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Functional co-activation of the default mode network in APOE ε4-carriers: a replication study

Lara J. Mentink, João P.O.F.T. Guimarães, Myrthe Faber, Emma Sprooten, Marcel G.M. Olde Rikkert, Koen V. Haak, Christian F. Beckmann
2021 NeuroImage  
Filippini et al. found that the default mode network (DMN) is already affected in young APOE ε4-carriers, with increased co-activation of the DMN during rest and increased hippocampal task activation.  ...  We studied morphometric features, functional DMN co-activation and functional task activation of recollection performance.  ...  A specific RSN is the default mode network (DMN), which comprises the anterior cingulate cortex, posterior cingulate cortex, precuneus, medial prefrontal cortex, retrosplenial cortex, parietal cortex and  ... 
doi:10.1016/j.neuroimage.2021.118304 pmid:34329959 fatcat:gdqa2zrbhzcwlkjpeswsqodvaq

Increased posterior default mode network activity and structural connectivity in young adult APOE-ε4 carriers: a multimodal imaging investigation

Carl J. Hodgetts, Jonathan P. Shine, Huw Williams, Mark Postans, Rebecca Sims, Julie Williams, Andrew D. Lawrence, Kim S. Graham
2019 Neurobiology of Aging  
Young adult APOE-ε4 carriers show increased activity in posterior regions of the default mode network (pDMN), but how this is related to structural connectivity is unknown.  ...  Critically, such changes may reflect reduced network efficiency/flexibility in APOE-ε4 carriers, which in itself may portend a faster decline in connectivity over the lifespan and ultimately trigger early  ...  Acknowledgements This work was supported by Alzheimer's Research UK (KSG), the Medical Research Council (MR/N01233X/1: KSG; G1002149: KSG,  ... 
doi:10.1016/j.neurobiolaging.2018.08.026 pmid:30339963 pmcid:PMC6261847 fatcat:7vhfafvax5brzb7nt2whazb7my

Alterations in dorsal and ventral posterior cingulate connectivity in APOE ε4 carriers at risk of Alzheimer's disease

Rebecca Kerestes, Pramit M. Phal, Chris Steward, Bradford A. Moffat, Simon Salinas, Kay L. Cox, Kathryn A. Ellis, Elizabeth V. Cyarto, David Ames, Ralph N. Martins, Colin L. Masters, Christopher C. Rowe (+6 others)
2015 BJPsych Open  
patterns.AimsTo examine the effect of physical activity and division of the PCC on brain functional connectivity measures in subjective memory complainers (SMC) carrying the epsilon 4 allele of apolipoprotein  ...  show distinct alterations in dorsal and ventral PCC functional connectivity.  ...  Acknowledgements We thank all the participants and our research staff for contributing to the study. We thank AIBL ( for their support.  ... 
doi:10.1192/bjpo.bp.115.001339 pmid:27703739 pmcid:PMC4995563 fatcat:q2pgxwrvvbhpbb7gryotfyrpeu

Resting-State Functional Connectivity Is Associated With Cerebrospinal Fluid Levels of the Synaptic Protein NPTX2 in Non-demented Older Adults

Anja Soldan, Abhay Moghekar, Keenan A. Walker, Corinne Pettigrew, Xirui Hou, Hanzhang Lu, Michael I. Miller, Alfonso Alfini, Marilyn Albert, Desheng Xu, Mei-Fang Xiao, Paul Worley (+1 others)
2019 Frontiers in Aging Neuroscience  
Levels of NPTX2 were not associated with connectivity in other networks (executive control, limbic, dorsal attention, and default-mode).  ...  Additionally, higher connectivity in the salience/ventral attention network was related to better performance on a composite measure of executive function.  ...  ACKNOWLEDGMENTS The BIOCARD Study consists of 7 Cores with the following members: (1) the Administrative Core (MA and Rostislav Brichko); ( 2  ... 
doi:10.3389/fnagi.2019.00132 pmid:31231205 pmcid:PMC6568192 fatcat:3cnlz5qi7ncp7llpjcjkrxsvt4

Modulation of APOE and SORL1 genes on hippocampal functional connectivity in healthy young adults

Junlin Shen, Wen Qin, Qiang Xu, Lixue Xu, Jiayuan Xu, Peng Zhang, Huaigui Liu, Bing Liu, Tianzi Jiang, Chunshui Yu
2017 Brain Structure and Function  
Compared with subjects with TT genotype, SORL1 G-allele carriers had a stronger negative rsFC in APOE ε4 carriers, but a weaker negative rsFC in APOE non-ε4 carriers.  ...  The SORL1-and APOE-dependent hippocampal connectivity changes may at least partly account for their association with AD.  ...  Acknowledgements This work was supported by the National Natural Science Foundation of China (Nos. 81425013, 91332113,  ... 
doi:10.1007/s00429-017-1377-3 pmid:28229235 pmcid:PMC5541082 fatcat:jfk6qg5zsvfbfglrr7dm6fyiou

