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Hämolytisch-urämisches Syndrom [chapter]

Franz Schaefer
<span title="">2019</span> <i title="Springer Berlin Heidelberg"> Pädiatrie </i> &nbsp;
Einleitung Das hämolytisch-urämische Syndrom (HUS) ist als Trias von hämolytischer Anämie, Thrombozytopenie und akuter Niereninsuffizienz definiert. Das HUS ist die häufigste Ursache des kindlichen akuten Nierenversagens jenseits der Neugeborenenperiode. Die jährliche Inzidenz beträgt ca. 3 Fälle pro 100.000 Kinder unter 5 Jahren. Man unterscheidet eine typische und eine atypische Form der Erkrankung. Das klassische HUS macht 90 % der HUS-Fälle aus. Es tritt überwiegend bei Kindern unter 5
more &raquo; ... n im Anschluss an eine Darminfektion (Diarrhö) auf (D + -Form). Die atypische HUS-Variante kann in jedem Lebensalter auftreten und beginnt meist schleichend ohne gastrointestinale Prodromalerkrankung (D À -Form). Dem atypischen HUS liegen zumeist genetische oder erworbene Anomalien des alternativen Komplementwegs zugrunde.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/978-3-642-54671-6_242-2">doi:10.1007/978-3-642-54671-6_242-2</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/gfpsn3dfx5dhlirdgc43asbkdu">fatcat:gfpsn3dfx5dhlirdgc43asbkdu</a> </span>
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Pediatric Nephrology

Michel Fischbach, Patrick Niaudet, Franz Schaefer, Lesly Rees
<span title="">2012</span> <i title="Hindawi Limited"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/3mahoznn35ay5dbxopw4ayq25q" style="color: black;">International Journal of Nephrology</a> </i> &nbsp;
Michel Fischbach Patrick Niaudet Franz Schaefer Lesly Rees  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1155/2012/416749">doi:10.1155/2012/416749</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/22536504">pmid:22536504</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3321283/">pmcid:PMC3321283</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/ystysq2c25h2jfyq2kdxx2vaka">fatcat:ystysq2c25h2jfyq2kdxx2vaka</a> </span>
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Non-Transgenic Mouse Models of Kidney Disease

Michael Rabe, Franz Schaefer
<span title="">2016</span> <i title="S. Karger AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/5gy4kv6ftja4bcvgbv4yqrejce" style="color: black;">Nephron</a> </i> &nbsp;
Models of Kidney Disease Nephron 2016;133:53-61 DOI: 10.1159/000445171 Rabe/SchaeferNephron 2016;133:53-61 DOI: 10.1159/000445171 4 Salt Downloaded by: 54.191.40.80 -9/17/2017 8:59:50 AM Rabe/Schaefer  ... 
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<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190223100738/http://pdfs.semanticscholar.org/459b/18e8a4e7c398abea1e2f9b6dd00f18e30edb.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/45/9b/459b18e8a4e7c398abea1e2f9b6dd00f18e30edb.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1159/000445171"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Caracterização morfométrica da península Fildes, Ilha Rei George, Antártica Marítima

André Medeiros de Andrade, Roberto Ferreira Machado Michel, Ulisses Franz Franz Bremer, Carlos Ernesto G. R. Schaefer
<span title="2015-06-21">2015</span> <i title="Universidade Federal do Rio Grande do Sul"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/4z24laic55eijpgugguegeegre" style="color: black;">Para onde!?</a> </i> &nbsp;
Na região da Antártica Marítima, apesar das severas condições climáticas, há vegetação, hidrografia e feições geomorfológicas que configuram os ecossistemas locais. Este trabalho tem como objetivo quantificar e analisar os parâmetros morfométricos da Península Fildes, localizada na Ilha Rei George, Antártica Marítima. O modelo digital do terreno (MDT) foi gerado a partir dos dados altimétricos da carta topográfica da Península Fildes e, a partir do MDT, foram gerados os produtos de hipsometria,
more &raquo; ... declividade, orientação das vertentes e forma do terreno. A partir desses produtos foi possível analisar a morfometria da Península Fildes e, posterior- mente, quantificar a relação entre os produtos morfométricos e a geomorfologia local. Os resultados obtidos apontam que a altimetria média da Península Fildes é de 58,73 m, com predominância de relevo ondulado e suave ondulado. As vertentes orientadas para oeste possuem a maior representatividade, e não houve uma classe de forma do terreno com área destacadamente superior às outras. Os resultados desse estudo demons- tram que os produtos morfométricos podem ser utilizados para fins de análise das variáveis que compõem o relevo dos ambientes da Antártica Marítima. Esse estudo contribui para ampliar as informações de ambientes antárticos obtidos com escalas detalhadas.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.22456/1982-0003.83823">doi:10.22456/1982-0003.83823</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/n2jldfxoirfrrpnnj7dkzldgdy">fatcat:n2jldfxoirfrrpnnj7dkzldgdy</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200208150639/https://seer.ufrgs.br/paraonde/article/download/83823/48518" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/b6/5e/b65efdf0897581eb44da614d5d3c6591cfce3210.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.22456/1982-0003.83823"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a>

