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Fractional anisotropy of cerebral white matter and thickness of cortical gray matter across the lifespan

P. Kochunov, D.C. Glahn, J. Lancaster, P.M. Thompson, V. Kochunov, B. Rogers, P. Fox, J. Blangero, D.E. Williamson
2011 NeuroImage  
We examined age trajectories of fractional anisotropy (FA) of cerebral white matter (WM) and thickness of cortical gray matter (GM) in 1,031 healthy human subjects (aged 11-90 years).  ...  in the microintegrity of cerebral WM.  ...  Acknowledgments This research was supported by a National Institute of Biomedical Imaging and Bioengineering (K01 EB006395) grant to P.K., by the National Institute on Alcohol Abuse and Alcoholism (R01AA016274  ... 
doi:10.1016/j.neuroimage.2011.05.050 pmid:21640837 pmcid:PMC3144306 fatcat:spjh3jdrj5b3lcfetzoo3z7nle

Sex differences in the developing brain: insights from multimodal neuroimaging

Antonia N. Kaczkurkin, Armin Raznahan, Theodore D. Satterthwaite
2018 Neuropsychopharmacology  
Here we review the evidence for sex differences in brain structure, white matter organization, and perfusion during development.  ...  Youth (including both childhood and adolescence) is a period when the brain undergoes dramatic remodeling and is also a time when neuropsychiatric conditions often emerge.  ...  [48] ) Cerebral gray matter and white matter volume Beyond total brain size, brain volume can be divided into cerebral gray and white matter using segmentation techniques.  ... 
doi:10.1038/s41386-018-0111-z pmid:29930385 pmcid:PMC6235840 fatcat:k3ryjbhi5zcqfgqc6nkx5ztl2e

Socioeconomic status and structural brain development

Natalie H. Brito, Kimberly G. Noble
2014 Frontiers in Neuroscience  
focuses on how early environmental variations shape the trajectory of cognitive development. She has published work examining multiple language exposure and memory development.  ...  This review focuses on studies examining links between structural brain development and SES disparities of the magnitude typically found in developing countries.  ...  ACKNOWLEDGMENT The authors are grateful for funding from the Robert Wood Johnson Foundation Health and Society Scholars program and the GH Sergievsky Center.  ... 
doi:10.3389/fnins.2014.00276 pmid:25249931 pmcid:PMC4155174 fatcat:egk3cwz75bfbfjbznnzkxrcxxe

Brain Networks Reorganization During Maturation and Healthy Aging-Emphases for Resilience

Gabriel Gonzalez-Escamilla, Muthuraman Muthuraman, Venkata C Chirumamilla, Johannes Vogt, Sergiu Groppa
2018 Frontiers in Psychiatry  
Here, we review research on brain reorganization processes across the lifespan, demonstrating brain circuits remodeling at the structural and functional level that support mental health and are parallelized  ...  Furthermore, important processes of preservation and compensation of brain function occur continuously in the cerebral brain networks and drive physiological responses to life events.  ...  ACKNOWLEDGMENTS The authors would like to thank Cheryl Ernest for proofreading the manuscript. This work was supported by a grant from the German Research Council (DFG; CRC-1193).  ... 
doi:10.3389/fpsyt.2018.00601 pmid:30519196 pmcid:PMC6258799 fatcat:od7cavrejrawzag3i2efviwquu

Brain structure, cognition, and brain age in schizophrenia, bipolar disorder, and healthy controls

Saba Shahab, Benoit H. Mulsant, Melissa L. Levesque, Navona Calarco, Arash Nazeri, Anne L. Wheeler, George Foussias, Tarek K. Rajji, Aristotle N. Voineskos
2018 Neuropsychopharmacology  
We analyzed associations among age, diagnosis, and cognition with cortical thickness and fractional anisotropy (FA) using general linear models.  ...  Direct comparison of healthy aging populations with schizophrenia and BD patients across the adult lifespan may help inform this theory.  ...  STATISTICAL ANALYSIS Analysis 1: cortical thickness and white matter FA We used a general linear model to compare both cortical thickness and white matter FA across diagnostic groups.  ... 
doi:10.1038/s41386-018-0298-z pmid:30635616 pmcid:PMC6461913 fatcat:3otrbau7hfhutem7mx3x2ks43e

