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Unravelling the Intrinsic Functional Organization of the Human Striatum: A Parcellation and Connectivity Study Based on Resting-State fMRI

Wi Hoon Jung, Joon Hwan Jang, Jin Woo Park, Euitae Kim, Eun-Hoe Goo, Oh-Soo Im, Jun Soo Kwon, Daniel Margulies
<span title="2014-09-09">2014</span> <i title="Public Library of Science (PLoS)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/s3gm7274mfe6fcs7e3jterqlri" style="color: black;">PLoS ONE</a> </i> &nbsp;
Thus, we applied unsupervised clustering algorithms to parcellate the human striatum based on its functional connectivity patterns to other brain regions without any anatomically or functionally defined  ...  Our findings also demonstrate that the clustering of functional connectivity patterns is a reliable feature in parcellating the striatum into anatomically and functionally meaningful subdivisions.  ...  Acknowledgments The authors thank the faculty and staff of the Clinical Cognitive Neuroscience Center (CCNC) for their help and support while preparing this paper.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1371/journal.pone.0106768">doi:10.1371/journal.pone.0106768</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/25203441">pmid:25203441</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4159235/">pmcid:PMC4159235</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/p4mhtbkiyrfqlekwkxnyytcooi">fatcat:p4mhtbkiyrfqlekwkxnyytcooi</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20171010065636/http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0106768&amp;type=printable" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/09/a1/09a17f4919bd04e143580cc92bc6ce7079cf3355.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1371/journal.pone.0106768"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> plos.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159235" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Individualized Functional Parcellation of the Human Amygdala Using a Semi-supervised Clustering Method: A 7T Resting State fMRI Study

Xianchang Zhang, Hewei Cheng, Zhentao Zuo, Ke Zhou, Fei Cong, Bo Wang, Yan Zhuo, Lin Chen, Rong Xue, Yong Fan
<span title="2018-04-26">2018</span> <i title="Frontiers Media SA"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/wrk3kouosrhcxiprcbguskdipu" style="color: black;">Frontiers in Neuroscience</a> </i> &nbsp;
Previous attempts to parcellate this small structure using unsupervised clustering methods based on resting state fMRI data suffered from the low spatial resolution of typical fMRI data, and it remains  ...  The amygdala plays an important role in emotional functions and its dysfunction is considered to be associated with multiple psychiatric disorders in humans.  ...  Jing An (Siemens Shenzhen Magnetic Resonance Ltd., China), Ms. Yifan Miao (Siemens HealthCare, China) and Ms. Kun Hu for their technical assistance in data acquisition. We thank Dr.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fnins.2018.00270">doi:10.3389/fnins.2018.00270</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/29755313">pmid:29755313</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5932177/">pmcid:PMC5932177</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/s4gsnlstgvgrrnuys26yjyxvbq">fatcat:s4gsnlstgvgrrnuys26yjyxvbq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190304105757/http://pdfs.semanticscholar.org/c54c/3f356a6b36b55a68081889329052d9ec221a.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/c5/4c/c54c3f356a6b36b55a68081889329052d9ec221a.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fnins.2018.00270"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> frontiersin.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932177" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Motor and higher‐order functions topography of the human dentate nuclei identified with tractography and clustering methods

Fulvia Palesi, Matteo Ferrante, Marta Gaviraghi, Anastasia Misiti, Giovanni Savini, Alessandro Lascialfari, Egidio D'Angelo, Claudia A. M. Gandini Wheeler‐Kingshott
<span title="2021-06-04">2021</span> <i title="Wiley"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/wtsn7qcbmrhjppax2iuhu4xj2m" style="color: black;">Human Brain Mapping</a> </i> &nbsp;
This is the first study that indicates that more than half of the DN volumes is involved in non-motor functions and that connectivity-based and microstructure-based atlases provide complementary information  ...  Based on results, we defined DN parcellations deputed to motor and to higher-order functions in humans in vivo.  ...  Open access funding enabled and organized by Projekt DEAL.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1002/hbm.25551">doi:10.1002/hbm.25551</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/34087040">pmid:34087040</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC8356999/">pmcid:PMC8356999</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/vr5wm5e445dp5n6225fqjy5eoy">fatcat:vr5wm5e445dp5n6225fqjy5eoy</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210715175831/https://discovery.ucl.ac.uk/id/eprint/10129636/1/hbm.25551.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/fe/89/fe89c65c0c5193daf25ccfe149e9a5325c0e6253.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1002/hbm.25551"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> wiley.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8356999" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

