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Longitudinal abnormalities in white matter extracellular free water volume fraction and neuropsychological functioning in patients with traumatic brain injury [article]

James J Gugger, Alexa E Walter, Drew Parker, Nishant Sinha, Justin Morrison, Jeffrey Ware, Andrea LC Schneider, Dmitriy Petrov, Danielle K Sandsmark, Ragini Verma, Ramon Diaz-Arrastia
2022 arXiv   pre-print
For each subject, we derived a summary score representing deviations in whole brain white matter (1) extracellular free water volume fraction (VF) and (2) free water-corrected fractional anisotropy (fw-FA  ...  Patients underwent brain MRI and clinical neuropsychological assessment in the subacute (2-weeks) and chronic (6-months) post-injury period, and controls underwent a single MRI.  ...  distance based summary score of free water VF as a measure of injury severity in moderate-to-severe TBI. 10 This measure was associated with worse long-term executive functioning and processing speed  ... 
arXiv:2206.01080v1 fatcat:lejxr5njargjnnlnbmmwfonyxq

Identifying the Neural Correlates of Executive Functions in Early Cerebral Microangiopathy: A Combined VBM and DTI Study

Eva M Quinque, Katrin Arélin, Juergen Dukart, Elisabeth Roggenhofer, Daniel-P Streitbuerger, Arno Villringer, Stefan Frisch, Karsten Mueller, Matthias L Schroeter
2012 Journal of Cerebral Blood Flow and Metabolism  
We found a clear distinction between speeded and nonspeeded executive measures in relationship to imaging parameters.  ...  Correlations were found in frontal and parietal areas exclusively with speeded, but not with speed-corrected executive measures. The VBM analyses showed reduced gray matter in frontal areas.  ...  However, the speed component is overrepresented in executive function results and interpretations.  ... 
doi:10.1038/jcbfm.2012.96 pmid:22781332 pmcid:PMC3463884 fatcat:cof5k5m7jfcnxor43k3oi2mgna

Probing myelin and axon abnormalities separately in psychiatric disorders using MRI techniques

Fei Du, Dost Öngür
2013 Frontiers in Integrative Neuroscience  
In this manuscript we present novel MRI approaches to dissecting axon vs. myelin abnormalities in psychiatric disorders.  ...  We review two approaches (magnetization transfer ratio-MTR; and diffusion tensor spectroscopy-DTS) and the theoretical framework for interpreting data derived from these approaches.  ...  in one component (e.g., bound water) and the loss of saturation in the other component is measured (e.g., free water).  ... 
doi:10.3389/fnint.2013.00024 pmid:23596402 pmcid:PMC3622889 fatcat:qxfhuuzupjf7xb5j3yzftby3qq

White matter correlates of cognitive domains in normal aging with diffusion tensor imaging

Efrat Sasson, Glen M. Doniger, Ofer Pasternak, Ricardo Tarrasch, Yaniv Assaf
2013 Frontiers in Neuroscience  
In a cohort of 52 healthy subjects (ages 25-82 years), we performed voxel-wise regression analysis correlating performance in higher-order cognitive domains (executive function, information processing  ...  Results showed that performance in the executive function domain is correlated with DTI parameters in the left SLF and right UF; performance in the information processing speed domain is correlated with  ...  the purchase and maintenance of the MRI system.  ... 
doi:10.3389/fnins.2013.00032 pmid:23493587 pmcid:PMC3595518 fatcat:kfispzfv6rfwbc6f7aqdr3m64u

Myelin breakdown in human Huntington's disease: Multi-modal evidence from diffusion MRI and quantitative magnetization transfer

José Bourbon-Teles, Sonya Bells, Derek K. Jones, Elizabeth Coulthard, Anne Rosser, Claudia Metzler-Baddeley
2017 Neuroscience  
Patients showed reductions in a component with high loadings on MMPF in all WM pathways and a trend for increases in a component loading on axial and radial diffusivities but no differences in a component  ...  While patients' performance in executive functioning was impaired, their working memory span was preserved.  ...  ACKNOWLEDGMENTS This research was funded by a Wellcome Trust Institutional Strategic Support Fund (506408) and a Neuroscience and Mental Health Research Institute Seedcorn Fund to Claudia Metzler-Baddeley  ... 
doi:10.1016/j.neuroscience.2017.05.042 pmid:28579146 pmcid:PMC6458992 fatcat:2z7qhomwozcdvmos7hdkea5jie

Brain white matter tract integrity as a neural foundation for general intelligence