Obesity associated with increased brain age from midlife

Lisa Ronan, Aaron F. Alexander-Bloch, Konrad Wagstyl, Sadaf Farooqi, Carol Brayne, Lorraine K. Tyler, Paul C. Fletcher
2016 Neurobiology of Aging  
Cortical reconstruction techniques were used to generate measures of whole-brain cerebral white-matter volume, cortical thickness, and surface area.  ...  Results indicated that cerebral white-matter volume in overweight and obese individuals was associated with a greater degree of atrophy, with maximal effects in middle-age corresponding to an estimated  ...  The authors also thank colleagues at the MRC Cognition and Brain Sciences Unit MEG and MRI facilities for their assistance.  ... 
doi:10.1016/j.neurobiolaging.2016.07.010 pmid:27562529 pmcid:PMC5082766 fatcat:6rd2er3x5za7rcpiubrhbaktfm

Unraveling the secrets of white matter – Bridging the gap between cellular, animal and human imaging studies

K.B. Walhovd, H. Johansen-Berg, R.T. Káradóttir
2014 Neuroscience  
The CNS white matter makes up about half of the human brain, and with advances in human imaging it is increasingly becoming clear that changes in the white matter play a major role in shaping human behavior  ...  Within this special issue of Neuroscience on white matter, recent advances in our knowledge of the function of white matter, from the molecular level to human imaging, are reviewed.  ...  Acknowledgments-We thank Anders Martin Fjell and Sonia  ... 
doi:10.1016/j.neuroscience.2014.06.058 pmid:25003711 pmcid:PMC4155933 fatcat:lh2owwltbnbi5kb3vdhd7bsrya

Genetic influences on brain developmental trajectories on neuroimaging studies: from infancy to young adulthood

Vanessa Douet, Linda Chang, Christine Cloak, Thomas Ernst
2013 Brain Imaging and Behavior  
Specifically, we focus on the heritability of brain structures across the ages, age-related genetic influences on brain development and sex-specific developmental trajectories.  ...  In addition, the majority of psychiatric and mental disorders are polygenic, and many have onsets during childhood and adolescence.  ...  Acknowledgments The authors would like to thank Jared Char, Youngsu Kown and Dr Sody Munsaka for their assistance with literature searches and proof reading of the manuscript.  ... 
doi:10.1007/s11682-013-9260-1 pmid:24077983 pmcid:PMC3969783 fatcat:lwj747mbjrgmvlsematuoffmxi

Associations Between Physical Fitness and Brain Structure in Young Adulthood

John R. Best, Elizabeth Dao, Ryan Churchill, Theodore D. Cosco
2020 Frontiers in Psychology  
Diffusion weighted imaging was acquired to assess white matter tract integrity, as measured by fractional anisotropy, following processing by the YA-HCP diffusion pipeline and tensor fit.  ...  Following correction for multiple testing, body mass index was negatively associated with fractional anisotropy in various white matter regions of interest (all | z| statistics > 3.9) and positively associated  ...  for body mass index and white matter fractional anisotropy.  ... 
doi:10.3389/fpsyg.2020.608049 pmid:33281692 pmcid:PMC7705380 fatcat:7n7wbv2j4bfjnpx3jybcuplmpe

Postnatal brain development [chapter]

Terry L. Jernigan, William F.C. Baaré, Joan Stiles, Kathrine Skak Madsen
2011 Progress in Brain Research  
After birth, there is striking biological and functional development of the brain's fiber tracts as well as remodeling of cortical and subcortical structures.  ...  This is a protracted process, beginning in the third week of gestation and continuing into early adulthood.  ...  Acknowledgments This work was supported by grants from the Lundbeck Foundation and by grants from the National Institute of Child Health and Human Development and the National Institute of Drug Abuse:  ... 
doi:10.1016/b978-0-444-53884-0.00019-1 pmid:21489384 pmcid:PMC3690327 fatcat:6ixlcg6z4naqnh7rmjgjda7nlu