The Role of Long-Range Connectivity for the Characterization of the Functional–Anatomical Organization of the Cortex

Thomas R. Knösche, Marc Tittgemeyer
<span title="">2011</span> <i title="Frontiers Media SA"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/j33hgvvadjhazfxeupgxga54ai" style="color: black;">Frontiers in Systems Neuroscience</a> </i> &nbsp;
We conclude that the use of non-invasively acquired connectivity estimates to characterize the functional-anatomical organization of the brain is a valid, relevant, and necessary endeavor.  ...  Given that brain regions frequently maintain characteristic connectivity profiles and the functional repertoire of a cortical area is closely related to its anatomical connections, long-range connectivity  ...  Of course the quality of the connectivity estimate itself has a decisive influence on the validity of connectivity-based models of functional-anatomical organization.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fnsys.2011.00058">doi:10.3389/fnsys.2011.00058</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/21779237">pmid:21779237</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3133730/">pmcid:PMC3133730</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/s32imoqsurcvll4pautpgnmwqe">fatcat:s32imoqsurcvll4pautpgnmwqe</a> </span>
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Ventral Intermediate Nucleus structural connectivity-derived segmentation: anatomical reliability and variability [article]

Salvatore Bertino, Gianpaolo Antonio Basile, Alessia Bramanti, Rossella Ciurleo, Adriana Tisano, Giuseppe Pio Anastasi, Demetrio Milardi, Alberto Cacciola
<span title="2021-05-02">2021</span> <i title="Cold Spring Harbor Laboratory"> bioRxiv </i> &nbsp; <span class="release-stage" >pre-print</span>
Finally, effect of data quality and parcellation pipelines on a volumetric index of connectivity clusters has been assessed.We found that the pipeline characterized by higher-order signal modeling and  ...  Finally, the volume of connectivity parcels resulted to be significantly influenced by data quality and parcellation pipelines.  ...  In such variant of the CSD-method, response functions for single-fibre WM as well as GM and CSF are estimated from the data using an unsupervised method (Dhollander et al., 2019) .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/2021.05.02.442321">doi:10.1101/2021.05.02.442321</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/64msht5tufe6rpi36rgia5lnje">fatcat:64msht5tufe6rpi36rgia5lnje</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20220129143405/https://www.biorxiv.org/content/biorxiv/early/2021/05/02/2021.05.02.442321.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/d0/7e/d07ebb50fa7c28fee4b8f1a607fc561fc689daed.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/2021.05.02.442321"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> biorxiv.org </button> </a>

Differential Reorganization of SMA Subregions After Stroke: A Subregional Level Resting-State Functional Connectivity Study