Averting the Legacy of Kidney Disease—Focus on Childhood

Julie Ingelfinger, Kamyar Kalantar-Zadeh, Franz Schaefer
<span title="2016-02-08">2016</span> <i title="MDPI AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/nxbfgpixpfbirhcqx7sfrdgok4" style="color: black;">Children</a> </i> &nbsp;
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/children3010004">doi:10.3390/children3010004</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/27417242">pmid:27417242</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4934478/">pmcid:PMC4934478</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/idhgzmhodrd47ntagem24yt2gy">fatcat:idhgzmhodrd47ntagem24yt2gy</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190503104138/https://res.mdpi.com/children/children-03-00004/article_deploy/children-03-00004-v2.pdf?filename=&amp;attachment=1" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/61/57/615792dc00fc6012e45a7798ed019c6c506681a1.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/children3010004"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> mdpi.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4934478" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Dialysis-associated peritonitis in children

Vimal Chadha, Franz S. Schaefer, Bradley A. Warady
<span title="2009-02-04">2009</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/bo3qpb4kqre6xdgsfnp2jkjzlm" style="color: black;">Pediatric nephrology (Berlin, West)</a> </i> &nbsp;
Peritonitis remains a frequent complication of peritoneal dialysis in children and is the most common reason for technique failure. The microbiology is characterized by a predominance of Gram-positive organisms, with fungi responsible for less than 5% of episodes. Data collected by the International Pediatric Peritonitis Registry have revealed a worldwide variation in the bacterial etiology of peritonitis, as well as in the rate of culturenegative peritonitis. Risk factors for infection include
more &raquo; ... young age, the absence of prophylactic antibiotics at catheter placement, spiking of dialysis bags, and the presence of a catheter exit-site or tunnel infection. Clinical symptoms at presentation are somewhat organism specific and can be objectively assessed with a Disease Severity Score. Whereas recommendations for empiric antibiotic therapy in children have been published by the International Society of Peritoneal Dialysis, epidemiologic data and antibiotic susceptibility data suggest that it may be desirable to take the patient-and center-specific history of microorganisms and their sensitivity patterns into account when prescribing initial therapy. The vast majority of patients are treated successfully and continue peritoneal dialysis, with the poorest outcome noted in patients with peritonitis secondary to Gram-negative organisms or fungi and in those with a relapsing infection.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s00467-008-1113-6">doi:10.1007/s00467-008-1113-6</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/19190935">pmid:19190935</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC2810362/">pmcid:PMC2810362</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/z36kyzwoerbr3f54oc6hnxjpna">fatcat:z36kyzwoerbr3f54oc6hnxjpna</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20171013210726/http://publisher-connector.core.ac.uk/resourcesync/data/Springer-OA/pdf/67d/aHR0cDovL2xpbmsuc3ByaW5nZXIuY29tLzEwLjEwMDcvczAwNDY3LTAwOC0xMTEzLTYucGRm.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/ac/fa/acfa27077dd8f069c31436c0c524ce1b93d060e8.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s00467-008-1113-6"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810362" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

DYNEVI - DYnamic News Entity Visualization [article]

