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Longitudinal abnormalities in white matter extracellular free water volume fraction and neuropsychological functioning in patients with traumatic brain injury
[article]
2022
arXiv
pre-print
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For each subject, we derived a summary score representing deviations in whole brain white matter (1) extracellular free water volume fraction (VF) and (2) free water-corrected fractional anisotropy (fw-FA ...
Patients underwent brain MRI and clinical neuropsychological assessment in the subacute (2-weeks) and chronic (6-months) post-injury period, and controls underwent a single MRI. ...
distance based summary score of free water VF as a measure of injury severity in moderate-to-severe TBI. 10 This measure was associated with worse long-term executive functioning and processing speed ...
arXiv:2206.01080v1
fatcat:lejxr5njargjnnlnbmmwfonyxq
Identifying the Neural Correlates of Executive Functions in Early Cerebral Microangiopathy: A Combined VBM and DTI Study
2012
Journal of Cerebral Blood Flow and Metabolism
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We found a clear distinction between speeded and nonspeeded executive measures in relationship to imaging parameters. ...
Correlations were found in frontal and parietal areas exclusively with speeded, but not with speed-corrected executive measures. The VBM analyses showed reduced gray matter in frontal areas. ...
However, the speed component is overrepresented in executive function results and interpretations. ...
doi:10.1038/jcbfm.2012.96
pmid:22781332
pmcid:PMC3463884
fatcat:cof5k5m7jfcnxor43k3oi2mgna
Probing myelin and axon abnormalities separately in psychiatric disorders using MRI techniques
2013
Frontiers in Integrative Neuroscience
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In this manuscript we present novel MRI approaches to dissecting axon vs. myelin abnormalities in psychiatric disorders. ...
We review two approaches (magnetization transfer ratio-MTR; and diffusion tensor spectroscopy-DTS) and the theoretical framework for interpreting data derived from these approaches. ...
in one component (e.g., bound water) and the loss of saturation in the other component is measured (e.g., free water). ...
doi:10.3389/fnint.2013.00024
pmid:23596402
pmcid:PMC3622889
fatcat:qxfhuuzupjf7xb5j3yzftby3qq
White matter correlates of cognitive domains in normal aging with diffusion tensor imaging
2013
Frontiers in Neuroscience
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In a cohort of 52 healthy subjects (ages 25-82 years), we performed voxel-wise regression analysis correlating performance in higher-order cognitive domains (executive function, information processing ...
Results showed that performance in the executive function domain is correlated with DTI parameters in the left SLF and right UF; performance in the information processing speed domain is correlated with ...
the purchase and maintenance of the MRI system. ...
doi:10.3389/fnins.2013.00032
pmid:23493587
pmcid:PMC3595518
fatcat:kfispzfv6rfwbc6f7aqdr3m64u
Myelin breakdown in human Huntington's disease: Multi-modal evidence from diffusion MRI and quantitative magnetization transfer
2017
Neuroscience
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Patients showed reductions in a component with high loadings on MMPF in all WM pathways and a trend for increases in a component loading on axial and radial diffusivities but no differences in a component ...
While patients' performance in executive functioning was impaired, their working memory span was preserved. ...
ACKNOWLEDGMENTS This research was funded by a Wellcome Trust Institutional Strategic Support Fund (506408) and a Neuroscience and Mental Health Research Institute Seedcorn Fund to Claudia Metzler-Baddeley ...
doi:10.1016/j.neuroscience.2017.05.042
pmid:28579146
pmcid:PMC6458992
fatcat:2z7qhomwozcdvmos7hdkea5jie
Brain white matter tract integrity as a neural foundation for general intelligence
2012
Molecular Psychiatry
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However, there is a lack of established associations between general intelligence and any basic structural brain parameters that have a clear functional meaning. ...
Each was independently associated with general intelligence, together explaining 10% of the variance, and their effect was completely mediated by information-processing speed. ...
exchange between any relatively free water protons and those water protons that are bound to protein macromolecules in cellular membranes. ...
doi:10.1038/mp.2012.66
pmid:22614288
fatcat:jspe7y5dsjcwtpozfo4y3hnjq4
The relationship between white matter microstructure, cardiovascular fitness, gross motor skills, and neurocognitive functioning in children
2021
Journal of Neuroscience Research
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This study investigates the role of white matter microstructure in the relationship of both cardiovascular fitness and gross motor skills with neurocognitive functioning in healthy children. ...
Information processing and motor response inhibition were associated with FA in a cluster located in the corpus callosum. ...
fitness and executive functioning. ...
doi:10.1002/jnr.24851
pmid:34019710
pmcid:PMC8453576
fatcat:oqsiptabjjgh3fhy2cnvshynba
Free water: A marker of age-related modifications of the cingulum white matter and its association with cognitive decline
2020
PLoS ONE
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The aim of this study was to evaluate the effect of free water elimination on diffusion measures of the cingulum in a group of 68 healthy elderly individuals. ...
Moreover, free water content and mean diffusivity measured along the cingulum were independently associated with changes in verbal fluency. ...