Huaigui Liu, Wangli Cai, Lixue Xu, Wei Li, Wen Qin
<span title="2020-02-28">2020</span> <i title="Frontiers Media SA"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/adcuz6lgabeidhngmk32v7egkq" style="color: black;">Frontiers in Human Neuroscience</a> </i> &nbsp;
The SMA proper and preSMA were identified by the rsFC-based parcellation, and the rsFCs of each SMA subregion were compared between stroke patients and healthy controls.  ...  We sought to identify the differential reorganization of the SMA subregions after subcortical stroke using the resting-state functional connectivity (rsFC) analysis.  ...  This parcellation framework is generally carried out using unsupervised clustering methods according to the similarity in either anatomical or functional connectivity profiles between voxels.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fnhum.2019.00468">doi:10.3389/fnhum.2019.00468</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/32184712">pmid:32184712</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC7059000/">pmcid:PMC7059000</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/arw6jeactre4vi777fxy4sp37u">fatcat:arw6jeactre4vi777fxy4sp37u</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200307021609/https://fjfsdata01prod.blob.core.windows.net/articles/files/469810/pubmed-zip/.versions/1/.package-entries/fnhum-13-00468/fnhum-13-00468.pdf?sv=2015-12-11&amp;sr=b&amp;sig=BSQi1nu%2BFzhGANEeUkxn5rz%2B3QvWMCETGVaHkLvzwEU%3D&amp;se=2020-03-07T02%3A16%3A38Z&amp;sp=r&amp;rscd=attachment%3B%20filename%2A%3DUTF-8%27%27fnhum-13-00468.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/68/03/680358ad700d4eac9a714767a440319d7ded71a3.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fnhum.2019.00468"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> frontiersin.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059000" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Parcellation of the cingulate cortex at rest and during tasks: a meta-analytic clustering and experimental study

Diana M. E. Torta, Tommaso Costa, Sergio Duca, Peter T. Fox, Franco Cauda
<span title="">2013</span> <i title="Frontiers Media SA"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/adcuz6lgabeidhngmk32v7egkq" style="color: black;">Frontiers in Human Neuroscience</a> </i> &nbsp;
These clusters covered different percentages of the cingulate parenchyma and had a different density of foci, with the first cluster being more densely connected.  ...  The MaC is a meta-analytic connectivity driven parcellation technique recently developed by our group which allowed us to parcellate the cingulate cortex on the basis of its pattern of co-activations during  ...  Recent studies have used magnetic resonance imaging (MRI) or functional MRI (fMRI) to investigate the connectivity based parcellation of the cingulate cortex.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fnhum.2013.00275">doi:10.3389/fnhum.2013.00275</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/23785324">pmid:23785324</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3682391/">pmcid:PMC3682391</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/px2abmebrrgv5al72bclcar7he">fatcat:px2abmebrrgv5al72bclcar7he</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20160429234727/http://brainmap.org/pubs/TortaFHN13.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/62/ab/62abdf3277864f21411718017deff609da8cde98.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fnhum.2013.00275"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> frontiersin.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682391" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Individualized Thalamic Parcellation Reveals Alterations in Shape and Microstructure of Thalamic Nuclei in Patients with Disorder of Consciousness