L Penke, S Muñoz Maniega, M E Bastin, M C Valdés Hernández, C Murray, N A Royle, J M Starr, J M Wardlaw, I J Deary
2012 Molecular Psychiatry  
However, there is a lack of established associations between general intelligence and any basic structural brain parameters that have a clear functional meaning.  ...  Each was independently associated with general intelligence, together explaining 10% of the variance, and their effect was completely mediated by information-processing speed.  ...  exchange between any relatively free water protons and those water protons that are bound to protein macromolecules in cellular membranes.  ... 
doi:10.1038/mp.2012.66 pmid:22614288 fatcat:jspe7y5dsjcwtpozfo4y3hnjq4

The relationship between white matter microstructure, cardiovascular fitness, gross motor skills, and neurocognitive functioning in children

Anna Meijer, Petra J W Pouwels, Joanne Smith, Chris Visscher, Roel J Bosker, Esther Hartman, Jaap Oosterlaan, Marsh Königs
2021 Journal of Neuroscience Research  
This study investigates the role of white matter microstructure in the relationship of both cardiovascular fitness and gross motor skills with neurocognitive functioning in healthy children.  ...  Information processing and motor response inhibition were associated with FA in a cluster located in the corpus callosum.  ...  fitness and executive functioning.  ... 
doi:10.1002/jnr.24851 pmid:34019710 pmcid:PMC8453576 fatcat:oqsiptabjjgh3fhy2cnvshynba

Free water: A marker of age-related modifications of the cingulum white matter and its association with cognitive decline

Manon Edde, Guillaume Theaud, François Rheault, Bixente Dilharreguy, Catherine Helmer, Jean-François Dartigues, Hélène Amieva, Michèle Allard, Maxime Descoteaux, Gwénaëlle Catheline
2020 PLoS ONE  
The aim of this study was to evaluate the effect of free water elimination on diffusion measures of the cingulum in a group of 68 healthy elderly individuals.  ...  Moreover, free water content and mean diffusivity measured along the cingulum were independently associated with changes in verbal fluency.  ...  Moreover, free water content per se appears to be a relevant parameter to describe age-related modifications of the white matter and its association with executive functioning.  ... 
doi:10.1371/journal.pone.0242696 pmid:33216815 pmcid:PMC7678997 fatcat:govhfr6dv5fypccohcm6xavfny

Imaging Findings Associated with Cognitive Performance in Primary Lateral Sclerosis and Amyotrophic Lateral Sclerosis

Avner Meoded, Justin Y. Kwan, Tracy L. Peters, Edward D. Huey, Laura E. Danielian, Edythe Wiggs, Arthur Morrissette, Tianxia Wu, James W. Russell, Elham Bayat, Jordan Grafman, Mary Kay Floeter
2013 Dementia and Geriatric Cognitive Disorders Extra  
The relationship between diffusion properties of selected association and commissural white matter and performance on executive function and memory tests was explored using a linear regression model.  ...  Seventeen of the PLS patients, 13 of the ALS patients, and 17 healthy controls underwent structural magnetic resonance imaging (MRI) and DTI.  ...  Russell and the Maryland ALS Clinic database was supported in part by the Department of Veterans Affairs, NIH RR024888, and NINDS/NIH grant U01AR057967-01.  ... 
doi:10.1159/000353456 pmid:24052798 pmcid:PMC3776403 fatcat:3qd5mvvprvfihce46ergrml36e

The Contribution of Various MRI Parameters to Clinical and Cognitive Disability in Multiple Sclerosis

Eszter Tóth, Péter Faragó, András Király, Nikoletta Szabó, Dániel Veréb, Krisztián Kocsis, Bálint Kincses, Dániel Sandi, Krisztina Bencsik, László Vécsei, Zsigmond Tamás Kincses
2019 Frontiers in Neurology  
High resolution T1 weighted structural and high angular resolution diffusion MRI images were measured in 53 patients with relapsing remitting MS and 53 healthy controls.  ...  Clinical disability was inflicted by EDSS and cognitive functions were evaluated with the BICAMS tests.  ...  Most commonly it affects the information processing speed, the episodic memory, the executive functions, and the visuospatial abilities.  ... 
doi:10.3389/fneur.2018.01172 pmid:30728801 pmcid:PMC6351478 fatcat:nytl3wx2qjgpfa2lklyhkqh3pu

Working Memory And Brain Tissue Microstructure: White Matter Tract Integrity Based On Multi-Shell Diffusion MRI

