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From IMGT-ONTOLOGY to IMGT/LIGMotif: the IMGT® standardized approach for immunoglobulin and T cell receptor gene identification and description in large genomic sequences

Jérôme Lane, Patrice Duroux, Marie-Paule Lefranc
2010 BMC Bioinformatics  
The antigen receptors, immunoglobulins (IG) and T cell receptors (TR), are specific molecular components of the adaptive immune response of vertebrates.  ...  and TR genes in large genomic sequences.  ...  Acknowledgements We are deeply grateful to Véronique Giudicelli, Géraldine Folch, Joumana Michaloud and Fatena Bellahcene for helpful comments.  ... 
doi:10.1186/1471-2105-11-223 pmid:20433708 pmcid:PMC2880031 fatcat:jbgpybbl55bd3gf7zl7iw6niba

IMGT-ONTOLOGY 2012

Véronique Giudicelli, Marie-Paule Lefranc
2012 Frontiers in Genetics  
IMGT-ONTOLOGY has become the global reference in immunogenetics and immunoinformatics for the knowledge representation of immunoglobulins (IG) or antibodies, T cell receptors (TR), and major histocompatibility  ...  The concepts of identification, description, classification, and numerotation generated from the axioms led to the elaboration of the IMGT ® standards that constitute the IMGT Scientific chart: IMGT ®  ...  ACKNOWLEDGMENTS We are grateful to Gérard Lefranc for helpful comments. We thank the IMGT® team, and all the previous collaborators and biocurators for the expertise and constant motivation.  ... 
doi:10.3389/fgene.2012.00079 pmid:22654892 pmcid:PMC3358611 fatcat:o7ny6ofyq5amjhko6z45wvbudq

IG and TR single chain fragment variable (scFv) sequence analysis: a new advanced functionality of IMGT/V-QUEST and IMGT/HighV-QUEST

Véronique Giudicelli, Patrice Duroux, Sofia Kossida, Marie-Paule Lefranc
2017 BMC Immunology  
Immunoglobulins (IG) or antibodies and T cell receptors (TR) are managed and described in the IMGT® databases and tools at the level of receptor, chain and domain.  ...  Each V-DOMAIN is fully characterized (gene identification, sequence description, junction analysis, characterization of mutations and amino changes).  ...  We are grateful to Gérard Lefranc, for helpful comments and to the IMGT team members for their constant motivation.  ... 
doi:10.1186/s12865-017-0218-8 pmid:28651553 pmcid:PMC5485737 fatcat:vlkvfytryzh4ricc22dsukuxqe

Immunoglobulins or Antibodies: IMGT® Bridging Genes, Structures and Functions

Marie-Paule Lefranc, Gérard Lefranc
2020 Biomedicines  
For the first time, the immunoglobulin (IG) or antibody and T cell receptor (TR) genes were officially recognized as 'genes' as well as were conventional genes.  ...  IMGT-ONTOLOGY axioms and concepts bridge genes, sequences, structures and functions, between biological and computational spheres in the IMGT® system (Web resources, databases and tools).  ...  Acknowledgments: We thank Safa Aouinti for the IMGT/StatClonotype development, Karima Cherouali and Anjana Kushwaha for the biocuration of the therapeutic monoclonal antibodies in the IMGT/mAb-DB and IMGT  ... 
doi:10.3390/biomedicines8090319 pmid:32878258 pmcid:PMC7555362 fatcat:lzzfnurkbvacncgifspyx5ifpi

IMGT® Homo sapiens IG and TR Loci, Gene Order, CNV and Haplotypes: New Concepts as a Paradigm for Jawed Vertebrates Genome Assemblies

Marie-Paule Lefranc, Gérard Lefranc
2022 Biomolecules  
IMGT® is based on a standardized nomenclature of the immunoglobulin (IG) and T cell receptor (TR) genes and alleles from fish to humans and on the IMGT unique numbering for the variable (V) and constant  ...  IMGT® comprises 7 databases, 17 tools and more than 25,000 pages of web resources for sequences, genes and structures, based on the IMGT Scientific chart rules generated from the IMGT-ONTOLOGY axioms and  ...  All the databases and tools referred to in this article are accessible from IMGT ® webpage.  ... 
doi:10.3390/biom12030381 pmid:35327572 pmcid:PMC8945572 fatcat:ydzcrvfs6jc4ndq7bnqxlrvpie