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The Role of Advanced Magnetic Resonance Imaging Techniques in Multiple Sclerosis Clinical Trials

Kedar R. Mahajan, Daniel Ontaneda
2017 Neurotherapeutics  
The current landscape of multiple sclerosis clinical trials is currently expanding to include testing not only of anti-inflammatory agents, but also neuroprotective, remyelinating, neuromodulating, and  ...  , glial activity, and demyelination.  ...  Cerebrospinal fluid levels of neurofilament and tau correlate with brain atrophy in natalizumab-treated multiple sclerosis. Eur J Neurol 2017;24(1): 112-121. 14.  ... 
doi:10.1007/s13311-017-0561-8 pmid:28770481 fatcat:nwefozrjtjafngwma3aibamu3a

Advanced MRI in Multiple Sclerosis: Current Status and Future Challenges

Robert J. Fox, Erik Beall, Pallab Bhattacharyya, Jacqueline T. Chen, Ken Sakaie
2011 Neurologic clinics  
Although atrophy correlates only modestly with existing clinical disability, progression of atrophy more strongly predicts later disability progression. 61 MS therapies might also impact the progression  ...  Synopsis Magnetic resonance imaging (MRI) has rapidly become a leading research tool in the study of multiple sclerosis (MS).  ...  Acknowledgments This work was supported by RG RG 4091A3/1 (RJF), RG 3751B2 (EB), RG 3753A1/2 PB) from the National MS Society, and R21 EB005302-02 (PB).  ... 
doi:10.1016/j.ncl.2010.12.011 pmid:21439446 pmcid:PMC3073625 fatcat:scd6lbjc3faulm7htr2573wpcm

Advanced magnetic resonance imaging techniques to better understand multiple sclerosis

Wafaa Zaaraoui, Bertrand Audoin, Jean Pelletier, Patrick J. Cozzone, Jean-Philippe Ranjeva
2010 Biophysical Reviews  
Magnetic resonance imaging (MRI) has considerably improved the diagnosis and monitoring of multiple sclerosis (MS).  ...  Conventional MRI such as T 2 -weighted and gadolinium-enhanced T 1 -weighted sequences detect focal lesions of the white matter, damage of the blood-brain barrier, and tissue loss and inflammatory activity  ...  of multiple sclerosis.  ... 
doi:10.1007/s12551-010-0031-6 pmid:28510010 pmcid:PMC5425675 fatcat:ehtufhajkncczm6m7vtoaoimbu

Magnetic Resonance Imaging in Multiple Sclerosis

Christopher C. Hemond, Rohit Bakshi
2018 Cold Spring Harbor Perspectives in Medicine  
ACKNOWLEDGMENTS The authors thank the following team members from Dr. Bakshi's laboratory for preparing Fig-  ...  level correlated with physical disability (Shu et al. 2011) .  ...  Typical multiple sclerosis (MS) lesions in the spinal cord. 3T magnetic resonance imaging (MRI) scans from a 46-year-old man with relapsing-remitting MS.  ... 
doi:10.1101/cshperspect.a028969 pmid:29358319 fatcat:ytdy4yzrsbabnejyqbwof4nefe

Neuroimaging in Multiple Sclerosis [chapter]

Elisabeth Andreadou
2012 Neuroimaging - Clinical Applications  
A decline in NAA levels in MS, with correlation with disability, has been shown in several studies.  ...  Moreover, quantitative variables derived from DTI were found to correlate with clinical disability (Filippi & Agosta, 2010) .  ...  .), ISBN: 978-953-51-0200-7, InTech, Available from:  ... 
doi:10.5772/24069 fatcat:dk3zwfkz6jhctdrgmrhj2hwhaq