Weihao Zheng, Xufei Tan, Tingting Liu, Xiaoxia Li, Jian Gao, Lirong Hong, Xiaotong Zhang, Zhiyong Zhao, Yamei Yu, Yi Zhang, Benyan Luo, Dan Wu
<span title="2021-04-02">2021</span> <i title="Oxford University Press (OUP)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/vk53aicmibf5feye3yeh3xydaa" style="color: black;">Cerebral Cortex Communications</a> </i> &nbsp;
Enlargement of dorsal posterior nucleus and atrophy of anterior nucleus in the right thalamus were observed in DOC cohort relative to the HCs, and the former was closely linked to the consciousness level  ...  Our findings provide the first evidence for the shape deformation of thalamic nuclei in DOC patients and the microstructural basis of the disrupted thalamocortical connections.  ...  Segmentation of thalamic nuclei for individuals We used an automatic thalamus segmentation algorithm with unsupervised k-means clustering based on FOD shape and spatial distance (Battistella G et al.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/texcom/tgab024">doi:10.1093/texcom/tgab024</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/ktohkbyburdptnc7le3blidlia">fatcat:ktohkbyburdptnc7le3blidlia</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210407082726/https://watermark.silverchair.com/tgab024.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAscwggLDBgkqhkiG9w0BBwagggK0MIICsAIBADCCAqkGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMCyCmLKJCp3jfYnEvAgEQgIICeoTrTif7n77hq9GQrx-Wr3rdmVSewiAmu9Et_63MsaT5JshCUJEINtXg1b4HdAfDjmqB7JwLF1KGHszpJlQfyPhKbyBQ4hPYDxIhBnGRkW5Yy0H-qa1fDvsJen4_Bg0Al3CI0uNpULQlzOazmgd2xu1A_WszuTRfXDO6urNkTzmx4VHlzveNcljgb9Fn9CW-bisHev08KYVllZusJw0GUKMcmuUAYS2FZMcIWsnk4EUIIqzQ1ZzUWHx9L0badvwKoKvqIAHa8_V3_sqCKQEmJuO2B3TWXgPUe5O1v8AeSqfm_LpUCxRyj4XXDw79JjI-rgWCc8O9dvc1aXNyGHXmPT83V5-0xBX6_xtnV7VnWQi2T-aekx3qIwVsfQvXouvOvVLn3L4jS4YsQUpj9rgAEmD2jWNuYHjao5Py8juDKadjT0Mii9EFE5waSKi9R6nJcF5g2eh0olKOaBmc5lCqsWscadSzakAfbfdFidPoQ-FHA0TMjBxNEdPrKb7ne3qoEC87cvsTcF51yJGOUcfhP5CcA0IFrdCCHAyOqD-QWkniH-LT1ByK5Ylb-jyhqp8FYZ0bdr6m2qmDtjOcJhOfQOu0xp97KlroO8eSERyu_MkuAKH3qagX3uWRdsyZ3hq597zmuCGyLSPUiXkl-1KcfWMgHnC-8wiXfoM_NVYk77gu7aX70wX-ay5iLjfwSyR2m6HCWGA3AAFvU8bwby-sLD3O3H_D_TCgkD1Xu1o_ab-NhpAisoVkdQnUb74OKgD7ulQBmPXFbcVxeADFdRvAVxPYK3kEa9SzlyIMWNIuofe2YkVMiLVXEhI1kf4XvEuKqCwgXzMfYgAy7Qg" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/d2/6e/d26ef8759b4d132e4571cd68e6eea5d3834411f2.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/texcom/tgab024"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> oup.com </button> </a>

A Shared Vision for Machine Learning in Neuroscience

Mai-Anh T. Vu, Tülay Adalı, Demba Ba, György Buzsáki, David Carlson, Katherine Heller, Conor Liston, Cynthia Rudin, Vikaas S. Sohal, Alik S. Widge, Helen S. Mayberg, Guillermo Sapiro (+1 others)
<span title="2018-01-26">2018</span> <i title="Society for Neuroscience"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/s7bticdwizdmhll4taefg57jde" style="color: black;">Journal of Neuroscience</a> </i> &nbsp;
At multiple stages and levels of neuroscience investigation, machine learning holds great promise as an addition to the arsenal of analysis tools for discovering how the brain works.  ...  There has been a growing interest in leveraging this vast volume of data across levels of analysis, measurement techniques, and experimental paradigms to gain more insight into brain function.  ...  In fMRI, data-driven algorithms have been used to parcellate the brain based on fMRI functional connectivity data, yielding a functionally relevant fMRI atlas free of the constraints of a priori brain  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1523/jneurosci.0508-17.2018">doi:10.1523/jneurosci.0508-17.2018</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/29374138">pmid:29374138</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5815449/">pmcid:PMC5815449</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/ysowjl7q5bctvjxhrzdvqu6qyu">fatcat:ysowjl7q5bctvjxhrzdvqu6qyu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190501082357/http://www.jneurosci.org/content/jneuro/38/7/1601.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/80/a9/80a93fe8bee8ffa57212af8377a358d0941f466c.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1523/jneurosci.0508-17.2018"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815449" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Bagging improves reproducibility of functional parcellation of the human brain

