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Fully automatic evaluation of the corneal endothelium from in vivo confocal microscopy
2015
BMC Medical Imaging
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Manual and semi-automatic analyses of images, acquired in vivo by confocal microscopy, are often used to determine the quality of corneal endothelium in the human eye. ...
Here, we present two fully automatic methods to analyze and quantify corneal endothelium imaged by in vivo white light slit-scanning confocal microscopy. ...
Conclusions In this paper we have introduced an algorithm that can automatically analyze the corneal endothelium, as imaged using in vivo confocal microscopy, with a reasonable accuracy. ...
doi:10.1186/s12880-015-0054-3
pmid:25928199
pmcid:PMC4451752
fatcat:zq5gj5v7iba2zawoczmcj7ddou
A fully automated cell segmentation and morphometric parameter system for quantifying corneal endothelial cell morphology
2018
Computer Methods and Programs in Biomedicine
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Conclusions: We demonstrate the effectiveness and robustness of the CEAS system, and the possibility of utilizing it in a real world clinical setting to enable rapid diagnosis and for patient follow-up ...
densities using a separate database of 40 images from controls (n=11), obese subjects (n=16) and patients with diabetes (n=13). ...
obtained by in vivo corneal confocal microscopy. ...
doi:10.1016/j.cmpb.2018.03.015
pmid:29728238
fatcat:tsm7hkhhmvawrkumkg56t4hvjm
Corneal Endothelial Cell Segmentation by Classifier-driven Merging of Oversegmented Images
2018
IEEE Transactions on Medical Imaging
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Corneal endothelium images obtained by in vivo specular microscopy provide important information to assess the health status of the cornea. ...
We evaluated the automatic segmentation on a data set of in vivo specular microscopy images (Topcon SP-1P), obtaining 95.8% correctly merged cells and 2.0% undersegmented cells. ...
Krijnen for acquiring the images of our dataset. ...
doi:10.1109/tmi.2018.2841910
pmid:29993573
fatcat:oulhbsvihnalldudjpukkghabu
Topical 1% 5-fluorouracil in ocular surface squamous neoplasia: a long-term safety study
2010
British Journal of Ophthalmology
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Background/aims The aim of this study was to evaluate the long-term corneal toxicity of topical chemotherapy with 1% 5-fluorouracil (5-FU) as a sole or adjuvant treatment of ocular surface squamous neoplasia ...
Clinical confocal microscopy showed no long-term difference between the treated eye and fellow (control) eye in: endothelial cells count, pleomorphism and polymegatism, anterior stromal keratocyte density ...
The aim of this study was to evaluate long-term corneal toxicity of topical chemotherapy with 1% 5-FU, as a sole or adjuvant treatment of OSSN, using clinical confocal microscopy (CCM). ...
doi:10.1136/bjo.2010.183244
pmid:20693564
fatcat:qp36e6kbf5fshgrhfx44uh43xi
Coupling of HRT II and AS-OCT to evaluate corneal endothelial cell loss and in vivo visualization of the Ahmed glaucoma valve implant
2008
Eye (London. 1987)
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Aims To report corneal endothelial cell loss and in vivo visualization of the Ahmed glaucoma valve implant in eyes with refractory glaucoma. ...
. 36 Hara et al 33 compared the clinical efficacy of confocal biomicroscopy with that of non-contact specular microscopy for the evaluation of the corneal endothelium. ...
The aforementioned studies evaluated white light in vivo confocal microscopy. HRT II is a laser scanning confocal microscope. ...
doi:10.1038/eye.2008.321
pmid:18949003
fatcat:vrwynvdugfbpjgyuetliuilctu
Confocal Microscopy of Corneal Wound Healing After Deep Lamellar Keratoplasty in Rabbits
2010
Archives of Ophthalmology
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A full-thickness graft devoid of endothelium and Descemet membrane was sutured in place. Confocal examination of lamellar interface and wound edge was performed throughout 6 months. ...
Results: Four days postoperatively, confocal microscopy revealed numerous highly reflective keratocytes at and adjacent to the interface in all eyes, fewer in the deep than the near group. ...
A series of confocal images was recorded as the focal plane was advanced manually or automatically from the epithelium posterior to the endothelium. ...
doi:10.1001/archophthalmol.2009.357
pmid:20065221
fatcat:n7a7nro7nzcljofbytpe7ba5ra
Changes in corneal parameters at confocal microscopy in treated glaucoma patients
2011
Clinical Ophthalmology
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The purpose of this study was to evaluate corneal parameters in treated glaucoma patients, nontreated glaucoma patients, and normal subjects using confocal microscopy. ...
Methods: Forty patients with primary open-angle glaucoma and 22 untreated controls underwent confocal microscopy of the cornea using the Heidelberg retinal tomograph cornea module. ...
in vivo laser confocal microscopy of cornea The Heidelberg retina tomograph (HRT) was initially designed to evaluate the optic nerve head in glaucoma. ...
doi:10.2147/opth.s22874
pmid:21845031
pmcid:PMC3151567
fatcat:qg56vdgiqvfnxnzm6gj6augrhm
Examination of corneal deposits in nephropathic cystinosis using in vivo confocal microscopy and anterior segment optical coherence tomography: an age-dependent cross sectional study
2020
BMC Ophthalmology
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Crystals appeared as randomly oriented hyperreflective, elongated structures on in vivo confocal microscopy images in all corneal layers except the endothelium. ...
In vivo confocal microscopy and anterior segment optical coherence tomography confirmed an age-related pattern of crystal deposition. ...