Franz Wanner, Matthias Schaefer, Florian Leitner-Fischer, Fabian Zintgraf, M. Atkinson, Daniel A. Keim
<span title="">2010</span> <i title="The Eurographics Association"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/fvnub6swsjfnhdwblr4kp44pry" style="color: black;">Eurographics Conference on Visualization</a> </i> &nbsp;
Dynamic news entity visualization shows an implementation of visualizing news entity data to give an overview as well as to display emerging and vanishing news topics. We present a robust and dynamic visualization system with case studies that show its benefits and high functionality.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2312/pe/eurovast/eurovast10/069-074">doi:10.2312/pe/eurovast/eurovast10/069-074</a> <a target="_blank" rel="external noopener" href="https://dblp.org/rec/conf/vissym/WannerSLZAK10.html">dblp:conf/vissym/WannerSLZAK10</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/xg4k4pxbb5asrnd6qlhukb3x5y">fatcat:xg4k4pxbb5asrnd6qlhukb3x5y</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20220119063654/https://diglib.eg.org/xmlui/bitstream/handle/10.2312/PE.EuroVAST.EuroVAST10.069-074/069-074.pdf;jsessionid=E045B1B41916FA071474A696C15D259A?sequence=1" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/3f/48/3f489fb3b57e8e31fec892acde0f862cd89e1e0b.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2312/pe/eurovast/eurovast10/069-074"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Oxidative stress in children with nephrotic syndrome

Om P. Mishra, Franz Schaefer
<span title="2011-10-08">2011</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/bo3qpb4kqre6xdgsfnp2jkjzlm" style="color: black;">Pediatric nephrology (Berlin, West)</a> </i> &nbsp;
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s00467-011-2032-5">doi:10.1007/s00467-011-2032-5</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/pda6sx6rc5h6rbzvzpvqhukewu">fatcat:pda6sx6rc5h6rbzvzpvqhukewu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180729040719/https://link.springer.com/content/pdf/10.1007%2Fs00467-011-2032-5.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/b6/65/b66538b244a8e5fa7120c7c54a51f64eae348f8b.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s00467-011-2032-5"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> springer.com </button> </a>

Quantitative Histomorphometry of the Healthy Peritoneum

Betti Schaefer, Maria Bartosova, Stephan Macher-Goeppinger, Akos Ujszaszi, Markus Wallwiener, Joanne Nyarangi-Dix, Peter Sallay, Dorothea Burkhardt, Uwe Querfeld, Viktoria Pfeifle, Bernd Lahrmann, Vedat Schwenger (+4 others)
<span title="2016-02-19">2016</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/tnqhc2x2aneavcd3gx5h7mswhm" style="color: black;">Scientific Reports</a> </i> &nbsp;
The peritoneum plays an essential role in preventing abdominal frictions and adhesions and can be utilized as a dialysis membrane. Its physiological ultrastructure, however, has not yet been studied systematically. 106 standardized peritoneal and 69 omental specimens were obtained from 107 patients (0.1-60 years) undergoing surgery for disease not affecting the peritoneum for automated quantitative histomorphometry and immunohistochemistry. The mesothelial cell layer morphology and protein
more &raquo; ... ssion pattern is similar across all age groups. Infants below one year have a thinner submesothelium; inflammation, profibrotic activity and mesothelial cell translocation is largely absent in all age groups. Peritoneal blood capillaries, lymphatics and nerve fibers locate in three distinct submesothelial layers. Blood vessel density and endothelial surface area follow a U-shaped curve with highest values in infants below one year and lowest values in children aged 7-12 years. Lymphatic vessel density is much lower, and again highest in infants. Omental blood capillary density correlates with parietal peritoneal findings, whereas only few lymphatic vessels are present. The healthy peritoneum exhibits major thus far unknown particularities, pertaining to functionally relevant structures, and subject to substantial changes with age. The reference ranges established here provide a framework for future histomorphometric analyses and peritoneal transport modeling approaches.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/srep21344">doi:10.1038/srep21344</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/26905058">pmid:26905058</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4763997/">pmcid:PMC4763997</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/p5tqfu6gpndyhdwbjcgualpham">fatcat:p5tqfu6gpndyhdwbjcgualpham</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200316004722/https://www.nature.com/articles/srep21344.pdf?error=cookies_not_supported&amp;code=88e50a9e-8aac-416e-8de7-39bfd9aee6cf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/21/d8/21d86c3a1bc43fb74ed3cfee15d81427233395f4.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/srep21344"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763997" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Therapeutic strategies to slow chronic kidney disease progression