MRI in multiple sclerosis: current status and future prospects

Rohit Bakshi, Alan J Thompson, Maria A Rocca, Daniel Pelletier, Vincent Dousset, Frederik Barkhof, Matilde Inglese, Charles RG Guttmann, Mark A Horsfield, Massimo Filippi
2008 Lancet Neurology  
Many promising MRI approaches for research or clinical management of multiple sclerosis (MS) have recently emerged, or are under development or refinement.  ...  VD has received honoraria from Biogen and Guerbet for lectures and travel expenses.  ...  Acknowledgments RB acknowledges support of research grants from the US National Institutes of Health (NIH; 1R01NS055083-01) and National Multiple Sclerosis Society (RG3705A1; RG3798A2).  ... 
doi:10.1016/s1474-4422(08)70137-6 pmid:18565455 pmcid:PMC2586926 fatcat:dlmkxtg4hreofisi4eplf2mfgm

Imaging of multiple sclerosis: Role in neurotherapeutics

Rohit Bakshi, Alireza Minagar, Zeenat Jaisani, Jerry S. Wolinsky
2005 Neurotherapeutics  
Magnetic resonance imaging (MRI) plays an everexpanding role in the evaluation of multiple sclerosis (MS).  ...  Conventional MRI techniques, including lesion detection and measurement of atrophy from T1-or T2-weighted images, have been the mainstay for monitoring disease activity in clinical trials, in which the  ...  less prominent resonances arise from myo-inositol, glutamate, glutamine and ␥-amino-butyric acid (GABA).  ... 
doi:10.1007/bf03206672 fatcat:jdde2nljprhsra6qzzwmzcq6ie

Imaging of multiple sclerosis: Role in neurotherapeutics

Rohit Bakshi, Alireza Minagar, Zeenat Jaisani, Jerry S. Wolinsky
2005 NeuroRx  
Magnetic resonance imaging (MRI) plays an everexpanding role in the evaluation of multiple sclerosis (MS).  ...  Conventional MRI techniques, including lesion detection and measurement of atrophy from T1-or T2-weighted images, have been the mainstay for monitoring disease activity in clinical trials, in which the  ...  less prominent resonances arise from myo-inositol, glutamate, glutamine and ␥-amino-butyric acid (GABA).  ... 
doi:10.1602/neurorx.2.2.277 pmid:15897951 pmcid:PMC1064992 fatcat:a4lslayntzcexphywsaqj2mhdq

Association between pathological and MRI findings in multiple sclerosis

Massimo Filippi, Maria A Rocca, Frederik Barkhof, Wolfgang Brück, Jacqueline T Chen, Giancarlo Comi, Gabriele DeLuca, Nicola De Stefano, Bradley J Erickson, Nikos Evangelou, Franz Fazekas, Jeroen JG Geurts (+5 others)
2012 Lancet Neurology  
The identifi cation of pathological processes that could be targeted by therapeutic interventions is a major goal of research into multiple sclerosis (MS).  ...  Correlation between Pathological and MRI fi ndings in MS workshop attendees Chairs-M Filippi (Neuroimaging  ...  Acknowledgments This paper reports the conclusions of the fi rst MRI-Path Workshop, which was held in Milan, Italy, on June 10-11, 2011, and chaired by Massimo Filippi and Hans Lassmann.  ... 
doi:10.1016/s1474-4422(12)70003-0 pmid:22441196 fatcat:wz7eyqevcrgfdp4wzmno66twzu

Failed, Interrupted, or Inconclusive Trials on Neuroprotective and Neuroregenerative Treatment Strategies in Multiple Sclerosis: Update 2015–2020

Niklas Huntemann, Leoni Rolfes, Marc Pawlitzki, Tobias Ruck, Steffen Pfeuffer, Heinz Wiendl, Sven G. Meuth
2021 Drugs  
In the recent past, a plethora of drugs have been approved for the treatment of multiple sclerosis (MS).  ...  Therefore, learning from their failure will help us to enforce the translation of findings acquired in pre-clinical studies into clinical application.  ...  relapsing multiple sclerosis Atorvastatin (plus interferon-β1b) Efficacy, Safety and Tolerability of Atorvastatin 40 mg in Patients with Relapsing-Remitting Multiple Sclerosis in Treatment with  ... 
doi:10.1007/s40265-021-01526-w pmid:34086251 pmcid:PMC8217012 fatcat:uft3lkbzjzhwtm2gxus2fo352a

