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HEKİMLERİN YAŞLI İHMAL VE İSTİSMARI KONUSUNDAKİ FARKINDALIĞINA YÖNELİK KISA BİR DEĞERLENDİRME

Yeşim GÖKÇE KUTSAL, Dilek ASLAN, Tolga Reşat AYDOS, Altuğ KUT, Nurper ERBERK ÖZEN, Meral SAYGUN, Meltem ŞENGELEN, Sevilay KARAHAN
2022 STED / Sürekli Tıp Eğitimi Dergisi  
Yeşim Gökçe Kutsal E-Posta: ygkutsal@gmail.com  ... 
doi:10.17942/sted.1098957 fatcat:tgz7uub7effbfki53xzhyux74a

Identification of Polycystic Ovary Syndrome (PCOS) Specific Genes in Cumulus and Mural Granulosa Cells

Alp Aydos, Aykut Gurel, Yasemin Oztemur Islakoglu, Senem Noyan, Bagdagul Gokce, Tolga Ecemis, Cemil Kaya, Arif Tarik Aksu, Bala Gur Dedeoglu, Andrew Wolfe
2016 PLoS ONE  
Polycystic ovary syndrome (PCOS) is a metabolic and endocrine disorder which affects women of reproductive age with prevalence of 8-18%. The oocyte within the follicle is surrounded by cumulus cells (CCs), which connect with mural granulosa cells (MGCs) that are responsible for secreting steroid hormones. The main aim of this study is comparing gene expression profiles of MGCs and CCs in PCOS and control samples to identify PCOS-specific differentially expressed genes (DEGs). In this study, two
more » ... microarray databases were searched for mRNA expression microarray studies performed with CCs and MGCs obtained from PCOS patients and control samples. Three independent studies were selected to be integrated with naive meta-analysis since raw meta-data from these studies were found to be highly correlated. DEGs in these somatic cells were identified for PCOS and control groups. This study enabled us to reveal dysregulation in MAPK (mitogen activated protein kinase), insulin and Wnt signaling pathways between CCs and MGCs in PCOS. The metaanalysis results together with qRT-PCR validations provide evidence that molecular signaling is dysregulated through MGCs and CCs in PCOS, which is important for follicle and oocyte maturation and may contribute to the pathogenesis of the syndrome.
doi:10.1371/journal.pone.0168875 pmid:27997581 pmcid:PMC5173369 fatcat:nln43v4hy5bklncd4kd4rsmdvu

Parity-based Soft Error Detection with Software-based Retry vs. Triplication-based Soft Error Correction - An Analytical Comparison on a Flash-based FPGA Architecture

Gökçe Aydos, Görschwin Fey
2015 Jahrestagung der Gesellschaft für Informatik  
Ab ac : Field-p og ammable ga e a a (FPGA ) a e of en ili ed in pace a ionic . To p o ec he FPGA logic again he ioni ing adia ion effec in pace, ed ndanc i nf o m of conc en e o de ec ion can be ed.
dblp:conf/gi/AydosF15 fatcat:kgppzkrobrdlzpdg3n2asr5ulu

Ribavirin shows antiviral activity against SARS-CoV-2 and downregulates the activity of TMPRSS2 and the expression of ACE2 in vitro [article]

Mehmet Altay Unal, Ceylan Verda Bitirim, Gokce Yagmur Summak, Sidar Bereketoglu, Inci Cevher Zeytin, Omur Besbinar, Cansu Gurcan, Dunya Aydos, Ezgi Goksoy, Ebru Kocakaya, Zeynep Eran, Merve Murat (+9 others)
2020 bioRxiv   pre-print
Ribavirin is a guanosine analog and has a broad-spectrum antiviral activity against RNA viruses. Based on this, we aimed to show the anti-SARS-CoV-2 activity of this drug molecule via in vitro, in silico and molecular techniques. Ribavirin showed antiviral activity in Vero E6 cells following SARS-CoV-2 infection. In silico analysis suggested that Ribarivin has a broad-spectrum impact on Vero E6 cells. According to the detailed molecular techniques, Ribavirin was shown to decrease TMPRSS2
more » ... ion both at mRNA and protein level 48 hours after treatment. The suppressive effect of Ribavirin in ACE2 protein expression was shown to be dependent on cell types. Finally, proteolytic activity assays showed that Ribavirin also showed an inhibitory effect on TMPRSS2 enzyme. As a conclusion, Ribavirin is a potential antiviral drug for the treatment against SARS-CoV-2, and it interferes with the effect of TMPRSS2 and ACE2 expression.
doi:10.1101/2020.12.04.410092 fatcat:u5s4rjgypfbk5hdmau7jbcgdpq