Elke Wühl, Franz Schaefer
<span title="2008-03-12">2008</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/bo3qpb4kqre6xdgsfnp2jkjzlm" style="color: black;">Pediatric nephrology (Berlin, West)</a> </i> &nbsp;
Childhood chronic kidney disease commonly progresses toward end-stage renal failure, largely independent of the underlying disorder, once a critical impairment of renal function has occurred. Hypertension and proteinuria are the most important independent risk factors for renal disease progression. Therefore, current therapeutic strategies to prevent progression aim at controlling blood pressure and reducing urinary protein excretion. Renin-angiotensin-system (RAS) antagonists preserve kidney
more &raquo; ... nction not only by lowering blood pressure but also by their antiproteinuric, antifibrotic, and anti-inflammatory properties. Intensified blood pressure control, probably aiming for a target blood pressure below the 75th percentile, may exert additional renoprotective effects. Other factors contributing in a multifactorial manner to renal disease progression include dyslipidemia, anemia, and disorders of mineral metabolism. Measures to preserve renal function should therefore also comprise the maintenance of hemoglobin, serum lipid, and calcium-phosphorus ion product levels in the normal range. Natural course of chronic kidney disease Progression of chronic kidney disease (CKD) toward endstage renal failure is common in CKD patients, and once Factors affecting renal disease progression There is clear evidence from clinical studies that hypertension and proteinuria are key players in the pathophysiology Pediatr Nephrol (2008) 23:705-716
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s00467-008-0789-y">doi:10.1007/s00467-008-0789-y</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/18335252">pmid:18335252</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC2275772/">pmcid:PMC2275772</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/bdyr3rllara4pfxtmcy3ppw3km">fatcat:bdyr3rllara4pfxtmcy3ppw3km</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20171015172940/http://publisher-connector.core.ac.uk/resourcesync/data/Springer-OA/pdf/8a2/aHR0cDovL2xpbmsuc3ByaW5nZXIuY29tLzEwLjEwMDcvczAwNDY3LTAwOC0wNzg5LXkucGRm.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/ee/b2/eeb2fb7d7c176f14c731856e955e7946b4d8a8d9.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s00467-008-0789-y"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275772" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Averting the Legacy of Kidney Disease - Focus on Childhood

Julie R. Ingelfinger, Kamyar Kalantar-Zadeh, Franz Schaefer
<span title="">2016</span> <i title="S. Karger AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/5gy4kv6ftja4bcvgbv4yqrejce" style="color: black;">Nephron</a> </i> &nbsp;
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1159/000444461">doi:10.1159/000444461</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/26926120">pmid:26926120</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/vocrnbquh5dtpeitmtlk432yya">fatcat:vocrnbquh5dtpeitmtlk432yya</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190224021243/http://pdfs.semanticscholar.org/5101/36439fa01bfcfb71e9d14474f1f4b4e77761.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/51/01/510136439fa01bfcfb71e9d14474f1f4b4e77761.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1159/000444461"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Averting the Legacy of Kidney Disease - Focus on Childhood

Julie R. Ingelfinger, Kamyar Kalantar-Zadeh, Franz Schaefer
<span title="">2016</span> <i title="S. Karger AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/lel3i7kcdjfypil3tbpphlh7yy" style="color: black;">Blood Purification</a> </i> &nbsp;
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1159/000444510">doi:10.1159/000444510</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/26930219">pmid:26930219</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/mhnmj55wnrfczkxko6yxlhb6em">fatcat:mhnmj55wnrfczkxko6yxlhb6em</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170922005113/http://pediatricurologycasereports.com/ojs/index.php/pucr/article/download/124/72" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/1e/e7/1ee719eaab80f27d35371196fbc77dc9a10fe30a.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1159/000444510"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Rare inherited kidney diseases: challenges, opportunities, and perspectives