Sohae Chung, Els Fieremans, Nuri E. Kucukboyaci, Xiuyuan Wang, Charles J. Morton, Dmitry S. Novikov, Joseph F. Rath, Yvonne W. Lui
2018 Scientific Reports  
Working memory is a complex cognitive process at the intersection of sensory processing, learning, and short-term memory and also has a general executive attention component.  ...  WMTI is a novel tool that helps us describe the microstructural characteristics in both the intra-and extra-axonal environments of WM such as axonal water fraction (AWF), intra-axonal diffusivity, extra-axonal  ...  Acknowledgements This work was supported in part by grant funding from the National Institutes of Health (NIH): R01 NS039135-11 and R21 NS090349, National Institute for Neurological Disorders and Stroke  ... 
doi:10.1038/s41598-018-21428-4 pmid:29453439 pmcid:PMC5816650 fatcat:jgrexsew3nhebmatlcu22gd6my

Diffusion tensor imaging of cerebral white matter integrity in cognitive aging

David J. Madden, Ilana J. Bennett, Agnieszka Burzynska, Guy G. Potter, Nan-kuei Chen, Allen W. Song
2012 Biochimica et Biophysica Acta - Molecular Basis of Disease  
Research integrating behavioral measures with DTI indicates that WM integrity supports the communication among cortical networks, particularly those involving executive function, perceptual speed, and  ...  In this article we review recent research on diffusion tensor imaging (DTI) of white matter (WM) integrity and the implications for age-related differences in cognition.  ...  We are grateful to Tim Salthouse for his comments on a previous version of this article.  ... 
doi:10.1016/j.bbadis.2011.08.003 pmid:21871957 pmcid:PMC3241892 fatcat:3tlgxrqiwzhstp4b2zq2b7q3bi

Better Brain and Cognition Prior to Surgery Is Associated With Elevated Postoperative Brain Extracellular Free-Water in Older Adults

Jared J. Tanner, Manish Amin, Cheshire Hardcastle, Hari Parvataneni, David E. Vaillancourt, Thomas H. Mareci, Catherine C. Price
2019 Frontiers in Aging Neuroscience  
Free-water analyses were performed using diffusion weighted images and tract-based spatial statistics with baseline cognitive data used to predict free-water changes.  ...  For adults age 65 and older, the brain shows acute functional connectivity decreases after total knee arthroplasty with the severity of change predicted by preoperative cognitive function and brain disease  ...  DISCUSSION Free-water imaging, a type of DWI analysis, can provide information regarding water diffusivity in tissue and extracellular components.  ... 
doi:10.3389/fnagi.2019.00117 pmid:31156423 pmcid:PMC6532420 fatcat:imbqddbvazgzboybud6g5blika

Early Segmental White Matter Fascicle Microstructural Damage Predicts the Corresponding Cognitive Domain Impairment in Cerebral Small Vessel Disease Patients by Automated Fiber Quantification

Lili Huang, Xin Chen, Wenshan Sun, Haifeng Chen, Qing Ye, Dan Yang, Mengchun Li, Caimei Luo, Junyi Ma, Pengfei Shao, Hengheng Xu, Bing Zhang (+2 others)
2021 Frontiers in Aging Neuroscience  
correlated with executive function and gait evaluation.  ...  The left ATR was a specific fiber bundle associated with episode memory and language function, whereas the fractional anisotropy (FA) values of the intermediate component of the right ATR were negatively  ...  We also recruited 100 healthy individuals from a free clinic or the community during the same time for the healthy control (HC) group.  ... 
doi:10.3389/fnagi.2020.598242 pmid:33505302 pmcid:PMC7829360 fatcat:pxapmewxirefdf7uiffmqcfqya

Advances in white matter imaging: A review of in vivo magnetic resonance methodologies and their applicability to the study of development and aging

Jeffrey R. Wozniak, Kelvin O. Lim
2006 Neuroscience and Biobehavioral Reviews  
We first provide an overview of white matter development and discuss the role of white matter and myelin in cognitive function.  ...  Studies examining brain development during childhood and adulthood as well as studies of the effects of aging are discussed. r ARTICLE IN PRESS www.elsevier.com/locate/neubiorev 0149-7634/$ -see front  ...  Acknowledgments The authors wish to thank Bryon Mueller for his suggestions and his assistance with the preparation of this paper.  ... 
doi:10.1016/j.neubiorev.2006.06.003 pmid:16890990 pmcid:PMC2895765 fatcat:meeatdmkizervixhkmpe53bgqm
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