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Functional co-activation of the default mode network in APOE ε4-carriers: a replication study
2021
NeuroImage
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Filippini et al. found that the default mode network (DMN) is already affected in young APOE ε4-carriers, with increased co-activation of the DMN during rest and increased hippocampal task activation. ...
We studied morphometric features, functional DMN co-activation and functional task activation of recollection performance. ...
A specific RSN is the default mode network (DMN), which comprises the anterior cingulate cortex, posterior cingulate cortex, precuneus, medial prefrontal cortex, retrosplenial cortex, parietal cortex and ...
doi:10.1016/j.neuroimage.2021.118304
pmid:34329959
fatcat:gdqa2zrbhzcwlkjpeswsqodvaq
Increased posterior default mode network activity and structural connectivity in young adult APOE-ε4 carriers: a multimodal imaging investigation
2019
Neurobiology of Aging
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Young adult APOE-ε4 carriers show increased activity in posterior regions of the default mode network (pDMN), but how this is related to structural connectivity is unknown. ...
Critically, such changes may reflect reduced network efficiency/flexibility in APOE-ε4 carriers, which in itself may portend a faster decline in connectivity over the lifespan and ultimately trigger early ...
Acknowledgements This work was supported by Alzheimer's Research UK (KSG), the Medical Research Council (MR/N01233X/1: KSG; G1002149: KSG, ...
doi:10.1016/j.neurobiolaging.2018.08.026
pmid:30339963
pmcid:PMC6261847
fatcat:7vhfafvax5brzb7nt2whazb7my
Alterations in dorsal and ventral posterior cingulate connectivity in APOE ε4 carriers at risk of Alzheimer's disease
2015
BJPsych Open
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patterns.AimsTo examine the effect of physical activity and division of the PCC on brain functional connectivity measures in subjective memory complainers (SMC) carrying the epsilon 4 allele of apolipoprotein ...
show distinct alterations in dorsal and ventral PCC functional connectivity. ...
Acknowledgements We thank all the participants and our research staff for contributing to the study. We thank AIBL (www.aibl.csiro.au) for their support. ...
doi:10.1192/bjpo.bp.115.001339
pmid:27703739
pmcid:PMC4995563
fatcat:q2pgxwrvvbhpbb7gryotfyrpeu
Resting-State Functional Connectivity Is Associated With Cerebrospinal Fluid Levels of the Synaptic Protein NPTX2 in Non-demented Older Adults
2019
Frontiers in Aging Neuroscience
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Levels of NPTX2 were not associated with connectivity in other networks (executive control, limbic, dorsal attention, and default-mode). ...
Additionally, higher connectivity in the salience/ventral attention network was related to better performance on a composite measure of executive function. ...
ACKNOWLEDGMENTS The BIOCARD Study consists of 7 Cores with the following members: (1) the Administrative Core (MA and Rostislav Brichko); ( 2 ...
doi:10.3389/fnagi.2019.00132
pmid:31231205
pmcid:PMC6568192
fatcat:3cnlz5qi7ncp7llpjcjkrxsvt4
Modulation of APOE and SORL1 genes on hippocampal functional connectivity in healthy young adults
2017
Brain Structure and Function
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Compared with subjects with TT genotype, SORL1 G-allele carriers had a stronger negative rsFC in APOE ε4 carriers, but a weaker negative rsFC in APOE non-ε4 carriers. ...
The SORL1-and APOE-dependent hippocampal connectivity changes may at least partly account for their association with AD. ...
Acknowledgements This work was supported by the National Natural Science Foundation of China (Nos. 81425013, 91332113, ...
doi:10.1007/s00429-017-1377-3
pmid:28229235
pmcid:PMC5541082
fatcat:jfk6qg5zsvfbfglrr7dm6fyiou
Neuroimaging markers for the prediction and early diagnosis of Alzheimer's disease dementia
2011
Trends in Neurosciences
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Recent studies that have identified AD-like structural and functional brain changes in elderly people who are cognitively within the normal range or who have mild cognitive impairment (MCI) are discussed ...
In this Review, we discuss various neuroimaging measures that are proving to have potential value as biomarkers of AD pathology for the detection and prediction of AD before the onset of dementia. ...
award 08/IN.1/ B1846 (to HH), the "Landesoffensive zur Entwicklung wissenschaftlich-ökonomischer Exzellenz" (LOEWE) ...
doi:10.1016/j.tins.2011.05.005
pmid:21696834
pmcid:PMC3275347
fatcat:6dk62eqplrhlvckqy2c7cwcqdm
A Network of Genetic Effects on Non-Demented Cognitive Aging: Alzheimer's Genetic Risk (CLU + CR1 + PICALM) Intensifies Cognitive Aging Genetic Risk (COMT + BDNF) Selectively for APOE ɛ4 Carriers
2018
Journal of Alzheimer's Disease
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Results-APOE ε4 carriers with high AD-GRS had poorer EF performance at the centering age (75 years) and steeper 9-year decline with increasing CA-GRS but this association was not present in APOE ε4 carriers ...
In the present study, we examine a network approach assembling three clusters of genetic risk: (1) a prominent and commonly examined AD risk gene (i.e., Apolipoprotein (APOE; rs7412, rs429358)), (2) three ...
