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Using proteomics in perinatal and neonatal sepsis: hopes and challenges for the future

Catalin S Buhimschi, Vineet Bhandari, Yiping W Han, Antonette T Dulay, Margaret A Baumbusch, Joseph A Madri, Irina A Buhimschi
2009 Current Opinion in Infectious Diseases  
Future challenges are finding biomarkers that provide insight into molecular mechanisms of chronic fetal and neonatal cellular damage and identify candidates for early neuro-protection strategies.  ...  The resulting inflammatory process has the potential to damage the fetus in utero.  ...  This work was supported in part from National Institutes of Health grants RO1 HD47321 (IAB), RO1 DE14924(YWH) and R37 HL28373 (JAM).  ... 
doi:10.1097/qco.0b013e32832a5963 pmid:19395960 pmcid:PMC2763282 fatcat:cmf6bextrjf65fhlqbqnuz26sm

Challenges, Current Status and Future Perspectives of Proteomics in Improving Understanding, Diagnosis and Treatment of Vascular Disease

J.V. Moxon, M.P. Padula, B.R. Herbert, J. Golledge
2009 European Journal of Vascular and Endovascular Surgery  
In this review we outline currently available proteomics techniques, the challenges to using these approaches and modifications which may improve the utilization of proteomics in the study of vascular  ...  The utilization of proteomics for the study of vascular diseases has been limited by comparison.  ...  In this review we outline proteomic techniques and discuss current technical challenges and likely future developments.  ... 
doi:10.1016/j.ejvs.2009.05.008 pmid:19541510 pmcid:PMC2727576 fatcat:32rlw7dcunf5xbw3r5xpcy4kzq

Future Challenges in Proteomics

Hartmut Schlüter, Christian G. Huber, Oliver Kohlbacher, Knut Reinert
It is recommended to guide future proteome analytical investigations by a hypothesis and to focus to a smaller number of proteins which should ideally be analyzed in detail covering 100 % sequence coverage  ...  In sum these problems may hinder progress in life science projects employing proteomic strategies and may be especially risky for system biology approaches since the ambiguities resulting from the above  ...  In the future top-down proteomics may enable the study of intact proteins including their PTMs.  ... 
doi:10.4230/dagsemproc.05471.7 fatcat:l6pa5p65kjbybdbzuytylgn5ne

Clinical Proteomics; protein expression research within disease —A challenging task

Gyorgy Marko-Varga, Thomas Laurell
2010 Journal of Proteomics  
Proteomics Society "EuPA" is needed, to take on the challenges and reach the goals set forth.  ...  With expertise within the biomarker diagnostics field, there is a major challenge for the proteomics scientists to apply cutting edge developments and to build new cross-functional links to meet this challenge  ... 
doi:10.1016/j.jprot.2010.03.011 pmid:20346426 fatcat:2zwekzlzsjcnney36dzr6fjktm

The EuPA2015 Congress. Proteomics: Back to the Future

Paola Roncada, Andrea Urbani, Concha Gil
2016 EuPA Open Proteomics  
The Italian Proteomics Association (ItPA) has been particularly focused in the last years to provide a common framework of exchange between the fast advancing challenges in Human Proteomics and the non-Human  ...  Proteomics: Back to the Future The EuPA2015 Congress (Milano, June 23-28, 2016) offered a unique scenario in which the proteomics community had an unprecedented window to disseminate to the general public  ... 
doi:10.1016/j.euprot.2016.03.011 fatcat:2imo5hos65gc5obcpcn2to52q4

Proteomics: Back to the future

Paola Roncada, Gabriella Tedeschi, Mauro Fasano, Peter Verhaert
2016 EuPA Open Proteomics  
During EuPA2015 in Milan, a common framework was provided for exchange between the fast advancing challenges in the Human Proteomics field and those in comparative (non-Human) proteome investigations.  ...  COST Action BM1403 co-organized a scientific session and an educational program which were a clear example of integration of the challenging field of 'Native Mass Spectrometry' with the Proteomics community  ...  This special issue of EuPA Open Proteomics was setup during EuPA2015 as a forum for both clinical proteomics investigations and non-human proteome studies highlighting the role of Proteomics in the One  ... 
doi:10.1016/j.euprot.2016.04.001 pmid:29900111 pmcid:PMC5988553 fatcat:n6ysyxyhfrb5fnycsc72rl4smu

New views of old proteins: clarifying the enigmatic proteome [article]

Participants in a NIH Workshop on Functional, Integrative Proteomics: Kristin E. Burnum Johnson
2021 arXiv   pre-print
Extrapolating recent trends, we offer potential futures for a next generation of disruptive approaches to define, quantify and visualize the multiple dimensions of the proteome, thereby transforming our  ...  understanding and interactions with human disease in the coming decade.  ...  The future lies in integration across scales 5a.  ... 
arXiv:2108.07660v1 fatcat:5i5fwukf4fckzp2oeilde7arp4

