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Modeling and incorporation of system response functions in 3-D whole body PET

A.M. Alessio, P.E. Kinahan, T.K. Lewellen
2006 IEEE Transactions on Medical Imaging  
The improved system model is applied in a modified ordered subsets expectation maximization (OSEM) algorithm to reconstruct images from rebinned, fully 3-D PET data.  ...  Index Terms-Detector response, Fourier rebinning (FORE), fully three-dimensional (3-D) positron emission tomography (PET), system model, system response.  ...  ACKNOWLEDGMENT The authors are thankful for image reconstruction conversations with J. Fessler and system modeling conversations with M. Defrise, C. Comtat, and L. Janeiro.  ... 
doi:10.1109/tmi.2006.873222 pmid:16827484 fatcat:oqukbgekcbab5k6px57wi2rd7q

Iterative reconstruction of Fourier-rebinned PET data using sinogram blurring function estimated from point source scans

Michel S. Tohme, Jinyi Qi
2010 Medical Physics (Lancaster)  
Methods: In a previous work, the authors developed an approach to estimating the sinogram blurring function of nonrebinned PET data from experimental scans of point sources.  ...  A radially and angularly variant 2D blurring function is estimated from Fourier-rebinned point source scans to model the transaxial blurring with consideration of the detector block structure of the scanner  ...  model that defines the mapping from sources to measurements.  ... 
doi:10.1118/1.3490711 pmid:21089788 pmcid:PMC2962665 fatcat:v7344kewe5a4nddehyc6ov7ele

Application and Evaluation of a Measured Spatially Variant System Model for PET Image Reconstruction

A.M. Alessio, C.W. Stearns, Shan Tong, S.G. Ross, S. Kohlmyer, A. Ganin, P.E. Kinahan
2010 IEEE Transactions on Medical Imaging  
We present a practical method for measuring the detector blurring component of a whole-body positron emission tomography (PET) system to form an approximate system model for use with fully-3-D reconstruction  ...  We measure the system response on a whole-body scanner, simplify it to a 2-D function, and incorporate a parameterized version of this response into a modified fully-3-D OSEM algorithm.  ...  Acknowledgments The authors are thankful for image reconstruction conversations with K. Thielemans, S. Wollenweber, E. Asma and R. Manjeshwar. The authors would like to thank R. Schmidtlein and A.  ... 
doi:10.1109/tmi.2010.2040188 pmid:20199927 pmcid:PMC2903538 fatcat:2xici3lgjjfw3fvb3ftasroiyy

Pragmatic fully 3D image reconstruction for the MiCES mouse imaging PET scanner

Kisung Lee, Paul E Kinahan, Jeffrey A Fessler, Robert S Miyaoka, Marie Janes, Tom K Lewellen
2004 Physics in Medicine and Biology  
We present a pragmatic approach to image reconstruction for data from the micro crystal elements system (MiCES) fully 3D mouse imaging positron emission tomography (PET) scanner under construction at the  ...  To model the effect of non-stationary detector blurring (DB) in the FORE+OSEM(DB) algorithm, we have added a factorized system matrix to the ASPIRE reconstruction library.  ...  We acknowledge helpful discussions with Dr Richard Leahy of USC and the assistance of Barbara Lewellen with the mouse experiments.  ... 
doi:10.1088/0031-9155/49/19/008 pmid:15552417 fatcat:asouo44eerb4rhbmpsfh2ue4qa

Iterative image reconstruction for positron emission tomography based on a detector response function estimated from point source measurements

Michel S Tohme, Jinyi Qi
2009 Physics in Medicine and Biology  
A monotonically convergent iterative algorithm has been derived to estimate the detector blurring matrix from the point source measurements.  ...  Point source measurements were acquired with high count statistics in a relatively fine grid inside the microPET II scanner using a high-precision 2-D motion stage.  ...  Yongfeng Yang at UC Davis for providing the point source phantom data.  ... 
doi:10.1088/0031-9155/54/12/007 pmid:19478379 pmcid:PMC2901798 fatcat:xkn2ngnpg5d3vdk4cpbjleyhe4

Resolution and noise properties of MAP reconstruction for fully 3-D PET

Jinyi Qi, R.M. Leahy
2000 IEEE Transactions on Medical Imaging  
We derive approximate analytical expressions for the local impulse response and covariance of images reconstructed from fully three-dimensional (3-D) positron emission tomography (PET) data using maximum  ...  The resulting spatially variant impulse response and covariance are computed using 3-D Fourier transforms.  ...  CONCLUSION We have derived simplified expressions for the resolution and noise properties of MAP reconstructions in fully 3-D PET. Fig. 19 .  ... 
doi:10.1109/42.870259 pmid:11021692 fatcat:ehuxdvvni5bnbf7a3gjpfpbt5q

Single scan parameterization of space-variant point spread functions in image space via a printed array: the impact for two PET/CT scanners

F A Kotasidis, J C Matthews, G I Angelis, P J Noonan, A Jackson, P Price, W R Lionheart, A J Reader
2011 Physics in Medicine and Biology  
and the robustness of measurements from a single point source array scan.  ...  A novel and practical methodology to rapidly and accurately determine the overall emission and detection blurring component of the system matrix using a printed point source array within a custom-made  ...  system matrix.  ... 
doi:10.1088/0031-9155/56/10/003 pmid:21490382 fatcat:xhm5t64upraopjvoagefahs7y4

A new virtual ring-based system matrix generator for iterative image reconstruction in high resolution small volume PET systems

