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These receptors are characterized by seven transmembrane domains with an extracellular N-terminus and a cytoplasmic C-terminus. ... These two opioid receptor types are also able to heterodimerize with each other and heterodimerization leads to changes in agonist affinity, efficacy and/or potency. ... This presentation will describe recent positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) studies of the functional integrity of these three regions in PTSD. ...doi:10.1017/s1461145702003176 fatcat:25u2fa2qmve7zpljmks4tqinge
Background: Cancer anorexia-cachexia syndrome is observed in 80% of patients in the advanced stages of cancer and is a strong independent risk factor for mortality. ... Accumulating evidence indicates that the pathogenesis of cancer anorexia is mediated by persistent anorexigenic signals into the hypothalamus. ... Sequential T1-weighted axial images of the thigh were obtained using magnetic resonance (MR) imaging. MR images were analysed offline to obtain quadriceps CSA. ...doi:10.1007/s13539-010-0001-7 pmid:22477519 pmcid:PMC3060650 fatcat:pqiwvimtajcfpduqkwvsfrfot4
HPG) axis function fundamentally affects the physiology of eating. We review sex differences in the physiological and pathophysiological controls of amounts eaten in rats, mice, monkeys, and humans. ... An activational effect of estrogens decreases eating 1) during the periovulatory period of the ovarian cycle in rats, mice, monkeys, and women and 2) tonically between puberty and reproductive senescence ... They are based on indirect detection of cerebral glucose metabolism (positron-emission tomography) or, more frequently, indirect detection of cerebral blood flow (functional magnetic resonance imaging) ...doi:10.1152/ajpregu.00446.2012 pmid:23904103 pmcid:PMC3882560 fatcat:k72ojy5r6zew7fgp6isrbbzfqy