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GABA levels are differentially associated with bimanual motor performance in older as compared to young adults

Celine Maes, Koen Cuypers, Kirstin-Friederike Heise, Richard A E Edden, Jolien Gooijers, Stephan P Swinnen
2021 NeuroImage  
Moreover, GABA levels across the motor network and DLPFC were differentially associated with performance in young as opposed to older adults on a manual dexterity and bimanual coordination task but not  ...  Results indicated that older adults, as compared to their younger counterparts, performed worse on all bimanual tasks and exhibited lower GABA levels in bilateral SM1 only.  ...  differentially predicted performance in young as compared to older adults.  ... 
doi:10.1016/j.neuroimage.2021.117871 pmid:33607278 pmcid:PMC8275071 fatcat:xvxtngkdobdn7pvgki2sj7d7oq

Age Differences in Interhemispheric Interactions: Callosal Structure, Physiological Function, and Behavior

Brett W. Fling, Scott J. Peltier, Jin Bo, Robert C. Welsh, Rachael D. Seidler
2011 Frontiers in Neuroscience  
There is a fundamental gap in understanding how brain structural and functional network connectivity are interrelated, how they change with age, and how such changes contribute to older adults' sensorimotor  ...  Declines in corpus callosum size and microstructure with advancing age have been well documented, but their contributions to age deficits in unimanual and bimanual function are not well defined.  ...  As proposed in the HAROLD model, older adults exhibit cortical over-activation relative to young adults when performing motor tasks.  ... 
doi:10.3389/fnins.2011.00038 pmid:21519384 pmcid:PMC3077973 fatcat:uvler7omingxxphqvqzwwgv224

The role of MRS-assessed GABA in human behavioral performance

Hong Li, Kirstin-Friederike Heise, Sima Chalavi, Nicolaas A.J. Puts, Richard A.E. Edden, Stephan P. Swinnen
2022 Progress in Neurobiology  
Converging evidence from both animal and human studies indicates that individual variations in GABAergic function are associated with behavioral performance.  ...  Nonetheless, additional studies using emerging advanced methods are required to further clarify the role of MRS-assessed GABA in behavioral performance.  ...  Thus, the GABA-behavior association may differ between young and older adults as higher overall GABA levels seem to show positive associations with performance in older adults while positive as well as  ... 
doi:10.1016/j.pneurobio.2022.102247 pmid:35149113 fatcat:3lcoaxvwkbe5lgw44dxf2s3qpq

Sensorimotor network segregation declines with age and is linked to GABA and to sensorimotor performance

Kaitlin Cassady, Holly Gagnon, Poortata Lalwani, Molly Simmonite, Bradley Foerster, Denise Park, Scott J. Peltier, Myria Petrou, Stephan F. Taylor, Daniel H. Weissman, Rachael D. Seidler, Thad A. Polk
2019 NeuroImage  
Second, less segregated networks are associated with lower GABA levels. Third, less segregated networks and lower GABA levels are associated with worse sensorimotor performance.  ...  For example, compared to young adults, older adults typically exhibit weaker functional connectivity within the same functional network but stronger functional connectivity between different networks.  ...  with poorer bimanual motor performance (King et al., 2018) .  ... 
doi:10.1016/j.neuroimage.2018.11.008 pmid:30414983 pmcid:PMC6338503 fatcat:zvi5fz2qqvfhhpd5dwutomjucm

Age-Related Reductions in Tactile and Motor Inhibitory Function Start Early but Are Independent

Marit F. L. Ruitenberg, Kaitlin E. Cassady, Patricia A. Reuter-Lorenz, Mark Tommerdahl, Rachael D. Seidler
2019 Frontiers in Aging Neuroscience  
Here we examined whether tactile surround inhibition also changes with age and whether these changes are associated with those in the motor domain.  ...  Aging is associated with declines in motor and somatosensory function. Some of these motor declines have been linked to age-related reductions in inhibitory function.  ...  ACKNOWLEDGMENTS We would like to thank Jameson Holden for providing technical assistance with the vibrotactile stimulation device, Kyle Latack for assistance with data collection, and Thad Polk for helpful  ... 
doi:10.3389/fnagi.2019.00193 pmid:31417396 pmcid:PMC6682653 fatcat:neypqak2vbglzgtlxx437tqdhm