Typical and atypical brain development: a review of neuroimaging studies

Emily L Dennis, Paul M Thompson
2013 Dialogues in Clinical Neuroscience  
We begin with typical development, summarizing research on changes in regional brain volume and tissue density, cortical thickness, white matter integrity, and functional connectivity.  ...  In the course of development, the brain undergoes a remarkable process of restructuring as it adapts to the environment and becomes more efficient in processing information.  ...  Cortical thickness assessments use semiautomated methods to reconstruct 3D representations of the gray matter-white matter boundary and the pial surface, and they calculate the distance between the two  ... 
pmid:24174907 pmcid:PMC3811107 fatcat:mexoj2zudvgevbyyd7eqaygfv4

Structural Imaging Measures of Brain Aging

Samuel N. Lockhart, Charles DeCarli
2014 Neuropsychology Review  
This review predominantly addresses structural MRI biomarkers, such as volumetric or thickness measures from anatomical images, and measures of white matter injury and integrity respectively from FLAIR  ...  Newer findings also suggest that degeneration of specific white matter tracts such as those passing through the genu and splenium of the corpus callosum may also be related to age-related differences in  ...  Cortical Thickness An additional method used for the examination of gray matter tissue shrinkage in aging includes the study of cortical thickness and surface area.  ... 
doi:10.1007/s11065-014-9268-3 pmid:25146995 pmcid:PMC4163469 fatcat:ue4tgbj3ife6hmpkb5c4lyiaua

A Correlational Study between Microstructural White Matter Properties and Macrostructural Gray Matter Volume Across Normal Ageing: Conjoint DTI and VBM Analysis

Vikas Pareek, VP Subramanyam Rallabandi, Prasun K Roy
2018 Magnetic Resonance Insights  
Across the life span, we observed an inter-relationship between the Gray matter and White matter, namely that both Axial diffusivity and Mean Diffusivity show strong correlation with Gray matter volume  ...  We used Voxel-based morphometry, and FDT-FSL analysis for estimation of Gray matter volume and White matter's diffusion indices respectively.  ...  Acknowledgements We extend appreciation to National Neuroimaging Facility, National Brain Research Centre, Manesar, and to School of Bio-Medical Engineering, Indian Institute of Technology, B.H.U., Varanasi  ... 
doi:10.1177/1178623x18799926 pmid:30349289 pmcid:PMC6194920 fatcat:7mrro7tsvfdzxplzgyugmfrx7a

The trajectory of gray matter development in Broca's area is abnormal in people who stutter

Deryk S. Beal, Jason P. Lerch, Brodie Cameron, Rhaeling Henderson, Vincent L. Gracco, Luc F. De Nil
2015 Frontiers in Human Neuroscience  
We hypothesized that the developmental trajectory of cortical thickness in people who stutter would differ across the lifespan in the left pars opercularis relative to a group of control participants.  ...  In people who stutter, the pars opercularis did not demonstrate the typical maturational pattern of gradual gray matter thinning with age across the lifespan that we observed in control participants.  ...  ACKNOWLEDGMENTS Financial support for this project was provided by the Canadian Institutes of Health Research Operating Grant MOP-68969 and the National Institute on Deafness and Other Communication Disorders  ... 
doi:10.3389/fnhum.2015.00089 pmid:25784869 pmcid:PMC4347452 fatcat:3iqymrd3tbfe3o3q2rqrfy33la

Methods and considerations for longitudinal structural brain imaging analysis across development

Kathryn L. Mills, Christian K. Tamnes
2014 Developmental Cognitive Neuroscience  
We focus on measurements of brain morphometry (e.g., volume, cortical thickness, surface area, folding patterns), as well as measurements derived from diffusion tensor imaging (DTI).  ...  This technique has paved the way for longitudinal studies exploring brain changes across the entire life span.  ...  Anne-Lise Goddings for providing the initial inspiration for this review, as well as for many helpful conversations on the topic.  ... 
doi:10.1016/j.dcn.2014.04.004 pmid:24879112 pmcid:PMC6989768 fatcat:bz4k6rrmlfacbbgiqfutax6zwi
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