Aki Nikolaidis, Anibal Solon Heinsfeld, Ting Xu, Pierre Bellec, Joshua Vogelstein, Michael Milham
<span title="2020-02-28">2020</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/sa477uo7lveh7hchpikpixop5u" style="color: black;">NeuroImage</a> </i> &nbsp;
This suggests that regardless of the specific parcellation strategy employed, bagging may be a key method for improving functional parcellation and bringing functional neuroimaging-based measurement closer  ...  Increasing the reproducibility of neuroimaging measurement addresses a central impediment to the advancement of human neuroscience and its clinical applications.  ...  Bagging for improved cluster stability 6 is not a new technique, nevertheless its rarely used in functional parcellation and clustering in 7 neuroimaging.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neuroimage.2020.116678">doi:10.1016/j.neuroimage.2020.116678</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/32119986">pmid:32119986</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC7302537/">pmcid:PMC7302537</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/pcn762ujzndffeosffh6425yhm">fatcat:pcn762ujzndffeosffh6425yhm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200306162715/https://pdf.sciencedirectassets.com/272508/AIP/1-s2.0-S1053811920301658/main.pdf?X-Amz-Security-Token=IQoJb3JpZ2luX2VjELf%2F%2F%2F%2F%2F%2F%2F%2F%2F%2FwEaCXVzLWVhc3QtMSJHMEUCIQCmougu1KF5SL9W4E%2BcwZ2aiKpjkcFV5bW5nGfySdYeAgIgQHMhGlN2%2BkpIseWDrLngCBKcxAq3zCPjZrXnRew%2FriMqvQMIkP%2F%2F%2F%2F%2F%2F%2F%2F%2F%2FARACGgwwNTkwMDM1NDY4NjUiDDWufgz932FMRdHWbSqRA5sY24WsCulZgUgfXC%2F4wSTZ0djuRdhycflh1ld9FIc53teHq8zAcx8rlJ7M7Td%2BJShypDKkquTTs%2BMm4RBEs7qN0vbx%2B51rrcKciif74Qfcx0cGYJz6NZeP5UdeWoKoRVGrIdwXImkya2g%2B82khVvEUx1dNQVG0zUG9HRBae8f9FAe3dp2tIBePrc4ygjFTeSWXOK1T2UFY97Tv3j5ws3IDuqwls2%2Fn9o3Q3ne0kNTU56cKq6YA8SXYv9YsRUrgyE%2BTiyG4DxV8KhI9eBhislRwQZeOL1GjRRXHTJCPytBBh2oQTZM8Jx%2Fswa%2Bu2RNapThE8Z9LupPG3I9xyEgM1hrRsnnbfC6u90sY49ptprWcJneLygDkPnyP06eBhywKYGEeJ%2FCphkM5vRfBWQen6ERm805LFG6%2BMOVs%2FURTyLQRKU4KVdphQCWCtCErWxECJ7awJ96DjkPuSy6x6AStzzn5%2Fxd2SUgbTxdE9mMLCwjMGkqyaoB6FwNYWaTy%2B7op4nhxaei9yDY%2FhoW30fC8xTO0MKLGifMFOusBKO%2FUwOMRb7roNWUKbgbdYVWWymIINwnrjBpiKrPoHhTSFXX8pPHpma1f%2BhsTWWU%2B8RgRsKvEDordpP6HhOKG3VAICQYCnJsnEBogAhx9%2BtOnwf1iTIoXq65qQYU8yeYlIvoyembEsqd3fmV34cohE5nv19ZXKZIROquOUYpTjN2e%2FaZfzj6cBzBlqhGl2emKofsATGYLJOx2g6vw8RtIGuULs8o4FSAS9fNz6wWNSW2zByr1X1le7VcedQMIAumR74RbxgZ6ZMhQSoMGlAhknlWlGbM4rT2gArzUNWPtEspm7hURurTVvoT7yw%3D%3D&amp;X-Amz-Algorithm=AWS4-HMAC-SHA256&amp;X-Amz-Date=20200306T162701Z&amp;X-Amz-SignedHeaders=host&amp;X-Amz-Expires=300&amp;X-Amz-Credential=ASIAQ3PHCVTYYFPC5U33%2F20200306%2Fus-east-1%2Fs3%2Faws4_request&amp;X-Amz-Signature=a38d28ff8a6c03a40b3ee72a091911c16f4679c50b6d23b580dfcdaabda3f577&amp;hash=ec26cc9cddd7ff36da6101a40102c05df8419f60820f115521c1eda7b5a554c7&amp;host=68042c943591013ac2b2430a89b270f6af2c76d8dfd086a07176afe7c76c2c61&amp;pii=S1053811920301658&amp;tid=spdf-209bdb2c-842e-4d39-a0ed-2561c6f5962b&amp;sid=a374487819c82548221bdcf428a108f3f7d7gxrqa&amp;type=client" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/c6/30/c630dd7e9df877dd0d69e0adf0867af8d2a18560.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neuroimage.2020.116678"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302537" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Hippocampus co-atrophy pattern in dementia deviates from covariance patterns across the lifespan