Neuroimaging Correlates of Cognitive Dysfunction in Adults with Multiple Sclerosis

Maria Petracca, Giuseppe Pontillo, Marcello Moccia, Antonio Carotenuto, Sirio Cocozza, Roberta Lanzillo, Arturo Brunetti, Vincenzo Brescia Morra
2021 Brain Sciences  
correlates of cognitive impairment in adults with MS, focusing on the mechanisms sustaining damage accrual and on the identification of useful imaging markers of cognitive decline.  ...  Cognitive impairment is a frequent and meaningful symptom in multiple sclerosis (MS), caused by the accrual of brain structural damage only partially counteracted by effective functional reorganization  ...  Selected T2-and T1-, together with DBSI-derived maps from a patient diagnosed with multiple sclerosis.  ... 
doi:10.3390/brainsci11030346 pmid:33803287 fatcat:4jfvrxiabvcitifwvhosdkdggm

The Upper Motor Neuron—Improved Knowledge from ALS and Related Clinical Disorders

Parvathi Menon, Steve Vucic
2021 Brain Sciences  
prominent UMN signs, namely, primary lateral sclerosis, hereditary spastic paraplegia and primary progressive multiple sclerosis, to help promote better understanding of the human motor system and, by  ...  Dysfunction of the upper motor neuron causes the classical clinical signs of spasticity, weakness, brisk tendon reflexes and extensor plantar response, which are associated with clinically well-recognised  ...  Further, grey matter pathology, while less understood, was correlated with disability in MS in general [97] .  ... 
doi:10.3390/brainsci11080958 fatcat:cdnh47457jd33gm5d4pweswbtu

High-field magnetic resonance imaging of structural alterations in first-episode, drug-naive patients with major depressive disorder

Z Chen, W Peng, H Sun, W Kuang, W Li, Z Jia, Q Gong
2016 Translational Psychiatry  
Whole-brain voxel-based analysis was used to compare MTR and gray matter volume across groups and to analyse correlations between MTR and age, symptom severity, and illness duration.  ...  The patients exhibited significantly lower MTR in the left superior parietal lobule and left middle occipital gyrus compared with healthy controls, which may be related to the attentional and cognitive  ...  the status of macromolecular proteins in several clinical brain disorders including depression, 20-23 schizophrenia 24 and multiple sclerosis, even when a conventional MRI is negative. 25, 26 Previous  ... 
doi:10.1038/tp.2016.209 pmid:27824357 pmcid:PMC5314121 fatcat:nhrqgzdrdrgztlmyj3luloaxvq

Advances in white matter imaging: A review of in vivo magnetic resonance methodologies and their applicability to the study of development and aging

Jeffrey R. Wozniak, Kelvin O. Lim
2006 Neuroscience and Biobehavioral Reviews  
These techniques go beyond traditional macrostructural volumetric methods and provide valuable information about underlying tissue integrity and organization at the microstructural and biochemical levels  ...  We first provide an overview of white matter development and discuss the role of white matter and myelin in cognitive function.  ...  Acknowledgments The authors wish to thank Bryon Mueller for his suggestions and his assistance with the preparation of this paper.  ... 
doi:10.1016/j.neubiorev.2006.06.003 pmid:16890990 pmcid:PMC2895765 fatcat:meeatdmkizervixhkmpe53bgqm

Interaction between Neurons and the Oligodendroglial Lineage in Multiple Sclerosis and Its Preclinical Models

Vasiliki Pantazou, Thomas Roux, Vanessa Oliveira Moreira, Catherine Lubetzki, Anne Desmazières
2021 Life  
Multiple sclerosis (MS) is a complex central nervous system inflammatory disease leading to demyelination and associated functional deficits.  ...  We further discuss the therapeutic possibilities resulting from this research field, which might allow to support remyelination and neuroprotection and thus limit MS progression.  ...  Figures were created with  ... 
doi:10.3390/life11030231 pmid:33799653 fatcat:etlmybalzvehvph3diedoxjlfu
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