Olivier Devuyst, Nine V A M Knoers, Giuseppe Remuzzi, Franz Schaefer
<span title="">2014</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/sn27gkxlkbhuzeexoqyapc756a" style="color: black;">The Lancet</a> </i> &nbsp;
At least 10% of adults and nearly all children who receive renal-replacement therapy have an inherited kidney disease. These patients rarely die when their disease progresses and can remain alive for many years because of advances in organ-replacement therapy. However, these disorders substantially decrease their quality of life and have a large effect on health-care systems. Since the kidneys regulate essential homoeostatic processes, inherited kidney disorders have multisystem complications,
more &raquo; ... hich add to the usual challenges for rare disorders. In this review, we discuss the nature of rare inherited kidney diseases, the challenges they pose, and opportunities from technological advances, which are well suited to target the kidney. Mechanistic insights from rare disorders are relevant for common disorders such as hypertension, kidney stones, cardiovascular disease, and progression of chronic kidney disease. Abstract: At least 10% of adults and virtually all children progressing to renal replacement therapy suffer from inherited kidney diseases. These patients rarely die when their disease progresses but remain alive for many years, thanks to progress in organ replacement therapy. However, these disorders have a large negative impact on the quality of life of the patients and on health care systems. Since the kidney regulates essential homeostatic processes, inherited kidney disorders have multisystemic complications which add to the typical challenges of rare disorders. In this review, we will discuss the specific nature of rare inherited kidney diseases, the challenges they are posing to the society, and the opportunities arising from technologic advances, which are particularly well suited to the kidney as a target organ. Mechanistic insights into rare disorders are relevant for common conditions such as hypertension, kidney stones, cardiovascular disease, and progression of chronic kidney disease in general. Search strategy and selection criteria: References included in this review were identified by the authors, based on their respective area of expertise and supplemented by unsystematic database searches. Manuscript Lancet Review -WGIKD 2 Summary At least 10% of adults and virtually all children progressing to renal replacement therapy suffer from inherited kidney diseases. These patients rarely die when their disease progresses but remain alive for many years, thanks to progress in organ replacement therapy. However, these disorders have a large negative impact on the quality of life of the patients and on health care systems. Since the kidney regulates essential homeostatic processes, inherited kidney disorders have multi-systemic complications which add to the typical challenges of rare disorders. In this review, we will discuss the specific nature of rare inherited kidney diseases, the challenges they are posing to the society, and the opportunities arising from technologic advances, which are particularly well suited to the kidney as a target organ. Mechanistic insights into rare disorders are relevant for common conditions such as hypertension, kidney stones, cardiovascular disease, and progression of chronic kidney disease in general. Lancet Review -WGIKD
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<a target="_blank" rel="noopener" href="https://web.archive.org/web/20181104135636/https://www.zora.uzh.ch/id/eprint/97243/1/Devuyst_THELANCET-S-13-11643-1_check_time_of_publication.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/71/24/712479ca3906dabb53403cf3bc32df8980c77121.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/s0140-6736(14)60659-0"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135047" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Averting the Legacy of Kidney Disease - Focus on Childhood

Julie R. Ingelfinger, Kamyar Kalantar-Zadeh, Franz Schaefer
<span title="">2016</span> <i title="S. Karger AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/m4xsuhslp5c6fd6cks777xfdte" style="color: black;">Kidney Diseases</a> </i> &nbsp;
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1159/000443819">doi:10.1159/000443819</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/27536691">pmid:27536691</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4946254/">pmcid:PMC4946254</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/2s4qgfi3lnejpe4jl7nb4jdmyq">fatcat:2s4qgfi3lnejpe4jl7nb4jdmyq</a> </span>
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Targeting tubulointerstitium to predict kidney outcomes in childhood nephrotic syndrome

Karolis Azukaitis, Franz Schaefer
<span title="2020-01-21">2020</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/7mr7qwrrsrc4najgasgjq7d7ka" style="color: black;">Kidney International Reports</a> </i> &nbsp;
., kidney injury COMMENTARY K Azukaitis and F Schaefer: Tubulointerstitium in Childhood Nephrotic Syndrome molecule-1, soluble urokinase plas- Kidney International Reports (2020) 5, 383-385  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.ekir.2020.01.005">doi:10.1016/j.ekir.2020.01.005</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/32281991">pmid:32281991</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC7136428/">pmcid:PMC7136428</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/5ak6s4euffbbtkoaoe2yvmwfbm">fatcat:5ak6s4euffbbtkoaoe2yvmwfbm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200510205434/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7136428&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/74/cd/74cd3a909baaef1105597f263ae83259963fd5f8.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.ekir.2020.01.005"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136428" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>
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