Age-Related Changes in Frontal Network Structural and Functional Connectivity in Relation to Bimanual Movement Control

H. Fujiyama, J. Van Soom, G. Rens, J. Gooijers, I. Leunissen, O. Levin, S. P. Swinnen
2016 Journal of Neuroscience  
Compared with young adults, older adults showed performance declines in the more difficult bimanual conditions, less optimal brain white matter (WM) microstructure, and a decreased ability to regulate  ...  Changes in both brain structure and neurophysiological function regulating homotopic as well as heterotopic interhemispheric interactions (IHIs) are assumed to be responsible for the bimanual performance  ...  Changes in DLPFC-M1 interaction are associated with declined bimanual movement in older adults In contrast to PMd-M1 IHI, older adults failed to show any taskrelated modulations in the DLPFC-M1 IHI, whereas  ... 
doi:10.1523/jneurosci.3355-15.2016 pmid:26865607 pmcid:PMC6602021 fatcat:i5zw76ldpbe2vc5shmijsrehwm

Aging alters the mediating effect of endogenous GABA on the interaction between functional connectivity and motor-state transitions [article]

Kirstin-Friederike Heise, Laura Milena Rueda Delgado, Sima Chalavi, Bradley Ross King, Thiago Santos Monteiro, Richard A.E. Edden, Dante Mantini, Stephan P. Swinnen
2020 bioRxiv   pre-print
Specifically, relatively lower GABA was more beneficial for the connectivity-behavior association in the young, whereas the older showed a beneficial behavioral effect in the presence of higher GABA given  ...  the specificity of the indirect effect of GABA concentration as measured with magnetic resonance spectroscopy.  ...  Acknowledgments We thank René Clerckx for software and technical support and Paul Meugens for technical support and skillful building the technical equipment, and all volunteers for their motivation to  ... 
doi:10.1101/2020.10.08.331637 fatcat:p4aud2oq3jd7dogt2yqwyxro7a

Baseline sensorimotor GABA levels shape neuroplastic processes induced by motor learning in older adults

Bradley R. King, Jost‐Julian Rumpf, Elvire Verbaanderd, Kirstin F. Heise, Nina Dolfen, Stefan Sunaert, Julien Doyon, Joseph Classen, Dante Mantini, Nicolaas A. J. Puts, Richard A. E. Edden, Geneviève Albouy (+1 others)
2020 Human Brain Mapping  
These data collectively indicate that motor learning-related decreases in sensorimotor GABA levels and increases in functional connectivity are limited to those older adults with higher baseline GABA levels  ...  Previous research in young adults has demonstrated that both motor learning and transcranial direct current stimulation (tDCS) trigger decreases in the levels of gamma-aminobutyric acid (GABA) in the sensorimotor  ...  These data collectively indicate that motor learning-related decreases in sensorimotor GABA levels and increases in functional connectivity are limited to those older adults with higher baseline GABA levels  ... 
doi:10.1002/hbm.25041 pmid:32583940 pmcid:PMC7416055 fatcat:affqfagp5ngxhmqjrg57mxdyhm

Premotor-Motor Interhemispheric Inhibition Is Released during Movement Initiation in Older but Not Young Adults

Mark R. Hinder, Hakuei Fujiyama, Jeffery J. Summers, Esteban Andres Fridman
2012 PLoS ONE  
Thirteen young (mean age 22.2 years) and thirteen older (68.5 years) adults rapidly abducted their left index finger as soon as possible in response to a visual imperative signal, presented 500 ms after  ...  Here we investigated whether healthy ageing is associated with a change in functional connectivity, as indicated by the ability to modulate interhemispheric interactions during movement preparation in  ...  Acknowledgments The authors would like to thank Dr Michael Garry for insightful conversations and two anonymous reviewers for their comments. Author Contributions  ... 
doi:10.1371/journal.pone.0052573 pmid:23285097 pmcid:PMC3526571 fatcat:ryokdio4anhvho2jegrm4vtgji

