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Evidence for Lateral Transfer of Genes Encoding Ferredoxins, Nitroreductases, NADH Oxidase, and Alcohol Dehydrogenase 3 from Anaerobic Prokaryotes toGiardialambliaandEntamoebahistolytica

Julie E. J. Nixon, Amy Wang, Jessica Field, Hilary G. Morrison, Andrew G. McArthur, Mitchell L. Sogin, Brendan J. Loftus, John Samuelson
2002 Eukaryotic Cell  
Putative giardial and amebic 6-kDa ferredoxins, ferredoxin-nitroreductase fusion proteins, and oxygen-insensitive nitroreductases each tentatively supported the lateral transfer hypothesis.  ...  A putative giardia [2Fe-2S]ferredoxin which had a hypothetical organelle-targeting sequence at its N terminus showed similarity to mitochondrial ferredoxins and the hydrogenosomal ferredoxin ofTrichomonasvaginalis  ...  When the G. lamblia and E. histolytica shotgun sequences were searched with TBLASTN and an H. pylori nitroreductase sequence, a G. lamblia gene encoding a putative nitroreductase was predicted, while no  ... 
doi:10.1128/ec.1.2.181-190.2002 pmid:12455953 pmcid:PMC118039 fatcat:46tubp3frjhbddmocakvezclo4

Quantitative proteomics approach to investigate the antibacterial response of Helicobacter pylori to daphnetin, a traditional Chinese medicine monomer

Yun Lu, Jing Pang, Genzhu Wang, Xinxin Hu, Xue Li, Guoqing Li, Xiukun Wang, Xinyi Yang, Congran Li, Xuefu You
2021 RSC Advances  
Acknowledgements This study was supported by the CAMS Initiative for Innovative Medicine (grant number 2016-I2M-3-014, 2017-I2M-1-012), the National Mega-project for Innovative Drugs (grant number 2019ZX09721001  ...  With increasing multi-drug resistance rate of H. pylori, drugs with multiple targets can effectively slow the development of drug resistance.  ...  Due to the lack of H. pylori ATCC 43504-related database in the KEGG pathway database, we replaced the gene name with the corresponding gene name of H. pylori ATCC 26695 by the Blast method to perform  ... 
doi:10.1039/d0ra06677j fatcat:d4rwjzki25amvddwdh4nek36x4

Genomics and antimicrobial drug discovery

D T Moir, K J Shaw, R S Hare, G F Vovis
1999 Antimicrobial Agents and Chemotherapy  
In particular, Skip Shimer, Brad Guild, and Lucy Ling were instrumental in the analysis of the approaches summarized here.  ...  ACKNOWLEDGMENTS We thank our colleagues at Genome Therapeutics Corporation and the Schering-Plough Research Institute for helpful discussions about genomic approaches to drug discovery.  ...  On the other hand, genes which are apparently unique to a species such as H. pylori might be ideal for targeting that species with a narrow-spectrum antibiotic.  ... 
pmid:10049248 pmcid:PMC89141 fatcat:cvjjoogc6bd33lprmpkoieajhm

Genomics and Antimicrobial Drug Discovery

Donald T. Moir, Karen J. Shaw, Roberta S. Hare, Gerald F. Vovis
1999 Antimicrobial Agents and Chemotherapy  
In particular, Skip Shimer, Brad Guild, and Lucy Ling were instrumental in the analysis of the approaches summarized here.  ...  ACKNOWLEDGMENTS We thank our colleagues at Genome Therapeutics Corporation and the Schering-Plough Research Institute for helpful discussions about genomic approaches to drug discovery.  ...  On the other hand, genes which are apparently unique to a species such as H. pylori might be ideal for targeting that species with a narrow-spectrum antibiotic.  ... 
doi:10.1128/aac.43.3.439 fatcat:gaia5gg7djetrl4kvhxj62qctq

Carbonic Anhydrases: New Perspectives on Protein Functional Role and Inhibition in Helicobacter pylori

Cristina Campestre, Viviana De Luca, Simone Carradori, Rossella Grande, Vincenzo Carginale, Andrea Scaloni, Claudiu T. Supuran, Clemente Capasso
2021 Frontiers in Microbiology  
H. pylori CAIs in combination with probiotic strains as a novel anti-ulcer treatment approach.  ...  /adaptation of the microbe within the human abdomen; (iv) the role of CAs played in the outer membrane vesicles spawned by H. pylori in its planktonic and biofilm phenotypes; (v) the possibility of using  ...  DNA mutations, gene transfer processes as well as other mechanisms, such as changes in the outer membrane permeability, drug extrusion by efflux pumps and modification of the drug target, can induce the  ... 
doi:10.3389/fmicb.2021.629163 pmid:33815311 pmcid:PMC8017301 fatcat:6ck2pqxtqvgrrh6rzbrpedq7sa