Moreover, free water content per se appears to be a relevant parameter to describe age-related modifications of the white matter and its association with executive functioning. ...
doi:10.1371/journal.pone.0242696
pmid:33216815
pmcid:PMC7678997
fatcat:govhfr6dv5fypccohcm6xavfny
Imaging Findings Associated with Cognitive Performance in Primary Lateral Sclerosis and Amyotrophic Lateral Sclerosis
2013
Dementia and Geriatric Cognitive Disorders Extra
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The relationship between diffusion properties of selected association and commissural white matter and performance on executive function and memory tests was explored using a linear regression model. ...
Seventeen of the PLS patients, 13 of the ALS patients, and 17 healthy controls underwent structural magnetic resonance imaging (MRI) and DTI. ...
Russell and the Maryland ALS Clinic database was supported in part by the Department of Veterans Affairs, NIH RR024888, and NINDS/NIH grant U01AR057967-01. ...
doi:10.1159/000353456
pmid:24052798
pmcid:PMC3776403
fatcat:3qd5mvvprvfihce46ergrml36e
The Contribution of Various MRI Parameters to Clinical and Cognitive Disability in Multiple Sclerosis
2019
Frontiers in Neurology
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High resolution T1 weighted structural and high angular resolution diffusion MRI images were measured in 53 patients with relapsing remitting MS and 53 healthy controls. ...
Clinical disability was inflicted by EDSS and cognitive functions were evaluated with the BICAMS tests. ...
Most commonly it affects the information processing speed, the episodic memory, the executive functions, and the visuospatial abilities. ...
doi:10.3389/fneur.2018.01172
pmid:30728801
pmcid:PMC6351478
fatcat:nytl3wx2qjgpfa2lklyhkqh3pu
Working Memory And Brain Tissue Microstructure: White Matter Tract Integrity Based On Multi-Shell Diffusion MRI
2018
Scientific Reports
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Working memory is a complex cognitive process at the intersection of sensory processing, learning, and short-term memory and also has a general executive attention component. ...
WMTI is a novel tool that helps us describe the microstructural characteristics in both the intra-and extra-axonal environments of WM such as axonal water fraction (AWF), intra-axonal diffusivity, extra-axonal ...
Acknowledgements This work was supported in part by grant funding from the National Institutes of Health (NIH): R01 NS039135-11 and R21 NS090349, National Institute for Neurological Disorders and Stroke ...
doi:10.1038/s41598-018-21428-4
pmid:29453439
pmcid:PMC5816650
fatcat:jgrexsew3nhebmatlcu22gd6my
Diffusion tensor imaging of cerebral white matter integrity in cognitive aging
2012
Biochimica et Biophysica Acta - Molecular Basis of Disease
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Research integrating behavioral measures with DTI indicates that WM integrity supports the communication among cortical networks, particularly those involving executive function, perceptual speed, and ...
In this article we review recent research on diffusion tensor imaging (DTI) of white matter (WM) integrity and the implications for age-related differences in cognition. ...
We are grateful to Tim Salthouse for his comments on a previous version of this article. ...
doi:10.1016/j.bbadis.2011.08.003
pmid:21871957
pmcid:PMC3241892
fatcat:3tlgxrqiwzhstp4b2zq2b7q3bi
Better Brain and Cognition Prior to Surgery Is Associated With Elevated Postoperative Brain Extracellular Free-Water in Older Adults
2019
Frontiers in Aging Neuroscience
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Free-water analyses were performed using diffusion weighted images and tract-based spatial statistics with baseline cognitive data used to predict free-water changes. ...
For adults age 65 and older, the brain shows acute functional connectivity decreases after total knee arthroplasty with the severity of change predicted by preoperative cognitive function and brain disease ...
DISCUSSION Free-water imaging, a type of DWI analysis, can provide information regarding water diffusivity in tissue and extracellular components. ...
doi:10.3389/fnagi.2019.00117
pmid:31156423
pmcid:PMC6532420
fatcat:imbqddbvazgzboybud6g5blika
Early Segmental White Matter Fascicle Microstructural Damage Predicts the Corresponding Cognitive Domain Impairment in Cerebral Small Vessel Disease Patients by Automated Fiber Quantification
2021
Frontiers in Aging Neuroscience
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correlated with executive function and gait evaluation. ...
The left ATR was a specific fiber bundle associated with episode memory and language function, whereas the fractional anisotropy (FA) values of the intermediate component of the right ATR were negatively ...
We also recruited 100 healthy individuals from a free clinic or the community during the same time for the healthy control (HC) group. ...
doi:10.3389/fnagi.2020.598242
pmid:33505302
pmcid:PMC7829360
fatcat:pxapmewxirefdf7uiffmqcfqya
Advances in white matter imaging: A review of in vivo magnetic resonance methodologies and their applicability to the study of development and aging
2006
Neuroscience and Biobehavioral Reviews
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We first provide an overview of white matter development and discuss the role of white matter and myelin in cognitive function. ...
Studies examining brain development during childhood and adulthood as well as studies of the effects of aging are discussed. r ARTICLE IN PRESS www.elsevier.com/locate/neubiorev 0149-7634/$ -see front ...
Acknowledgments The authors wish to thank Bryon Mueller for his suggestions and his assistance with the preparation of this paper. ...
doi:10.1016/j.neubiorev.2006.06.003
pmid:16890990
pmcid:PMC2895765
fatcat:meeatdmkizervixhkmpe53bgqm
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