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An adaptive coarse graining method for signal transduction in three dimensions
2012
Fundamenta Informaticae
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The spatio-temporal landscape of the plasma membrane regulates activation and signal transduction of membrane bound receptors by restricting their two-dimensional mobility and by inducing receptor clustering. This regulation also extends to complex formation between receptors and adaptor proteins, which are the intermediate signaling molecules involved in cellular signaling that relay the received cues from cell surface to cytoplasm and eventually to the nucleus. Although their investigation
doi:10.3233/fi-2012-720
pmid:24357890
pmcid:PMC3865981
fatcat:xl3hvdz555a75c6luorf54cwli
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... es challenging technical difficulties, there is a crucial need to understand the impact of the receptor diffusivity, clustering, and spatial heterogeneity, and of receptor-adaptor protein complex formation on the cellular signal transduction patterns. Building upon our earlier studies, we have developed an adaptive coarse-grained Monte Carlo method that can be used to investigate the role of diffusion, clustering and membrane corralling on receptor association and receptor-adaptor protein complex formation dynamics in three dimensions. The new Monte Carlo lattice based approach allowed us to introduce spatial resolution on the 2-D plasma membrane and to model the cytoplasm in three-dimensions. Being a multi-resolution approach, our new method makes it possible to represent various parts of the cellular system at different levels of detail and enabled us to utilize the locally homogeneous assumption when justified (e.g., cytoplasmic region away from the cell membrane) and avoid its use when high spatial resolution is needed (e.g., cell membrane and cytoplasmic region near the membrane) while keeping the required computational complexity manageable. Our results have shown that diffusion has a significant impact on receptor-receptor dimerization and receptor-adaptor protein complex formation kinetics. We have observed an "adaptor protein hopping" mechanism where the receptor binding proteins may hop between receptors to form short-lived transient complexes. This increased residence time of the adaptor proteins near cell membrane and their ability to frequently change signaling partners may explain the increase in signaling efficiency when receptors are clustered. We also hypothesize that the adaptor protein hopping mechanism can cause concurrent or sequential activation of multiple signaling pathways, thus leading to crosstalk between diverse biological functions.
Page 1308 of Neural Computation Vol. 7, Issue 6
[page]
1995
Neural Computation
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Fundamenta Informaticae (ISSN: 0169-2968) is published in three volumes of four issues. ...
FUNDAMENTA INFORMATICAE |
under the auspices of EATCS (the European Association for Theoretical Computer Science)
Editor-in-Chief
Helena Rasiowat Institute of Mathematics University of Warsaw ul. ...
Preface
2009
Theoretical Computer Science
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Yu, Fundamenta Informaticae 73(1-2) (2006) 237-264. [12] ''Subword conditions and subword histories'', by A. Salomaa, S. ...
Yu, Fundamenta Informaticae 64(1-4) (2005) 471-480. [15] ''Mergible states in large NFA'', by C. Campeanu, N. Santean, S. ...
doi:10.1016/j.tcs.2009.02.026
fatcat:cicq6v3jezbsdovjyzfvp5gebi
L morphisms: Bounded delay and regularity of ambiguity
[chapter]
1991
Lecture Notes in Computer Science
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Juha Honkala: The equivalence problem of D0L and DF0L power series,
Fundamenta Informaticae 38 (1999) 201-208.
31. ...
Juha Honkala and Werner Kuich: On a power series generalization of
ET0L languages, Fundamenta Informaticae 25 (1996) 257-270.
19. ...
doi:10.1007/3-540-54233-7_164
fatcat:7mgxxwzh2vbw3kmkaxb4bldi64
Internal state recovery of keystream generator LILI-128 based on a novel weakness of the employed Boolean function
2012
Information Processing Letters
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Garg M. and Gangopadhyay S., A lower bound of the second-order nonlinearities of
Boolean bent functions, Fundamenta Informaticae, 111(4), pp. 413-422, 2011.
9. ...
., On second-order nonlinearities of some D 0 type
bent functions, Fundamenta Informaticae, vol. 114(3-4), pp. 271-285, 2012.
6. Stȃnicȃ P, Martinsen T., Gangopadhyay S. and Singh B. ...
doi:10.1016/j.ipl.2012.07.013
fatcat:vnkoxm4vkfgp5g6tmh4mr3dr3m
In memoriam of Yurii Rogozhin
2019
Computer Science Journal of Moldova
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Fundamenta Informaticae 138, 1-2, 273-284, 2015 3 http://www.math.md/en/people/rogojin-iurie/ 4 https://scholar.google.com/citations? ...
The staff of the Vladimir Andrunachievici Institute of Mathematics and Computer Science 1 Fundamenta Informaticae 138, 1-2, 2015 2 Yurii Rogozhin's Biography and Publications. ...
doaj:22bcf3f0a9ae4fb88b4abe1c2392fdeb
fatcat:juivdl43fraxpizu3rxq6mh6ly
Competencia Informática Pedagógica del Docente. Teorías y Modelos que la Fundamentan
2018
Revista de Investigación , Formación y Desarrollo: Generando Productividad Institucional
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En este trabajo se propone exponer brevemente los aportes de algunas de esas teorías a la explicación del proceso de formación informática pedagógica del docente. ...
Con el fin de argumentar un modelo pedagógico se realizó un estudio de algunas teorías de la tecnología educativa que se relacionan con la formación informática del docente. ...
Este modelo admite y fundamenta la posibilidad de integrar el componente tecnológico al conocimiento del contenido que requiere el docente en el contexto actual. ...
doi:10.34070/rif.v6i1.91
fatcat:5wwjxjqyjzbgvl3rc4qkwsxxfu
Resumos de Teses
2021
Informática na educação: teoria & prática
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Resumos de Teses homologadas de setembro a dezembro de 2021 no PPGI - Programa de Pós-graduação em Informática na Educação da UFRGS. ...