Anna Plachti, Shahrzad Kharabian, Simon B Eickhoff, Somayeh Maleki Balajoo, Felix Hoffstaedter, Deepthi P Varikuti, Christiane Jockwitz, Svenja Caspers, Katrin Amunts, Sarah Genon
<span title="2020-08-27">2020</span> <i title="Oxford University Press"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/3yly6om4ynhcta4fdjenhrdk5y" style="color: black;">Brain</a> </i> &nbsp;
In contrast, in dementia patients, the pattern of subdivision was closer to known functional differentiation into an anterior, body and tail subregions.  ...  We examined the pattern of structural covariance of hippocampus voxels in young, middle-aged, elderly, mild cognitive impairment and dementia disease samples by applying a clustering algorithm revealing  ...  Acknowledgements Data collection and sharing for this project was provided by the Cambridge Centre for Ageing  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/brain/awaa222">doi:10.1093/brain/awaa222</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/32851402">pmid:32851402</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC7523701/">pmcid:PMC7523701</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/loaqo5mturag7pbmjkbu3h22ka">fatcat:loaqo5mturag7pbmjkbu3h22ka</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200828124239/https://watermark.silverchair.com/awaa222.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAArowggK2BgkqhkiG9w0BBwagggKnMIICowIBADCCApwGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMOUUXOs0OAlYW6-apAgEQgIICbR1azF_Yq1XbF-AJTWN-ITS01zKLaFJOb-T1bokQ54yv0H79yb5yC9tx-iRwl1XXDH85X29Aie3UpeEKp94dIx4jWCKubQ2Zf2gUXltoouzUMjEfSpVL2fp8NeyGE-6-JOZGfY594Eto36G0zRHezX0VN9Na1S2H5T9QGLFyEkC6-cfMH8i8PiBTnwL9miomqCvHK3m577IMQFmXyZqVOkxkNkzpaNscXSwiLiK6SpHtWvRmDwTjZxsGtaqmY5M7r0bwskT5VFQbgHW595FLzWEFLdc-HSpcxfBErfmNzKm3WUr0ujXCHFlOkNC-RnRtD9RWpgs_nPKg_KqsfA7kKwan3G4TB6V5QjMISZDNZzsPfA3BlxYCVZUhGjiLdvEHpxyfHmuyXV3TLRcoozuOM2PzDzW-uiCAgGOr-LOzymgFrYhDNxgAG6R1jiXt8YcyTpARzMhip1IqM7Ha7eoIAURUqfWToTLf_yu6k7bEeUhgcnWz1kfSNH2aRcdgueJ1wiy2k2P7jMmq3mbmsEaTWAAE8RZspSy_skmp3IXjeXxaYAtKH3KlP_6TyIWsdJXXz4h5TfPrfBuLSY3rTp_dpjH42_KfRs-6JZycho3SGNGbamlpA9rIEkDbAGZU1EQ5gbrl48yssHbaJU-vaVk81BrUixRyssTeilXb5Q9pePTWkOItMLeGVmdMrx2OphPu8uwuOx18MlDK8ZtohtL5IS1UJr71dBdWCf14pmXIiETLkdBrpSbLVlZrlyk0q7AnlUYy3XjcfQFrLqpT3ZdNcxQ9P1VoUrUfx-OyK2qKCrA5xDiIeXWVhvqteaexGg" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/brain/awaa222"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> oup.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7523701" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

