jd7dogt2yqwyxro7a
Baseline sensorimotor GABA levels shape neuroplastic processes induced by motor learning in older adults
2020
Human Brain Mapping
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These data collectively indicate that motor learning-related decreases in sensorimotor GABA levels and increases in functional connectivity are limited to those older adults with higher baseline GABA levels ...
Previous research in young adults has demonstrated that both motor learning and transcranial direct current stimulation (tDCS) trigger decreases in the levels of gamma-aminobutyric acid (GABA) in the sensorimotor ...
These data collectively indicate that motor learning-related decreases in sensorimotor GABA levels and increases in functional connectivity are limited to those older adults with higher baseline GABA levels ...
doi:10.1002/hbm.25041
pmid:32583940
pmcid:PMC7416055
fatcat:affqfagp5ngxhmqjrg57mxdyhm
Premotor-Motor Interhemispheric Inhibition Is Released during Movement Initiation in Older but Not Young Adults
2012
PLoS ONE
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Thirteen young (mean age 22.2 years) and thirteen older (68.5 years) adults rapidly abducted their left index finger as soon as possible in response to a visual imperative signal, presented 500 ms after ...
Here we investigated whether healthy ageing is associated with a change in functional connectivity, as indicated by the ability to modulate interhemispheric interactions during movement preparation in ...
Acknowledgments The authors would like to thank Dr Michael Garry for insightful conversations and two anonymous reviewers for their comments.
Author Contributions ...
doi:10.1371/journal.pone.0052573
pmid:23285097
pmcid:PMC3526571
fatcat:ryokdio4anhvho2jegrm4vtgji
Bimanual digit training improves right-hand dexterity in older adults by reactivating declined ipsilateral motor-cortical inhibition
[article]
2021
bioRxiv
pre-print
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The capability of the brain to inhibit ipsilateral motor-cortical activity during a simple right-hand sensory-motor task is tightly related to right-hand dexterity in older adults. ...
Previous studies suggested that the declined interhemispheric sensorimotor inhibition observed in older adults is associated with their deteriorated hand/finger dexterity. ...
Acknowledgments The authors are grateful to Ms. Chie Kawakami and Ms. Keiko Ueyama and the CiNet technical staff for their support during the study. ...
doi:10.1101/2021.05.21.445083
fatcat:oqv5sktm6rcxth4dgwvhd74xqy
Brain plasticity in health and disease
2004
The Keio Journal of Medicine
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There is evidence that frequent participation in challenging and stimulating activities is associated with reduced cognitive decline during aging. ...
dystonia as well as in sensory re-education after nerve repair in hand surgery. ...
One difference was a bilateral activity in prefrontal regions in the older subjects compared to a left activation in young.216 More bilateral patterns of prefrontal activity in older adults than in younger ...
doi:10.2302/kjm.53.231
pmid:15647628
fatcat:6qj7fpd4d5fprnpfwigg5zxp2i
Handedness Development: A Model for Investigating the Development of Hemispheric Specialization and Interhemispheric Coordination
2021
Symmetry
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The author's work on the development of early handedness is reviewed and placed within a context of cascading events in which different forms of handedness emerge from earlier forms but not in a deterministic ...
Finally, the relation of the development of handedness to the development of several language and cognitive skills is examined. ...
in the various studies conducted by the author and colleagues. ...
doi:10.3390/sym13060992
fatcat:4zkqgp55dbeqld6ouslzq65wju
Long-Term Effects of Sports Concussions: Bridging the Neurocognitive Repercussions of the Injury with the Newest Neuroimaging Data
2016
The Neuroscientist
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Furthermore, subclinical, neurophysiological alterations found in young concussed athletes were exacerbated in former athletes with concussions who displayed quantifiable cognitive and motor functions ...
Moreover, findings from the present thesis indicate that the deleterious effects of sports concussion on cognitive and motor system functions combined to those associated with the aging process lead to ...
These findings suggest that high performing older adults managed the task by a compensatory neural mechanism associated with the allocation of more resources, as indexed by greater P300 component amplitude ...
doi:10.1177/1073858416651034
pmid:27188455
fatcat:z3o3edjdd5bxvbxnrflf7mmv4a
Impact of Peripheral Nerve Injury on Sensorimotor Control
2005
Journal of Hand Therapy
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essential tasks and activities.
282 JOURNAL OF HAND THERAPY
Problems associated with each level of this approach are reviewed in Table 2. ...
Degrees of
April-June 2005 277
freedom are the number of independent elements available to perform a motor task, such as joint motion, muscles, motor units, or neural ensembles. ...
doi:10.1197/j.jht.2005.02.007
pmid:15891985
fatcat:arhhesjtpzerpamdxxbn5mcv6u
Final Program Forty First Annual Meeting International Neuropsychological Society February 6–9, 2013 Waikoloa, Hawaii, USA
2013
Journal of the International Neuropsychological Society
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The organizers of this course will first review the principles and technical issues involved in several neuroimaging techniques that are used to study these alterations in vivo. ...
Learning Objectives: 1) Describe the basic principles of the neuroimaging techniques used in the clinical and the research settings, as well as some technical limitations in the use of these techniques ...
, in healthy older adults compared to healthy young adults. ...
doi:10.1017/s1355617713000362
fatcat:4bgx6f2nwfhd7fwsgabtjpdr4a
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