A proposta metodológica deste estudo fundamenta-se na abordagem qualitativa, com caráter explicativo e com a modalidade investigativa da intervenção. ...
doi:10.22456/1982-1654.121286
fatcat:aldeywxikzbyzhpxw5s4jaqd5a
Habilidade Cognitiva Espacial: uma medida com eletroencefalografia
2011
Informática na educação: teoria & prática
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A proposta contextualiza e fundamenta experimentos com um grupo de alunos voluntários dos cursos de graduação, selecionados para a pesquisa, classificados por idade e sexo e avaliados e selecionados por ...
Entende-se que os resultados obtidos nesse experimento possam colaborar com a Informática aplicada à Educação no planejamento, desenvol- vimento e uso de objetos virtuais em ambientes destinados a mediar ...
A proposta contextualiza e fundamenta experimentos com um grupo de alunos voluntários dos cursos de graduação, selecionados para a pesquisa, classificados por idade e sexo e avaliados e selecionados por ...
doi:10.22456/1982-1654.21075
fatcat:if4ddlbeevebvcp6aezgk3kxka
La informática médica en la formación integral de los futuros profesionales de las Ciencias Médicas
2006
Revista de ciencias médicas La Habana
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Se fundamenta la importancia de la informática médica en la formación integral del futuro profesional de las Ciencias Médicas. ...
También del uso de la informática en todos sus aspectos y las posibilidades que le brinda al profesional de la salud de desarrollo y profundización en su especialidad, cómo los profesores en sus clases ...
Asistente
RESUMEN
Se fundamenta la importancia de la informática médica en la formación integral del futuro
profesional de las Ciencias Médicas. ...
doaj:04396c58f3014a0da0fc5aec5389ce0b
fatcat:7bcucilvavbyjm23ctgzm3fegi
Index
1995
Neural Computation
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Fundamenta Informaticae (ISSN: 0169-2968) is published in three volumes of four issues. ...
Winkowski
Aims and Scope
Fundamenta Informaticae, an international journal, pub- lishes original results of research in all areas of the mathe- matical foundations of computer science. ...
doi:10.1162/neco.1995.7.6.1305
fatcat:ei6h4mc5rbefbisvpxlwwkbfiy
Formación docente en seguridad TIC: cuestiones pendientes
2014
Revista Iberoamericana de Educación
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En el presente trabajo se fundamenta la necesidad de incorporar esa temática no solo en la formación docente sino también en los últimos tramos de la educación media, teniendo en cuenta que muchos estudiantes ...
masivo de las tecnologías de la información y la comunicación (tic) ha traído consigo una consecuencia sobre la que los sistemas educativos no pueden mantenerse al margen: la cuestión de la seguridad informática ...
No presente trabalho fundamenta-se a necessidade de incorporar essa temática não somente na formação docente como também na última etapa da educação média, tendo em conta que muitos estudantes se incorporam ...
doi:10.35362/rie650397
fatcat:i34jjoyberd53dcuittxcjjogq
Las Tecnologías de la Informática y la Comunicación (TIC) Integradas a una Unidad Didáctica Interactiva para el Aprendizaje de la Bioquímica y Estructurada a partir del Modelo de Resolución de Problemas
2009
Tecné, Episteme y Didaxis
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La didáctica de las ciencias ha desarrollado en los últimos años un importante trabajo en la aplicación de las Tecnologías de la Informática y la Comunicación (TIC) en las aulas. ...
nivel académico en Ciencias Naturales y el fomento del uso de las Tecnologías, son algunos de los pilares sobre los cuales se soportan los principales cambios educativos, y es en este aspecto donde se fundamenta ...
Una de estas herramientas adoptadas en los últimos años es la informática, la cual ha tenido una considerable influencia en la actividad humana y junto con la internet ha establecido canales de comunicación ...
doi:10.17227/01203916.192
fatcat:ywoa5l6gtnfp7b2jxm26wz3bmq
Preface, Contents
1993
Banach Center Publications
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Informaticae. ...
The present volume contains papers from all four sections, although the majority of papers from Section III (Algebra and Logic in Computer Science) have already appeared in a special issue of Fundamenta ...
doi:10.4064/-28-1-1-7
fatcat:iuaw5kua2re4no5zckcjnh2l6a
INCIDENCIA DEL MODELO EDUCATIVO EN LA FORMACIÓN DE LOS EGRESADOS Y DEL COLECTIVO DE DOCENTES DE LA ESPAM MFL
2010
Revista Espamciencia
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implementación del modelo desde el año 2007 hasta el 2010 se realizaron 252 sesiones de trabajo con los docentes de las 7 carreras que oferta la institución: Agroindustria, Medio Ambiente, Pecuaria, Agrícola, Informática ...
9.15
Pecuaria
9.50
Medio Ambiente
9.36
Nov./08 -
Abril/09
Administración
9.14
Agrícola
8.99
Pecuaria
8.91
Medio Ambiente
8.75
Mayo/09 -
Oct./09
Administración
9.03
Agrícola
9.15
Informática ...
Jefatura Académica y de Postgrado
Volúmen 1, Número 2
ESPAMCIENCIA
Cuadro 2 : 2 Egresados por carrera CARRERAS
EGRESADOS
Agroindustrias
230
Medio Ambiente
127
Pecuaria
184
Agrícola
78
Informática ...
doaj:bfc7d78e99da440c9bd548a743fae16b
fatcat:wqqpbyen75ce7ehcdqxbknksg4
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