The Functional Segregation and Integration Model: Mixture Model Representations of Consistent and Variable Group-Level Connectivity in fMRI

Nathan W. Churchill, Kristoffer Madsen, Morten Mørup
<span title="">2016</span> <i title="MIT Press - Journals"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/rckx6fqoszfvva5c53bqivu5am" style="color: black;">Neural Computation</a> </i> &nbsp;
This extension of the GMM framework simultaneously estimates spatial clustering and the most consistent group functional connectivity structure.  ...  Gaussian mixture models (GMMs) are a powerful tool for parcellating the brain, based on the similarity of voxel time series.  ...  K.H.M. was supported by Lundbeckfonden (Grant of Excellence "ContAct" R59-5399 to Hartwig Roman Siebner) and by a Novo Nordisk Foundation Interdisciplinary Synergy Grant (NNF14OC0011413).  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1162/neco_a_00877">doi:10.1162/neco_a_00877</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/27557105">pmid:27557105</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/mfs7yb7hbra2rg6eagoc7urcea">fatcat:mfs7yb7hbra2rg6eagoc7urcea</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210325115202/https://watermark.silverchair.com/neco_a_00877.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAp4wggKaBgkqhkiG9w0BBwagggKLMIIChwIBADCCAoAGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMljtf8YJdqbAEDTzsAgEQgIICUU4qpr7kA0Qc7ONH3FxtduOQcL5ufASD0-BHmHbZcQtkjazpEIaOi68uNWIjk2AFyg0jKZwYnEVjeIWl3HHNTm3YParT1V2vRnbr1Yh6GCCORPrrTulMjn5D1sspm0wcgklBUzarB5OnS1Q2pzKtDu83Nmc_feG5x_TVx_CGL1efP2JwLMA7M1AwSyHcL1xaWx-0xPJIAo8uHi9-TJImmi41_U86jUH8hZghRz8CDeC0F27CYFG7_mAp6V52NT0Pgx7OrjKs1H0o7E8cC8Rwu4FCz_jE1UUXDhKlHKMx_DT6GyZO6Z1eYiMmsC3TUvemRty8AVjC-wxhW1_CB9JQ62KLDgVD0_w4Mtp00ipZ9G4s8KiGeISbQDSfSTOIy8lrvwXuQXw6NIoYfOFJ9_42VZTTJiFTtziclHkO0G4N8KLLweeioOBFW4FQLt0ufRyo4wrORJ3sBMTIeDGZYPANKytq2SFXui73FwTGvmAeYPJ0Uad-nPe148PpJU5lHm4_rD9e3rNWd_BK5ksf4GjY-ylqviH2-0TsZGCQs-QAE6qsMyVLpN64CIQqVVi2O0vuExvatyQkS04Qgd_Od5uMYj7jNGhohAPB2TkI-YXhaTFfn096H6OXoLqy7ErSNC3KW3OSI5P0E3xcLPLVmfpUoPXD8WfkpUmGmCPRrQjj4pIFed5few1ngLlJIe04KSu_Qii-WAa2fBYm2dVC8ICGOZ4Rnmlww7leoLDPtmVonbjP5diyxNy6aknTxWAMHreEzNjjq7vvPOo313e4jhKq_fzc" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/7b/41/7b4175613d20bd8bbfad2987c0f8437b0309fb72.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1162/neco_a_00877"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> mitpressjournals.org </button> </a>

Parsing heterogeneity in autism spectrum disorder and attention-deficit/hyperactivity disorder with individual connectome mapping [article]