Neuroimaging markers for the prediction and early diagnosis of Alzheimer's disease dementia

Michael Ewers, Reisa A. Sperling, William E. Klunk, Michael W. Weiner, Harald Hampel
2011 Trends in Neurosciences  
Recent studies that have identified AD-like structural and functional brain changes in elderly people who are cognitively within the normal range or who have mild cognitive impairment (MCI) are discussed  ...  In this Review, we discuss various neuroimaging measures that are proving to have potential value as biomarkers of AD pathology for the detection and prediction of AD before the onset of dementia.  ...  award 08/IN.1/ B1846 (to HH), the "Landesoffensive zur Entwicklung wissenschaftlich-ökonomischer Exzellenz" (LOEWE)  ... 
doi:10.1016/j.tins.2011.05.005 pmid:21696834 pmcid:PMC3275347 fatcat:6dk62eqplrhlvckqy2c7cwcqdm

A Network of Genetic Effects on Non-Demented Cognitive Aging: Alzheimer's Genetic Risk (CLU + CR1 + PICALM) Intensifies Cognitive Aging Genetic Risk (COMT + BDNF) Selectively for APOE ɛ4 Carriers

Shraddha Sapkota, Roger A. Dixon
2018 Journal of Alzheimer's Disease  
Results-APOE ε4 carriers with high AD-GRS had poorer EF performance at the centering age (75 years) and steeper 9-year decline with increasing CA-GRS but this association was not present in APOE ε4 carriers  ...  In the present study, we examine a network approach assembling three clusters of genetic risk: (1) a prominent and commonly examined AD risk gene (i.e., Apolipoprotein (APOE; rs7412, rs429358)), (2) three  ...  The funding sources did not have a role in the study design, data collection, statistical analysis, results interpretation, report writing, or submission decisions.  ... 
doi:10.3233/jad-170909 pmid:29480189 pmcid:PMC5830167 fatcat:wf7kie6hqjhlhjvq6pu4clqc5i

Patterns of functional connectivity in an aging population: The Rotterdam Study

Hazel I. Zonneveld, Raimon HR. Pruim, Daniel Bos, Henri A. Vrooman, Ryan L. Muetzel, Albert Hofman, Serge ARB. Rombouts, Aad van der Lugt, Wiro J. Niessen, M. Arfan Ikram, Meike W. Vernooij
2019 NeuroImage  
Within the anterior default mode network, ventral attention network, and sensorimotor network, functional connectivity was significantly lower with older age.  ...  Structural brain markers are studied extensively in the field of neurodegeneration, but are thought to occur rather late in the process.  ...  Acknowledgements We are grateful to the study participants, the staff from the Rotterdam Study, and participating general practitioners and pharmacists. H.I. Zonneveld et al.  ... 
doi:10.1016/j.neuroimage.2019.01.041 pmid:30659958 fatcat:vcal3k4cizcb3lprxdsjfonwb4

Sex Moderates Amyloid and Apolipoprotein ε4 Effects on Default Mode Network Connectivity at Rest

Jessica Z. K. Caldwell, Xiaowei Zhuang, MacKenzie J. Leavitt, Sarah J. Banks, Jeffrey Cummings, Dietmar Cordes, The Alzheimer's Disease Neuroimaging Initiative
2019 Frontiers in Neurology  
Resting state functional MRI (fMRI) investigations demonstrate interactions between sex and AD risk factors in default mode network (DMN) connectivity, a network of brain regions showing progressive dysfunction  ...  It is unknown whether left prefrontal functional connectivity with anterior and posterior default mode network (aDMN, pDMN) might differ by sex in AD.  ...  ACKNOWLEDGMENTS We thank the ADNI for their contribution to the field and for specific use of these data.  ... 
doi:10.3389/fneur.2019.00900 pmid:31481928 pmcid:PMC6710397 fatcat:6ebbxpfcinhmvnwhjnnw2nj7di