EM recruited the patients, participated in study design. ASz and MCs helped in recruiting patients. NSz, OAM, MR, IL, KK: helped in formatting, language. ...
doi:10.1186/s12886-020-01336-w
pmid:32102651
pmcid:PMC7045449
fatcat:4pnl3qufhve5dctwk6eve74jky
Assessment of Corneal Thickness and Keratocyte Density in a Rabbit Model of Laser In Situ Keratomileusis Using Scanning Laser Confocal Microscopy
2011
American Journal of Ophthalmology
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In this research, we evaluate the use of in vivo scanning laser confocal microscopy to evaluate the accuracy and repeatability of in vivo measurements of corneal thickness and keratocyte density to determine ...
of the confocal microscope. 6 Likewise, others have shown that measurements of cell density and corneal thickness differ from other standard measurement techniques, e.g. specular microscopy 7 or ultrasonic ...
Twa, NIH/NEI: P30EY07551; confocal microscopy instrumentation provided by Heidelberg Engineering; M. Giese, None. Other Acknowledgments: The authors wish to thank Dr. ...
doi:10.1016/j.ajo.2011.05.023
pmid:21871603
pmcid:PMC3304505
fatcat:6cydd4pkufc5nhgsbx3db7sjem
In Vivo Confocal Microscopy of the Cornea: New Developments in Image Acquisition, Reconstruction, and Analysis Using the HRT-Rostock Corneal Module
2015
The ocular surface
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In vivo confocal microscopy has been used in a variety of corneal research and clinical applications since its development over 25 years ago. ...
The optical sectioning ability of confocal microscopy allows high magnification images to be obtained from different depths within a thick tissue specimen, and is thus ideally suited to the study of intact ...
Acknowledgments This study was supported in part by NIH R01 EY013322, EY024433, EY024546, NIH P30 EY020799, OneSight Research Foundation (DMR), and an unrestricted grant from Research to Prevent Blindness ...
doi:10.1016/j.jtos.2015.05.002
pmid:25998608
pmcid:PMC4499020
fatcat:cdia7i772bbojgtxqjrskg652a
Morphologic study of the cornea by in vivo confocal microscopy and optical coherence tomography after bifocal refractive corneal inlay implantation
2014
Journal of cataract and refractive surgery
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PURPOSE: To evaluate the biocompatibility of the Flexivue Microlens intracorneal inlay based on healing of corneal wounds and analysis of corneal structural features using in vivo confocal microscopy ( ...
Figure 7 . 7 In vivo confocal microscopy (reconstruction of image) shows the edge of the intracorneal inlay with its central hole (scale Z 100 mm).
Figure 8 . 8 In vivo confocal microscopy. ...
Patients were asked to look straight ahead, and an in vivo confocal microscope equipped with a standard 40.0 D water-immersion front lens automatically captured images of the full thickness of the central ...
doi:10.1016/j.jcrs.2013.08.057
pmid:24680518
fatcat:l5rty7al45bo7kskesyqdgpyni
Unbiased corneal tissue analysis using Gabor-domain optical coherence microscopy and machine learning for automatic segmentation of corneal endothelial cells
2020
Journal of Biomedical Optics
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To improve accuracy and reduce bias in endothelial cell density (ECD) quantification by combining Gabor-domain optical coherence microscopy (GDOCM) for three-dimensional, wide field-of-view (1 mm2) corneal ...
ECD obtained from automatic cell segmentation of GDOCM images yielded a correlation of 0.94 (p < 0.001) with the manual segmentation on the same images, and correlation of 0.91 (p < 0.001) with the corresponding ...
We thank the Sight Society of Northeastern NY for providing the specular microscope analysis for the corneal tissues used in this study. ...
doi:10.1117/1.jbo.25.9.092902
pmid:32770867
pmcid:PMC7413309
fatcat:jskplrmmwbevvk2gmxoolgtdau
Imaging and Quantification of Subbasal Nerve Plexus in Healthy Volunteers and Diabetic Patients with or without Retinopathy
2013
PLoS ONE
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in vivo confocal laser-scanning microscopy (CLSM). ...
Although automatic adapted image analysis simplifies the evaluation of in vivo CLSM data, image acquisition and quantitative analysis should be optimised for the everyday clinical practice. ...
Engineering of in vivo confocal laser-scanning microscopy (CLSM) in recent years has facilitated examination of the human cornea. ...
doi:10.1371/journal.pone.0052157
pmid:23341892
pmcid:PMC3546080
fatcat:6iv4o2muafalplfk7cfwncq4kq
Corneal Confocal Microscopy in the Diagnosis of Small Fiber Neuropathy: Faster, Easier, and More Efficient Than Skin Biopsy?
2021
Pathophysiology
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Corneal confocal microscopy (CCM) is a rapid, non-invasive, reproducible method for quantifying small nerve fiber degeneration and regeneration, and could be an important tool for diagnosing SFN. ...
This review considers the advantages and disadvantages of CCM and highlights the evolution of this technique from a research tool to a diagnostic test for small fiber damage, which can be a valuable contribution ...
Conflicts of Interest: The authors declare no conflict of interest. ...
doi:10.3390/pathophysiology29010001
pmid:35366285
pmcid:PMC8954271
fatcat:ips5y5aennahpn46fzm57nxz2a
Potential Factors of Corneal Endothelial Cells for Progression in Children with Uveitis
2021
Disease Markers
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Corneal endothelial microscopy is one of the important methods for the detection of uveitis with high sensitivity. ...
There are four abnormal forms of the corneal endothelium in children with uveitis: enlarged cell area gap, irregular cell shape, blurred intercellular space, and cell loss. ...
We will use confocal microscopy in vivo to study pediatric uveitis in more detail. ...
doi:10.1155/2021/8432774
pmid:34992695
pmcid:PMC8727170
fatcat:u7rdqrhrvfe45miw67kkkbn65u
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