Dina R Dajani, Catherine A Burrows, Mary Beth Nebel, Stewart H Mostofsky, Kathleen M Gates, Lucina Q Uddin
<span title="2018-12-08">2018</span> <i title="Cold Spring Harbor Laboratory"> bioRxiv </i> &nbsp; <span class="release-stage" >pre-print</span>
Ultimately, this work may provide a foundation for the development of a revised nosology focused on neurobiological substrates of mental illness as an alternative to traditional symptom-based classification  ...  Results shed light on the validity of conceptualizing the neural substrates of cognitive flexibility categorically in children.  ...  These shortcomings limit the validity of past factor and cluster-based studies of psychopathology.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/490672">doi:10.1101/490672</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/4seabqdmvrgubadpnfmnw3wjoq">fatcat:4seabqdmvrgubadpnfmnw3wjoq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190502183939/https://www.biorxiv.org/content/biorxiv/early/2018/12/08/490672.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/08/f2/08f28f7ee80349a200cb68bd4a55d8c5c965cde1.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/490672"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> biorxiv.org </button> </a>

Distributed Patterns of Brain Activity Underlying Real-Time fMRI Neurofeedback Training

Rotem Kopel, Kirsten Emmert, Frank Scharnowski, Sven Haller, Dimitri Van De Ville
<span title="">2017</span> <i title="Institute of Electrical and Electronics Engineers (IEEE)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/nrcoa2vuhjcvfctty6zgus57um" style="color: black;">IEEE Transactions on Biomedical Engineering</a> </i> &nbsp;
Cross validation of the multivariate model showed that it generalized across the participants.  ...  Cross-validation of the multivariate model showed that it generalized across participants.  ...  Image series were then parcelated into V = 90 regions based on the Greicius functional atlas [11] , and time courses were regionally averaged, de-meaned and linearly de-trended using Matlab standard functions  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1109/tbme.2016.2598818">doi:10.1109/tbme.2016.2598818</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/28541186">pmid:28541186</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/5y5quiuum5esldvbptvgoozjhe">fatcat:5y5quiuum5esldvbptvgoozjhe</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20181104154713/https://www.zora.uzh.ch/id/eprint/136194/1/ZORA136194.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/1c/bb/1cbba0cdf65ed51487da80d48f699329d47b3c91.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1109/tbme.2016.2598818"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> ieee.com </button> </a>

Investigating the Correspondence of Clinical Diagnostic Grouping With Underlying Neurobiological and Phenotypic Clusters Using Unsupervised Machine Learning

Xinyu Zhao, D. Rangaprakash, Bowen Yuan, Thomas S. Denney Jr, Jeffrey S. Katz, Michael N. Dretsch, Gopikrishna Deshpande
<span title="2018-09-25">2018</span> <i title="Frontiers Media SA"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/hg5divkqhvd33ped3qg2dcv44q" style="color: black;">Frontiers in Applied Mathematics and Statistics</a> </i> &nbsp;
In this study, we adopted various unsupervised clustering methods using static and dynamic rs-fMRI connectivity measures to investigate whether the clinical diagnostic grouping of different disorders is  ...  In order to do so, we derived a general analysis pipeline for identifying different brain-based disorders using genetic algorithm-based feature selection, and unsupervised clustering methods on four different  ...  In this study, we adopted various unsupervised clustering methods using static and dynamic rs-fMRI connectivity measures to investigate whether the clinical diagnostic grouping of different disorders is  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fams.2018.00025">doi:10.3389/fams.2018.00025</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/30393630">pmid:30393630</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6214192/">pmcid:PMC6214192</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/gjteyz7im5b5nogyklxomkyuq4">fatcat:gjteyz7im5b5nogyklxomkyuq4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190306211515/http://pdfs.semanticscholar.org/cc1b/0fcac906f4683037eb6459274cce92e8f97c.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/cc/1b/cc1b0fcac906f4683037eb6459274cce92e8f97c.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fams.2018.00025"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> frontiersin.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214192" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>
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