K Li, M Safavi-Naeini, D R Franklin, Z Han, A B Rosenfeld, B Hutton, M L F Lerch
2015 Physics in Medicine and Biology  
Images reconstructed from Monte Carlo simulations of various point source and phantom models, produced using system matrices generated via both geometric and simulation methods, are used to evaluate the  ...  Two methods for populating the system matrix are compared; the first utilises a geometrically-derived system matrix based on Siddon's ray tracer method with the addition of an accurate detector response  ...  For a reconstructed image with a total of I pixels generated using Virtual ring-based system matrix generator for high resolution small-volume PET 3 data from a scanner with J possible detector pairs or  ... 
doi:10.1088/0031-9155/60/17/6949 pmid:26305868 fatcat:qclafu7m6rc55er35xinkobkay

Current Technologies in PET

水田 哲郎
2014 The Journal of the Institute of Electrical Installation Engineers of Japan  
.Conti: State of the art and challenges of time-of-flight PET ,Physica Medica.Vol.25,2009,p.1 2) VY.Panin,et al: Fully 3D PET reconstruction with system matrix derived from point source measurements ,  ...  K i t a m u r a , e t a l : I n t e g r a t e d S E T -3 0 0 0 G / X positron emission tomography scanner ,Cancer Imaging ed.M.A.Hayat,Academic Press,2008,ch 1.4 5) 日本核医学会: 乳房専用 PET 診療ガイドライン ,2013 6) S.Gross  ... 
doi:10.14936/ieiej.34.239 fatcat:zpevh6rkifekhnfb3kmnix4f2u


1999 International Journal of Modern Physics C  
system can be significantly improved by the 3-D acquisition and reconstruction.  ...  The low-count nature of these studies necessitates 3-D reconstruction in order to improve the sensitivity of the PET system: by including axially oblique Lines Of Response (LORs), the sensitivity of the  ...  Alberto Del Guerra, and the INFN of Ferrara, for providing data from the PET experimental apparatus. I would also like to thank Prof.  ... 
doi:10.1142/s0129183199000541 fatcat:wmmltbg7hbfurd3jjkkcelidnu

Fisher Information-Based Evaluation of Image Quality for Time-of-Flight PET

K. Vunckx, Lin Zhou, S. Matej, M. Defrise, J. Nuyts
2010 IEEE Transactions on Medical Imaging  
Simplified as well as realistic phantoms, measured both with TOF PET systems and with a conventional PET system, were simulated.  ...  Using this latter method the weighting function for filtered backprojection reconstruction of TOF PET data proposed by C. Watson can be derived.  ...  , including 2D and fully 3D PET [22] , [23] .  ... 
doi:10.1109/tmi.2009.2029098 pmid:19709969 pmcid:PMC2828326 fatcat:t5jr5s52rncozklteeqy37eujm

Cardiac motion compensation and resolution modeling in simultaneous PET-MR: a cardiac lesion detection study

Y Petibon, J Ouyang, X Zhu, C Huang, T G Reese, S Y Chun, Q Li, G El Fakhri
2013 Physics in Medicine and Biology  
(PSF) directly into the PET system matrix.  ...  In this perspective, we develop a list-mode iterative reconstruction framework incorporating both tagged-MR derived non-rigid myocardial wall motion and position dependent detector Point Spread Function  ...  The authors would like to thank Grae Arabasz for his help during the point sources and phantom acquisitions.  ... 
doi:10.1088/0031-9155/58/7/2085 pmid:23470288 pmcid:PMC3657754 fatcat:kcd4bpbc65efxmu5qecj5v75dq

Transmission imaging for integrated PET-MR systems

Spencer L Bowen, Niccolò Fuin, Michael A Levine, Ciprian Catana
2016 Physics in Medicine and Biology  
We utilized a Bayesian reconstruction algorithm, which directly generates μ-map estimates from multiple bed positions, combined with a robust scatter correction method.  ...  An implementation of the single torus source was filled with 18 F-fluorodeoxyglucose and the proposed method quantified for several test cases alone or in comparison with CT-derived μ-maps.  ...  Images were reconstructed from noiseless TX measurements.  ... 
doi:10.1088/0031-9155/61/15/5547 pmid:27384608 pmcid:PMC5004490 fatcat:y3qadptgxjb2tfzpya6m7zu4y4

Relative role of motion and PSF compensation in whole-body oncologic PET-MR imaging

Yoann Petibon, Chuan Huang, Jinsong Ouyang, Timothy G. Reese, Quanzheng Li, Aleksandra Syrkina, Yen-Lin Chen, Georges El Fakhri
2014 Medical Physics (Lancaster)  
Methods: An asymmetric exponential PSF model accounting for radially varying and axial detector blurring effects was obtained from point source acquisitions performed in the PET-MR scanner.  ...  Improved PET images may be obtained by modeling respiratory motion and point spread function (PSF) within the PET iterative reconstruction process.  ...  PSF models can be derived from Monte Carlo simulations, 23 analytical calculation, 24 and physical measurements with point or line sources [25] [26] [27] [28] or positron beams in combined PET-MR  ... 
doi:10.1118/1.4868458 pmid:24694156 pmcid:PMC3971824 fatcat:v7hndzhnczfu3lfc6tb4o3bwju

Advances in PET Image Reconstruction

Andrew J. Reader, Habib Zaidi
2007 PET Clinics  
The key point to note is that a PET scanner does not measure the space-time-dependent radiotracer concentration directly.  ...  functional parametric images from the raw PET data.  ...  at many Three examples of a single column j of the system matrix (in forward modeling, to get mean data q from c, the columns are weighted by each point source intensity [ie, each pixel value in the c  ... 
doi:10.1016/j.cpet.2007.08.001 pmid:27157872 fatcat:qlqlq7li2nagnp35mqimd52g4e
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