Kapak-İçindekiler

Pamukkale Üniversitesi Mühendislik Bilim Dergisi
2006 Pamukkale University Journal of Engineering Sciences  
Mühendislik Fakültesi Adına Dekan/Dean Sebahattin NAS Yayın Kurulu/Editorial Board Sebahattin NAS Muzaffer TOPCU Hasan KAPLAN Mustafa TEMİZ Güngör ÜLKÜ Hulusi KARGI Ahmet Hilmi ÇON Sema PALAMUTÇU Murat AYDOS  ...  Serdar YILMAZ, Murat GÖRMEMİŞ 359-368 Gıda Endüstrisinde Yüksek Hidrostatik Basınç Uygulamaları Applications of High Hydrostatic Pressure in the Food Industry Yahya TÜLEK, Gökçe FİLİZAY 369-377 Isıl  ... 
doaj:bbbc3899aad243a793f7fd76a099433c fatcat:7y7jvcnykfdf3jge6xnkh456ru

The Potential of Medicinal and Aromatic Plants in the Central Anatolian Steppe Rangeland and the Actions to Be Taken For These Plants

Nur KOÇ, Ramazan ACAR, Ayşe ÇELİK
2018 Selcuk Journal of Agricultural and Food Sciences  
The central Anatolian steppe rangelands have 5 Tanacetum genus which both has potential pest control in organic farming and is the raw material in medicinal (Alkan and Gokce, 2012).  ...  ) 1050-1750 Çubuk-Karagöl surroundings Aydos mountains (Ankara) 1500-2100 Sultandağları (Akşehir) H. aviculariifolium subsp. depilatum + 600-900 Çayırhan-Beypazarı-Kırbaşı 600-800 Regions  ... 
doi:10.15316/sjafs.2018.87 fatcat:lrwxkcvrifevnnwb2jeqo7uiwe

Kapak-İçindekiler

Pamukkale Üniversitesi Mühendislik Bilim Dergisi
2006 Pamukkale University Journal of Engineering Sciences  
Mühendislik Fakültesi Adına Dekan/Dean Sebahattin NAS Yayın Kurulu/Editorial Board Sebahattin NAS Muzaffer TOPCU Hasan KAPLAN Mustafa TEMİZ Güngör ÜLKÜ Hulusi KARGI Ahmet Hilmi ÇON Sema PALAMUTÇU Murat AYDOS  ...  Drop in Tube Heat Exchanger Zeki ARGUNHAN, Cengiz YILDIZ Gıda Endüstrisinde Kullanılan Yüksek Hidrostatik Basınç Sistemleri 225-231 High Hydrostatic Pressure Systems Use in Food Industry Yahya TÜLEK, Gökçe  ... 
doaj:bbc990ea96594f38857daa48dac897dd fatcat:2oaioeade5ayhc76ce76s45ijq

934 (1528) TARİHLİ BİR BELGEYE GÖRE RUMELİ DE KADILIK MÜESSESİ

ERCAN ALAN
2016 Journal of International Social Research  
50-40-30-25 30-70-80-100-130-150 Moton 35 35 100-80 50-100-130-150-200 Taman 30 40 100-70-60-40-35 50-80-100-130-150-200-300 Azak 30 30 100-70-50-45 40-50-70-80-100-130-150 12 Turan Gökçe  ...  Selami Pulaha-Yaşar Yücel, Ankara: TTK, s.42. 9 Turan Gökçe, (1994), "Anadolu Vilayetine Dâir 919 (1513) Tarihli Bir Kadı Defteri", s. 215-259. 10 Enver Çakar, (2002), "Kanuni Sultan Süleyman Kanun-nâmesine  ... 
doi:10.17719/jisr.20164622587 fatcat:vt5jtdywlvgk7o2wn62zfee4pe

PENGARUH PEMBERIAN MINYAK JINTAN HITAM (Nigella sativa L.) TERHADAP PENINGKATAN SPERMATOGENESIS TIKUS WISTAR YANG TERPAPAR ASAP ROKOK

Mujahidatul Musfiroh, Sri Gustari
2015 Jurnal Kedokteran Hewan  
Gokce et al. (2011) melaporkan bahwa pemberian thymoquinone dapat menurunkan efek destruktif metotrexat pada jaringan testis.  ...  rokok cenderung mengurangi kualitas sperma dan memengaruhi susunan sel-sel spermatogenik, mengurangi motilitas, memberikan efek negatif pada spermatogenesis, dan berpengaruh pada epididimis sperma (Aydos  ... 
doi:10.21157/j.ked.hewan.v9i2.2820 fatcat:hswpjerpebfjposvvvaetckxqi

COĞRAFİ BİLGİ SİSTEMİ TABANLI MANTIKSAL REGRESYON YÖNTEMİ KULLANILARAK ÇUBUK-KALECİK (ANKARA) ŞABANÖZÜ (ÇANKIRI) ARASININ HEYELAN DUYARLILIK DEĞERLENDİRMESİ