Default mode network connectivity: effects of age, sex, and analytic approach

Robyn L. Bluhm, Elizabeth A. Osuch, Ruth A. Lanius, Kristine Boksman, Richard W.J. Neufeld, Jean Théberge, Peter Williamson
2008 NeuroReport  
Resting state functional MRI (fMRI) investigations demonstrate interactions between sex and AD risk factors in default mode network (DMN) connectivity, a network of brain regions showing progressive dysfunction  ...  It is unknown whether left prefrontal functional connectivity with anterior and posterior default mode network (aDMN, pDMN) might differ by sex in AD.  ...  ACKNOWLEDGMENTS We thank the ADNI for their contribution to the field and for specific use of these data.  ... 
doi:10.1097/wnr.0b013e328300ebbf pmid:18463507 fatcat:nua3rmre2ngerk3x6st6nnr2ue

Imaging markers of structural and functional brain changes that precede cognitive symptoms in risk for Alzheimer's disease

Alison Burggren, Jesse Brown
2013 Brain Imaging and Behavior  
Focusing on prodromal subjects, we will discuss structural changes to hippocampal subregions, alterations to functional activity both within the hippocampus and elsewhere in the cortex, as well as changes  ...  Neuroimaging has rapidly advanced investigations into dysfunction both within and emanating from the hippocampus in early Alzheimer's disease.  ...  Acknowledgments The authors thank Ms. Natacha Donoghue and Ms. Jacqueline Martinez for help in subject recruitment, data management, and study coordination.  ... 
doi:10.1007/s11682-013-9278-4 pmid:24317680 pmcid:PMC4012007 fatcat:fth5gb2f7zcbbkdswjt7c7hwx4

Dementia with Lewy bodies: association of Alzheimer pathology with functional connectivity networks

Julia Schumacher, Jeffrey L Gunter, Scott A Przybelski, David T Jones, Jonathan Graff-Radford, Rodolfo Savica, Christopher G Schwarz, Matthew L Senjem, Clifford R Jack, Val J Lowe, David S Knopman, Julie A Fields (+8 others)
2021 Brain  
The first objective of this study was to investigate the effect of AD co-pathology on functional network changes within the default mode network (DMN) in DLB.  ...  Our findings suggest that a higher burden of AD co-pathology in DLB patients is associated with more AD-like changes in functional connectivity.  ...  Competing interests The authors report no competing interests. Supplementary material Supplementary material is available at Brain online.  ... 
doi:10.1093/brain/awab218 pmid:34114602 pmcid:PMC8634124 fatcat:sjdb2ygbhvgkncfhqqndi5lzqi

Sex differences in the association between apolipoprotein E ε4 allele and Alzheimer's disease markers

Erin E. Sundermann, My Tran, Pauline M. Maki, Mark W. Bondi
2018 Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring  
Methods: Among normal control (NC) participants (N 5 702) and participants with mild cognitive impairment (N 5 576) and AD (N 5 305), we examined the associations of sex and APOE-ε4 carrier status with  ...  We determined whether the effect of apolipoprotein E (APOE)-ε4 genotype on Alzheimer's disease (AD) markers differs in men and women across AD stages.  ...  connectivity in the default mode network [18] was stronger in women versus men, although not consistently [19, 20] .  ... 
doi:10.1016/j.dadm.2018.06.004 pmid:30182053 pmcid:PMC6120724 fatcat:pfptuto5hjccxmmlfqpvr2eu3i

Using event-related fMRI to examine sustained attention processes and effects of APOE ε4 in young adults

Simon Evans, Devin Clarke, Nicholas G. Dowell, Naji Tabet, Sarah L. King, Samuel B. Hutton, Jennifer M. Rusted, Linda Chao
2018 PLoS ONE  
The data indicate that, in the absence of behavioural differences, young adult ε4 carriers already show a different linkage between functional brain activity and behaviour, as well as aberrant hippocampal  ...  In this study we investigated effects of the APOE ε4 allele (which confers an enhanced risk of poorer cognitive ageing, and Alzheimer's Disease) on sustained attention (vigilance) performance in young  ...  Young adult e4+ also show enhanced co-activation within hippocampal [19] and default mode [20, 21] resting state networks.  ... 
doi:10.1371/journal.pone.0198312 pmid:29856823 pmcid:PMC5983530 fatcat:7jphj72zrncslbb66mjdsp7hrm

Alzheimer's disease: The influence of age on clinical heterogeneity through the human brain connectome

Bradford C. Dickerson, Michael Brickhouse, Scott McGinnis, David A. Wolk
2017 Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring  
), 54% females, 5 APOE ε4 carriers.  ...  56-70), education 16.7 years (SD 2.6), 57% females, a single apolipoprotein E (APOE) ε4 carrier.  ... 
doi:10.1016/j.dadm.2016.12.007 pmid:28239637 pmcid:PMC5318292 fatcat:wd4vka4uj5ga5mqgkl2g3kjtpq
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