Bimanual digit training improves right-hand dexterity in older adults by reactivating declined ipsilateral motor-cortical inhibition [article]

Eiichi Naito, Tomoyo Morita, Satoshi Hirose, Nodoka Kimura, Hideya Okamoto, Chikako Kamimukai, Minoru Asada
2021 bioRxiv   pre-print
The capability of the brain to inhibit ipsilateral motor-cortical activity during a simple right-hand sensory-motor task is tightly related to right-hand dexterity in older adults.  ...  Previous studies suggested that the declined interhemispheric sensorimotor inhibition observed in older adults is associated with their deteriorated hand/finger dexterity.  ...  Acknowledgments The authors are grateful to Ms. Chie Kawakami and Ms. Keiko Ueyama and the CiNet technical staff for their support during the study.  ... 
doi:10.1101/2021.05.21.445083 fatcat:oqv5sktm6rcxth4dgwvhd74xqy

Brain plasticity in health and disease

Barbro B Johansson
2004 The Keio Journal of Medicine  
There is evidence that frequent participation in challenging and stimulating activities is associated with reduced cognitive decline during aging.  ...  dystonia as well as in sensory re-education after nerve repair in hand surgery.  ...  One difference was a bilateral activity in prefrontal regions in the older subjects compared to a left activation in young.216 More bilateral patterns of prefrontal activity in older adults than in younger  ... 
doi:10.2302/kjm.53.231 pmid:15647628 fatcat:6qj7fpd4d5fprnpfwigg5zxp2i

Handedness Development: A Model for Investigating the Development of Hemispheric Specialization and Interhemispheric Coordination

George F. Michel
2021 Symmetry  
The author's work on the development of early handedness is reviewed and placed within a context of cascading events in which different forms of handedness emerge from earlier forms but not in a deterministic  ...  Finally, the relation of the development of handedness to the development of several language and cognitive skills is examined.  ...  in the various studies conducted by the author and colleagues.  ... 
doi:10.3390/sym13060992 fatcat:4zkqgp55dbeqld6ouslzq65wju

Long-Term Effects of Sports Concussions: Bridging the Neurocognitive Repercussions of the Injury with the Newest Neuroimaging Data

Luke C. Henry, Sebastien Tremblay, Louis De Beaumont
2016 The Neuroscientist  
Furthermore, subclinical, neurophysiological alterations found in young concussed athletes were exacerbated in former athletes with concussions who displayed quantifiable cognitive and motor functions  ...  Moreover, findings from the present thesis indicate that the deleterious effects of sports concussion on cognitive and motor system functions combined to those associated with the aging process lead to  ...  These findings suggest that high performing older adults managed the task by a compensatory neural mechanism associated with the allocation of more resources, as indexed by greater P300 component amplitude  ... 
doi:10.1177/1073858416651034 pmid:27188455 fatcat:z3o3edjdd5bxvbxnrflf7mmv4a

Impact of Peripheral Nerve Injury on Sensorimotor Control

Susan V. Duff
2005 Journal of Hand Therapy  
essential tasks and activities. 282 JOURNAL OF HAND THERAPY Problems associated with each level of this approach are reviewed in Table 2.  ...  Degrees of April-June 2005 277 freedom are the number of independent elements available to perform a motor task, such as joint motion, muscles, motor units, or neural ensembles.  ... 
doi:10.1197/j.jht.2005.02.007 pmid:15891985 fatcat:arhhesjtpzerpamdxxbn5mcv6u

Final Program Forty First Annual Meeting International Neuropsychological Society February 6–9, 2013 Waikoloa, Hawaii, USA

2013 Journal of the International Neuropsychological Society  
The organizers of this course will first review the principles and technical issues involved in several neuroimaging techniques that are used to study these alterations in vivo.  ...  Learning Objectives: 1) Describe the basic principles of the neuroimaging techniques used in the clinical and the research settings, as well as some technical limitations in the use of these techniques  ...  , in healthy older adults compared to healthy young adults.  ... 
doi:10.1017/s1355617713000362 fatcat:4bgx6f2nwfhd7fwsgabtjpdr4a
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