Prediction of Extracellular Proteases of the Human Pathogen Helicobacter pylori Reveals Proteolytic Activity of the Hp1018/19 Protein HtrA

Martin Löwer, Christiane Weydig, Dirk Metzler, Andreas Reuter, Anna Starzinski-Powitz, Silja Wessler, Gisbert Schneider, Raphael H. Valdivia
2008 PLoS ONE  
These data demonstrate that H. pylori secretes HtrA as an active protease, which might represent a novel candidate target for therapeutic intervention strategies.  ...  Importantly, we further found that the H. pylori genes hp1018 and hp1019 represent a single gene likely coding for an exported protein.  ...  H. pylori mediated pathogenesis, which represent attractive vaccine and drug target candidates.  ... 
doi:10.1371/journal.pone.0003510 pmid:18946507 pmcid:PMC2567035 fatcat:lhxe4m2o3vgvrjowl4a3dyyo3q

Helicobacter pylori-Induced Signaling Pathways Contribute to Intestinal Metaplasia and Gastric Carcinogenesis

Soichiro Sue, Wataru Shibata, Shin Maeda
2015 BioMed Research International  
Helicobacter pylori(H. pylori) induces chronic gastric inflammation, atrophic gastritis, intestinal metaplasia, and cancer.  ...  instability (MSI), which are classified as two major subtypes of gastric cancer.  ...  of target genes [71] .  ... 
doi:10.1155/2015/737621 pmid:26064948 pmcid:PMC4441984 fatcat:4bxeqxwrlfe5plffbhgjght5la

Multidrug Efflux Systems in Microaerobic and Anaerobic Bacteria

Zeling Xu, Aixin Yan
2015 Antibiotics  
Active drug efflux constitutes an important mechanism of antibiotic and multidrug resistance in bacteria.  ...  In this article, we summarize research development on multidrug efflux pumps in the medicinally relevant microaerobic and anaerobic pathogens and their implications in the effort to combat drugresistant  ...  It was reported that in S. aureus N315, there are at least 30 genes encoding putative drug efflux pumps, and most of them are major facilitator superfamily (MFS) proteins (Table 1 ) [55] .  ... 
doi:10.3390/antibiotics4030379 pmid:27025630 pmcid:PMC4790292 fatcat:n5xdhlz2u5e3ffeemcpm2jdtbm

Gastric Cancer: Advances in Carcinogenesis Research and New Therapeutic Strategies

Lornella Seeneevassen, Emilie Bessède, Francis Mégraud, Philippe Lehours, Pierre Dubus, Christine Varon
2021 International Journal of Molecular Sciences  
New and recent potential biomarkers were assessed as well as emerging therapeutical strategies involving cancer stem cells targeting as well as immunotherapy.  ...  A focus was made on the different actors of gastric carcinogenesis, including, Helicobacter pylori cancer stem cells, tumour microenvironment and microbiota.  ...  Drug repositioning was also used as strategy to target signalling pathways exacerbated in CD44+ GCSCs.  ... 
doi:10.3390/ijms22073418 pmid:33810350 fatcat:umxgmxddyjhgrnwjspndmjbpmy

Discovery of Anti-Infective Drugs Using Genome-Based Technologies

HIRONOBU NAKAYAMA, TSUTOMU NISHIHARA
2003 Biocontrol Science  
In M. genitalium, 468 proteins were estimated and 1703 putative proteins were encoded in H. influenzae.  ...  Furthermore, the drug would function as a broad-spectrum drug if the target gene were comprehensively found in pathogens.  ... 
doi:10.4265/bio.8.43 fatcat:r6xcsfalzvcxtba42oxkogwzjq

Bacterial Extracellular Vesicles in Gastrointestinal Tract Cancer: An Unexplored Territory