Opportunities in proteomics to understand hepatitis C and HIV coinfection

Eric G Meissner, Anthony F Suffredini, Shyamasundaran Kottilil
2012 Future Virology  
In this review, we discuss recent advances in proteomics as applied to HCV and HIV and highlight issues in coinfection that are amenable to further discovery through proteomic approaches.  ...  However, coinfection with HCV results in a more complicated disease course for both infections. HIV infection dramatically impacts the natural history of chronic liver disease due to HCV.  ...  Ideal for in methylation sites, protein vitro and in vivo protein ID in substrates and animal models subcellular proteomics iTRAQ-DIGE: Future Virol.  ... 
doi:10.2217/fvl.12.67 pmid:23105947 pmcid:PMC3480018 fatcat:72l2w5u6qbcknnipjwi354n354

Marine Proteomics: Challenges and Opportunities

Kondethimmanahalli Chandramouli
2016 Journal of Data Mining in Genomics & Proteomics  
for survival in future acidic oceans [3] .  ...  In another study, they revealed proteomic plasticity enabled oysters larvae a short-term adaptation or acclimation to a near-future OA scenario.  ...  for survival in future acidic oceans [3] .  ... 
doi:10.4172/2153-0602.1000e122 fatcat:ehrcvqkw6beatckrrkp7pwcac4

Proteomics – advances, applications and the challenges that remain

Ruedi Aebersold, Benjamin F. Cravatt
2002 Trends in Biotechnology  
In 2002, he was the recipient of the Widmer Award, the Biemann Medal and the World Technology Network Award for Biotechnology.  ...  Aebersold is senior editor of Physiological Genomics, an associate editor of Molecular Cellular Proteomics and on the Editorial Advisory Boards of Proteomics and the Journal of Proteome Research.  ...  We hope that the reader will agree that our unabashed enthusiasm for the future of proteomics has been tempered throughout by a critical tone highlighting the many challenges that still face this field  ... 
doi:10.1016/s1471-1931(02)00206-9 pmid:12570151 fatcat:i2jrqeopnvfv3e4rqhmca3loqe

Trials, Skills, and Future Standpoints of AI Based Research in Bioinformatics

2020 International journal of recent technology and engineering  
This article reviews Artificial Intelligence subset such as Machine learning and Deep learning in the genomics and proteomics domain.  ...  Computational biology, genomics, proteomics, Drug designing, gene expression level analysis are the major research areas in bioinformatics. These areas are also discussed in the paper.  ...  Overall, we have discussed about the importance, challenges and future perspective of bioinformatics in the field of computer science and its applications.  ... 
doi:10.35940/ijrte.a1920.059120 fatcat:hmqqdp5hx5a3fi52gydffn5ffy

EuPA Open Proteomics beyond 2013

Peter Verhaert
2014 EuPA Open Proteomics  
We are confident in the bright future which lies ahead of EuPA Open Proteomics, and which will start in 2014.  ...  EuPA Open Proteomics is definitely in the air, and flying. Looking forward Even more importantly, I want to communicate our future vision for EUPROT.  ... 
doi:10.1016/j.euprot.2013.12.001 fatcat:xymftzmzmfcxxlkzmuac7adnia

The Green Proteome: Challenges in Plant Proteomics

Joshua L. Heazlewood
2011 Frontiers in Plant Science  
In general the area of plant proteomics suffers from the similar challenges that face other research fields.  ...  Significant challenges still lie ahead of this field and it is envisioned that future advances in techniques and instrumentation will ultimately deliver the ability to analyze, characterize and quantify  ... 
doi:10.3389/fpls.2011.00006 pmid:22639573 pmcid:PMC3355608 fatcat:jpz3gt526nbhbbevnkwxyn5cpa

Progresses and Challenges of Omics Studies and Their Impacts in Personalized Medicine

Sompop Bencharit
2012 Journal of Pharmacogenomics & Pharmacoproteomics  
I believe that with the rapid progression of technology and careful design of omics studies, in the near future we may be able to truly apply personalized medicine.  ...  We are in the exciting age of omics and personalized medicine.  ...  Drugs that effectively cure a condition in one person may not work at all in another individual. This challenge can in theory be understood using current omics tools.  ... 
doi:10.4172/2153-0645.1000e105 fatcat:mwnfn47vszdavic22qjunkmnim

A decade of metaproteomics: Where we stand and what the future holds

Paul Wilmes, Anna Heintz-Buschart, Philip L. Bond
2015 Proteomics  
By using these case studies, we highlight current challenges and possible solutions for metaproteomics to realize its full potential, i.e. to enable conclusive links between microbial community composition  ...  Although initial progress in analytical capacities and resulting numbers of proteins identified was extremely fast, this trend slowed rapidly.  ...  The authors have declared no conflict of interest. Page 16 Proteomics This article is protected by copyright. All rights reserved.  ... 
doi:10.1002/pmic.201500183 pmid:26315987 pmcid:PMC5049639 fatcat:rdqvqvbnxvc35abxvzdtftzrhq
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