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GA-Novo: De Novo Peptide Sequencing via Tandem Mass Spectrometry using Genetic Algorithm [article]

Samaneh Azari, Bing Xue, Mengjie Zhang, Lifeng Peng
2019 arXiv   pre-print
In this study, we propose a genetic algorithm based method, GA-Novo, to solve the complex optimisation task of de novo peptide sequencing, aiming at constructing full length sequences.  ...  The common method for identifying proteins and characterising their amino acid sequences is to digest the proteins into peptides, analyse the peptides using mass spectrometry and assign the resulting tandem  ...  De novo sequencing has been performed via stochastic optimisation using a genetic algorithm (GA) [12, 13] , where a GA tries to optimise the amino acid sequence in respect to a scoring function.  ... 
arXiv:1902.00845v1 fatcat:b7xqfkqz6rcjbgl4zkezomudem