Sajeen Bahadur Amatya, Sonja Salmi, Veera Kainulainen, Peeter Karihtala, Justus Reunanen
2021 Cancers  
metabolites, as their cargo.  ...  The current systemic review outlines the possible impact of gut microbiota derived bEVs in GIT cancer in light of present-day understanding.  ...  in 12 h post-infection in contrast to free DOX, which accumulated only after 24 h, indicating improved transport of the drug when it was encapsulated in the bEVs.  ... 
doi:10.3390/cancers13215450 pmid:34771614 pmcid:PMC8582403 fatcat:kek4e4nyzvdvpnybzsteeeat4u

Functional Organization and Insertion Specificity of IS607, a Chimeric Element of Helicobacter pylori

D. Kersulyte, A. K. Mukhopadhyay, M. Shirai, T. Nakazawa, D. E. Berg
2000 Journal of Bacteriology  
One ORF (orfB) exhibited protein-level homology to one of two putative transposase genes found in several other chimeric elements including IS605 (also of H. pylori) and IS1535 (of Mycobacterium tuberculosis  ...  IS607 was found to transpose in Escherichia coli, and analyses of sequences of IS607-target DNA junctions in H. pylori and E. coli indicated that it inserted either next to or between adjacent GG nucleotides  ...  in only a subset of strains, also affect H. pylori-human host interactions.  ... 
doi:10.1128/jb.182.19.5300-5308.2000 pmid:10986230 pmcid:PMC110970 fatcat:a5vqynxwmza4zpcvjc4sxyeaza

Pan-Genome Analysis of Human Gastric PathogenH. pylori: Comparative Genomics and Pathogenomics Approaches to Identify Regions Associated with Pathogenicity and Prediction of Potential Core Therapeutic Targets

Amjad Ali, Anam Naz, Siomar C Soares, Marriam Bakhtiar, Sandeep Tiwari, Syed S Hassan, Fazal Hanan, Rommel Ramos, Ulisses Pereira, Debmalya Barh, Henrique César Pereira Figueiredo, David W. Ussery (+3 others)
2015 BioMed Research International  
Total of 28 nonhost homolog proteins were characterized as universal therapeutic targets againstH. pyloribased on their functional annotation and protein-protein interaction.  ...  Finally, pathogenomics and genome plasticity analysis revealed 3 highly conserved and 2 highly variable putative pathogenicity islands in all of theH. pylorigenomes been analyzed.  ...  Acknowledgment The authors thank The World Academy of Sciences for the advancement of science in developing countries (TWAS), National Council for Scientific and Technological Development (CNPq) for the  ... 
doi:10.1155/2015/139580 pmid:25705648 pmcid:PMC4325212 fatcat:ino77adj4zcwljkuuodz7shr6q

From Genetic Footprinting to Antimicrobial Drug Targets: Examples in Cofactor Biosynthetic Pathways

S. Y. Gerdes, M. D. Scholle, M. D'Souza, A. Bernal, M. V. Baev, M. Farrell, O. V. Kurnasov, M. D. Daugherty, F. Mseeh, B. M. Polanuyer, J. W. Campbell, S. Anantha (+4 others)
2002 Journal of Bacteriology  
Several drug targets within these pathways, including three distantly related adenylyltransferases (orthologs of the E. coli genes nadD, coaD, and ribF), are discussed in detail.  ...  Novel drug targets are required in order to design new defenses against antibiotic-resistant pathogens.  ...  A systematic analysis of essential genes conserved exclusively in H. pylori (23) did not recognize the potential of this pathway as a target for drug development, because it did not take into account  ... 
doi:10.1128/jb.184.16.4555-4572.2002 pmid:12142426 pmcid:PMC135229 fatcat:ltjqflhw6zb7vc7fgmoxsqrpca

Helicobacter pylori Expresses an Autolytic Enzyme: Gene Identification, Cloning, and Theoretical Protein Structure

E. Marsich, P. Zuccato, S. Rizzi, A. Vetere, E. Tonin, S. Paoletti
2002 Journal of Bacteriology  
Here we describe a novel H. pylori gene which expresses an autolytic enzyme that is also capable of degrading the cell walls of both gram-positive and gram-negative bacteria.  ...  We designated this gene lys. We found this gene and observed its expression in a number of unrelated clinical strains, a fact that suggests that it is well conserved in the species.  ...  H. pylori gene HP0339 was described after genomic sequencing of strain ATCC 26695 (53) as a putative gene that codes for a hypothetical lysozyme-like protein.  ... 
doi:10.1128/jb.184.22.6270-6279.2002 pmid:12399497 pmcid:PMC151945 fatcat:kilxkmtlp5f4lhueco4t7o2bsm
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