The funding sources did not have a role in the study design, data collection, statistical analysis, results interpretation, report writing, or submission decisions. ...
doi:10.3233/jad-170909
pmid:29480189
pmcid:PMC5830167
fatcat:wf7kie6hqjhlhjvq6pu4clqc5i
Patterns of functional connectivity in an aging population: The Rotterdam Study
2019
NeuroImage
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Within the anterior default mode network, ventral attention network, and sensorimotor network, functional connectivity was significantly lower with older age. ...
Structural brain markers are studied extensively in the field of neurodegeneration, but are thought to occur rather late in the process. ...
Acknowledgements We are grateful to the study participants, the staff from the Rotterdam Study, and participating general practitioners and pharmacists. H.I. Zonneveld et al. ...
doi:10.1016/j.neuroimage.2019.01.041
pmid:30659958
fatcat:vcal3k4cizcb3lprxdsjfonwb4
Sex Moderates Amyloid and Apolipoprotein ε4 Effects on Default Mode Network Connectivity at Rest
2019
Frontiers in Neurology
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Resting state functional MRI (fMRI) investigations demonstrate interactions between sex and AD risk factors in default mode network (DMN) connectivity, a network of brain regions showing progressive dysfunction ...
It is unknown whether left prefrontal functional connectivity with anterior and posterior default mode network (aDMN, pDMN) might differ by sex in AD. ...
ACKNOWLEDGMENTS We thank the ADNI for their contribution to the field and for specific use of these data. ...
doi:10.3389/fneur.2019.00900
pmid:31481928
pmcid:PMC6710397
fatcat:6ebbxpfcinhmvnwhjnnw2nj7di
Default mode network connectivity: effects of age, sex, and analytic approach
2008
NeuroReport
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Resting state functional MRI (fMRI) investigations demonstrate interactions between sex and AD risk factors in default mode network (DMN) connectivity, a network of brain regions showing progressive dysfunction ...
It is unknown whether left prefrontal functional connectivity with anterior and posterior default mode network (aDMN, pDMN) might differ by sex in AD. ...
ACKNOWLEDGMENTS We thank the ADNI for their contribution to the field and for specific use of these data. ...
doi:10.1097/wnr.0b013e328300ebbf
pmid:18463507
fatcat:nua3rmre2ngerk3x6st6nnr2ue
Imaging markers of structural and functional brain changes that precede cognitive symptoms in risk for Alzheimer's disease
2013
Brain Imaging and Behavior
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Focusing on prodromal subjects, we will discuss structural changes to hippocampal subregions, alterations to functional activity both within the hippocampus and elsewhere in the cortex, as well as changes ...
Neuroimaging has rapidly advanced investigations into dysfunction both within and emanating from the hippocampus in early Alzheimer's disease. ...
Acknowledgments The authors thank Ms. Natacha Donoghue and Ms. Jacqueline Martinez for help in subject recruitment, data management, and study coordination. ...
doi:10.1007/s11682-013-9278-4
pmid:24317680
pmcid:PMC4012007
fatcat:fth5gb2f7zcbbkdswjt7c7hwx4
Dementia with Lewy bodies: association of Alzheimer pathology with functional connectivity networks
2021
Brain
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The first objective of this study was to investigate the effect of AD co-pathology on functional network changes within the default mode network (DMN) in DLB. ...
Our findings suggest that a higher burden of AD co-pathology in DLB patients is associated with more AD-like changes in functional connectivity. ...
Competing interests The authors report no competing interests.
Supplementary material Supplementary material is available at Brain online. ...
doi:10.1093/brain/awab218
pmid:34114602
pmcid:PMC8634124
fatcat:sjdb2ygbhvgkncfhqqndi5lzqi
Sex differences in the association between apolipoprotein E ε4 allele and Alzheimer's disease markers
2018
Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
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Methods: Among normal control (NC) participants (N 5 702) and participants with mild cognitive impairment (N 5 576) and AD (N 5 305), we examined the associations of sex and APOE-ε4 carrier status with ...
We determined whether the effect of apolipoprotein E (APOE)-ε4 genotype on Alzheimer's disease (AD) markers differs in men and women across AD stages. ...
connectivity in the default mode network [18] was stronger in women versus men, although not consistently [19, 20] . ...
doi:10.1016/j.dadm.2018.06.004
pmid:30182053
pmcid:PMC6120724
fatcat:pfptuto5hjccxmmlfqpvr2eu3i
Using event-related fMRI to examine sustained attention processes and effects of APOE ε4 in young adults
2018
PLoS ONE
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The data indicate that, in the absence of behavioural differences, young adult ε4 carriers already show a different linkage between functional brain activity and behaviour, as well as aberrant hippocampal ...
In this study we investigated effects of the APOE ε4 allele (which confers an enhanced risk of poorer cognitive ageing, and Alzheimer's Disease) on sustained attention (vigilance) performance in young ...
Young adult e4+ also show enhanced co-activation within hippocampal [19] and default mode [20, 21] resting state networks. ...
doi:10.1371/journal.pone.0198312
pmid:29856823
pmcid:PMC5983530
fatcat:7jphj72zrncslbb66mjdsp7hrm
Alzheimer's disease: The influence of age on clinical heterogeneity through the human brain connectome
2017
Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
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), 54% females, 5 APOE ε4 carriers. ...
56-70), education 16.7 years (SD 2.6), 57% females, a single apolipoprotein E (APOE) ε4 carrier. ...
doi:10.1016/j.dadm.2016.12.007
pmid:28239637
pmcid:PMC5318292
fatcat:wd4vka4uj5ga5mqgkl2g3kjtpq
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