Hasan ELMACI, Senem TEKİN, Nail ÜNSAL
2017 Maden Tetkik ve Arama Dergisi  
Figure 1 - 1 The location map of the study area.Hançili, Karakoca formations and Miocene Kalecik and Aydos volcanics.  ...  Figure 6 - 6 Landslide historical inventory (Duman et al., 2009 ) and archive (Gökçe et al., 2008) inventory maps.  ... 
doi:10.19076/mta.304329 fatcat:gzunlyajmne4hjuebgvqj6ehve

XVI. Yüzyılın İkinci Yarısında Osmanlı Devleti'nde Vergi Muâfiyeti: Derbendçilik

Almıla Gökçe Özcan
2018 Gazi Akademik Bakış  
Buna göre Aydos kazasından Yanbolu'da yer alan matbah-ı âmire için arpa ve Edirne'de yer alan matbah-ı âmire için odun salınmıştı.  ...  Derbendçiler 1565 yılında Niğbolu sancağında Tırnovi ve Kızanlık kazalarında, 63 Silistre sancağında 1572 yılında Yanbolu kazasında Maraş karyesinde, 64 1573 yılında Aydos kazasında 65 ve 1573 yılında  ... 
doi:10.19060/gav.437828 fatcat:usi3xxot3ffofdmmwvzlfugjra

XVI. YÜZYILIN İKİNCİ YARISINDA RUMELİ KADILIKLARI

Levent KURU
2019 Balkan Araştırma Enstitüsü Dergisi  
Yıl Türkçülük Armağanı, Akademi Kitapevi Yayınevi, İzmir 1994, s. 77-94; Turan Gökçe, "Anadolu Vilâyetine Dair 919 (1513) Tarihli Bir Kadı Defteri", Tarih İncelemeleri Dergisi, C.  ...  Defter Sırası Kaza İsmi Akçe Değeri 22 İmroz 50 23 Akçakızanlık 100 24 İnebahtı 150 25 Andurusa 50 26 İrig 40 27 Aydos 100 28 Alacahisar 60 29 Ayamavra 30 30 İzdin 150 31  ... 
doi:10.30903/balkan.657744 fatcat:fgkni5ylqver3h3go3p4k4taei

Selçukluların Yıkılışından Sonra Irak ve Azerbaycan'ın Durumu

Hüseyin Kayhan
2007 Belleten (Turk Tarih Kurumu)  
Râvendi, II, 366. 37 Râvendi, Il, 367-368. 38 Râvendi, II, 368. 38 Aydo~mu~~ hâkim oldu.  ...  Kafeso~lu, 139-140. göze alamayan Gökçe, bir kaç yeri ya~malad~ktan sonra Hemedân'a geri döndü32.  ... 
doi:10.37879/belleten.2007.891 fatcat:4wbi3ffv2je4jpcsul6j37rxnq

ÜÇOKLU OĞUZ BOYLARINA AİT (Bayad - Karkın) VESİKALAR I BAYAD

Faruk DEMİRTAŞ
1949 Ankara Üniversitesi Dil ve Tarih-Coğrafya Fakültesi Dergisi  
Cemâat-i Af ş arı Pirl B e g tâbi-i Gökçe Hac ı, antâife-i Ziiikadriyye; mücerred: 27, müzevvec: 53, neferân: 80 8.  ...  Köpeklü Av şarı ; der vilâyet-i Şark ; mücerred : 8, hâne : 14, nefer : 22. 12 -Cemâat-i di ğer Keçelü, tâbi-i Köpeklü Av şar ı ; mücerred : 2, hâne : 11, nefer : 11.376 FARUK DEM İ RTA Ş 13 -Cemâat-i Aydo  ...  ; mücerred: 1, hâne : 2. 6 -Cemâat-i C a n d ı k, an-tâife-i Av şar, Erkin nam mezreada ekerler; mücerred: 2, hâne : 9. 7 -Cemâat-i C a n d ı k, an-tâife-i Av şar; göçer evdir, hâne: 10. 8 Cemâat-i Aydo  ... 
doi:10.1501/dtcfder_0000000737 fatcat:imhsbnva3fdc7g4n6sr6lhuh5e

Lymphocyte-to-monocyte ratio is a valuable marker to predict prostate cancer in patients with prostate specific antigen between 4 and 10 ng/dl

Volkan Caglayan, Efe Onen, Sinan Avci, Murat Sambel, Metin Kilic, Sedat Oner, Mustafa Murat Aydos, Halil Emre Yıldız
2019 Archivio Italiano di Urologia e Andrologia  
Additionally, controversial to the study performed by Gokce et al., we did not observe a significant highness in the prostatitis group compared to the PCa and BPH group.  ... 
doi:10.4081/aiua.2018.4.270 fatcat:4xgtdxc4fzb2jpeiniamq67aoi
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